Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11-18

AUTHORS

Mark W Kieran, Steve Katz, Brenda Vail, Leonard I Zon, Bruce J Mayer

ABSTRACT

There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well understood. We show that SEK1/MKK4, a MAP kinase kinase proposed to activate SAPK/JNK, is a very potent inhibitor of p54 SAPKβ/JNK3 both in vitro and in vivo if present at equimolar or higher ratios. In contrast SEK can activate SAPK when present in substoichiometric amounts, but this activation is slow, consistent with the rate-limiting step in activation being the dissociation of an inactive SEK : SAPK complex. The N-terminal unique region of SEK is both necessary and partially sufficient for inhibition of SAPK, and is also necessary for activation of SAPK by SEK in vitro. We have also used the p38 MAP kinase and its activator MKK6 to examine the regulatory relationships among different kinases involved in stress responses. We show using purified kinases that inhibitory activity is specific for the combination of SEK and SAPK: SEK can activate but not inhibit p38, and MKK6 can activate but not inhibit SAPKβ and p38. These results reveal a potential mechanism for regulating stress-activated kinases, adding to a growing body of evidence suggesting that MAP kinases are controlled by relatively stable interactions with their activators. More... »

PAGES

6647-6657

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1203057

DOI

http://dx.doi.org/10.1038/sj.onc.1203057

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017934345

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10597270


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenopus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kieran", 
        "givenName": "Mark W", 
        "id": "sg:person.01112662540.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112662540.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Molecular Genetics, Harvard Medical School, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Microbiology and Molecular Genetics, Harvard Medical School, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katz", 
        "givenName": "Steve", 
        "id": "sg:person.01247670437.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247670437.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vail", 
        "givenName": "Brenda", 
        "id": "sg:person.01303361314.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303361314.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.2515.3", 
          "name": [
            "Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zon", 
        "givenName": "Leonard I", 
        "id": "sg:person.015341736157.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Molecular Genetics, Harvard Medical School, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Microbiology and Molecular Genetics, Harvard Medical School, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayer", 
        "givenName": "Bruce J", 
        "id": "sg:person.01244537451.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/372739a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047199166", 
          "https://doi.org/10.1038/372739a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372794a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012539120", 
          "https://doi.org/10.1038/372794a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369156a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029771272", 
          "https://doi.org/10.1038/369156a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/385350a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045861763", 
          "https://doi.org/10.1038/385350a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/381804a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039976901", 
          "https://doi.org/10.1038/381804a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-11-18", 
    "datePublishedReg": "1999-11-18", 
    "description": "There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well understood. We show that SEK1/MKK4, a MAP kinase kinase proposed to activate SAPK/JNK, is a very potent inhibitor of p54 SAPK\u03b2/JNK3 both in vitro and in vivo if present at equimolar or higher ratios. In contrast SEK can activate SAPK when present in substoichiometric amounts, but this activation is slow, consistent with the rate-limiting step in activation being the dissociation of an inactive SEK\u2009:\u2009SAPK complex. The N-terminal unique region of SEK is both necessary and partially sufficient for inhibition of SAPK, and is also necessary for activation of SAPK by SEK in vitro. We have also used the p38 MAP kinase and its activator MKK6 to examine the regulatory relationships among different kinases involved in stress responses. We show using purified kinases that inhibitory activity is specific for the combination of SEK and SAPK: SEK can activate but not inhibit p38, and MKK6 can activate but not inhibit SAPK\u03b2 and p38. These results reveal a potential mechanism for regulating stress-activated kinases, adding to a growing body of evidence suggesting that MAP kinases are controlled by relatively stable interactions with their activators.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1203057", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "48", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "MAP kinase kinase", 
      "MAP kinase", 
      "kinase kinase", 
      "N-terminal unique region", 
      "family of kinases", 
      "SEK1/MKK4", 
      "MAP kinase cascade", 
      "distinct MAP kinases", 
      "stress-activated kinases", 
      "activation of SAPK", 
      "SAPK/JNK", 
      "p38 MAP kinase", 
      "kinase cascade", 
      "mammalian cells", 
      "different kinases", 
      "negative regulation", 
      "regulatory relationships", 
      "SAPK", 
      "stress response", 
      "kinase", 
      "unique region", 
      "stable interaction", 
      "rate-limiting step", 
      "p38", 
      "potent inhibitor", 
      "activator", 
      "activation", 
      "potential mechanisms", 
      "body of evidence", 
      "MKK6", 
      "MKK4", 
      "JNK", 
      "substoichiometric amounts", 
      "JNK3", 
      "regulation", 
      "inhibitory activity", 
      "mechanism", 
      "cascade", 
      "signal output", 
      "cells", 
      "vivo", 
      "family", 
      "inhibitors", 
      "complexes", 
      "inhibition", 
      "high ratio", 
      "SEK", 
      "specificity", 
      "interaction", 
      "activity", 
      "region", 
      "response", 
      "dissociation", 
      "signals", 
      "evidence", 
      "body", 
      "step", 
      "combination", 
      "amount", 
      "relationship", 
      "module", 
      "results", 
      "ratio", 
      "output", 
      "input signal"
    ], 
    "name": "Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase", 
    "pagination": "6647-6657", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017934345"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1203057"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10597270"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1203057", 
      "https://app.dimensions.ai/details/publication/pub.1017934345"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_323.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1203057"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203057'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203057'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203057'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1203057'


 

This table displays all metadata directly associated to this object as RDF triples.

221 TRIPLES      21 PREDICATES      106 URIs      92 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1203057 schema:about N0005bfebcc8d415d95f71f935920e42c
2 N12daba3869e34440897bf9f25f9a4db6
3 N1b17990b168443b59f557cb1d2cd6b76
4 N1c6c9d8c7b2d4d9b8049bb09cab599b6
5 N2842f928ced54619b1a474388f2bf882
6 N462200a4acfd4d788b43a339d82ad3bd
7 N47e5e836c7d74d5ebc9d3d5c7b5fb041
8 N94d20abead124129adfddab5c60a6c6c
9 Nac4dd7c1140c413db21079bee0ccd69a
10 Neb68164aaa134098b345001ee91649ee
11 anzsrc-for:11
12 anzsrc-for:1103
13 anzsrc-for:1112
14 schema:author N09bc1d3b86834d57af3db5e824097fe9
15 schema:citation sg:pub.10.1038/369156a0
16 sg:pub.10.1038/372739a0
17 sg:pub.10.1038/372794a0
18 sg:pub.10.1038/381804a0
19 sg:pub.10.1038/385350a0
20 schema:datePublished 1999-11-18
21 schema:datePublishedReg 1999-11-18
22 schema:description There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well understood. We show that SEK1/MKK4, a MAP kinase kinase proposed to activate SAPK/JNK, is a very potent inhibitor of p54 SAPKβ/JNK3 both in vitro and in vivo if present at equimolar or higher ratios. In contrast SEK can activate SAPK when present in substoichiometric amounts, but this activation is slow, consistent with the rate-limiting step in activation being the dissociation of an inactive SEK : SAPK complex. The N-terminal unique region of SEK is both necessary and partially sufficient for inhibition of SAPK, and is also necessary for activation of SAPK by SEK in vitro. We have also used the p38 MAP kinase and its activator MKK6 to examine the regulatory relationships among different kinases involved in stress responses. We show using purified kinases that inhibitory activity is specific for the combination of SEK and SAPK: SEK can activate but not inhibit p38, and MKK6 can activate but not inhibit SAPKβ and p38. These results reveal a potential mechanism for regulating stress-activated kinases, adding to a growing body of evidence suggesting that MAP kinases are controlled by relatively stable interactions with their activators.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf Nab5f6d3c64894b8a86b781386a61a359
26 Nb92af3ecdfab4dbf9e46f4e3a7e39a11
27 sg:journal.1097543
28 schema:keywords JNK
29 JNK3
30 MAP kinase
31 MAP kinase cascade
32 MAP kinase kinase
33 MKK4
34 MKK6
35 N-terminal unique region
36 SAPK
37 SAPK/JNK
38 SEK
39 SEK1/MKK4
40 activation
41 activation of SAPK
42 activator
43 activity
44 amount
45 body
46 body of evidence
47 cascade
48 cells
49 combination
50 complexes
51 different kinases
52 dissociation
53 distinct MAP kinases
54 evidence
55 family
56 family of kinases
57 high ratio
58 inhibition
59 inhibitors
60 inhibitory activity
61 input signal
62 interaction
63 kinase
64 kinase cascade
65 kinase kinase
66 mammalian cells
67 mechanism
68 module
69 negative regulation
70 output
71 p38
72 p38 MAP kinase
73 potent inhibitor
74 potential mechanisms
75 rate-limiting step
76 ratio
77 region
78 regulation
79 regulatory relationships
80 relationship
81 response
82 results
83 signal output
84 signals
85 specificity
86 stable interaction
87 step
88 stress response
89 stress-activated kinases
90 substoichiometric amounts
91 unique region
92 vivo
93 schema:name Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase
94 schema:pagination 6647-6657
95 schema:productId N59216ec866bb442586ff21c1796bc5ad
96 Na13a69daa31e4e4caf795e0b55127615
97 Ncc3366a129f24112b3ac206a3d813b81
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017934345
99 https://doi.org/10.1038/sj.onc.1203057
100 schema:sdDatePublished 2022-09-02T15:48
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher N8af301e3e0b94cc5a414a27d0d3e939f
103 schema:url https://doi.org/10.1038/sj.onc.1203057
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N0005bfebcc8d415d95f71f935920e42c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Cell Line
109 rdf:type schema:DefinedTerm
110 N09bc1d3b86834d57af3db5e824097fe9 rdf:first sg:person.01112662540.20
111 rdf:rest N580c22c2e1824da4a2921a0a45e00a2e
112 N12daba3869e34440897bf9f25f9a4db6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Animals
114 rdf:type schema:DefinedTerm
115 N1b17990b168443b59f557cb1d2cd6b76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Rats
117 rdf:type schema:DefinedTerm
118 N1c6c9d8c7b2d4d9b8049bb09cab599b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Molecular Sequence Data
120 rdf:type schema:DefinedTerm
121 N2842f928ced54619b1a474388f2bf882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mitogen-Activated Protein Kinases
123 rdf:type schema:DefinedTerm
124 N2ece9c9092a64f1c88ec1d8808aba624 rdf:first sg:person.01244537451.59
125 rdf:rest rdf:nil
126 N462200a4acfd4d788b43a339d82ad3bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Mitogen-Activated Protein Kinase Kinases
128 rdf:type schema:DefinedTerm
129 N47e5e836c7d74d5ebc9d3d5c7b5fb041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 N580c22c2e1824da4a2921a0a45e00a2e rdf:first sg:person.01247670437.41
133 rdf:rest Nd6dfe97aa94c43999ae6b25dd0dec61e
134 N59216ec866bb442586ff21c1796bc5ad schema:name dimensions_id
135 schema:value pub.1017934345
136 rdf:type schema:PropertyValue
137 N8af301e3e0b94cc5a414a27d0d3e939f schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 N8dcfb4e5d6cd497ba402b92fcb098a1e rdf:first sg:person.015341736157.56
140 rdf:rest N2ece9c9092a64f1c88ec1d8808aba624
141 N94d20abead124129adfddab5c60a6c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Enzyme Activation
143 rdf:type schema:DefinedTerm
144 Na13a69daa31e4e4caf795e0b55127615 schema:name doi
145 schema:value 10.1038/sj.onc.1203057
146 rdf:type schema:PropertyValue
147 Nab5f6d3c64894b8a86b781386a61a359 schema:volumeNumber 18
148 rdf:type schema:PublicationVolume
149 Nac4dd7c1140c413db21079bee0ccd69a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Kinetics
151 rdf:type schema:DefinedTerm
152 Nb92af3ecdfab4dbf9e46f4e3a7e39a11 schema:issueNumber 48
153 rdf:type schema:PublicationIssue
154 Ncc3366a129f24112b3ac206a3d813b81 schema:name pubmed_id
155 schema:value 10597270
156 rdf:type schema:PropertyValue
157 Nd6dfe97aa94c43999ae6b25dd0dec61e rdf:first sg:person.01303361314.36
158 rdf:rest N8dcfb4e5d6cd497ba402b92fcb098a1e
159 Neb68164aaa134098b345001ee91649ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Xenopus
161 rdf:type schema:DefinedTerm
162 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
163 schema:name Medical and Health Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
166 schema:name Clinical Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
169 schema:name Oncology and Carcinogenesis
170 rdf:type schema:DefinedTerm
171 sg:journal.1097543 schema:issn 0950-9232
172 1476-5594
173 schema:name Oncogene
174 schema:publisher Springer Nature
175 rdf:type schema:Periodical
176 sg:person.01112662540.20 schema:affiliation grid-institutes:grid.2515.3
177 schema:familyName Kieran
178 schema:givenName Mark W
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112662540.20
180 rdf:type schema:Person
181 sg:person.01244537451.59 schema:affiliation grid-institutes:grid.38142.3c
182 schema:familyName Mayer
183 schema:givenName Bruce J
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59
185 rdf:type schema:Person
186 sg:person.01247670437.41 schema:affiliation grid-institutes:grid.38142.3c
187 schema:familyName Katz
188 schema:givenName Steve
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247670437.41
190 rdf:type schema:Person
191 sg:person.01303361314.36 schema:affiliation grid-institutes:grid.2515.3
192 schema:familyName Vail
193 schema:givenName Brenda
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303361314.36
195 rdf:type schema:Person
196 sg:person.015341736157.56 schema:affiliation grid-institutes:grid.2515.3
197 schema:familyName Zon
198 schema:givenName Leonard I
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56
200 rdf:type schema:Person
201 sg:pub.10.1038/369156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029771272
202 https://doi.org/10.1038/369156a0
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/372739a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047199166
205 https://doi.org/10.1038/372739a0
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/372794a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012539120
208 https://doi.org/10.1038/372794a0
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/381804a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039976901
211 https://doi.org/10.1038/381804a0
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/385350a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045861763
214 https://doi.org/10.1038/385350a0
215 rdf:type schema:CreativeWork
216 grid-institutes:grid.2515.3 schema:alternateName Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA
217 schema:name Division of Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA
218 rdf:type schema:Organization
219 grid-institutes:grid.38142.3c schema:alternateName Department of Microbiology and Molecular Genetics, Harvard Medical School, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA
220 schema:name Department of Microbiology and Molecular Genetics, Harvard Medical School, Howard Hughes Medical Institute, Children's Hospital, 320 Longwood Avenue, 02115, Boston, Massachusetts, MA, USA
221 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...