Activators and target genes of Rel/NF-κB transcription factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-11

AUTHORS

Heike L Pahl

ABSTRACT

The vertebrate transcription factor NF-kappaB is induced by over 150 different stimuli. Active NF-kappaB, in turn, participates in the control of transcription of over 150 target genes. Because a large variety of bacteria and viruses activate NF-kappaB and because the transcription factor regulates the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules, NF-kappaB has often been termed a 'central mediator of the human immune response'. This article contains a complete listing of all NF-kappaB inducers and target genes described to date. The collected data argue that NF-kappaB functions more generally as a central regulator of stress responses. In addition, NF-kappaB activation blocks apoptosis in several cell types. Coupling stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults. More... »

PAGES

1203239

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203239

DOI

http://dx.doi.org/10.1038/sj.onc.1203239

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046798251

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10602461


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HOW TO GET THIS DATA PROGRAMMATICALLY:

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RDF/XML is a standard XML format for linked data.

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