A new candidate site for a tumor suppressor gene involved in mouse thymic lymphomagenesis is located on the distal part ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-08

AUTHORS

Javier Santos, Michel Herranz, Ignacío Pérez de Castro, Angel Pellicer, José Fernández-Piqueras

ABSTRACT

In a previous work we provided preliminary evidence of the existence of a putative tumor suppressor gene region on the distal part of chromosome 4 in gamma-radiation-induced T-cell lymphomas of (C57BL/6J x RF/J) F1 hybrid mice. This region, named as TLSR2 (Thymic Lymphoma Suppressor Region 2), was located centered at D4Mit54. A more detailed allelotype analysis in the mentioned tumors with new informative microsatellites on distal chromosome 4 region, as well as in thymic lymphomas induced with gamma-rays in F1 hybrids generated from reciprocal crosses between the strains C57BL/6J and BALB/cJ, and having in mind the new map position of D4Mit205b, allowed us to confirm the existence of TLSR2 and to define it more precisely as centered at D4Mit205b. In addition, we identified a new candidate region, named as TLSR3 (Thymic Lymphoma Suppressor Region 3), located between the Mom-1 locus and D4Mit68, as the site of another putative tumor suppressor region involved in thymic lymphomagenesis. More... »

PAGES

1202009

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1202009

DOI

http://dx.doi.org/10.1038/sj.onc.1202009

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022746209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9780010


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