Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-02-04

AUTHORS

Bogdan Czerniak, Vijaya Chaturvedi, Li Li, Sherie Hodges, Dennis Johnston, Jae Y Ro, Rajyalakshmi Luthra, Christopher Logothetis, Andrew C Von Eschenbach, H Barton Grossman, William F Benedict, John G Batsakis

ABSTRACT

The evolution of alterations on chromosome 9, including the putative tumor suppressor genes mapped to the 9p21-22 region (the MTS genes), was studied in relation to the progression of human urinary bladder neoplasia by using whole organ superimposed histologic and genetic mapping in cystectomy specimens and was verified in urinary bladder tumors of various pathogenetic subsets with long-term follow-up. The applicability of chromosome 9 allelic losses as non-invasive markers of urothelial neoplasia was tested on voided urine and/or bladder washings of patients with urinary bladder cancer. Although sequential multiple hits in the MTS locus were documented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represent a major target for p21-23 deletions in bladder cancer. Two additional tumor suppressor genes involved in bladder neoplasia located distally and proximally to the MTS locus within p22-23 and p11-13 regions respectively were identified. Several distinct putative tumor suppressor gene loci within the q12-13, q21-22, and q34 regions were identified on the q arm. In particular, the pericentromeric q12-13 area may contain the critical tumor suppressor gene or genes for the development of early urothelial neoplasia. Allelic losses of chromosome 9 were associated with expansion of the abnormal urothelial clone which frequently involved large areas of urinary bladder mucosa. These losses could be found in a high proportion of urothelial tumors and in voided urine or bladder washing samples of nearly all patients with urinary bladder carcinoma. More... »

PAGES

1185-1196

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202385

DOI

http://dx.doi.org/10.1038/sj.onc.1202385

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024660747

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10022124


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34 schema:description The evolution of alterations on chromosome 9, including the putative tumor suppressor genes mapped to the 9p21-22 region (the MTS genes), was studied in relation to the progression of human urinary bladder neoplasia by using whole organ superimposed histologic and genetic mapping in cystectomy specimens and was verified in urinary bladder tumors of various pathogenetic subsets with long-term follow-up. The applicability of chromosome 9 allelic losses as non-invasive markers of urothelial neoplasia was tested on voided urine and/or bladder washings of patients with urinary bladder cancer. Although sequential multiple hits in the MTS locus were documented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represent a major target for p21-23 deletions in bladder cancer. Two additional tumor suppressor genes involved in bladder neoplasia located distally and proximally to the MTS locus within p22-23 and p11-13 regions respectively were identified. Several distinct putative tumor suppressor gene loci within the q12-13, q21-22, and q34 regions were identified on the q arm. In particular, the pericentromeric q12-13 area may contain the critical tumor suppressor gene or genes for the development of early urothelial neoplasia. Allelic losses of chromosome 9 were associated with expansion of the abnormal urothelial clone which frequently involved large areas of urinary bladder mucosa. These losses could be found in a high proportion of urothelial tumors and in voided urine or bladder washing samples of nearly all patients with urinary bladder carcinoma.
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41 allelic loss
42 alterations
43 applicability
44 area
45 arm
46 bladder
47 bladder cancer
48 bladder carcinoma
49 bladder mucosa
50 bladder neoplasia
51 bladder tumors
52 bladder washings
53 cancer
54 carcinogenesis
55 carcinoma
56 chromosome 9
57 clones
58 critical tumor suppressor genes
59 cystectomy specimens
60 deletion
61 detection
62 development
63 early detection
64 evolution
65 evolution of alterations
66 expansion
67 gene locus
68 genes
69 genetic mapping
70 genetic models
71 higher proportion
72 hits
73 implications
74 large areas
75 lesions
76 loci
77 loss
78 major target
79 mapping
80 markers
81 model
82 mucosa
83 multiple hits
84 neoplasia
85 non-invasive marker
86 organs
87 p22-23
88 patients
89 precursor lesions
90 progression
91 proportion
92 putative tumor suppressor gene
93 putative tumor suppressor gene loci
94 q arm
95 q34 region
96 region
97 relation
98 samples
99 specimens
100 subset
101 suppressor gene
102 target
103 tumor suppressor gene
104 tumor suppressor gene loci
105 tumors
106 urinary bladder cancer
107 urinary bladder carcinoma
108 urinary bladder mucosa
109 urinary bladder neoplasia
110 urinary bladder tumors
111 urine
112 urothelial carcinogenesis
113 urothelial neoplasia
114 urothelial tumors
115 voided urine
116 washing
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