p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-06

AUTHORS

Ian de Belle, Ruo-Pan Huang, Yan Fan, Chaoting Liu, Dan Mercola, Eileen D Adamson

ABSTRACT

The human fibrosarcoma cell line, HT1080, clone H4, was used to determine if the transformation suppressive functions of p53 and Egr-1 have the same underlying mechanism. This cell line expresses only mutant p53 and no detectable Egr-1. H4 clones stably expressing Egr-1 are less transformed in proportion to the level of Egr-1 expressed, acting through the induction of the TGFbeta1 gene. Here, H4 cells and the highest Egr-1 expressing clone were transfected with a vector expressing normal human p53 to derive stable clones expressing p53. The expression of p53 in H4 cells inhibited transformed growth and reduced tumorigenicity. The effect of coexpression of both p53 and Egr-1 was additive, producing cell lines with 30% of normal growth rate and sevenfold reduced tumorigenicity compared with control lines. These results indicated that each factor may act independently by different pathways, although each additively increased the level of p21WAF1 cell cycle inhibitor. However, exposure of the H4-derived cells to UV-C irradiation produced contrasting effects. Cell cycle analyses showed that the presence of p53 was associated with loss of the G1 and S cells to apoptosis after irradiation. In contrast, the expression of Egr-1 increased entry into S/G2 phase of the cell cycle with little apoptosis via a mechanism involving elevated FAK and low caspase activities. Apoptosis was observed only in the cell lines that expressed no Egr-1, especially those expressing wt-p53, and was preceded by high caspase activity. In summary, Egr-1 suppressed transformation and counteracted apoptosis by the coordinated activation of TGFbeta1, FN, p21 and FAK, leading to enhanced cell attachment and reduced caspase activity. In the doubly expressing cell line, the survival effect of Egr-1 was dominant over the apoptotic effect of p53. More... »

PAGES

1202696

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202696

DOI

http://dx.doi.org/10.1038/sj.onc.1202696

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040304525

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10380885


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Calmodulin-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinogenicity Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion Molecules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p21", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Fragmentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Early Growth Response Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Focal Adhesion Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Focal Adhesion Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immediate-Early Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "JNK Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultraviolet Rays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "La Jolla Cancer Research Center, The Burnham Institute, 10901, N Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Belle", 
        "givenName": "Ian", 
        "id": "sg:person.0575727644.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575727644.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwest Hospital and Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416561.1", 
          "name": [
            "Molecular Medicine, Northwest Hospital, 120 Northgate Plaza, Suite 230, Seattle, Washington, WA 98125, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Ruo-Pan", 
        "id": "sg:person.013654676132.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013654676132.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwest Hospital and Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416561.1", 
          "name": [
            "Molecular Medicine, Northwest Hospital, 120 Northgate Plaza, Suite 230, Seattle, Washington, WA 98125, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fan", 
        "givenName": "Yan", 
        "id": "sg:person.0727361665.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727361665.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California, CA 92121, USA", 
            "Center for Molecular Genetics, University of California at San Diego, California, CA 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Chaoting", 
        "id": "sg:person.0731440272.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731440272.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California, CA 92121, USA", 
            "Center for Molecular Genetics, University of California at San Diego, California, CA 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mercola", 
        "givenName": "Dan", 
        "id": "sg:person.01161073200.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161073200.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "La Jolla Cancer Research Center, The Burnham Institute, 10901, N Torrey Pines Road, La Jolla, California, CA 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adamson", 
        "givenName": "Eileen D", 
        "id": "sg:person.01034452734.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034452734.65"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.272.44.27987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000334819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81871-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005306554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.135.5.1383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006890328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.7.4400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007157099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1996.tb00233.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007975083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1996.tb00233.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007975083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.124.4.619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009095815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.36.21898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009490741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90485-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011190436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90660-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011430147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.7.3756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011842334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240560407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012966834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.240560407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012966834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.21.11831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013361369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015400453", 
          "https://doi.org/10.1038/40901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015400453", 
          "https://doi.org/10.1038/40901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(05)80340-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016143886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-437x(05)80340-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016143886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19980911)77:6<880::aid-ijc14>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016740892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19970703)72:1<102::aid-ijc15>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019254523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.52.33056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020612501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1327.1998.2570242.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022698749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.133.1.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025497969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.12.1455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029067214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12332650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029100119", 
          "https://doi.org/10.1111/1523-1747.ep12332650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0027-5107(95)00103-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029942076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)90539-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030044599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.134.3.793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030212510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.32.20131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032908309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.13.6161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034625653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90500-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038576682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.17.2184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039966261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.11.6262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040670318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.139.2.529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040714789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.30.19207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041112412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.7.11.2135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041334361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.41.26056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042288759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044476393", 
          "https://doi.org/10.1038/sj.onc.1201091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044476393", 
          "https://doi.org/10.1038/sj.onc.1201091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4400322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044892511", 
          "https://doi.org/10.1038/sj.cdd.4400322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4400322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044892511", 
          "https://doi.org/10.1038/sj.cdd.4400322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.51.30303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046938020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.46.29231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049367172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0898-6568(97)89890-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050810740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.127.4.1085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052928353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.11.5772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053488905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.1994.059.01.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060406577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2144057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062524133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424564", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082439519", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082470986", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082532972", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082659570", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082675989", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082690820", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082698918", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082741001", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082855807", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082962696", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083054065", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083099541", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083110105", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083130775", 
          "https://doi.org/10.1007/bf03401691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083148244", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083200942", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083254211", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-06", 
    "datePublishedReg": "1999-06-01", 
    "description": "The human fibrosarcoma cell line, HT1080, clone H4, was used to determine if the transformation suppressive functions of p53 and Egr-1 have the same underlying mechanism. This cell line expresses only mutant p53 and no detectable Egr-1. H4 clones stably expressing Egr-1 are less transformed in proportion to the level of Egr-1 expressed, acting through the induction of the TGFbeta1 gene. Here, H4 cells and the highest Egr-1 expressing clone were transfected with a vector expressing normal human p53 to derive stable clones expressing p53. The expression of p53 in H4 cells inhibited transformed growth and reduced tumorigenicity. The effect of coexpression of both p53 and Egr-1 was additive, producing cell lines with 30% of normal growth rate and sevenfold reduced tumorigenicity compared with control lines. These results indicated that each factor may act independently by different pathways, although each additively increased the level of p21WAF1 cell cycle inhibitor. However, exposure of the H4-derived cells to UV-C irradiation produced contrasting effects. Cell cycle analyses showed that the presence of p53 was associated with loss of the G1 and S cells to apoptosis after irradiation. In contrast, the expression of Egr-1 increased entry into S/G2 phase of the cell cycle with little apoptosis via a mechanism involving elevated FAK and low caspase activities. Apoptosis was observed only in the cell lines that expressed no Egr-1, especially those expressing wt-p53, and was preceded by high caspase activity. In summary, Egr-1 suppressed transformation and counteracted apoptosis by the coordinated activation of TGFbeta1, FN, p21 and FAK, leading to enhanced cell attachment and reduced caspase activity. In the doubly expressing cell line, the survival effect of Egr-1 was dominant over the apoptotic effect of p53.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1202696", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2472003", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2473387", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2472386", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "24", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis", 
    "pagination": "1202696", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bffe57710e1ae2dafb18b5dd007cd13912c6daee90c189858879f37fb67353a2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10380885"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1202696"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040304525"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1202696", 
      "https://app.dimensions.ai/details/publication/pub.1040304525"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29222_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1202696"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202696'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202696'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202696'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202696'


 

This table displays all metadata directly associated to this object as RDF triples.

425 TRIPLES      21 PREDICATES      124 URIs      56 LITERALS      44 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1202696 schema:about N09876472bb7345c9bef443b5b7e57b52
2 N0c92b7e74efd4479be571c5bd8e7f3a1
3 N10c6fefff6224e17a57b07cfdc6c9881
4 N1adf00e3f0f247e0af809fc42a5170eb
5 N1b6da97a920640a3b3db16e4b1340b5e
6 N1c0a5996dbf4452d802e77a1d64a8984
7 N1ef89b6aa3874be6a46006356f8f002e
8 N2877ea43b8504deba96e74c9c0f4fa29
9 N32ecaad81f3c407689ca6fe364c5732f
10 N45f2cf309cfd462bace08dd2fa89b3f0
11 N4ecbd8c0a3ea4c37985cf76938ba16e1
12 N542aaa09e9bd4bedbe6e477c4693ad28
13 N587e7ae46eb8471098cccc5197d99772
14 N69d485b6c33d46cdbdec8ead3dd49643
15 N6a3c34e64e324de7abb4b662142ba80f
16 N6b27ed7b1d7c40d8ad04829b7a78d4f8
17 N709476d96bcf4a8bb90ccf624bf6d23a
18 N8106a401a7b54a31b843f28039b1175f
19 N8377ded8377e4466afcb94195ff7b1e9
20 N8e3f5be8e2ef48b28fa7665cca15ea3e
21 N8e5deca58d9b496e9c2f9c280fb31999
22 Na03e0b9e40b7406cb3fb3b52577e5dc5
23 Na7c63e78b1934c5089cc862ed73cecb2
24 Nb01aed72908f4ecd966cf9bfad99e07f
25 Nb77c703f72d146e4b1402102a52624fd
26 Nb802e9894a9f44eea15276954e4dc4d9
27 Nbe91f9b7e38c45359efd72994f4bbb9e
28 Nc759f345b8ea4d5a80fc7595b4d2461c
29 Ncb2a20604f724c09a4e4d65a2be43de5
30 Nd06e7d49362a4e12a1e936e86cf52d63
31 Nd4857945b50b4376b3217bd4dff0443f
32 Ndaaf6c2c6bd040d09f483c6d83d2cdb0
33 Ne48173578d3149fa9a126e424f560c9e
34 Nefdb243155734d4e95ecbf77cb4c4665
35 Nf6e0be7e445f4cc58e44d77192475c1a
36 anzsrc-for:11
37 anzsrc-for:1112
38 schema:author N073c4cdf39c9417b8448c79243f1ce39
39 schema:citation sg:pub.10.1007/bf03401691
40 sg:pub.10.1038/40901
41 sg:pub.10.1038/sj.cdd.4400322
42 sg:pub.10.1038/sj.onc.1201091
43 sg:pub.10.1111/1523-1747.ep12332650
44 https://app.dimensions.ai/details/publication/pub.1082424564
45 https://app.dimensions.ai/details/publication/pub.1082439519
46 https://app.dimensions.ai/details/publication/pub.1082470986
47 https://app.dimensions.ai/details/publication/pub.1082532972
48 https://app.dimensions.ai/details/publication/pub.1082659570
49 https://app.dimensions.ai/details/publication/pub.1082675989
50 https://app.dimensions.ai/details/publication/pub.1082690820
51 https://app.dimensions.ai/details/publication/pub.1082698918
52 https://app.dimensions.ai/details/publication/pub.1082741001
53 https://app.dimensions.ai/details/publication/pub.1082855807
54 https://app.dimensions.ai/details/publication/pub.1082962696
55 https://app.dimensions.ai/details/publication/pub.1083054065
56 https://app.dimensions.ai/details/publication/pub.1083099541
57 https://app.dimensions.ai/details/publication/pub.1083110105
58 https://app.dimensions.ai/details/publication/pub.1083148244
59 https://app.dimensions.ai/details/publication/pub.1083200942
60 https://app.dimensions.ai/details/publication/pub.1083254211
61 https://doi.org/10.1002/(sici)1097-0215(19970703)72:1<102::aid-ijc15>3.0.co;2-l
62 https://doi.org/10.1002/(sici)1097-0215(19980911)77:6<880::aid-ijc14>3.0.co;2-5
63 https://doi.org/10.1002/jcb.240560407
64 https://doi.org/10.1016/0027-5107(95)00103-4
65 https://doi.org/10.1016/0092-8674(88)90485-0
66 https://doi.org/10.1016/0092-8674(93)90500-p
67 https://doi.org/10.1016/0092-8674(93)90660-i
68 https://doi.org/10.1016/0360-3016(94)90539-8
69 https://doi.org/10.1016/s0092-8674(00)81871-1
70 https://doi.org/10.1016/s0898-6568(97)89890-7
71 https://doi.org/10.1016/s0959-437x(05)80340-5
72 https://doi.org/10.1046/j.1432-1327.1998.2570242.x
73 https://doi.org/10.1073/pnas.92.13.6161
74 https://doi.org/10.1073/pnas.93.21.11831
75 https://doi.org/10.1074/jbc.270.51.30303
76 https://doi.org/10.1074/jbc.271.36.21898
77 https://doi.org/10.1074/jbc.271.46.29231
78 https://doi.org/10.1074/jbc.271.7.3756
79 https://doi.org/10.1074/jbc.272.32.20131
80 https://doi.org/10.1074/jbc.272.41.26056
81 https://doi.org/10.1074/jbc.272.44.27987
82 https://doi.org/10.1074/jbc.272.52.33056
83 https://doi.org/10.1074/jbc.273.30.19207
84 https://doi.org/10.1074/jbc.274.7.4400
85 https://doi.org/10.1083/jcb.124.4.619
86 https://doi.org/10.1083/jcb.127.4.1085
87 https://doi.org/10.1083/jcb.133.1.211
88 https://doi.org/10.1083/jcb.134.3.793
89 https://doi.org/10.1083/jcb.135.5.1383
90 https://doi.org/10.1083/jcb.139.2.529
91 https://doi.org/10.1101/gad.10.12.1455
92 https://doi.org/10.1101/gad.7.11.2135
93 https://doi.org/10.1101/gad.9.17.2184
94 https://doi.org/10.1101/sqb.1994.059.01.026
95 https://doi.org/10.1111/j.1349-7006.1996.tb00233.x
96 https://doi.org/10.1126/science.2144057
97 https://doi.org/10.1128/mcb.10.11.5772
98 https://doi.org/10.1128/mcb.15.11.6262
99 schema:datePublished 1999-06
100 schema:datePublishedReg 1999-06-01
101 schema:description The human fibrosarcoma cell line, HT1080, clone H4, was used to determine if the transformation suppressive functions of p53 and Egr-1 have the same underlying mechanism. This cell line expresses only mutant p53 and no detectable Egr-1. H4 clones stably expressing Egr-1 are less transformed in proportion to the level of Egr-1 expressed, acting through the induction of the TGFbeta1 gene. Here, H4 cells and the highest Egr-1 expressing clone were transfected with a vector expressing normal human p53 to derive stable clones expressing p53. The expression of p53 in H4 cells inhibited transformed growth and reduced tumorigenicity. The effect of coexpression of both p53 and Egr-1 was additive, producing cell lines with 30% of normal growth rate and sevenfold reduced tumorigenicity compared with control lines. These results indicated that each factor may act independently by different pathways, although each additively increased the level of p21WAF1 cell cycle inhibitor. However, exposure of the H4-derived cells to UV-C irradiation produced contrasting effects. Cell cycle analyses showed that the presence of p53 was associated with loss of the G1 and S cells to apoptosis after irradiation. In contrast, the expression of Egr-1 increased entry into S/G2 phase of the cell cycle with little apoptosis via a mechanism involving elevated FAK and low caspase activities. Apoptosis was observed only in the cell lines that expressed no Egr-1, especially those expressing wt-p53, and was preceded by high caspase activity. In summary, Egr-1 suppressed transformation and counteracted apoptosis by the coordinated activation of TGFbeta1, FN, p21 and FAK, leading to enhanced cell attachment and reduced caspase activity. In the doubly expressing cell line, the survival effect of Egr-1 was dominant over the apoptotic effect of p53.
102 schema:genre research_article
103 schema:inLanguage en
104 schema:isAccessibleForFree true
105 schema:isPartOf N1f590955f6f5443fb1d5062b22b26b85
106 N29a5ff70885c486eb1c34bea412a79ee
107 sg:journal.1097543
108 schema:name p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis
109 schema:pagination 1202696
110 schema:productId N03df9b05129a4a1796e1b2727d7fb20b
111 N2b654518c2dc43c38b28d8f798ba105f
112 N5eacf7007e8647a0a8e7043e5f09afb7
113 Ndb10de6de5474ee6996ed59379af77ef
114 Nf6a3feaeb89c48d68ef8bb78dc626a45
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040304525
116 https://doi.org/10.1038/sj.onc.1202696
117 schema:sdDatePublished 2019-04-11T11:58
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher N675cb66e691c4a79b496599afbf466c7
120 schema:url http://www.nature.com/articles/1202696
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N03df9b05129a4a1796e1b2727d7fb20b schema:name doi
125 schema:value 10.1038/sj.onc.1202696
126 rdf:type schema:PropertyValue
127 N07069b922ae0442bbe0dc5332feadbf7 rdf:first sg:person.01034452734.65
128 rdf:rest rdf:nil
129 N073c4cdf39c9417b8448c79243f1ce39 rdf:first sg:person.0575727644.57
130 rdf:rest N8146bebf0a4c46378657fc2499a81868
131 N09876472bb7345c9bef443b5b7e57b52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mitogen-Activated Protein Kinase 3
133 rdf:type schema:DefinedTerm
134 N0c92b7e74efd4479be571c5bd8e7f3a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Cell Division
136 rdf:type schema:DefinedTerm
137 N10c6fefff6224e17a57b07cfdc6c9881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Protein-Tyrosine Kinases
139 rdf:type schema:DefinedTerm
140 N1adf00e3f0f247e0af809fc42a5170eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Protein Kinases
142 rdf:type schema:DefinedTerm
143 N1b6da97a920640a3b3db16e4b1340b5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cell Adhesion
145 rdf:type schema:DefinedTerm
146 N1c0a5996dbf4452d802e77a1d64a8984 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Humans
148 rdf:type schema:DefinedTerm
149 N1ef89b6aa3874be6a46006356f8f002e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cell Transformation, Neoplastic
151 rdf:type schema:DefinedTerm
152 N1f590955f6f5443fb1d5062b22b26b85 schema:volumeNumber 18
153 rdf:type schema:PublicationVolume
154 N2877ea43b8504deba96e74c9c0f4fa29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name JNK Mitogen-Activated Protein Kinases
156 rdf:type schema:DefinedTerm
157 N29a5ff70885c486eb1c34bea412a79ee schema:issueNumber 24
158 rdf:type schema:PublicationIssue
159 N2b654518c2dc43c38b28d8f798ba105f schema:name readcube_id
160 schema:value bffe57710e1ae2dafb18b5dd007cd13912c6daee90c189858879f37fb67353a2
161 rdf:type schema:PropertyValue
162 N32ecaad81f3c407689ca6fe364c5732f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Cell Cycle
164 rdf:type schema:DefinedTerm
165 N3caa7042a3ca4537b88c9466811fd4d2 rdf:first sg:person.01161073200.62
166 rdf:rest N07069b922ae0442bbe0dc5332feadbf7
167 N4549ce5588914a5d8d9832c992d4efa5 rdf:first sg:person.0727361665.91
168 rdf:rest Na371bb15e8154ecb84ae82e0a90de675
169 N45f2cf309cfd462bace08dd2fa89b3f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Tumor Suppressor Protein p53
171 rdf:type schema:DefinedTerm
172 N4ecbd8c0a3ea4c37985cf76938ba16e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name DNA-Binding Proteins
174 rdf:type schema:DefinedTerm
175 N542aaa09e9bd4bedbe6e477c4693ad28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Transcription Factors
177 rdf:type schema:DefinedTerm
178 N587e7ae46eb8471098cccc5197d99772 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Signal Transduction
180 rdf:type schema:DefinedTerm
181 N5eacf7007e8647a0a8e7043e5f09afb7 schema:name nlm_unique_id
182 schema:value 8711562
183 rdf:type schema:PropertyValue
184 N675cb66e691c4a79b496599afbf466c7 schema:name Springer Nature - SN SciGraph project
185 rdf:type schema:Organization
186 N69d485b6c33d46cdbdec8ead3dd49643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Fibrosarcoma
188 rdf:type schema:DefinedTerm
189 N6a3c34e64e324de7abb4b662142ba80f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Immediate-Early Proteins
191 rdf:type schema:DefinedTerm
192 N6b27ed7b1d7c40d8ad04829b7a78d4f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Apoptosis
194 rdf:type schema:DefinedTerm
195 N709476d96bcf4a8bb90ccf624bf6d23a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Focal Adhesion Protein-Tyrosine Kinases
197 rdf:type schema:DefinedTerm
198 N8106a401a7b54a31b843f28039b1175f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Caspase 3
200 rdf:type schema:DefinedTerm
201 N8146bebf0a4c46378657fc2499a81868 rdf:first sg:person.013654676132.54
202 rdf:rest N4549ce5588914a5d8d9832c992d4efa5
203 N8377ded8377e4466afcb94195ff7b1e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Mitogen-Activated Protein Kinase Kinases
205 rdf:type schema:DefinedTerm
206 N8e3f5be8e2ef48b28fa7665cca15ea3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Focal Adhesion Kinase 1
208 rdf:type schema:DefinedTerm
209 N8e5deca58d9b496e9c2f9c280fb31999 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Tumor Cells, Cultured
211 rdf:type schema:DefinedTerm
212 Na03e0b9e40b7406cb3fb3b52577e5dc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Mitogen-Activated Protein Kinases
214 rdf:type schema:DefinedTerm
215 Na371bb15e8154ecb84ae82e0a90de675 rdf:first sg:person.0731440272.12
216 rdf:rest N3caa7042a3ca4537b88c9466811fd4d2
217 Na7c63e78b1934c5089cc862ed73cecb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Caspases
219 rdf:type schema:DefinedTerm
220 Nb01aed72908f4ecd966cf9bfad99e07f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Carcinogenicity Tests
222 rdf:type schema:DefinedTerm
223 Nb77c703f72d146e4b1402102a52624fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Cell Adhesion Molecules
225 rdf:type schema:DefinedTerm
226 Nb802e9894a9f44eea15276954e4dc4d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name DNA Fragmentation
228 rdf:type schema:DefinedTerm
229 Nbe91f9b7e38c45359efd72994f4bbb9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Cyclin-Dependent Kinase Inhibitor p21
231 rdf:type schema:DefinedTerm
232 Nc759f345b8ea4d5a80fc7595b4d2461c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name MAP Kinase Kinase 4
234 rdf:type schema:DefinedTerm
235 Ncb2a20604f724c09a4e4d65a2be43de5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name RNA, Messenger
237 rdf:type schema:DefinedTerm
238 Nd06e7d49362a4e12a1e936e86cf52d63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Ultraviolet Rays
240 rdf:type schema:DefinedTerm
241 Nd4857945b50b4376b3217bd4dff0443f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
242 schema:name Mutation
243 rdf:type schema:DefinedTerm
244 Ndaaf6c2c6bd040d09f483c6d83d2cdb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
245 schema:name Calcium-Calmodulin-Dependent Protein Kinases
246 rdf:type schema:DefinedTerm
247 Ndb10de6de5474ee6996ed59379af77ef schema:name pubmed_id
248 schema:value 10380885
249 rdf:type schema:PropertyValue
250 Ne48173578d3149fa9a126e424f560c9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
251 schema:name Early Growth Response Protein 1
252 rdf:type schema:DefinedTerm
253 Nefdb243155734d4e95ecbf77cb4c4665 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
254 schema:name Transfection
255 rdf:type schema:DefinedTerm
256 Nf6a3feaeb89c48d68ef8bb78dc626a45 schema:name dimensions_id
257 schema:value pub.1040304525
258 rdf:type schema:PropertyValue
259 Nf6e0be7e445f4cc58e44d77192475c1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
260 schema:name Cyclins
261 rdf:type schema:DefinedTerm
262 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
263 schema:name Medical and Health Sciences
264 rdf:type schema:DefinedTerm
265 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
266 schema:name Oncology and Carcinogenesis
267 rdf:type schema:DefinedTerm
268 sg:grant.2472003 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1202696
269 rdf:type schema:MonetaryGrant
270 sg:grant.2472386 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1202696
271 rdf:type schema:MonetaryGrant
272 sg:grant.2473387 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1202696
273 rdf:type schema:MonetaryGrant
274 sg:journal.1097543 schema:issn 0950-9232
275 1476-5594
276 schema:name Oncogene
277 rdf:type schema:Periodical
278 sg:person.01034452734.65 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
279 schema:familyName Adamson
280 schema:givenName Eileen D
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034452734.65
282 rdf:type schema:Person
283 sg:person.01161073200.62 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
284 schema:familyName Mercola
285 schema:givenName Dan
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161073200.62
287 rdf:type schema:Person
288 sg:person.013654676132.54 schema:affiliation https://www.grid.ac/institutes/grid.416561.1
289 schema:familyName Huang
290 schema:givenName Ruo-Pan
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013654676132.54
292 rdf:type schema:Person
293 sg:person.0575727644.57 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
294 schema:familyName de Belle
295 schema:givenName Ian
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575727644.57
297 rdf:type schema:Person
298 sg:person.0727361665.91 schema:affiliation https://www.grid.ac/institutes/grid.416561.1
299 schema:familyName Fan
300 schema:givenName Yan
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727361665.91
302 rdf:type schema:Person
303 sg:person.0731440272.12 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
304 schema:familyName Liu
305 schema:givenName Chaoting
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731440272.12
307 rdf:type schema:Person
308 sg:pub.10.1007/bf03401691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083130775
309 https://doi.org/10.1007/bf03401691
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/40901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015400453
312 https://doi.org/10.1038/40901
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/sj.cdd.4400322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044892511
315 https://doi.org/10.1038/sj.cdd.4400322
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/sj.onc.1201091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044476393
318 https://doi.org/10.1038/sj.onc.1201091
319 rdf:type schema:CreativeWork
320 sg:pub.10.1111/1523-1747.ep12332650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029100119
321 https://doi.org/10.1111/1523-1747.ep12332650
322 rdf:type schema:CreativeWork
323 https://app.dimensions.ai/details/publication/pub.1082424564 schema:CreativeWork
324 https://app.dimensions.ai/details/publication/pub.1082439519 schema:CreativeWork
325 https://app.dimensions.ai/details/publication/pub.1082470986 schema:CreativeWork
326 https://app.dimensions.ai/details/publication/pub.1082532972 schema:CreativeWork
327 https://app.dimensions.ai/details/publication/pub.1082659570 schema:CreativeWork
328 https://app.dimensions.ai/details/publication/pub.1082675989 schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1082690820 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1082698918 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1082741001 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1082855807 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1082962696 schema:CreativeWork
334 https://app.dimensions.ai/details/publication/pub.1083054065 schema:CreativeWork
335 https://app.dimensions.ai/details/publication/pub.1083099541 schema:CreativeWork
336 https://app.dimensions.ai/details/publication/pub.1083110105 schema:CreativeWork
337 https://app.dimensions.ai/details/publication/pub.1083148244 schema:CreativeWork
338 https://app.dimensions.ai/details/publication/pub.1083200942 schema:CreativeWork
339 https://app.dimensions.ai/details/publication/pub.1083254211 schema:CreativeWork
340 https://doi.org/10.1002/(sici)1097-0215(19970703)72:1<102::aid-ijc15>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1019254523
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1002/(sici)1097-0215(19980911)77:6<880::aid-ijc14>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016740892
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1002/jcb.240560407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012966834
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/0027-5107(95)00103-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029942076
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/0092-8674(88)90485-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011190436
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/0092-8674(93)90500-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1038576682
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/0092-8674(93)90660-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1011430147
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/0360-3016(94)90539-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030044599
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/s0092-8674(00)81871-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005306554
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/s0898-6568(97)89890-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050810740
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0959-437x(05)80340-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016143886
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1046/j.1432-1327.1998.2570242.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022698749
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1073/pnas.92.13.6161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034625653
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1073/pnas.93.21.11831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013361369
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1074/jbc.270.51.30303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046938020
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1074/jbc.271.36.21898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009490741
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1074/jbc.271.46.29231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049367172
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1074/jbc.271.7.3756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011842334
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1074/jbc.272.32.20131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032908309
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1074/jbc.272.41.26056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042288759
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1074/jbc.272.44.27987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000334819
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1074/jbc.272.52.33056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020612501
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1074/jbc.273.30.19207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041112412
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1074/jbc.274.7.4400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007157099
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1083/jcb.124.4.619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009095815
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1083/jcb.127.4.1085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052928353
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1083/jcb.133.1.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025497969
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1083/jcb.134.3.793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030212510
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1083/jcb.135.5.1383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006890328
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1083/jcb.139.2.529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040714789
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1101/gad.10.12.1455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029067214
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1101/gad.7.11.2135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041334361
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1101/gad.9.17.2184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039966261
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1101/sqb.1994.059.01.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060406577
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1111/j.1349-7006.1996.tb00233.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007975083
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1126/science.2144057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062524133
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1128/mcb.10.11.5772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053488905
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1128/mcb.15.11.6262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040670318
415 rdf:type schema:CreativeWork
416 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
417 schema:name Center for Molecular Genetics, University of California at San Diego, California, CA 92093, USA
418 Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California, CA 92121, USA
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.416561.1 schema:alternateName Northwest Hospital and Medical Center
421 schema:name Molecular Medicine, Northwest Hospital, 120 Northgate Plaza, Suite 230, Seattle, Washington, WA 98125, USA
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.479509.6 schema:alternateName Sanford Burnham Prebys Medical Discovery Institute
424 schema:name La Jolla Cancer Research Center, The Burnham Institute, 10901, N Torrey Pines Road, La Jolla, California, CA 92037, USA
425 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...