Mechanisms of switching on p53: a role for covalent modification? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-12

AUTHORS

David W Meek

ABSTRACT

The p53 protein plays a pivotal role in activating and integrating adaptive cellular responses to a wide range of environmental stresses. Activation of p53 can occur by different molecular routes, depending on the nature of the activating signal. Central to the activation process, by whichever route, is the destabilization of the p53-MDM2 interaction. The molecular mechanisms which activate p53 involve elements of post-translational modification, protein stabilization and protein-protein interaction. Two central themes are emerging from recent work in this area. The first is that there are common events in the p53 activation process among different activating pathways. The second is that activation involves not just a single molecular event such as disruption of the p53-MDM2 interaction, but a series of sequential events the nature of which is governed by the type of activating stimulus. This review summarizes our current knowledge of the p53 activation process in response to two stimuli, DNA damage and activated oncogenes, and considers the contribution made by multisite phosphorylation in determining the nature of the p53 response. More... »

PAGES

1202951

References to SciGraph publications

  • 1998-08. DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site in ONCOGENE
  • 1998-12. ATM associates with and phosphorylates p53: mapping the region of interaction in NATURE GENETICS
  • 1998-08. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage in NATURE
  • 1993-12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 in NATURE
  • 1995-07. Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases in NATURE
  • 1998-09. p19ARF links the tumour suppressor p53 to Ras in NATURE
  • 1999-03. DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation in ONCOGENE
  • 1998-06. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins in NATURE GENETICS
  • 1992-03. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours in NATURE
  • 1997-11. JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases in ONCOGENE
  • 1997-07. Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential in ONCOGENE
  • 1997-05. Regulation of p53 stability by Mdm2 in NATURE
  • 1997-09. Genomic instability and apoptosis are frequent in p53 deficient young mice in ONCOGENE
  • 1993-04. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 in NATURE
  • 1997-04. Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms in ONCOGENE
  • 1997-05. Mdm2 promotes the rapid degradation of p53 in NATURE
  • 1997-10. p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs in ONCOGENE
  • 1999-01. Comparative study of the p53-mdm2 and p53-MDMX interfaces in ONCOGENE
  • 1999-02. Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.onc.1202951

    DOI

    http://dx.doi.org/10.1038/sj.onc.1202951

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039095393

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10618706


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Damage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oncogenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Processing, Post-Translational", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Species Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Protein p53", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ultraviolet Rays", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meek", 
            "givenName": "David W", 
            "id": "sg:person.01344771325.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344771325.80"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1006/scel.1994.1050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000468498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.17.11.6255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000569112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.24.13825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001271606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.7.1805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002965187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.19.2973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003377897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387296a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004301257", 
              "https://doi.org/10.1038/387296a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.10.16.2038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005375077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.3.1751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006170118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/362857a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008690526", 
              "https://doi.org/10.1038/362857a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008796984", 
              "https://doi.org/10.1038/sj.onc.1202014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008796984", 
              "https://doi.org/10.1038/sj.onc.1202014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.7a.1126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009683263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.15.2424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010677913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/24.1.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011946546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012299542", 
              "https://doi.org/10.1038/3882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012299542", 
              "https://doi.org/10.1038/3882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.10.16.2055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013753084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.6.2834", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014535243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90593-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014799709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90244-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014811237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.11.24.3471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015398377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366704a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015821919", 
              "https://doi.org/10.1038/366704a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.1.159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016058982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/29343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016163271", 
              "https://doi.org/10.1038/29343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/29343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016163271", 
              "https://doi.org/10.1038/29343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016851853", 
              "https://doi.org/10.1038/25870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.15.2434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017695723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi970759w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017737883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi970759w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017737883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0898-6568(97)00119-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017890201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80416-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018480669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.11.6399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021017422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80452-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021286113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024634861", 
              "https://doi.org/10.1038/sj.onc.1201037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024634861", 
              "https://doi.org/10.1038/sj.onc.1201037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.5.2284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025041048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90214-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025466811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.49.33048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026140048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026441349", 
              "https://doi.org/10.1038/sj.onc.1201482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026441349", 
              "https://doi.org/10.1038/sj.onc.1201482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/356215a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027559823", 
              "https://doi.org/10.1038/356215a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.2.152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028446157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.2.1202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028830383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.31.18626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029379604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.14.8292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029931314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030360781", 
              "https://doi.org/10.1038/sj.onc.1201174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030360781", 
              "https://doi.org/10.1038/sj.onc.1201174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.18.2831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030715028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.10.5405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030818245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.17.10.5923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031334757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90562-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032297023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033043235", 
              "https://doi.org/10.1038/sj.onc.1201401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033043235", 
              "https://doi.org/10.1038/sj.onc.1201401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.13.7445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034383084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034617899", 
              "https://doi.org/10.1038/542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034617899", 
              "https://doi.org/10.1038/542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035478532", 
              "https://doi.org/10.1038/sj.onc.1202454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035478532", 
              "https://doi.org/10.1038/sj.onc.1202454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035546615", 
              "https://doi.org/10.1038/sj.onc.1202281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035546615", 
              "https://doi.org/10.1038/sj.onc.1202281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035786989", 
              "https://doi.org/10.1038/sj.onc.1201541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035786989", 
              "https://doi.org/10.1038/sj.onc.1201541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036191397", 
              "https://doi.org/10.1038/sj.onc.1202480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036191397", 
              "https://doi.org/10.1038/sj.onc.1202480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387299a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037935695", 
              "https://doi.org/10.1038/387299a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.7.1815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038347422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.1.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038415220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.270.10.5511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038475688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90243-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039400395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.10.12.6472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039625699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.17.5001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041283101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.46.29380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042083315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(06)00374-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043267646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.17.2658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043481099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043798122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043798122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.18.10541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044142458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.19.3008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045402908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81400-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045408048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.17.12.7220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045458241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/23.14.2584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045737863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81401-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047534651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.12.11.5041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049237754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376088a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049499733", 
              "https://doi.org/10.1038/376088a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.5.1686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050407437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80521-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050450850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.23.11627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051052233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(00)89090-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051543108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.1.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051882779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.1994.059.01.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060406575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5383.1674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062562416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5383.1677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062562417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077122392", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07524.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078374929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082392354", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082584332", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082720599", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082720611", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05941.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082762184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05678.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082807455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082915079", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082961710", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083027626", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083173468", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083288847", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083328706", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1999-12", 
        "datePublishedReg": "1999-12-01", 
        "description": "The p53 protein plays a pivotal role in activating and integrating adaptive cellular responses to a wide range of environmental stresses. Activation of p53 can occur by different molecular routes, depending on the nature of the activating signal. Central to the activation process, by whichever route, is the destabilization of the p53-MDM2 interaction. The molecular mechanisms which activate p53 involve elements of post-translational modification, protein stabilization and protein-protein interaction. Two central themes are emerging from recent work in this area. The first is that there are common events in the p53 activation process among different activating pathways. The second is that activation involves not just a single molecular event such as disruption of the p53-MDM2 interaction, but a series of sequential events the nature of which is governed by the type of activating stimulus. This review summarizes our current knowledge of the p53 activation process in response to two stimuli, DNA damage and activated oncogenes, and considers the contribution made by multisite phosphorylation in determining the nature of the p53 response.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.onc.1202951", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "53", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "Mechanisms of switching on p53: a role for covalent modification?", 
        "pagination": "1202951", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ba3b2503813c9d5e1a9ff3c95cb9887a94539351be338929d9bf3486effe52ff"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "10618706"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.onc.1202951"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1039095393"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.onc.1202951", 
          "https://app.dimensions.ai/details/publication/pub.1039095393"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29207_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/1202951"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202951'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202951'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202951'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202951'


     

    This table displays all metadata directly associated to this object as RDF triples.

    392 TRIPLES      21 PREDICATES      131 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.onc.1202951 schema:about N17aef36d8677470d8f181c422468bf70
    2 N4e17ca5f44cc4d3292dfb3193c364976
    3 N59254006cf7d447bbb1366b1d1e36713
    4 N645f48d1f8bd41f3b286405eebb45d99
    5 N948e92c5d513467c82718be3d18d5ed9
    6 Nb6f5266bf2c9494fae398d641289935b
    7 Nb8dc264f5e954036a23f5cfbfe293c07
    8 Nba04196946c04d049b8a24235305c503
    9 Necd9614b27f34f108d4cfb6abc0c0c17
    10 Nf071b5c09e6c453aa5f82c3bb4d5de57
    11 anzsrc-for:06
    12 anzsrc-for:0601
    13 schema:author Nded301b5afe542ff947161d817b5aa4b
    14 schema:citation sg:pub.10.1038/25870
    15 sg:pub.10.1038/29343
    16 sg:pub.10.1038/356215a0
    17 sg:pub.10.1038/362857a0
    18 sg:pub.10.1038/366704a0
    19 sg:pub.10.1038/376088a0
    20 sg:pub.10.1038/387296a0
    21 sg:pub.10.1038/387299a0
    22 sg:pub.10.1038/3882
    23 sg:pub.10.1038/542
    24 sg:pub.10.1038/sj.onc.1201037
    25 sg:pub.10.1038/sj.onc.1201174
    26 sg:pub.10.1038/sj.onc.1201401
    27 sg:pub.10.1038/sj.onc.1201482
    28 sg:pub.10.1038/sj.onc.1201541
    29 sg:pub.10.1038/sj.onc.1202014
    30 sg:pub.10.1038/sj.onc.1202281
    31 sg:pub.10.1038/sj.onc.1202454
    32 sg:pub.10.1038/sj.onc.1202480
    33 https://app.dimensions.ai/details/publication/pub.1077122392
    34 https://app.dimensions.ai/details/publication/pub.1082392354
    35 https://app.dimensions.ai/details/publication/pub.1082584332
    36 https://app.dimensions.ai/details/publication/pub.1082720599
    37 https://app.dimensions.ai/details/publication/pub.1082720611
    38 https://app.dimensions.ai/details/publication/pub.1082915079
    39 https://app.dimensions.ai/details/publication/pub.1082961710
    40 https://app.dimensions.ai/details/publication/pub.1083027626
    41 https://app.dimensions.ai/details/publication/pub.1083173468
    42 https://app.dimensions.ai/details/publication/pub.1083288847
    43 https://app.dimensions.ai/details/publication/pub.1083328706
    44 https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.0.co;2-3
    45 https://doi.org/10.1002/j.1460-2075.1990.tb07524.x
    46 https://doi.org/10.1002/j.1460-2075.1993.tb05678.x
    47 https://doi.org/10.1002/j.1460-2075.1993.tb05941.x
    48 https://doi.org/10.1006/scel.1994.1050
    49 https://doi.org/10.1016/0092-8674(92)90243-6
    50 https://doi.org/10.1016/0092-8674(92)90244-7
    51 https://doi.org/10.1016/0092-8674(92)90562-q
    52 https://doi.org/10.1016/0092-8674(92)90593-2
    53 https://doi.org/10.1016/0092-8674(95)90214-7
    54 https://doi.org/10.1016/s0092-8674(00)80416-x
    55 https://doi.org/10.1016/s0092-8674(00)80452-3
    56 https://doi.org/10.1016/s0092-8674(00)80521-8
    57 https://doi.org/10.1016/s0092-8674(00)81400-2
    58 https://doi.org/10.1016/s0092-8674(00)81401-4
    59 https://doi.org/10.1016/s0898-6568(97)00119-8
    60 https://doi.org/10.1016/s0960-9822(06)00374-5
    61 https://doi.org/10.1016/s0968-0004(00)89090-8
    62 https://doi.org/10.1021/bi970759w
    63 https://doi.org/10.1073/pnas.89.23.11627
    64 https://doi.org/10.1073/pnas.93.24.13825
    65 https://doi.org/10.1073/pnas.94.5.1686
    66 https://doi.org/10.1073/pnas.95.11.6399
    67 https://doi.org/10.1073/pnas.95.13.7445
    68 https://doi.org/10.1073/pnas.95.14.8292
    69 https://doi.org/10.1073/pnas.95.18.10541
    70 https://doi.org/10.1073/pnas.95.5.2284
    71 https://doi.org/10.1073/pnas.95.6.2834
    72 https://doi.org/10.1074/jbc.270.10.5405
    73 https://doi.org/10.1074/jbc.270.10.5511
    74 https://doi.org/10.1074/jbc.270.31.18626
    75 https://doi.org/10.1074/jbc.271.46.29380
    76 https://doi.org/10.1074/jbc.273.1.1
    77 https://doi.org/10.1074/jbc.273.49.33048
    78 https://doi.org/10.1093/emboj/17.1.159
    79 https://doi.org/10.1093/emboj/17.17.5001
    80 https://doi.org/10.1093/emboj/18.1.22
    81 https://doi.org/10.1093/emboj/18.7.1805
    82 https://doi.org/10.1093/emboj/18.7.1815
    83 https://doi.org/10.1093/nar/23.14.2584
    84 https://doi.org/10.1093/nar/24.1.141
    85 https://doi.org/10.1101/gad.10.16.2038
    86 https://doi.org/10.1101/gad.10.16.2055
    87 https://doi.org/10.1101/gad.11.24.3471
    88 https://doi.org/10.1101/gad.12.15.2424
    89 https://doi.org/10.1101/gad.12.15.2434
    90 https://doi.org/10.1101/gad.12.17.2658
    91 https://doi.org/10.1101/gad.12.18.2831
    92 https://doi.org/10.1101/gad.12.19.2973
    93 https://doi.org/10.1101/gad.12.19.3008
    94 https://doi.org/10.1101/gad.13.2.152
    95 https://doi.org/10.1101/gad.7.7a.1126
    96 https://doi.org/10.1101/sqb.1994.059.01.024
    97 https://doi.org/10.1126/science.281.5383.1674
    98 https://doi.org/10.1126/science.281.5383.1677
    99 https://doi.org/10.1128/mcb.10.12.6472
    100 https://doi.org/10.1128/mcb.12.11.5041
    101 https://doi.org/10.1128/mcb.17.10.5923
    102 https://doi.org/10.1128/mcb.17.11.6255
    103 https://doi.org/10.1128/mcb.17.12.7220
    104 https://doi.org/10.1128/mcb.19.2.1202
    105 https://doi.org/10.1128/mcb.19.3.1751
    106 schema:datePublished 1999-12
    107 schema:datePublishedReg 1999-12-01
    108 schema:description The p53 protein plays a pivotal role in activating and integrating adaptive cellular responses to a wide range of environmental stresses. Activation of p53 can occur by different molecular routes, depending on the nature of the activating signal. Central to the activation process, by whichever route, is the destabilization of the p53-MDM2 interaction. The molecular mechanisms which activate p53 involve elements of post-translational modification, protein stabilization and protein-protein interaction. Two central themes are emerging from recent work in this area. The first is that there are common events in the p53 activation process among different activating pathways. The second is that activation involves not just a single molecular event such as disruption of the p53-MDM2 interaction, but a series of sequential events the nature of which is governed by the type of activating stimulus. This review summarizes our current knowledge of the p53 activation process in response to two stimuli, DNA damage and activated oncogenes, and considers the contribution made by multisite phosphorylation in determining the nature of the p53 response.
    109 schema:genre research_article
    110 schema:inLanguage en
    111 schema:isAccessibleForFree true
    112 schema:isPartOf N752f1be3458f4a27be3a8fb54a018a30
    113 N91658ec82cf9461e9c46f39f92939c85
    114 sg:journal.1097543
    115 schema:name Mechanisms of switching on p53: a role for covalent modification?
    116 schema:pagination 1202951
    117 schema:productId N5b19bdc45f97423bb31f3eaac65023c0
    118 N747fca4b2b95475297b446836107871d
    119 N86488da5e53444448b90d6cf44f32ec2
    120 Na26c8c3efda44fa6b7f388f32b1496ea
    121 Na75f8b74cf2e45c29f525288a7d96794
    122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039095393
    123 https://doi.org/10.1038/sj.onc.1202951
    124 schema:sdDatePublished 2019-04-11T11:55
    125 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    126 schema:sdPublisher N7c8c107bd7324613b39e21e708bf2f30
    127 schema:url http://www.nature.com/articles/1202951
    128 sgo:license sg:explorer/license/
    129 sgo:sdDataset articles
    130 rdf:type schema:ScholarlyArticle
    131 N17aef36d8677470d8f181c422468bf70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Tumor Suppressor Protein p53
    133 rdf:type schema:DefinedTerm
    134 N40cf2c8d85614776bb5e94020692136a schema:name Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    135 rdf:type schema:Organization
    136 N4e17ca5f44cc4d3292dfb3193c364976 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Ultraviolet Rays
    138 rdf:type schema:DefinedTerm
    139 N59254006cf7d447bbb1366b1d1e36713 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Phosphorylation
    141 rdf:type schema:DefinedTerm
    142 N5b19bdc45f97423bb31f3eaac65023c0 schema:name dimensions_id
    143 schema:value pub.1039095393
    144 rdf:type schema:PropertyValue
    145 N645f48d1f8bd41f3b286405eebb45d99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Protein Processing, Post-Translational
    147 rdf:type schema:DefinedTerm
    148 N747fca4b2b95475297b446836107871d schema:name nlm_unique_id
    149 schema:value 8711562
    150 rdf:type schema:PropertyValue
    151 N752f1be3458f4a27be3a8fb54a018a30 schema:volumeNumber 18
    152 rdf:type schema:PublicationVolume
    153 N7c8c107bd7324613b39e21e708bf2f30 schema:name Springer Nature - SN SciGraph project
    154 rdf:type schema:Organization
    155 N86488da5e53444448b90d6cf44f32ec2 schema:name doi
    156 schema:value 10.1038/sj.onc.1202951
    157 rdf:type schema:PropertyValue
    158 N91658ec82cf9461e9c46f39f92939c85 schema:issueNumber 53
    159 rdf:type schema:PublicationIssue
    160 N948e92c5d513467c82718be3d18d5ed9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Protein Kinases
    162 rdf:type schema:DefinedTerm
    163 Na26c8c3efda44fa6b7f388f32b1496ea schema:name readcube_id
    164 schema:value ba3b2503813c9d5e1a9ff3c95cb9887a94539351be338929d9bf3486effe52ff
    165 rdf:type schema:PropertyValue
    166 Na75f8b74cf2e45c29f525288a7d96794 schema:name pubmed_id
    167 schema:value 10618706
    168 rdf:type schema:PropertyValue
    169 Nb6f5266bf2c9494fae398d641289935b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Animals
    171 rdf:type schema:DefinedTerm
    172 Nb8dc264f5e954036a23f5cfbfe293c07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name DNA Damage
    174 rdf:type schema:DefinedTerm
    175 Nba04196946c04d049b8a24235305c503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Species Specificity
    177 rdf:type schema:DefinedTerm
    178 Nded301b5afe542ff947161d817b5aa4b rdf:first sg:person.01344771325.80
    179 rdf:rest rdf:nil
    180 Necd9614b27f34f108d4cfb6abc0c0c17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Oncogenes
    182 rdf:type schema:DefinedTerm
    183 Nf071b5c09e6c453aa5f82c3bb4d5de57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Humans
    185 rdf:type schema:DefinedTerm
    186 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Biological Sciences
    188 rdf:type schema:DefinedTerm
    189 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    190 schema:name Biochemistry and Cell Biology
    191 rdf:type schema:DefinedTerm
    192 sg:journal.1097543 schema:issn 0950-9232
    193 1476-5594
    194 schema:name Oncogene
    195 rdf:type schema:Periodical
    196 sg:person.01344771325.80 schema:affiliation N40cf2c8d85614776bb5e94020692136a
    197 schema:familyName Meek
    198 schema:givenName David W
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344771325.80
    200 rdf:type schema:Person
    201 sg:pub.10.1038/25870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016851853
    202 https://doi.org/10.1038/25870
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/29343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016163271
    205 https://doi.org/10.1038/29343
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/356215a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027559823
    208 https://doi.org/10.1038/356215a0
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/362857a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008690526
    211 https://doi.org/10.1038/362857a0
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/366704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015821919
    214 https://doi.org/10.1038/366704a0
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/376088a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049499733
    217 https://doi.org/10.1038/376088a0
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/387296a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004301257
    220 https://doi.org/10.1038/387296a0
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/387299a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037935695
    223 https://doi.org/10.1038/387299a0
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/3882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012299542
    226 https://doi.org/10.1038/3882
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034617899
    229 https://doi.org/10.1038/542
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/sj.onc.1201037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024634861
    232 https://doi.org/10.1038/sj.onc.1201037
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/sj.onc.1201174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030360781
    235 https://doi.org/10.1038/sj.onc.1201174
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/sj.onc.1201401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033043235
    238 https://doi.org/10.1038/sj.onc.1201401
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/sj.onc.1201482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026441349
    241 https://doi.org/10.1038/sj.onc.1201482
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/sj.onc.1201541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035786989
    244 https://doi.org/10.1038/sj.onc.1201541
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/sj.onc.1202014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008796984
    247 https://doi.org/10.1038/sj.onc.1202014
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/sj.onc.1202281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035546615
    250 https://doi.org/10.1038/sj.onc.1202281
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/sj.onc.1202454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035478532
    253 https://doi.org/10.1038/sj.onc.1202454
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/sj.onc.1202480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036191397
    256 https://doi.org/10.1038/sj.onc.1202480
    257 rdf:type schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1077122392 schema:CreativeWork
    259 https://app.dimensions.ai/details/publication/pub.1082392354 schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1082584332 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1082720599 schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1082720611 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1082915079 schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1082961710 schema:CreativeWork
    265 https://app.dimensions.ai/details/publication/pub.1083027626 schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1083173468 schema:CreativeWork
    267 https://app.dimensions.ai/details/publication/pub.1083288847 schema:CreativeWork
    268 https://app.dimensions.ai/details/publication/pub.1083328706 schema:CreativeWork
    269 https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043798122
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/j.1460-2075.1990.tb07524.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078374929
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/j.1460-2075.1993.tb05678.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082807455
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/j.1460-2075.1993.tb05941.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082762184
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1006/scel.1994.1050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000468498
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/0092-8674(92)90243-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039400395
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/0092-8674(92)90244-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014811237
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/0092-8674(92)90562-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1032297023
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/0092-8674(92)90593-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014799709
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/0092-8674(95)90214-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025466811
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s0092-8674(00)80416-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018480669
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/s0092-8674(00)80452-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021286113
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/s0092-8674(00)80521-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050450850
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/s0092-8674(00)81400-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045408048
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/s0092-8674(00)81401-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047534651
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/s0898-6568(97)00119-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017890201
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0960-9822(06)00374-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043267646
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0968-0004(00)89090-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051543108
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1021/bi970759w schema:sameAs https://app.dimensions.ai/details/publication/pub.1017737883
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1073/pnas.89.23.11627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051052233
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1073/pnas.93.24.13825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001271606
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1073/pnas.94.5.1686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050407437
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1073/pnas.95.11.6399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021017422
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1073/pnas.95.13.7445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034383084
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1073/pnas.95.14.8292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029931314
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.95.18.10541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044142458
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.95.5.2284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025041048
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1073/pnas.95.6.2834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014535243
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1074/jbc.270.10.5405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030818245
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1074/jbc.270.10.5511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038475688
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1074/jbc.270.31.18626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029379604
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1074/jbc.271.46.29380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042083315
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1074/jbc.273.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038415220
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1074/jbc.273.49.33048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026140048
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/emboj/17.1.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016058982
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1093/emboj/17.17.5001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041283101
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1093/emboj/18.1.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051882779
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1093/emboj/18.7.1805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002965187
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1093/emboj/18.7.1815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038347422
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1093/nar/23.14.2584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045737863
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1093/nar/24.1.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011946546
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1101/gad.10.16.2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005375077
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1101/gad.10.16.2055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013753084
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1101/gad.11.24.3471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015398377
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1101/gad.12.15.2424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010677913
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1101/gad.12.15.2434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017695723
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1101/gad.12.17.2658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043481099
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1101/gad.12.18.2831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030715028
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1101/gad.12.19.2973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003377897
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1101/gad.12.19.3008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045402908
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1101/gad.13.2.152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028446157
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1101/gad.7.7a.1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009683263
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1101/sqb.1994.059.01.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060406575
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1126/science.281.5383.1674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562416
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1126/science.281.5383.1677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562417
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1128/mcb.10.12.6472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039625699
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1128/mcb.12.11.5041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049237754
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1128/mcb.17.10.5923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031334757
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1128/mcb.17.11.6255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000569112
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1128/mcb.17.12.7220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045458241
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1128/mcb.19.2.1202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028830383
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1128/mcb.19.3.1751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006170118
    392 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...