Evidence for interaction between human PRUNE and nm23-H1 NDPKinase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-12-08

AUTHORS

Alexandre Reymond, Sara Volorio, Giuseppe Merla, Mai Al-Maghtheh, Orsetta Zuffardi, Alessandro Bulfone, Andrea Ballabio, Massimo Zollo

ABSTRACT

We have isolated a human and murine homologue of the Drosophila prune gene through dbEST searches. The gene is ubiquitously expressed in human adult tissues, while in mouse developing embryos a high level of expression is confined to the nervous system particularly in the dorsal root ganglia, cranial nerves, and neural retina. The gene is composed of eight exons and is located in the 1q21.3 chromosomal region. A pseudogene has been sequenced and mapped to chromosomal region 13q12. PRUNE protein retains the four characteristic domains of DHH phosphoesterases. The synergism between prune and awdK-pn in Drosophila has led various authors to propose an interaction between these genes. However, such an interaction has never been supported by biochemical data. By using interaction-mating and in vitro co-immunoprecipitation experiments, we show for the first time the ability of human PRUNE to interact with the human homologue of awd protein (nm23-H1). In contrast, PRUNE is impaired in its interaction with nm-23-H1-S120G mutant, a gain-of-function mutation associated with advanced neuroblastoma stages. Consistently, PRUNE and nm23-H1 proteins partially colocalize in the cytoplasm. The data presented are consistent with the view that PRUNE acts as a negative regulator of the nm23-H1 protein. We discuss how PRUNE regulates nm23-H1 protein and postulate possible implications of PRUNE in neuroblastoma progression. More... »

PAGES

7244-7252

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203140

DOI

http://dx.doi.org/10.1038/sj.onc.1203140

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026529957

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10602478


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90 neural retina
91 neuroblastoma progression
92 neuroblastoma stages
93 nm23-H1 NDPKinase
94 nm23-H1 protein
95 phosphoesterases
96 possible implications
97 progression
98 protein
99 prune gene
100 prune protein
101 prunes
102 pseudogenes
103 region
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105 regulator
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107 root ganglia
108 search
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