Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-11-25

AUTHORS

Shuji Nomoto, Nobuhiro Haruki, Takao Takahashi, Akira Masuda, Takashi Koshikawa, Toshitada Takahashi, Yoshitaka Fujii, Hirotaka Osada, Takashi Takahashi

ABSTRACT

We previously reported the presence of mitotic checkpoint impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mutation, which substitutes alanine (GCG) for threonine (ACG) at codon 299, together with a number of amino acid substituting, single nucleotide polymorphisms. This is the first demonstration of hMAD1 mutation in any type of human cancers. The present finding marks hMAD1 as a potential target, although with low frequency, for genetic alterations in lung cancer. Thus, further studies of hMAD1 dysfunction caused by other mechanisms appear to be warranted, as well as potential involvement of other components of the mitotic checkpoint. More... »

PAGES

7180-7183

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203141

DOI

http://dx.doi.org/10.1038/sj.onc.1203141

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001837213

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10597320


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomoto", 
        "givenName": "Shuji", 
        "id": "sg:person.01041163033.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041163033.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery II, Nagoya City University Medical School, 467-8601, Mizuho-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
            "Department of Surgery II, Nagoya City University Medical School, 467-8601, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haruki", 
        "givenName": "Nobuhiro", 
        "id": "sg:person.01207336112.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207336112.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Takao", 
        "id": "sg:person.01215301603.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215301603.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masuda", 
        "givenName": "Akira", 
        "id": "sg:person.013530340105.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013530340105.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, 464-8681, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, 464-8681, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koshikawa", 
        "givenName": "Takashi", 
        "id": "sg:person.0731552331.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731552331.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Immunology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Laboratory of Immunology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Toshitada", 
        "id": "sg:person.015206120374.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015206120374.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery II, Nagoya City University Medical School, 467-8601, Mizuho-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.260433.0", 
          "name": [
            "Department of Surgery II, Nagoya City University Medical School, 467-8601, Mizuho-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujii", 
        "givenName": "Yoshitaka", 
        "id": "sg:person.0601755401.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601755401.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathophysiology Unit, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
            "Pathophysiology Unit, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osada", 
        "givenName": "Hirotaka", 
        "id": "sg:person.01065013051.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065013051.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathophysiology Unit, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan", 
            "Pathophysiology Unit, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Takashi", 
        "id": "sg:person.010323517221.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010323517221.79"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1996.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047250652", 
          "https://doi.org/10.1038/bjc.1996.36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/32688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011887818", 
          "https://doi.org/10.1038/32688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049366469", 
          "https://doi.org/10.1038/sj.onc.1202807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033871070", 
          "https://doi.org/10.1038/25292"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-11-25", 
    "datePublishedReg": "1999-11-25", 
    "description": "We previously reported the presence of mitotic checkpoint impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mutation, which substitutes alanine (GCG) for threonine (ACG) at codon\u2009299, together with a number of amino acid substituting, single nucleotide polymorphisms. This is the first demonstration of hMAD1 mutation in any type of human cancers. The present finding marks hMAD1 as a potential target, although with low frequency, for genetic alterations in lung cancer. Thus, further studies of hMAD1 dysfunction caused by other mechanisms appear to be warranted, as well as potential involvement of other components of the mitotic checkpoint.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1203141", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "50", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "lung cancer", 
      "lung cancer cell lines", 
      "lung cancer specimens", 
      "human lung cancer", 
      "mitotic checkpoint genes", 
      "cancer cell lines", 
      "vivo somatic mutations", 
      "checkpoint genes", 
      "cancer specimens", 
      "non-conservative missense mutation", 
      "cancer", 
      "single nucleotide polymorphisms", 
      "potential target", 
      "genetic alterations", 
      "human cancers", 
      "mitotic checkpoint impairment", 
      "potential involvement", 
      "Further studies", 
      "cell lines", 
      "somatic mutations", 
      "missense mutations", 
      "impairment", 
      "checkpoint impairment", 
      "nucleotide polymorphisms", 
      "mitotic checkpoint", 
      "molecular basis", 
      "alterations", 
      "mutations", 
      "dysfunction", 
      "first demonstration", 
      "genes", 
      "involvement", 
      "low frequency", 
      "polymorphism", 
      "codon", 
      "threonine", 
      "target", 
      "checkpoint", 
      "study", 
      "specimens", 
      "alanine", 
      "presence", 
      "mechanism", 
      "frequency", 
      "lines", 
      "demonstration", 
      "number", 
      "insights", 
      "types", 
      "basis", 
      "components", 
      "substituting"
    ], 
    "name": "Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers", 
    "pagination": "7180-7183", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001837213"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1203141"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10597320"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1203141", 
      "https://app.dimensions.ai/details/publication/pub.1001837213"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T09:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_336.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1203141"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203141'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203141'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203141'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203141'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      22 PREDICATES      93 URIs      81 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1203141 schema:about N0210540a9143478a9db30ccfbaa9b60b
2 N0b3e4f9b76104bccbe6ac15621666273
3 N0e65d06edbdf44df86fb2ac78c305fbe
4 N296c8f0ec3e14028833373ddcf89cdb3
5 N38bd54c2814b423a8bb673a1b83d7f32
6 N39f2082c508648d389a1ffd0cb610c48
7 N41e4c9fcd79d4188bc509adda3b05d41
8 N62077de9a5154be2ae9052e80f021bc7
9 N6d11403b236c47729e227fc50f037a68
10 Nbed6c245912b4b20aa45c1c03da94b6a
11 Ndb6267c9ae8248e2865e7fb9af4ca23d
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N69db6892e25b45228e8067b3a538d25c
15 schema:citation sg:pub.10.1038/25292
16 sg:pub.10.1038/32688
17 sg:pub.10.1038/bjc.1996.36
18 sg:pub.10.1038/sj.onc.1202807
19 schema:datePublished 1999-11-25
20 schema:datePublishedReg 1999-11-25
21 schema:description We previously reported the presence of mitotic checkpoint impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mutation, which substitutes alanine (GCG) for threonine (ACG) at codon 299, together with a number of amino acid substituting, single nucleotide polymorphisms. This is the first demonstration of hMAD1 mutation in any type of human cancers. The present finding marks hMAD1 as a potential target, although with low frequency, for genetic alterations in lung cancer. Thus, further studies of hMAD1 dysfunction caused by other mechanisms appear to be warranted, as well as potential involvement of other components of the mitotic checkpoint.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree true
25 schema:isPartOf N96856c535c5b4ebb94575884eeae8461
26 Ne25c594308a54a7b81288e26834a848c
27 sg:journal.1097543
28 schema:keywords Further studies
29 alanine
30 alterations
31 basis
32 cancer
33 cancer cell lines
34 cancer specimens
35 cell lines
36 checkpoint
37 checkpoint genes
38 checkpoint impairment
39 codon
40 components
41 demonstration
42 dysfunction
43 first demonstration
44 frequency
45 genes
46 genetic alterations
47 human cancers
48 human lung cancer
49 impairment
50 insights
51 involvement
52 lines
53 low frequency
54 lung cancer
55 lung cancer cell lines
56 lung cancer specimens
57 mechanism
58 missense mutations
59 mitotic checkpoint
60 mitotic checkpoint genes
61 mitotic checkpoint impairment
62 molecular basis
63 mutations
64 non-conservative missense mutation
65 nucleotide polymorphisms
66 number
67 polymorphism
68 potential involvement
69 potential target
70 presence
71 single nucleotide polymorphisms
72 somatic mutations
73 specimens
74 study
75 substituting
76 target
77 threonine
78 types
79 vivo somatic mutations
80 schema:name Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers
81 schema:pagination 7180-7183
82 schema:productId N14bdf022163a4e17be498e934393cd64
83 N786652b452694c1281d9d1797b467c67
84 Naca5aed3c53f43d68072325f9d2f8814
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001837213
86 https://doi.org/10.1038/sj.onc.1203141
87 schema:sdDatePublished 2022-05-10T09:49
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher Nb0eb6e86b2bf4452870955452b6306b9
90 schema:url https://doi.org/10.1038/sj.onc.1203141
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0210540a9143478a9db30ccfbaa9b60b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Mutation
96 rdf:type schema:DefinedTerm
97 N0b3e4f9b76104bccbe6ac15621666273 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N0e65d06edbdf44df86fb2ac78c305fbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Nuclear Proteins
102 rdf:type schema:DefinedTerm
103 N12f44a5709b046a982065bd600b8a0b4 rdf:first sg:person.01207336112.63
104 rdf:rest N135fc58a2a394fe3beacbe1b9161dbba
105 N135fc58a2a394fe3beacbe1b9161dbba rdf:first sg:person.01215301603.02
106 rdf:rest N18059eac8ce047a791440993b84c7071
107 N14bdf022163a4e17be498e934393cd64 schema:name pubmed_id
108 schema:value 10597320
109 rdf:type schema:PropertyValue
110 N18059eac8ce047a791440993b84c7071 rdf:first sg:person.013530340105.19
111 rdf:rest N357aeb225c844b67abaefd5cf2c73ae4
112 N296c8f0ec3e14028833373ddcf89cdb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mitosis
114 rdf:type schema:DefinedTerm
115 N357aeb225c844b67abaefd5cf2c73ae4 rdf:first sg:person.0731552331.33
116 rdf:rest Ne4d5eaf5c51f495fa8c1857448a645ce
117 N38bd54c2814b423a8bb673a1b83d7f32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Base Sequence
119 rdf:type schema:DefinedTerm
120 N39f2082c508648d389a1ffd0cb610c48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Lung Neoplasms
122 rdf:type schema:DefinedTerm
123 N41e4c9fcd79d4188bc509adda3b05d41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Phosphoproteins
125 rdf:type schema:DefinedTerm
126 N5870629ec5f64fd8b63b93bc3b880c3b rdf:first sg:person.0601755401.31
127 rdf:rest N948c0c6aad154c31bd472acf7619e916
128 N62077de9a5154be2ae9052e80f021bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name DNA Primers
130 rdf:type schema:DefinedTerm
131 N69db6892e25b45228e8067b3a538d25c rdf:first sg:person.01041163033.36
132 rdf:rest N12f44a5709b046a982065bd600b8a0b4
133 N6d11403b236c47729e227fc50f037a68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Repressor Proteins
135 rdf:type schema:DefinedTerm
136 N786652b452694c1281d9d1797b467c67 schema:name dimensions_id
137 schema:value pub.1001837213
138 rdf:type schema:PropertyValue
139 N948c0c6aad154c31bd472acf7619e916 rdf:first sg:person.01065013051.08
140 rdf:rest N94edf4aa80c44df181c7adc9d2057d30
141 N94edf4aa80c44df181c7adc9d2057d30 rdf:first sg:person.010323517221.79
142 rdf:rest rdf:nil
143 N96856c535c5b4ebb94575884eeae8461 schema:issueNumber 50
144 rdf:type schema:PublicationIssue
145 Naca5aed3c53f43d68072325f9d2f8814 schema:name doi
146 schema:value 10.1038/sj.onc.1203141
147 rdf:type schema:PropertyValue
148 Nb0eb6e86b2bf4452870955452b6306b9 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 Nbed6c245912b4b20aa45c1c03da94b6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Cell Cycle Proteins
152 rdf:type schema:DefinedTerm
153 Ndb6267c9ae8248e2865e7fb9af4ca23d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Carrier Proteins
155 rdf:type schema:DefinedTerm
156 Ne25c594308a54a7b81288e26834a848c schema:volumeNumber 18
157 rdf:type schema:PublicationVolume
158 Ne4d5eaf5c51f495fa8c1857448a645ce rdf:first sg:person.015206120374.50
159 rdf:rest N5870629ec5f64fd8b63b93bc3b880c3b
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
164 schema:name Oncology and Carcinogenesis
165 rdf:type schema:DefinedTerm
166 sg:journal.1097543 schema:issn 0950-9232
167 1476-5594
168 schema:name Oncogene
169 schema:publisher Springer Nature
170 rdf:type schema:Periodical
171 sg:person.010323517221.79 schema:affiliation grid-institutes:grid.410800.d
172 schema:familyName Takahashi
173 schema:givenName Takashi
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010323517221.79
175 rdf:type schema:Person
176 sg:person.01041163033.36 schema:affiliation grid-institutes:grid.410800.d
177 schema:familyName Nomoto
178 schema:givenName Shuji
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041163033.36
180 rdf:type schema:Person
181 sg:person.01065013051.08 schema:affiliation grid-institutes:grid.410800.d
182 schema:familyName Osada
183 schema:givenName Hirotaka
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065013051.08
185 rdf:type schema:Person
186 sg:person.01207336112.63 schema:affiliation grid-institutes:grid.260433.0
187 schema:familyName Haruki
188 schema:givenName Nobuhiro
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207336112.63
190 rdf:type schema:Person
191 sg:person.01215301603.02 schema:affiliation grid-institutes:grid.410800.d
192 schema:familyName Takahashi
193 schema:givenName Takao
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215301603.02
195 rdf:type schema:Person
196 sg:person.013530340105.19 schema:affiliation grid-institutes:grid.410800.d
197 schema:familyName Masuda
198 schema:givenName Akira
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013530340105.19
200 rdf:type schema:Person
201 sg:person.015206120374.50 schema:affiliation grid-institutes:grid.410800.d
202 schema:familyName Takahashi
203 schema:givenName Toshitada
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015206120374.50
205 rdf:type schema:Person
206 sg:person.0601755401.31 schema:affiliation grid-institutes:grid.260433.0
207 schema:familyName Fujii
208 schema:givenName Yoshitaka
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601755401.31
210 rdf:type schema:Person
211 sg:person.0731552331.33 schema:affiliation grid-institutes:grid.410800.d
212 schema:familyName Koshikawa
213 schema:givenName Takashi
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731552331.33
215 rdf:type schema:Person
216 sg:pub.10.1038/25292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033871070
217 https://doi.org/10.1038/25292
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/32688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011887818
220 https://doi.org/10.1038/32688
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/bjc.1996.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047250652
223 https://doi.org/10.1038/bjc.1996.36
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/sj.onc.1202807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049366469
226 https://doi.org/10.1038/sj.onc.1202807
227 rdf:type schema:CreativeWork
228 grid-institutes:grid.260433.0 schema:alternateName Department of Surgery II, Nagoya City University Medical School, 467-8601, Mizuho-ku, Nagoya, Japan
229 schema:name Department of Surgery II, Nagoya City University Medical School, 467-8601, Mizuho-ku, Nagoya, Japan
230 Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan
231 rdf:type schema:Organization
232 grid-institutes:grid.410800.d schema:alternateName Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, 464-8681, Chikusa-ku, Nagoya, Japan
233 Laboratory of Immunology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan
234 Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan
235 Pathophysiology Unit, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan
236 schema:name Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, 464-8681, Chikusa-ku, Nagoya, Japan
237 Laboratory of Immunology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan
238 Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan
239 Pathophysiology Unit, Aichi Cancer Center Research Institute, 1-1 Kanokoden, 464-8681, Chikusa-ku, Nagoya, Japan
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...