The role of cyclooxygenases in inflammation, cancer, and development View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-12

AUTHORS

Christopher S Williams, Moss Mann, Raymond N DuBois

ABSTRACT

The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate to PGH2, the immediate substrate for a series of cell specific prostaglandin and thromboxane synthases. Prostaglandins play critical roles in numerous biologic processes, including the regulation of immune function, kidney development, reproductive biology, and gastrointestinal integrity. There are two COX isoforms, which differ mainly in their pattern of expression. COX-1 is expressed in most tissues, whereas COX-2 usually is absent, but is induced by numerous physiologic stimuli. Surprisingly, disruption of Cox1 (Ptgs1) in the mouse did not result in gastrointestinal abnormalities. cox-2 (Ptgs2) null mice show reproductive anomalies and defects in kidney development. Epidemiologic, animal, and human data indicate that NSAIDs, inhibitors of cyclooxygenase, are chemopreventive for colon cancer. COX-2 is overexpressed in 50% of benign polyps and 80-85% of adenocarcinomas. Offspring from cox-2 null by Apcdelta716 matings exhibit an 86% reduction in polyp number when compared to offspring from control animals, thus providing genetic evidence that COX-2 contributes to tumor formation or growth. The in vivo mechanism by which COX-2 affects tumor growth has not been determined. It is possible that both tumor and stromally derived COX-2 could influence tumor angiogenesis and/ or immune function. More... »

PAGES

1203286

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203286

DOI

http://dx.doi.org/10.1038/sj.onc.1203286

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022281051

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10630643


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticarcinogenic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2 Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic and Fetal Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoenzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostaglandin-Endoperoxide Synthases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA", 
            "Department of Cell Biology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Christopher S", 
        "id": "sg:person.013521357262.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013521357262.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA", 
            "Department of Cell Biology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mann", 
        "givenName": "Moss", 
        "id": "sg:person.01175441060.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175441060.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA", 
            "Department of Cell Biology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA", 
            "V.A. Medical Center, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DuBois", 
        "givenName": "Raymond N", 
        "id": "sg:person.0626301614.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626301614.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejm199209103271101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000743618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/20.2.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005298431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.6.3406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006288342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(91)90519-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006519488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(76)90044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007415288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(76)90044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007415288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90126-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010609542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0701076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012820304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.neo.7900024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016357197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2744(199903)24:3<177::aid-mc4>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017100006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.10.4816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017243878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(94)90246-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020082397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(92)91313-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020401916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90125-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020932979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199305063281805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020972146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1993.1343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023391195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(96)70083-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023694261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023711478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024090772", 
          "https://doi.org/10.1038/sj.bjc.6690224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024090772", 
          "https://doi.org/10.1038/sj.bjc.6690224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025487684", 
          "https://doi.org/10.1038/9550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/9550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025487684", 
          "https://doi.org/10.1038/9550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.23.11202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028328960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378406a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028548438", 
          "https://doi.org/10.1038/378406a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0701672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029132114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.38.27307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029363378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/19.12.2195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030456351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1997.v112.pm9024292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032757356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(95)00930-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033106608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/newbio231232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018058", 
          "https://doi.org/10.1038/newbio231232a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/newbio231232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018058", 
          "https://doi.org/10.1038/newbio231232a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/newbio231232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018058", 
          "https://doi.org/10.1038/newbio231232a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v110.pm8613017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034145839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/jme.0.0160107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034379528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034579610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81433-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034592591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.12.5252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034852681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v111.pm8690211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037300471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199112053252301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038254600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1993.1485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038595799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800801244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042686895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.48.1.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043478946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.35.5.675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043787774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045563643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1552-4604.1995.tb04050.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046707109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9610(94)90089-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048030007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80402-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048051791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81988-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048354178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci6400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051166504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.12.1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052270491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.4.1178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052572015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00010a023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055157025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi962476u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055213008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi962476u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055213008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/15.5.1049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059451171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.274.5291.1383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5366.1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5367.1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7291992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062645247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.80.2.7852513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064319337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-114-4-307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073695307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-115-10-787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073695750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076333717", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076604423", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077002881", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1992.263.1.f97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077164991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077328484", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078324262", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1983.245.5.g601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081613572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082212741", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082432988", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082442113", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082446080", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082504432", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082585709", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082640686", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jlb.55.4.476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082672028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082683194", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082808997", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082821489", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895719", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083071654", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083134800", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083159042", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083360569", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-12", 
    "datePublishedReg": "1999-12-01", 
    "description": "The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate to PGH2, the immediate substrate for a series of cell specific prostaglandin and thromboxane synthases. Prostaglandins play critical roles in numerous biologic processes, including the regulation of immune function, kidney development, reproductive biology, and gastrointestinal integrity. There are two COX isoforms, which differ mainly in their pattern of expression. COX-1 is expressed in most tissues, whereas COX-2 usually is absent, but is induced by numerous physiologic stimuli. Surprisingly, disruption of Cox1 (Ptgs1) in the mouse did not result in gastrointestinal abnormalities. cox-2 (Ptgs2) null mice show reproductive anomalies and defects in kidney development. Epidemiologic, animal, and human data indicate that NSAIDs, inhibitors of cyclooxygenase, are chemopreventive for colon cancer. COX-2 is overexpressed in 50% of benign polyps and 80-85% of adenocarcinomas. Offspring from cox-2 null by Apcdelta716 matings exhibit an 86% reduction in polyp number when compared to offspring from control animals, thus providing genetic evidence that COX-2 contributes to tumor formation or growth. The in vivo mechanism by which COX-2 affects tumor growth has not been determined. It is possible that both tumor and stromally derived COX-2 could influence tumor angiogenesis and/ or immune function.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1203286", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435709", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634812", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2495079", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439080", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "55", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "The role of cyclooxygenases in inflammation, cancer, and development", 
    "pagination": "1203286", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6a26c12d3e5039a647ed06c011ec70cb6f1ea34b76dd37725499af605c2af2df"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10630643"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1203286"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022281051"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1203286", 
      "https://app.dimensions.ai/details/publication/pub.1022281051"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29183_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1203286"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203286'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203286'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203286'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203286'


 

This table displays all metadata directly associated to this object as RDF triples.

374 TRIPLES      21 PREDICATES      123 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1203286 schema:about N0cea14b006044fd796a2ff33becca6d6
2 N0ceb199665ef4b3fb6e54045f2082536
3 N19a6df1569694303a6e7f888aa779c93
4 N2b7526d664ef47748a027785115e1fc7
5 N308069d333cb49af82975d11667ecb2e
6 N3f6a94f1cfe54dc29b2562137b8ccb89
7 N6f710c79ff964bfbaa15019f6ca000f9
8 N7c208bb774ee43339a1eeeef3390786e
9 N935b7b859cc24f619a517afb5fb4f74f
10 N95e0a2779241416aaa58527702a0d064
11 N9620be5e66e244639fd2170497d25677
12 Nb4f6eabeb0fa461fa5a1abf595c2c2b4
13 Nbba23400aa314629819b70e9f4e24bcf
14 Ne96bfdd3729941a2b1f9bb8dd740210c
15 Nf84accf6cee749d2beb4a2baade57d79
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author Nfa46399c5b8a467bb0a4797edabb2693
19 schema:citation sg:pub.10.1038/378406a0
20 sg:pub.10.1038/9550
21 sg:pub.10.1038/newbio231232a0
22 sg:pub.10.1038/sj.bjc.6690224
23 https://app.dimensions.ai/details/publication/pub.1076333717
24 https://app.dimensions.ai/details/publication/pub.1076604423
25 https://app.dimensions.ai/details/publication/pub.1077002881
26 https://app.dimensions.ai/details/publication/pub.1077328484
27 https://app.dimensions.ai/details/publication/pub.1078324262
28 https://app.dimensions.ai/details/publication/pub.1082212741
29 https://app.dimensions.ai/details/publication/pub.1082432988
30 https://app.dimensions.ai/details/publication/pub.1082442113
31 https://app.dimensions.ai/details/publication/pub.1082446080
32 https://app.dimensions.ai/details/publication/pub.1082504432
33 https://app.dimensions.ai/details/publication/pub.1082585709
34 https://app.dimensions.ai/details/publication/pub.1082640686
35 https://app.dimensions.ai/details/publication/pub.1082683194
36 https://app.dimensions.ai/details/publication/pub.1082808997
37 https://app.dimensions.ai/details/publication/pub.1082821489
38 https://app.dimensions.ai/details/publication/pub.1082895719
39 https://app.dimensions.ai/details/publication/pub.1083071654
40 https://app.dimensions.ai/details/publication/pub.1083134800
41 https://app.dimensions.ai/details/publication/pub.1083159042
42 https://app.dimensions.ai/details/publication/pub.1083360569
43 https://doi.org/10.1002/(sici)1098-2744(199903)24:3<177::aid-mc4>3.0.co;2-6
44 https://doi.org/10.1002/bjs.1800801244
45 https://doi.org/10.1002/j.1552-4604.1995.tb04050.x
46 https://doi.org/10.1002/jlb.55.4.476
47 https://doi.org/10.1006/abbi.1993.1343
48 https://doi.org/10.1006/abbi.1993.1485
49 https://doi.org/10.1016/0002-9610(94)90089-2
50 https://doi.org/10.1016/0006-291x(92)91313-f
51 https://doi.org/10.1016/0014-2999(76)90044-3
52 https://doi.org/10.1016/0014-5793(95)00930-8
53 https://doi.org/10.1016/0016-5085(91)90519-q
54 https://doi.org/10.1016/0016-5085(94)90246-1
55 https://doi.org/10.1016/0092-8674(95)90125-6
56 https://doi.org/10.1016/0092-8674(95)90126-4
57 https://doi.org/10.1016/s0016-5085(96)70083-5
58 https://doi.org/10.1016/s0092-8674(00)80402-x
59 https://doi.org/10.1016/s0092-8674(00)81433-6
60 https://doi.org/10.1016/s0092-8674(00)81988-1
61 https://doi.org/10.1021/bi00010a023
62 https://doi.org/10.1021/bi962476u
63 https://doi.org/10.1038/sj.bjp.0701076
64 https://doi.org/10.1038/sj.bjp.0701672
65 https://doi.org/10.1038/sj.neo.7900024
66 https://doi.org/10.1053/gast.1996.v110.pm8613017
67 https://doi.org/10.1053/gast.1996.v111.pm8690211
68 https://doi.org/10.1053/gast.1997.v112.pm9024292
69 https://doi.org/10.1056/nejm199112053252301
70 https://doi.org/10.1056/nejm199209103271101
71 https://doi.org/10.1056/nejm199305063281805
72 https://doi.org/10.1073/pnas.86.4.1178
73 https://doi.org/10.1073/pnas.91.12.5252
74 https://doi.org/10.1073/pnas.91.23.11202
75 https://doi.org/10.1073/pnas.93.10.4816
76 https://doi.org/10.1074/jbc.272.6.3406
77 https://doi.org/10.1074/jbc.274.38.27307
78 https://doi.org/10.1093/carcin/15.5.1049
79 https://doi.org/10.1093/carcin/19.12.2195
80 https://doi.org/10.1093/carcin/20.2.185
81 https://doi.org/10.1101/gad.13.12.1561
82 https://doi.org/10.1126/science.274.5291.1383
83 https://doi.org/10.1126/science.280.5366.1036
84 https://doi.org/10.1126/science.280.5367.1268
85 https://doi.org/10.1126/science.7291992
86 https://doi.org/10.1136/gut.35.5.675
87 https://doi.org/10.1152/ajpgi.1983.245.5.g601
88 https://doi.org/10.1152/ajprenal.1992.263.1.f97
89 https://doi.org/10.1172/jci116998
90 https://doi.org/10.1172/jci117620
91 https://doi.org/10.1172/jci119400
92 https://doi.org/10.1172/jci6400
93 https://doi.org/10.1210/jcem.80.2.7852513
94 https://doi.org/10.1677/jme.0.0160107
95 https://doi.org/10.3322/canjclin.48.1.6
96 https://doi.org/10.7326/0003-4819-114-4-307
97 https://doi.org/10.7326/0003-4819-115-10-787
98 schema:datePublished 1999-12
99 schema:datePublishedReg 1999-12-01
100 schema:description The cyclooxygenase (COX) enzymes catalyze a key step in the conversion of arachidonate to PGH2, the immediate substrate for a series of cell specific prostaglandin and thromboxane synthases. Prostaglandins play critical roles in numerous biologic processes, including the regulation of immune function, kidney development, reproductive biology, and gastrointestinal integrity. There are two COX isoforms, which differ mainly in their pattern of expression. COX-1 is expressed in most tissues, whereas COX-2 usually is absent, but is induced by numerous physiologic stimuli. Surprisingly, disruption of Cox1 (Ptgs1) in the mouse did not result in gastrointestinal abnormalities. cox-2 (Ptgs2) null mice show reproductive anomalies and defects in kidney development. Epidemiologic, animal, and human data indicate that NSAIDs, inhibitors of cyclooxygenase, are chemopreventive for colon cancer. COX-2 is overexpressed in 50% of benign polyps and 80-85% of adenocarcinomas. Offspring from cox-2 null by Apcdelta716 matings exhibit an 86% reduction in polyp number when compared to offspring from control animals, thus providing genetic evidence that COX-2 contributes to tumor formation or growth. The in vivo mechanism by which COX-2 affects tumor growth has not been determined. It is possible that both tumor and stromally derived COX-2 could influence tumor angiogenesis and/ or immune function.
101 schema:genre research_article
102 schema:inLanguage en
103 schema:isAccessibleForFree true
104 schema:isPartOf N0873cd5e3c4145aeaf7b632809bbafc1
105 N49b09d35dc5a4c0ca83826484ce1d57f
106 sg:journal.1097543
107 schema:name The role of cyclooxygenases in inflammation, cancer, and development
108 schema:pagination 1203286
109 schema:productId N9b8c4797bed948e2b496a424909a4dc3
110 Na5824d690159419d9222c0a4a5fd1f14
111 Nbb850399ce95484cb5a8e0b314c23e85
112 Nd1766a8737aa418db6b5ea97d14e9727
113 Ndd184bc0c160493881c53c79a4b0e09b
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022281051
115 https://doi.org/10.1038/sj.onc.1203286
116 schema:sdDatePublished 2019-04-11T11:51
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher Ned513fcba3ac4a32ac0159664f3110aa
119 schema:url http://www.nature.com/articles/1203286
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N0873cd5e3c4145aeaf7b632809bbafc1 schema:volumeNumber 18
124 rdf:type schema:PublicationVolume
125 N0cea14b006044fd796a2ff33becca6d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Isoenzymes
127 rdf:type schema:DefinedTerm
128 N0ceb199665ef4b3fb6e54045f2082536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Colonic Neoplasms
130 rdf:type schema:DefinedTerm
131 N19a6df1569694303a6e7f888aa779c93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Animals
133 rdf:type schema:DefinedTerm
134 N2b7526d664ef47748a027785115e1fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mice, Knockout
136 rdf:type schema:DefinedTerm
137 N2f2119d3fdb84f30a1a7aeb838eccf99 rdf:first sg:person.01175441060.52
138 rdf:rest N5b07c0e5b73b4346a29d6552ce27d84b
139 N308069d333cb49af82975d11667ecb2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Prostaglandin-Endoperoxide Synthases
141 rdf:type schema:DefinedTerm
142 N3f6a94f1cfe54dc29b2562137b8ccb89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Membrane Proteins
144 rdf:type schema:DefinedTerm
145 N49b09d35dc5a4c0ca83826484ce1d57f schema:issueNumber 55
146 rdf:type schema:PublicationIssue
147 N5b07c0e5b73b4346a29d6552ce27d84b rdf:first sg:person.0626301614.27
148 rdf:rest rdf:nil
149 N6f710c79ff964bfbaa15019f6ca000f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cyclooxygenase 1
151 rdf:type schema:DefinedTerm
152 N7c208bb774ee43339a1eeeef3390786e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cyclooxygenase Inhibitors
154 rdf:type schema:DefinedTerm
155 N935b7b859cc24f619a517afb5fb4f74f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mice
157 rdf:type schema:DefinedTerm
158 N95e0a2779241416aaa58527702a0d064 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Colorectal Neoplasms
160 rdf:type schema:DefinedTerm
161 N9620be5e66e244639fd2170497d25677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Anticarcinogenic Agents
163 rdf:type schema:DefinedTerm
164 N9b8c4797bed948e2b496a424909a4dc3 schema:name doi
165 schema:value 10.1038/sj.onc.1203286
166 rdf:type schema:PropertyValue
167 Na5824d690159419d9222c0a4a5fd1f14 schema:name dimensions_id
168 schema:value pub.1022281051
169 rdf:type schema:PropertyValue
170 Nb4f6eabeb0fa461fa5a1abf595c2c2b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 Nbb850399ce95484cb5a8e0b314c23e85 schema:name nlm_unique_id
174 schema:value 8711562
175 rdf:type schema:PropertyValue
176 Nbba23400aa314629819b70e9f4e24bcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Cyclooxygenase 2 Inhibitors
178 rdf:type schema:DefinedTerm
179 Nd1766a8737aa418db6b5ea97d14e9727 schema:name readcube_id
180 schema:value 6a26c12d3e5039a647ed06c011ec70cb6f1ea34b76dd37725499af605c2af2df
181 rdf:type schema:PropertyValue
182 Ndd184bc0c160493881c53c79a4b0e09b schema:name pubmed_id
183 schema:value 10630643
184 rdf:type schema:PropertyValue
185 Ne96bfdd3729941a2b1f9bb8dd740210c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Cyclooxygenase 2
187 rdf:type schema:DefinedTerm
188 Ned513fcba3ac4a32ac0159664f3110aa schema:name Springer Nature - SN SciGraph project
189 rdf:type schema:Organization
190 Nf84accf6cee749d2beb4a2baade57d79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Embryonic and Fetal Development
192 rdf:type schema:DefinedTerm
193 Nfa46399c5b8a467bb0a4797edabb2693 rdf:first sg:person.013521357262.17
194 rdf:rest N2f2119d3fdb84f30a1a7aeb838eccf99
195 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
196 schema:name Biological Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
199 schema:name Biochemistry and Cell Biology
200 rdf:type schema:DefinedTerm
201 sg:grant.2435709 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1203286
202 rdf:type schema:MonetaryGrant
203 sg:grant.2439080 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1203286
204 rdf:type schema:MonetaryGrant
205 sg:grant.2495079 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1203286
206 rdf:type schema:MonetaryGrant
207 sg:grant.2634812 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1203286
208 rdf:type schema:MonetaryGrant
209 sg:journal.1097543 schema:issn 0950-9232
210 1476-5594
211 schema:name Oncogene
212 rdf:type schema:Periodical
213 sg:person.01175441060.52 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
214 schema:familyName Mann
215 schema:givenName Moss
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175441060.52
217 rdf:type schema:Person
218 sg:person.013521357262.17 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
219 schema:familyName Williams
220 schema:givenName Christopher S
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013521357262.17
222 rdf:type schema:Person
223 sg:person.0626301614.27 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
224 schema:familyName DuBois
225 schema:givenName Raymond N
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626301614.27
227 rdf:type schema:Person
228 sg:pub.10.1038/378406a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028548438
229 https://doi.org/10.1038/378406a0
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/9550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025487684
232 https://doi.org/10.1038/9550
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/newbio231232a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034018058
235 https://doi.org/10.1038/newbio231232a0
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/sj.bjc.6690224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024090772
238 https://doi.org/10.1038/sj.bjc.6690224
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1076333717 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1076604423 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1077002881 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1077328484 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1078324262 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1082212741 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1082432988 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1082442113 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1082446080 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1082504432 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1082585709 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1082640686 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1082683194 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1082808997 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1082821489 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082895719 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1083071654 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1083134800 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1083159042 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1083360569 schema:CreativeWork
260 https://doi.org/10.1002/(sici)1098-2744(199903)24:3<177::aid-mc4>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017100006
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/bjs.1800801244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042686895
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/j.1552-4604.1995.tb04050.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707109
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/jlb.55.4.476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082672028
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1006/abbi.1993.1343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023391195
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1006/abbi.1993.1485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038595799
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/0002-9610(94)90089-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048030007
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/0006-291x(92)91313-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1020401916
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/0014-2999(76)90044-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007415288
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/0014-5793(95)00930-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033106608
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/0016-5085(91)90519-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1006519488
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/0016-5085(94)90246-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020082397
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/0092-8674(95)90125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020932979
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/0092-8674(95)90126-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010609542
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0016-5085(96)70083-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023694261
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s0092-8674(00)80402-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048051791
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s0092-8674(00)81433-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034592591
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/s0092-8674(00)81988-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048354178
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1021/bi00010a023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055157025
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1021/bi962476u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055213008
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1038/sj.bjp.0701076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012820304
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1038/sj.bjp.0701672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029132114
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1038/sj.neo.7900024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016357197
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1053/gast.1996.v110.pm8613017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034145839
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1053/gast.1996.v111.pm8690211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037300471
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1053/gast.1997.v112.pm9024292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032757356
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1056/nejm199112053252301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038254600
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1056/nejm199209103271101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000743618
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1056/nejm199305063281805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020972146
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1073/pnas.86.4.1178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052572015
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1073/pnas.91.12.5252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034852681
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1073/pnas.91.23.11202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028328960
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.93.10.4816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017243878
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1074/jbc.272.6.3406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006288342
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1074/jbc.274.38.27307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029363378
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1093/carcin/15.5.1049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059451171
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1093/carcin/19.12.2195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030456351
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/carcin/20.2.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005298431
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1101/gad.13.12.1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052270491
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1126/science.274.5291.1383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554942
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1126/science.280.5366.1036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561056
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1126/science.280.5367.1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561190
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1126/science.7291992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062645247
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1136/gut.35.5.675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043787774
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1152/ajpgi.1983.245.5.g601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081613572
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1152/ajprenal.1992.263.1.f97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077164991
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1172/jci116998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034579610
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1172/jci117620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045563643
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1172/jci119400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023711478
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1172/jci6400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051166504
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1210/jcem.80.2.7852513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064319337
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1677/jme.0.0160107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034379528
363 rdf:type schema:CreativeWork
364 https://doi.org/10.3322/canjclin.48.1.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043478946
365 rdf:type schema:CreativeWork
366 https://doi.org/10.7326/0003-4819-114-4-307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073695307
367 rdf:type schema:CreativeWork
368 https://doi.org/10.7326/0003-4819-115-10-787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073695750
369 rdf:type schema:CreativeWork
370 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
371 schema:name Department of Cell Biology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA
372 Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA
373 V.A. Medical Center, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, TN 37232-2279, USA
374 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...