Transformation of intestinal epithelial cells by chronic TGF-β1 treatment results in downregulation of the type II TGF-β receptor and induction ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-01

AUTHORS

Hongmiao Sheng, Jinyi Shao, Christine A O'Mahony, Laura Lamps, Daniel Albo, Peter C Isakson, David H Berger, Raymond N DuBois, R Daniel Beauchamp

ABSTRACT

The precise role of TGF-beta in colorectal carcinogenesis is not clear. The purpose of this study was to determine the phenotypic alterations caused by chronic exposure to TGF-beta in non-transformed intestinal epithelial (RIE-1) cells. Growth of RIE-1 cells was inhibited by >75% following TGF-beta1 treatment for 7 days, after which the cells resumed a normal growth despite the presence of TGF-beta1. These 'TGF-beta-resistant' cells (RIE-Tr) were continuously exposed to TGF-beta for >50 days. Unlike the parental RIE cells, RIE-Tr cells lost contact inhibition, formed foci in culture, grew in soft agarose. RIE-Tr cells demonstrated TGF-beta-dependent invasive potential in an in vitro assay and were resistant to Matrigel and Na-butyrate-induced apoptosis. The RIE-Tr cells were also tumorigenic in nude mice. The transformed phenotype of RIE-Tr cells was associated with a 95% decrease in the level of the type II TGF-beta receptor (TbetaRII) protein, a 40-fold increase in cyclooxygenase-2 (COX-2) protein, and 5.9-fold increase in the production of prostacyclin. Most RIE-Tr subclones that expressed low levels of TbetaRII and high levels of COX-2 were tumorigenic. Those subclones that express abundant TbetaRII and low levels of COX-2 were not tumorigenic in nude mice. A selective COX-2 inhibitor inhibited RIE-Tr cell growth in culture and tumor growth in nude mice. The reduced expression of TbetaRII, increased expression of COX-2, and the ability to form colonies in Matrigel were all reversible upon withdrawal of exogenous TGF-beta1 for the RIE-Tr cells. More... »

PAGES

855

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202397

DOI

http://dx.doi.org/10.1038/sj.onc.1202397

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011970400

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10023661


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoenzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostaglandin-Endoperoxide Synthases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Transforming Growth Factor-beta Type II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Surgery, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sheng", 
        "givenName": "Hongmiao", 
        "id": "sg:person.01305166203.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305166203.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Surgery, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA", 
            "Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shao", 
        "givenName": "Jinyi", 
        "id": "sg:person.01063521507.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063521507.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Drexel University", 
          "id": "https://www.grid.ac/institutes/grid.166341.7", 
          "name": [
            "Department of Surgery, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Mahony", 
        "givenName": "Christine A", 
        "id": "sg:person.01323503556.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323503556.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Pathology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamps", 
        "givenName": "Laura", 
        "id": "sg:person.013355461651.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013355461651.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Drexel University", 
          "id": "https://www.grid.ac/institutes/grid.166341.7", 
          "name": [
            "Department of Surgery, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albo", 
        "givenName": "Daniel", 
        "id": "sg:person.01235552457.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235552457.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Inflammatory Disease Research, Searle R & D, St Louis, Missouri 63198, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Isakson", 
        "givenName": "Peter C", 
        "id": "sg:person.01253543620.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253543620.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Drexel University", 
          "id": "https://www.grid.ac/institutes/grid.166341.7", 
          "name": [
            "Department of Surgery, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "David H", 
        "id": "sg:person.01153613737.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153613737.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA", 
            "Department of Cell Biology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DuBois", 
        "givenName": "Raymond N", 
        "id": "sg:person.0626301614.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626301614.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Surgery, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA", 
            "Department of Cell Biology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beauchamp", 
        "givenName": "R Daniel", 
        "id": "sg:person.01355254152.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355254152.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1201902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000680860", 
          "https://doi.org/10.1038/sj.onc.1201902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000680860", 
          "https://doi.org/10.1038/sj.onc.1201902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81335-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002180451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/383382b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003390594", 
          "https://doi.org/10.1038/383382b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80128-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006370759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.4.1486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006647224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90127-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007200098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81983-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008830068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.23.14154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010214895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910550329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010883302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.13.6076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014716073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81333-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014745301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199007000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016198823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006676-199007000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016198823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.25.12013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019347281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(94)90246-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020082397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.20.2429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023676008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023711478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(89)90101-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024450034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.127.6.2021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025022548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.9.4978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025422595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v111.pm8898652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029064582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030079669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.10.4254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031026444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1996.v110.pm8613017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034145839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034579610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0309-1651(84)90054-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036881719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.5.1578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037289639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(97)70007-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037413044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.7.3336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038658027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.12.7239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039041278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/17.5.989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043278531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(87)91481-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046619226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.129.3.853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047833392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81988-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048354178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(94)90059-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050752694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.37.22044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052504683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80127-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052923588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(93)90011-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053506807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00591a005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055181913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2163544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062525126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.271.5247.350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2895499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062571075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7761852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8388126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062654919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critrevoncog.v5.i2-3.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068132609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075479334", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075951696", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077748054", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078617780", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079589037", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079767004", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082524223", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082569670", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082581462", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082581512", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082588267", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082842694", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082995754", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083027645", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083083391", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083083393", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083202753", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-01", 
    "datePublishedReg": "1999-01-01", 
    "description": "The precise role of TGF-beta in colorectal carcinogenesis is not clear. The purpose of this study was to determine the phenotypic alterations caused by chronic exposure to TGF-beta in non-transformed intestinal epithelial (RIE-1) cells. Growth of RIE-1 cells was inhibited by >75% following TGF-beta1 treatment for 7 days, after which the cells resumed a normal growth despite the presence of TGF-beta1. These 'TGF-beta-resistant' cells (RIE-Tr) were continuously exposed to TGF-beta for >50 days. Unlike the parental RIE cells, RIE-Tr cells lost contact inhibition, formed foci in culture, grew in soft agarose. RIE-Tr cells demonstrated TGF-beta-dependent invasive potential in an in vitro assay and were resistant to Matrigel and Na-butyrate-induced apoptosis. The RIE-Tr cells were also tumorigenic in nude mice. The transformed phenotype of RIE-Tr cells was associated with a 95% decrease in the level of the type II TGF-beta receptor (TbetaRII) protein, a 40-fold increase in cyclooxygenase-2 (COX-2) protein, and 5.9-fold increase in the production of prostacyclin. Most RIE-Tr subclones that expressed low levels of TbetaRII and high levels of COX-2 were tumorigenic. Those subclones that express abundant TbetaRII and low levels of COX-2 were not tumorigenic in nude mice. A selective COX-2 inhibitor inhibited RIE-Tr cell growth in culture and tumor growth in nude mice. The reduced expression of TbetaRII, increased expression of COX-2, and the ability to form colonies in Matrigel were all reversible upon withdrawal of exogenous TGF-beta1 for the RIE-Tr cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1202397", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2472568", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438863", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2495856", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Transformation of intestinal epithelial cells by chronic TGF-\u03b21 treatment results in downregulation of the type II TGF-\u03b2 receptor and induction of cyclooxygenase-2", 
    "pagination": "855", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3908c212c47615a10eb9437cca2fb6cac4b898b78c16f7445d2f0c94686d9274"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10023661"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1202397"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011970400"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1202397", 
      "https://app.dimensions.ai/details/publication/pub.1011970400"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118342_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1202397"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202397'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202397'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202397'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202397'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      21 PREDICATES      109 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1202397 schema:about N038b029d60ab477b86309d286a23e758
2 N16725efc96284b6a99ed22ae4bb74c06
3 N231c2e00e32d49d69278681acba56dc7
4 N3026b78b2a0845a3a8caf846cc49bd8f
5 N38ca69b70f93489e99f9623180e04554
6 N3de5d155852546e2b4d8f820f72267fb
7 N3fca3115fb5c40259129e928ac47bef1
8 N5cc95282bf474182a239d314a96368a1
9 N60db89e95e374286844396b6f0d584c7
10 N61b2f02da9ad4341a68add3b31a77376
11 N74b261b5bdb445e9b5b56becf9ca685b
12 N78bb2e7cbcd048d28912145b9c74277f
13 N936c1a7b035b441ea84e2349c8e6fb82
14 N936dba2082cd486a940ddfe34fc7db5e
15 N967e5b989e994ec6a8ef054d69385a71
16 Ncd95709444034ac8a705f573a8f527ce
17 Nd6c457dcc8d847249ad198bb4c6f4e68
18 Ne4d40b692c7c4e9bbbd145ab392eac78
19 Nfdad9d9c92584138b6bb02b2a850f118
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author Nbd21fdefadb24d9fa98ac32e3bea9eb1
23 schema:citation sg:pub.10.1038/383382b0
24 sg:pub.10.1038/sj.onc.1201902
25 https://app.dimensions.ai/details/publication/pub.1075479334
26 https://app.dimensions.ai/details/publication/pub.1075951696
27 https://app.dimensions.ai/details/publication/pub.1077748054
28 https://app.dimensions.ai/details/publication/pub.1078617780
29 https://app.dimensions.ai/details/publication/pub.1079589037
30 https://app.dimensions.ai/details/publication/pub.1079767004
31 https://app.dimensions.ai/details/publication/pub.1082524223
32 https://app.dimensions.ai/details/publication/pub.1082569670
33 https://app.dimensions.ai/details/publication/pub.1082581462
34 https://app.dimensions.ai/details/publication/pub.1082581512
35 https://app.dimensions.ai/details/publication/pub.1082588267
36 https://app.dimensions.ai/details/publication/pub.1082842694
37 https://app.dimensions.ai/details/publication/pub.1082995754
38 https://app.dimensions.ai/details/publication/pub.1083027645
39 https://app.dimensions.ai/details/publication/pub.1083083391
40 https://app.dimensions.ai/details/publication/pub.1083083393
41 https://app.dimensions.ai/details/publication/pub.1083202753
42 https://doi.org/10.1002/ijc.2910550329
43 https://doi.org/10.1016/0006-291x(87)91481-1
44 https://doi.org/10.1016/0014-4827(89)90101-8
45 https://doi.org/10.1016/0016-5085(93)90011-z
46 https://doi.org/10.1016/0016-5085(94)90246-1
47 https://doi.org/10.1016/0092-8674(95)90127-2
48 https://doi.org/10.1016/0309-1651(84)90054-7
49 https://doi.org/10.1016/0968-0004(94)90059-0
50 https://doi.org/10.1016/s0016-5085(97)70007-6
51 https://doi.org/10.1016/s0092-8674(00)80127-0
52 https://doi.org/10.1016/s0092-8674(00)80128-2
53 https://doi.org/10.1016/s0092-8674(00)81333-1
54 https://doi.org/10.1016/s0092-8674(00)81335-5
55 https://doi.org/10.1016/s0092-8674(00)81983-2
56 https://doi.org/10.1016/s0092-8674(00)81988-1
57 https://doi.org/10.1021/bi00591a005
58 https://doi.org/10.1053/gast.1996.v110.pm8613017
59 https://doi.org/10.1053/gast.1996.v111.pm8898652
60 https://doi.org/10.1073/pnas.86.5.1578
61 https://doi.org/10.1073/pnas.87.4.1486
62 https://doi.org/10.1073/pnas.90.13.6076
63 https://doi.org/10.1073/pnas.91.25.12013
64 https://doi.org/10.1073/pnas.92.10.4254
65 https://doi.org/10.1073/pnas.94.7.3336
66 https://doi.org/10.1074/jbc.270.23.14154
67 https://doi.org/10.1074/jbc.270.37.22044
68 https://doi.org/10.1083/jcb.127.6.2021
69 https://doi.org/10.1083/jcb.129.3.853
70 https://doi.org/10.1093/carcin/17.5.989
71 https://doi.org/10.1097/00006676-199007000-00001
72 https://doi.org/10.1101/gad.8.20.2429
73 https://doi.org/10.1126/science.2163544
74 https://doi.org/10.1126/science.271.5247.350
75 https://doi.org/10.1126/science.2895499
76 https://doi.org/10.1126/science.7761852
77 https://doi.org/10.1126/science.8388126
78 https://doi.org/10.1128/mcb.10.9.4978
79 https://doi.org/10.1128/mcb.13.12.7239
80 https://doi.org/10.1172/jci116998
81 https://doi.org/10.1172/jci118717
82 https://doi.org/10.1172/jci119400
83 https://doi.org/10.1615/critrevoncog.v5.i2-3.90
84 schema:datePublished 1999-01
85 schema:datePublishedReg 1999-01-01
86 schema:description The precise role of TGF-beta in colorectal carcinogenesis is not clear. The purpose of this study was to determine the phenotypic alterations caused by chronic exposure to TGF-beta in non-transformed intestinal epithelial (RIE-1) cells. Growth of RIE-1 cells was inhibited by >75% following TGF-beta1 treatment for 7 days, after which the cells resumed a normal growth despite the presence of TGF-beta1. These 'TGF-beta-resistant' cells (RIE-Tr) were continuously exposed to TGF-beta for >50 days. Unlike the parental RIE cells, RIE-Tr cells lost contact inhibition, formed foci in culture, grew in soft agarose. RIE-Tr cells demonstrated TGF-beta-dependent invasive potential in an in vitro assay and were resistant to Matrigel and Na-butyrate-induced apoptosis. The RIE-Tr cells were also tumorigenic in nude mice. The transformed phenotype of RIE-Tr cells was associated with a 95% decrease in the level of the type II TGF-beta receptor (TbetaRII) protein, a 40-fold increase in cyclooxygenase-2 (COX-2) protein, and 5.9-fold increase in the production of prostacyclin. Most RIE-Tr subclones that expressed low levels of TbetaRII and high levels of COX-2 were tumorigenic. Those subclones that express abundant TbetaRII and low levels of COX-2 were not tumorigenic in nude mice. A selective COX-2 inhibitor inhibited RIE-Tr cell growth in culture and tumor growth in nude mice. The reduced expression of TbetaRII, increased expression of COX-2, and the ability to form colonies in Matrigel were all reversible upon withdrawal of exogenous TGF-beta1 for the RIE-Tr cells.
87 schema:genre research_article
88 schema:inLanguage en
89 schema:isAccessibleForFree true
90 schema:isPartOf Nba0b11759aa84a56afb3066f6709af09
91 Nfdf535c246a94692ac480886b7f93a08
92 sg:journal.1097543
93 schema:name Transformation of intestinal epithelial cells by chronic TGF-β1 treatment results in downregulation of the type II TGF-β receptor and induction of cyclooxygenase-2
94 schema:pagination 855
95 schema:productId N134f5c1d10f24f6fa8597b734f0061a7
96 N392021b4fd43487f8cceac25d1e68521
97 N758138b0a20b4564a1cf845957a8eb4e
98 N8d913f24383447eba2a659b81da8bdfb
99 Ne1d686b543684e6cab6e4ef4d523b212
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011970400
101 https://doi.org/10.1038/sj.onc.1202397
102 schema:sdDatePublished 2019-04-11T12:06
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nfbe475f38d644fdfbb4fb94930da1193
105 schema:url https://www.nature.com/articles/1202397
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N038b029d60ab477b86309d286a23e758 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Receptors, Transforming Growth Factor beta
111 rdf:type schema:DefinedTerm
112 N08172f4a1c7a49e28b5fb6116eade36d rdf:first sg:person.01063521507.06
113 rdf:rest Nc8fd11b1126a476bb1b963d735d6a922
114 N134f5c1d10f24f6fa8597b734f0061a7 schema:name dimensions_id
115 schema:value pub.1011970400
116 rdf:type schema:PropertyValue
117 N16725efc96284b6a99ed22ae4bb74c06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cyclooxygenase 2
119 rdf:type schema:DefinedTerm
120 N231c2e00e32d49d69278681acba56dc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Down-Regulation
122 rdf:type schema:DefinedTerm
123 N3026b78b2a0845a3a8caf846cc49bd8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Intestines
125 rdf:type schema:DefinedTerm
126 N38ca69b70f93489e99f9623180e04554 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 N392021b4fd43487f8cceac25d1e68521 schema:name doi
130 schema:value 10.1038/sj.onc.1202397
131 rdf:type schema:PropertyValue
132 N3de5d155852546e2b4d8f820f72267fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Apoptosis
134 rdf:type schema:DefinedTerm
135 N3fca3115fb5c40259129e928ac47bef1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Phenotype
137 rdf:type schema:DefinedTerm
138 N4f8db097fc0449a9be77c940e42a44a9 rdf:first sg:person.01235552457.39
139 rdf:rest N944c5ccb544d457c87b11eb4fcd21773
140 N5cc95282bf474182a239d314a96368a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Prostaglandin-Endoperoxide Synthases
142 rdf:type schema:DefinedTerm
143 N60db89e95e374286844396b6f0d584c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Isoenzymes
145 rdf:type schema:DefinedTerm
146 N61b2f02da9ad4341a68add3b31a77376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Receptor, Transforming Growth Factor-beta Type II
148 rdf:type schema:DefinedTerm
149 N74b261b5bdb445e9b5b56becf9ca685b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Rats
151 rdf:type schema:DefinedTerm
152 N758138b0a20b4564a1cf845957a8eb4e schema:name nlm_unique_id
153 schema:value 8711562
154 rdf:type schema:PropertyValue
155 N78bb2e7cbcd048d28912145b9c74277f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Drug Resistance
157 rdf:type schema:DefinedTerm
158 N87b397807691479b9938f02efd582770 schema:name Department of Inflammatory Disease Research, Searle R & D, St Louis, Missouri 63198, USA
159 rdf:type schema:Organization
160 N8d913f24383447eba2a659b81da8bdfb schema:name readcube_id
161 schema:value 3908c212c47615a10eb9437cca2fb6cac4b898b78c16f7445d2f0c94686d9274
162 rdf:type schema:PropertyValue
163 N936c1a7b035b441ea84e2349c8e6fb82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Cell Transformation, Neoplastic
165 rdf:type schema:DefinedTerm
166 N936dba2082cd486a940ddfe34fc7db5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Cell Count
168 rdf:type schema:DefinedTerm
169 N944c5ccb544d457c87b11eb4fcd21773 rdf:first sg:person.01253543620.23
170 rdf:rest Ncadfdf30732b4a94bac581fbef710ee1
171 N967e5b989e994ec6a8ef054d69385a71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Transforming Growth Factor beta
173 rdf:type schema:DefinedTerm
174 Na9399c469427495f99ad2dfce3bede4a rdf:first sg:person.013355461651.60
175 rdf:rest N4f8db097fc0449a9be77c940e42a44a9
176 Nadc32296c8b04717b59ebb30ae757dd1 rdf:first sg:person.01355254152.34
177 rdf:rest rdf:nil
178 Nba0b11759aa84a56afb3066f6709af09 schema:issueNumber 4
179 rdf:type schema:PublicationIssue
180 Nbd21fdefadb24d9fa98ac32e3bea9eb1 rdf:first sg:person.01305166203.28
181 rdf:rest N08172f4a1c7a49e28b5fb6116eade36d
182 Nc8fd11b1126a476bb1b963d735d6a922 rdf:first sg:person.01323503556.25
183 rdf:rest Na9399c469427495f99ad2dfce3bede4a
184 Ncadfdf30732b4a94bac581fbef710ee1 rdf:first sg:person.01153613737.38
185 rdf:rest Nccea95d92f1f471583e6020280ddedf0
186 Nccea95d92f1f471583e6020280ddedf0 rdf:first sg:person.0626301614.27
187 rdf:rest Nadc32296c8b04717b59ebb30ae757dd1
188 Ncd95709444034ac8a705f573a8f527ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Enzyme Induction
190 rdf:type schema:DefinedTerm
191 Nd6c457dcc8d847249ad198bb4c6f4e68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Protein-Serine-Threonine Kinases
193 rdf:type schema:DefinedTerm
194 Ne1d686b543684e6cab6e4ef4d523b212 schema:name pubmed_id
195 schema:value 10023661
196 rdf:type schema:PropertyValue
197 Ne4d40b692c7c4e9bbbd145ab392eac78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Cell Division
199 rdf:type schema:DefinedTerm
200 Nfbe475f38d644fdfbb4fb94930da1193 schema:name Springer Nature - SN SciGraph project
201 rdf:type schema:Organization
202 Nfdad9d9c92584138b6bb02b2a850f118 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Epithelial Cells
204 rdf:type schema:DefinedTerm
205 Nfdf535c246a94692ac480886b7f93a08 schema:volumeNumber 18
206 rdf:type schema:PublicationVolume
207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
208 schema:name Medical and Health Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
211 schema:name Clinical Sciences
212 rdf:type schema:DefinedTerm
213 sg:grant.2438863 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1202397
214 rdf:type schema:MonetaryGrant
215 sg:grant.2472568 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1202397
216 rdf:type schema:MonetaryGrant
217 sg:grant.2495856 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.onc.1202397
218 rdf:type schema:MonetaryGrant
219 sg:journal.1097543 schema:issn 0950-9232
220 1476-5594
221 schema:name Oncogene
222 rdf:type schema:Periodical
223 sg:person.01063521507.06 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
224 schema:familyName Shao
225 schema:givenName Jinyi
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063521507.06
227 rdf:type schema:Person
228 sg:person.01153613737.38 schema:affiliation https://www.grid.ac/institutes/grid.166341.7
229 schema:familyName Berger
230 schema:givenName David H
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153613737.38
232 rdf:type schema:Person
233 sg:person.01235552457.39 schema:affiliation https://www.grid.ac/institutes/grid.166341.7
234 schema:familyName Albo
235 schema:givenName Daniel
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235552457.39
237 rdf:type schema:Person
238 sg:person.01253543620.23 schema:affiliation N87b397807691479b9938f02efd582770
239 schema:familyName Isakson
240 schema:givenName Peter C
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253543620.23
242 rdf:type schema:Person
243 sg:person.01305166203.28 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
244 schema:familyName Sheng
245 schema:givenName Hongmiao
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305166203.28
247 rdf:type schema:Person
248 sg:person.01323503556.25 schema:affiliation https://www.grid.ac/institutes/grid.166341.7
249 schema:familyName O'Mahony
250 schema:givenName Christine A
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323503556.25
252 rdf:type schema:Person
253 sg:person.013355461651.60 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
254 schema:familyName Lamps
255 schema:givenName Laura
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013355461651.60
257 rdf:type schema:Person
258 sg:person.01355254152.34 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
259 schema:familyName Beauchamp
260 schema:givenName R Daniel
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355254152.34
262 rdf:type schema:Person
263 sg:person.0626301614.27 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
264 schema:familyName DuBois
265 schema:givenName Raymond N
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626301614.27
267 rdf:type schema:Person
268 sg:pub.10.1038/383382b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003390594
269 https://doi.org/10.1038/383382b0
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/sj.onc.1201902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000680860
272 https://doi.org/10.1038/sj.onc.1201902
273 rdf:type schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1075479334 schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1075951696 schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1077748054 schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1078617780 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1079589037 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1079767004 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1082524223 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1082569670 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1082581462 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1082581512 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1082588267 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1082842694 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1082995754 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1083027645 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1083083391 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1083083393 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1083202753 schema:CreativeWork
291 https://doi.org/10.1002/ijc.2910550329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010883302
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/0006-291x(87)91481-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046619226
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/0014-4827(89)90101-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024450034
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/0016-5085(93)90011-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1053506807
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/0016-5085(94)90246-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020082397
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/0092-8674(95)90127-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007200098
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/0309-1651(84)90054-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036881719
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/0968-0004(94)90059-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050752694
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0016-5085(97)70007-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037413044
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s0092-8674(00)80127-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052923588
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s0092-8674(00)80128-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006370759
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s0092-8674(00)81333-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014745301
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s0092-8674(00)81335-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002180451
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s0092-8674(00)81983-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008830068
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s0092-8674(00)81988-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048354178
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1021/bi00591a005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181913
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1053/gast.1996.v110.pm8613017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034145839
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1053/gast.1996.v111.pm8898652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029064582
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1073/pnas.86.5.1578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037289639
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1073/pnas.87.4.1486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006647224
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1073/pnas.90.13.6076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014716073
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1073/pnas.91.25.12013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019347281
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1073/pnas.92.10.4254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031026444
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1073/pnas.94.7.3336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038658027
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1074/jbc.270.23.14154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010214895
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1074/jbc.270.37.22044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052504683
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1083/jcb.127.6.2021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025022548
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1083/jcb.129.3.853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047833392
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1093/carcin/17.5.989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278531
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1097/00006676-199007000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016198823
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1101/gad.8.20.2429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023676008
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1126/science.2163544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062525126
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1126/science.271.5247.350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552031
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1126/science.2895499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571075
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1126/science.7761852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649192
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1126/science.8388126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654919
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1128/mcb.10.9.4978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025422595
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1128/mcb.13.12.7239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039041278
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1172/jci116998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034579610
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1172/jci118717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030079669
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1172/jci119400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023711478
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1615/critrevoncog.v5.i2-3.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068132609
374 rdf:type schema:CreativeWork
375 https://www.grid.ac/institutes/grid.166341.7 schema:alternateName Drexel University
376 schema:name Department of Surgery, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
379 schema:name Department of Cell Biology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA
380 Department of Medicine, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA
381 Department of Pathology, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA
382 Department of Surgery, The Vanderbilt Cancer Center, Vanderbilt University Medical Center, and VA Medical Center, Nashville, Tennessee 37232, USA
383 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...