Regulation of DNA binding by Rel/NF-κB transcription factors: structural views View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-11

AUTHORS

Frances E Chen, Gourisankar Ghosh

ABSTRACT

Rel/NF-kappaB transcription factors form homo- and heterodimers with different DNA binding site specificities and DNA binding affinities. Several intracellular pathways evoked by a wide range of biological factors and environmental conditions can lead to the activation of Rel/NF-kappaB dimers by signaling degradation of the inhibitory IkappaB protein. In the nucleus Rel/NF-kappaB dimers modulate the expression of a variety of genes including those encoding cytokines, growth factors, acute phase response proteins, immunoreceptors, other transcription factors, cell adhesion molecules, viral proteins and regulators of apoptosis. The primary focus of this review is on structural and functional aspects of Rel/NF-kappaB:DNA complexes and their formation. The salient features of the Rel/NF-kappaB dimer:DNA structure are described, as are modes of transcriptional regulation by phosphorylation, altered DNA binding properties, varying protein conformations, and interactions with IkappaB proteins. More... »

PAGES

1203224

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203224

DOI

http://dx.doi.org/10.1038/sj.onc.1203224

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10602460


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