Roles of STAT3 defined by tissue-specific gene targeting View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-05-25

AUTHORS

Shizuo Akira

ABSTRACT

The physiological role of each individual STAT protein is now being examined through the study of ‘knockout’ (KO) mice, harboring a null allele for the particular gene. In contrast to other STATs deficient mice that are born alive, STAT3-deficient mice die during early embryogenesis. However, the role of STAT3 in adult tissues can be assessed by utilizing the Cre-loxP recombination system to ablate the gene in later life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3 plays a crucial role in a variety of biological functions including cell growth, suppression and induction of apoptosis, and cell motility. More... »

PAGES

2607-2611

References to SciGraph publications

Journal

TITLE

Oncogene

ISSUE

21

VOLUME

19

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1203478

    DOI

    http://dx.doi.org/10.1038/sj.onc.1203478

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002051407

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10851059


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