Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-06

AUTHORS

Sabine Kirchhoff, Hansjörg Hauser

ABSTRACT

The tumor suppressor transcription factor IRF-1 inhibits cell growth. In this report we show that IRF-1 also induces apoptosis of highly transformed and tumorigenic cell lines. This activity of IRF-1 is demonstrated with cell lines expressing HER oncogenes and an activatable IRF-1 fusion protein. Growth of cell lines expressing inactive HER1 is inhibited on IRF-1 activation. In contrast, the same cells are killed by apoptosis when HER1 and IRF-1 are activated simultaneously. We identified promoters stimulated synergistically by IRF-1 and by activated HER1. To determine the signals causing transcriptional synergism and/or apoptosis we tried to modulate these effects by various dominant negative acting proteins. Dominant negative STAT5alpha abolished both induction of apoptosis and transcriptional synergy of IRF-1 and HER. Thus, these results provide new insights into the mechanism of oncogene-dependent apoptosis induced by the activation of a tumor suppressor. More... »

PAGES

1202704

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202704

DOI

http://dx.doi.org/10.1038/sj.onc.1202704

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021162380

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10391680


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