Methylation and silencing of the Thrombospondin-1 promoter in human cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-05

AUTHORS

Qing Li, Nita Ahuja, Peter C Burger, Jean-Pierre J Issa

ABSTRACT

Neovascularization is a common feature of many human cancers, but relatively few molecular defects have been demonstrated in genes regulating angiogenesis. Decreased expression of Thrombospondin-1 (THBS1), a P53 and Rb regulated angiogenesis inhibitor, has been observed in some human tumors, including glioblastoma multiforme (GBM). To study whether methylation-associated inactivation is involved in down-regulating THBS1 expression in cancer, we analysed the methylation status of THBS1 in several cell lines and primary tumors. Three cell lines (RKO, CEM and RAJI) were completely methylated at several CpG sites within the THBS1 5' CpG island, and had no detectable expression by RT-PCR. THBS1 expression was readily reactivated using the methylation-inhibitor 5-deoxy-azacytidine in all three lines. Furthermore, THBS1 methylation was present in 33% (14/42) of primary GBMs. Thus, de novo methylation may serve as a potential way to inactivate THBS1 expression in human neoplasms. More... »

PAGES

1202663

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202663

DOI

http://dx.doi.org/10.1038/sj.onc.1202663

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024693896

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10359534


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