PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-01

AUTHORS

Susana Velasco-Miguel, Leonard Buckbinder, Patrice Jean, Larry Gelbert, Randy Talbott, Jana Laidlaw, Bernd Seizinger, Nikolai Kley

ABSTRACT

Exposure of mammalian cells to hypoxia, radiation and certain chemotherapeutic agents promotes cell cycle arrest and/or apoptosis. Activation of p53 responsive genes is believed to play an important role in mediating such responses. In this study we identified a novel gene, PA26, which maps to chromosome 6q21 and encodes at least three transcript isoforms, of which two are differentially induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53-dependent manner. A functional p53-responsive element was identified in the second intron of the PA26 gene, in consistance with a mechanism of transcriptional induction of the PA26 gene by p53. No clues to its functions were revealed by sequence analysis, although pronounced negative regulation by serum factors argues for a potential role of PA26 in growth regulation. Immunological analysis suggests that PA26 protein(s) is localized to the cell nucleus. Our results suggest that the PA26 gene is a novel p53 target gene with properties common to the GADD family of growth arrest and DNA damage-inducible stress-response genes, and, thus, a potential novel regulator of cellular growth. More... »

PAGES

1202274

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202274

DOI

http://dx.doi.org/10.1038/sj.onc.1202274

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036577903

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9926927


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