c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-10

AUTHORS

J M Knowlden, J M W Gee, L T Seery, L Farrow, W J Gullick, I O Ellis, R W Blamey, J F R Robertson, R I Nicholson

ABSTRACT

We examined c-erbB3 and c-erbB4 mRNA expression in 47 primary breast cancer samples by simultaneous RT-PCR and have investigated correlations between these parameters and the expression of both ER and EGFR mRNA and protein as measured by RT-PCR and ICA and with Ki67 immunostaining. A direct association was found between c-erbB3 and c-erbB4 mRNA and ER marker status measured by either RT-PCR (c-erbB3 P = 0.0003; c-erbB4 P = 0.02) or ICA (c-erbB-3 P = 0.002; c-erbB4 P = 0.01). Inverse associations were seen between c-erbB3 and c-erbB4 mRNA marker status and EGFR membrane protein (c-erbB3: P = 0.003; cerbB4: P = 0.003) and mRNA (c-erbB4: P = 0.009) status. These associations were reinforced by Spearman Rank Correlation Tests. A significant relationship was seen between Ki67 and c-erbB4 mRNA status and level. Measurements of c-erbB3 protein levels in tumour samples removed from a further 89 patients of known response to endocrine therapy: (i) confirmed the relationship between c-erbB3 and ER and (ii) identified that patients whose ER positive tumours expressed high levels of c-erbB3 were most likely to benefit from endocrine measures. A non-significant trend was recorded between c-erbB3 levels and Ki67 immunostaining. These results clearly demonstrate that increased c-erbB3 and c-erbB4 expression appears to be associated with the prognostically-favourable ER phenotype. More... »

PAGES

1949

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202107

DOI

http://dx.doi.org/10.1038/sj.onc.1202107

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037929238

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9788438


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