Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-09

AUTHORS

Knut Husmann, Christine Sers, Ellen Fietze, Antoaneta Mincheva, Peter Lichter, Reinhold Schäfer

ABSTRACT

The H-rev107 tumour suppressor was isolated as a gene specifically expressed in rat fibroblasts resistant toward malignant transformation by the activated HRAS gene (Sers et al., 1997; Hajnal et al., 1994). Here we describe the human homologue of the rat H-rev107 gene. The predicted rat and human proteins are highly conserved exhibiting an overall amino acid identity of 83%. The H-REV107-1 gene is ubiquitously expressed with the exception of haematopoetic cells and tissues. In contrast, H-REV107-1 mRNA was found only in eight of 27 cell lines derived from mammary carcinoma, lung carcinoma, gastric carcinoma, kidney carcinoma, melanoma, neuroblastoma and other tumours. The H-REV107-1 protein was not detectable in any of these tumour cells. Loss of H-REV107-1 expression was not restricted to cultured human tumour cell lines, but also found in primary squamous cell carcinomas. Gross structural aberrations of the H-REV107-1 gene were absent in tumorigenic cell lines. Thus, the block to H-REV107-1 expression is achieved both at the level of transcription and translation. By fluorescence in situ hybridisation the human H-REV107-1 gene was localised to chromosome 11q11-12. More... »

PAGES

1202060

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202060

DOI

http://dx.doi.org/10.1038/sj.onc.1202060

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001239913

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9771974


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