p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-10

AUTHORS

Elisabeth Genot, Karin Reif, Sarah Beach, Ijsbrand Kramer, Doreen Cantrell

ABSTRACT

p21ras is activated by the T cell antigen receptor (TCR) and then co-ordinates important signaling pathways for T lymphocyte activation. Effector pathways for this guanine nucleotide binding protein in T cells are mediated by the serine/threonine kinase Raf-1 and the Ras-related GTPase Rac-1. In fibroblasts, an important effector for the Ras oncogene is Phosphatidylinositol 3-kinase (PtdIns 3-kinase). Activation of this lipid kinase is able to induce critical Rac-1 signaling pathways and can couple p21ras to cell survival mechanisms via the serine/threonine kinase Akt/PKB. The role of PtdIns 3-kinase in Ras signaling in T cells has not been explored. In the present study, we examined the ability of PtdIns 3-kinase to initiate the Rac-1 signaling pathways important for T cell activation. We also examined the possibility that Akt/PKB is regulated by Ras signaling pathways in T lymphocytes. The results show that Ras can initiate a Rac-1 mediated pathway that regulates the transcriptional function of AP-1 complexes. PtdIns 3-kinase signals cannot mimic p21ras and induce the Rac mediated responses of AP-1 transcriptional activation. Moreover, neither TCR or Ras activation of AP-1 is dependent on PtdIns 3-kinase. PKB is activated in response to triggering of the T cell antigen receptor; PtdIns 3-kinase activity is both required and sufficient for this TCR response. In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR. The present data thus highlight that PtdIns 3-kinase and Akt/PKB are not universal Ras effector molecules. Ras can initiate Rac-1 regulated signaling pathways in the context of T cell antigen receptor function independently of PtdIns 3-kinase activity. More... »

PAGES

1731

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202101

DOI

http://dx.doi.org/10.1038/sj.onc.1202101

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000000111

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9796702


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Calmodulin-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP Phosphohydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "JNK Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Jurkat Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor AP-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "rac GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Current address: Department of Immunology, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Genot", 
        "givenName": "Elisabeth", 
        "id": "sg:person.01100143613.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100143613.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Current address: Department of Microbiology and Immunology, 513 Parnassus, Box 0414, Rm HSE301, University of California, San Francisco California 94143\u20130414, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reif", 
        "givenName": "Karin", 
        "id": "sg:person.0771307206.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771307206.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Current address: Department of Immunology, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beach", 
        "givenName": "Sarah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College London", 
          "id": "https://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Department of Pharmacology, University College London, Gower Street, London WC1E 6BT"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kramer", 
        "givenName": "Ijsbrand", 
        "id": "sg:person.010621332735.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010621332735.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK", 
          "id": "https://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cantrell", 
        "givenName": "Doreen", 
        "id": "sg:person.01102077044.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102077044.50"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-10", 
    "datePublishedReg": "1998-10-01", 
    "description": "p21ras is activated by the T cell antigen receptor (TCR) and then co-ordinates important signaling pathways for T lymphocyte activation. Effector pathways for this guanine nucleotide binding protein in T cells are mediated by the serine/threonine kinase Raf-1 and the Ras-related GTPase Rac-1. In fibroblasts, an important effector for the Ras oncogene is Phosphatidylinositol 3-kinase (PtdIns 3-kinase). Activation of this lipid kinase is able to induce critical Rac-1 signaling pathways and can couple p21ras to cell survival mechanisms via the serine/threonine kinase Akt/PKB. The role of PtdIns 3-kinase in Ras signaling in T cells has not been explored. In the present study, we examined the ability of PtdIns 3-kinase to initiate the Rac-1 signaling pathways important for T cell activation. We also examined the possibility that Akt/PKB is regulated by Ras signaling pathways in T lymphocytes. The results show that Ras can initiate a Rac-1 mediated pathway that regulates the transcriptional function of AP-1 complexes. PtdIns 3-kinase signals cannot mimic p21ras and induce the Rac mediated responses of AP-1 transcriptional activation. Moreover, neither TCR or Ras activation of AP-1 is dependent on PtdIns 3-kinase. PKB is activated in response to triggering of the T cell antigen receptor; PtdIns 3-kinase activity is both required and sufficient for this TCR response. In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR. The present data thus highlight that PtdIns 3-kinase and Akt/PKB are not universal Ras effector molecules. Ras can initiate Rac-1 regulated signaling pathways in the context of T cell antigen receptor function independently of PtdIns 3-kinase activity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1202101", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "13", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes", 
    "pagination": "1731", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "00001f3fb3bfee8563d06438dad3686f0d8bec6318a463cdd14a313a0ca522a9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9796702"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1202101"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000000111"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1202101", 
      "https://app.dimensions.ai/details/publication/pub.1000000111"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118305_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1202101"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202101'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202101'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202101'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1202101'


 

This table displays all metadata directly associated to this object as RDF triples.

176 TRIPLES      20 PREDICATES      47 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1202101 schema:about N0a9b4028371442d3a6fceb3d372749d2
2 N2e96cc1568af4e09b6a057fb257c8b28
3 N2ecbcc4d87ce4861ac494f2a4ed7a686
4 N2ecbf18154ce47b8a3348b1a602e3078
5 N58c2b6168f1f45e6a4639778a5a1bb9e
6 N5b2f4348a6b34cfea58cdff6bd563952
7 N6d7d622d3bd64a699079473f8a8dfd33
8 N763bb3d47af345a5b96aef4fc2dbe84c
9 N7b2dc8cd7f834d3691e6a29f3d7677cb
10 N93f6c0e1f36a45adbede3f372bf23464
11 N97cbc566822f4722bd8b36fb89a22ec5
12 Nb7c25feca22541aca84aba588451a74e
13 Nbcbabc3b8c4a484ba90102ee56fe58ed
14 Nbd09a0b02e2746dabc8ef883c76873f0
15 Ncd3559f001854431949f761502cf35e6
16 Nd69c4eb7acc54784b2d3e9ddd579ec07
17 Nd8012e7ecf774f1bb2f3bf92b9a3541d
18 Neb10728e7f2d479ea8743b421ace959d
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author N5db72238f64540998622d3c5fa1ce9dd
22 schema:datePublished 1998-10
23 schema:datePublishedReg 1998-10-01
24 schema:description p21ras is activated by the T cell antigen receptor (TCR) and then co-ordinates important signaling pathways for T lymphocyte activation. Effector pathways for this guanine nucleotide binding protein in T cells are mediated by the serine/threonine kinase Raf-1 and the Ras-related GTPase Rac-1. In fibroblasts, an important effector for the Ras oncogene is Phosphatidylinositol 3-kinase (PtdIns 3-kinase). Activation of this lipid kinase is able to induce critical Rac-1 signaling pathways and can couple p21ras to cell survival mechanisms via the serine/threonine kinase Akt/PKB. The role of PtdIns 3-kinase in Ras signaling in T cells has not been explored. In the present study, we examined the ability of PtdIns 3-kinase to initiate the Rac-1 signaling pathways important for T cell activation. We also examined the possibility that Akt/PKB is regulated by Ras signaling pathways in T lymphocytes. The results show that Ras can initiate a Rac-1 mediated pathway that regulates the transcriptional function of AP-1 complexes. PtdIns 3-kinase signals cannot mimic p21ras and induce the Rac mediated responses of AP-1 transcriptional activation. Moreover, neither TCR or Ras activation of AP-1 is dependent on PtdIns 3-kinase. PKB is activated in response to triggering of the T cell antigen receptor; PtdIns 3-kinase activity is both required and sufficient for this TCR response. In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR. The present data thus highlight that PtdIns 3-kinase and Akt/PKB are not universal Ras effector molecules. Ras can initiate Rac-1 regulated signaling pathways in the context of T cell antigen receptor function independently of PtdIns 3-kinase activity.
25 schema:genre research_article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N29174967a531402e8057c511dd542af6
29 N787b4c7837aa4d2492ed4a2525c3a0d5
30 sg:journal.1097543
31 schema:name p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes
32 schema:pagination 1731
33 schema:productId N62b740415e6040ca9f94709febcabd41
34 N8693761b73eb47d18c20d385d483849e
35 Na154e9fee7304b00a2d94ead745f7d21
36 Naeb829e4026d4e06afabcec936233349
37 Nc4636cfffdb84328a2fe35aee7b97282
38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000000111
39 https://doi.org/10.1038/sj.onc.1202101
40 schema:sdDatePublished 2019-04-11T12:03
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher Ncff99c68cd3d44bba3f14e23b70f5eee
43 schema:url https://www.nature.com/articles/1202101
44 sgo:license sg:explorer/license/
45 sgo:sdDataset articles
46 rdf:type schema:ScholarlyArticle
47 N0a9b4028371442d3a6fceb3d372749d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
48 schema:name Signal Transduction
49 rdf:type schema:DefinedTerm
50 N29174967a531402e8057c511dd542af6 schema:issueNumber 13
51 rdf:type schema:PublicationIssue
52 N2e96cc1568af4e09b6a057fb257c8b28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
53 schema:name Enzyme Activation
54 rdf:type schema:DefinedTerm
55 N2ecbcc4d87ce4861ac494f2a4ed7a686 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Calcium-Calmodulin-Dependent Protein Kinases
57 rdf:type schema:DefinedTerm
58 N2ecbf18154ce47b8a3348b1a602e3078 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Jurkat Cells
60 rdf:type schema:DefinedTerm
61 N58c2b6168f1f45e6a4639778a5a1bb9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Mitogen-Activated Protein Kinases
63 rdf:type schema:DefinedTerm
64 N5a0c296aa982481187ef52a27a5b3cf2 schema:name Current address: Department of Microbiology and Immunology, 513 Parnassus, Box 0414, Rm HSE301, University of California, San Francisco California 94143–0414, USA
65 rdf:type schema:Organization
66 N5b2f4348a6b34cfea58cdff6bd563952 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Proto-Oncogene Proteins c-akt
68 rdf:type schema:DefinedTerm
69 N5db72238f64540998622d3c5fa1ce9dd rdf:first sg:person.01100143613.69
70 rdf:rest Nb3222fe40b3a4337b7637cb70a6b5cac
71 N62b740415e6040ca9f94709febcabd41 schema:name readcube_id
72 schema:value 00001f3fb3bfee8563d06438dad3686f0d8bec6318a463cdd14a313a0ca522a9
73 rdf:type schema:PropertyValue
74 N6d7d622d3bd64a699079473f8a8dfd33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name rac GTP-Binding Proteins
76 rdf:type schema:DefinedTerm
77 N763bb3d47af345a5b96aef4fc2dbe84c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name T-Lymphocytes
79 rdf:type schema:DefinedTerm
80 N787b4c7837aa4d2492ed4a2525c3a0d5 schema:volumeNumber 17
81 rdf:type schema:PublicationVolume
82 N7b2dc8cd7f834d3691e6a29f3d7677cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Transcription Factor AP-1
84 rdf:type schema:DefinedTerm
85 N7cfac6dcf890472babe98f02b764e62e rdf:first sg:person.010621332735.67
86 rdf:rest Ne5b93d86a24948068eca03dc956eb0a0
87 N8693761b73eb47d18c20d385d483849e schema:name doi
88 schema:value 10.1038/sj.onc.1202101
89 rdf:type schema:PropertyValue
90 N93f6c0e1f36a45adbede3f372bf23464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Phosphatidylinositol 3-Kinases
92 rdf:type schema:DefinedTerm
93 N97cbc566822f4722bd8b36fb89a22ec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Humans
95 rdf:type schema:DefinedTerm
96 Na154e9fee7304b00a2d94ead745f7d21 schema:name nlm_unique_id
97 schema:value 8711562
98 rdf:type schema:PropertyValue
99 Na6a26b2dd0a94051b22b3578744f8710 rdf:first Neb7872b4d8fe48d183facc0065c12b0b
100 rdf:rest N7cfac6dcf890472babe98f02b764e62e
101 Naeb829e4026d4e06afabcec936233349 schema:name pubmed_id
102 schema:value 9796702
103 rdf:type schema:PropertyValue
104 Nb3222fe40b3a4337b7637cb70a6b5cac rdf:first sg:person.0771307206.05
105 rdf:rest Na6a26b2dd0a94051b22b3578744f8710
106 Nb7c25feca22541aca84aba588451a74e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Proto-Oncogene Proteins p21(ras)
108 rdf:type schema:DefinedTerm
109 Nbcbabc3b8c4a484ba90102ee56fe58ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name GTP Phosphohydrolases
111 rdf:type schema:DefinedTerm
112 Nbd09a0b02e2746dabc8ef883c76873f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Transcription, Genetic
114 rdf:type schema:DefinedTerm
115 Nc4636cfffdb84328a2fe35aee7b97282 schema:name dimensions_id
116 schema:value pub.1000000111
117 rdf:type schema:PropertyValue
118 Ncd3559f001854431949f761502cf35e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Protein-Serine-Threonine Kinases
120 rdf:type schema:DefinedTerm
121 Ncff99c68cd3d44bba3f14e23b70f5eee schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 Nd69c4eb7acc54784b2d3e9ddd579ec07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name JNK Mitogen-Activated Protein Kinases
125 rdf:type schema:DefinedTerm
126 Nd8012e7ecf774f1bb2f3bf92b9a3541d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name GTP-Binding Proteins
128 rdf:type schema:DefinedTerm
129 Ne5b93d86a24948068eca03dc956eb0a0 rdf:first sg:person.01102077044.50
130 rdf:rest rdf:nil
131 Neb10728e7f2d479ea8743b421ace959d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Proto-Oncogene Proteins
133 rdf:type schema:DefinedTerm
134 Neb7872b4d8fe48d183facc0065c12b0b schema:affiliation https://www.grid.ac/institutes/grid.7445.2
135 schema:familyName Beach
136 schema:givenName Sarah
137 rdf:type schema:Person
138 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
139 schema:name Biological Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
142 schema:name Biochemistry and Cell Biology
143 rdf:type schema:DefinedTerm
144 sg:journal.1097543 schema:issn 0950-9232
145 1476-5594
146 schema:name Oncogene
147 rdf:type schema:Periodical
148 sg:person.010621332735.67 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
149 schema:familyName Kramer
150 schema:givenName Ijsbrand
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010621332735.67
152 rdf:type schema:Person
153 sg:person.01100143613.69 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
154 schema:familyName Genot
155 schema:givenName Elisabeth
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100143613.69
157 rdf:type schema:Person
158 sg:person.01102077044.50 schema:affiliation https://www.grid.ac/institutes/grid.11485.39
159 schema:familyName Cantrell
160 schema:givenName Doreen
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102077044.50
162 rdf:type schema:Person
163 sg:person.0771307206.05 schema:affiliation N5a0c296aa982481187ef52a27a5b3cf2
164 schema:familyName Reif
165 schema:givenName Karin
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771307206.05
167 rdf:type schema:Person
168 https://www.grid.ac/institutes/grid.11485.39 schema:alternateName Cancer Research UK
169 schema:name Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
170 rdf:type schema:Organization
171 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
172 schema:name Current address: Department of Immunology, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
173 rdf:type schema:Organization
174 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
175 schema:name Department of Pharmacology, University College London, Gower Street, London WC1E 6BT
176 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...