Modulation of cellular apoptotic potential: contributions to oncogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11-01

AUTHORS

Vuk Stambolic, Tak W Mak, James R Woodgett

ABSTRACT

The importance of apoptosis as a natural means to eliminate unwanted or damaged cells has been realized over the past decade. Many components required to exercise programmed cell death have been identified and shown to pre-exist in most, if not all, cells. Such ubiquity requires that apoptosis be tightly controlled and suggests the propensity of cells to trigger the cellular death machinery can be regulated. Recently, several signaling pathways have been demonstrated to impact the apoptotic potential of cells, most notably the phosphatidylinositol 3′ kinase (PI3′K) pathway. The 3′ phosphorylated lipid products generated by this enzyme promote activation of a protein-serine kinase, PKB/AKT, which is necessary and sufficient to confer cell PI3′K-dependent survival signals. The relevance of this pathway to human cancer was revealed by the recent finding that the product of the PTEN tumor suppressor gene acts to antagonize PI3′K. This review focuses on the regulation and mechanisms by which PKB activation protects cells and the oncologic consequences of dysregulation of the pathway. More... »

PAGES

6094-6103

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1203126

    DOI

    http://dx.doi.org/10.1038/sj.onc.1203126

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012402646

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10557100


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