Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-07

AUTHORS

Hanina Hibshoosh, Mary Beth Terry, Ramon Parsons, Shikha Bose, Steven I Wang

ABSTRACT

To determine the status of chromosome 10q23 in primary breast carcinomas, in situ and invasive carcinomas were analysed for allelic loss using microsatellite markers spanning the 10q23 region. No LOH was seen in pure intraductal carcinomas (0/20 cases). On the other hand, LOH was observed in 40% (17/42) of invasive carcinomas (P = 0.0005). Interestingly, in situ lesions found in invasive tumors displayed LOH. Allelic loss was also significantly associated with loss of the estrogen receptor (P = 0.011). Thus, loss of the 10q23 is strongly associated with tumor progression. More... »

PAGES

123

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201940

DOI

http://dx.doi.org/10.1038/sj.onc.1201940

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051610015

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9671321


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma in Situ", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Ductal, Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "PTEN Phosphohydrolase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoric Monoester Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Tyrosine Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Pathology, Medicine and Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hibshoosh", 
        "givenName": "Hanina", 
        "id": "sg:person.0760461320.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760461320.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terry", 
        "givenName": "Mary Beth", 
        "id": "sg:person.012504154737.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012504154737.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Pathology, Medicine and Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA", 
            "Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parsons", 
        "givenName": "Ramon", 
        "id": "sg:person.01112011460.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112011460.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Pathology, Medicine and Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bose", 
        "givenName": "Shikha", 
        "id": "sg:person.0712316337.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712316337.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Pathology, Medicine and Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA", 
            "Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Steven I", 
        "id": "sg:person.0745542377.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745542377.36"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-07", 
    "datePublishedReg": "1998-07-01", 
    "description": "To determine the status of chromosome 10q23 in primary breast carcinomas, in situ and invasive carcinomas were analysed for allelic loss using microsatellite markers spanning the 10q23 region. No LOH was seen in pure intraductal carcinomas (0/20 cases). On the other hand, LOH was observed in 40% (17/42) of invasive carcinomas (P = 0.0005). Interestingly, in situ lesions found in invasive tumors displayed LOH. Allelic loss was also significantly associated with loss of the estrogen receptor (P = 0.011). Thus, loss of the 10q23 is strongly associated with tumor progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1201940", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas", 
    "pagination": "123", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f5d822c156f2a2e1ebad9bf93d6e8bb771bbdf69ea66e3eef47ecfc645460052"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9671321"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1201940"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051610015"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1201940", 
      "https://app.dimensions.ai/details/publication/pub.1051610015"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118327_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1201940"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201940'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201940'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201940'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201940'


 

This table displays all metadata directly associated to this object as RDF triples.

155 TRIPLES      20 PREDICATES      43 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1201940 schema:about N07e4b097724d4c4395570d0e7ffe896f
2 N10d0836583f54a2193e40e4f0c3de889
3 N3b5024cbfd2847ccb1d1410f7194c87a
4 N41de3bcefc6f4f91aa04ec60b1ef0a43
5 N4a95b4806da240cc8770b27cabb29811
6 N5020f24afca34cccad0c46c155fb4a0b
7 N5cf7b1416607447da64180fe2ba59a21
8 N622db8701dfd476289d429a5bf67a323
9 N7ae368e37e7b456ebf1368a651e75ab2
10 N839abd198f09447992aa67b48ebcd37f
11 N98c3bd6446094ba3933eec64559fce90
12 Na8c7319013504b4e82c7f11667d24dbe
13 Nab85e7ca951c4a479866c60059ca67db
14 Ne78d98b91f5546488733a937f6dd0540
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author Ne5d7b5dd9b834403b956d27b7c0a8216
18 schema:datePublished 1998-07
19 schema:datePublishedReg 1998-07-01
20 schema:description To determine the status of chromosome 10q23 in primary breast carcinomas, in situ and invasive carcinomas were analysed for allelic loss using microsatellite markers spanning the 10q23 region. No LOH was seen in pure intraductal carcinomas (0/20 cases). On the other hand, LOH was observed in 40% (17/42) of invasive carcinomas (P = 0.0005). Interestingly, in situ lesions found in invasive tumors displayed LOH. Allelic loss was also significantly associated with loss of the estrogen receptor (P = 0.011). Thus, loss of the 10q23 is strongly associated with tumor progression.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N187a345958614f7999c7ae8441127392
25 Nfb5e8518b3f54bebb4a62289269a9b99
26 sg:journal.1097543
27 schema:name Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas
28 schema:pagination 123
29 schema:productId N4d2619b6128e46f7b94e0e4f07e2ab2b
30 N4e52b82669f64a6a82a7e62462c856ed
31 N59596ec37339437bab31b2d6c30ab448
32 N92138ddb582849e7b4bdfb3bdf642cc0
33 Nf232564d5e964a40b5a2affc264b500b
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051610015
35 https://doi.org/10.1038/sj.onc.1201940
36 schema:sdDatePublished 2019-04-11T12:05
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher N2c305083caee4423bd326a6eade42e3d
39 schema:url https://www.nature.com/articles/1201940
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N07e4b097724d4c4395570d0e7ffe896f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
44 schema:name Mutation
45 rdf:type schema:DefinedTerm
46 N10d0836583f54a2193e40e4f0c3de889 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
47 schema:name Loss of Heterozygosity
48 rdf:type schema:DefinedTerm
49 N187a345958614f7999c7ae8441127392 schema:issueNumber 1
50 rdf:type schema:PublicationIssue
51 N2bdf0559041e43b5b11694d83d8d904c rdf:first sg:person.01112011460.11
52 rdf:rest N9c3fb4d6e7134dccaee92f0b1cc5e7ae
53 N2c305083caee4423bd326a6eade42e3d schema:name Springer Nature - SN SciGraph project
54 rdf:type schema:Organization
55 N3b5024cbfd2847ccb1d1410f7194c87a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Breast Neoplasms
57 rdf:type schema:DefinedTerm
58 N41de3bcefc6f4f91aa04ec60b1ef0a43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Humans
60 rdf:type schema:DefinedTerm
61 N4a95b4806da240cc8770b27cabb29811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Neoplasm Invasiveness
63 rdf:type schema:DefinedTerm
64 N4d2619b6128e46f7b94e0e4f07e2ab2b schema:name readcube_id
65 schema:value f5d822c156f2a2e1ebad9bf93d6e8bb771bbdf69ea66e3eef47ecfc645460052
66 rdf:type schema:PropertyValue
67 N4e52b82669f64a6a82a7e62462c856ed schema:name dimensions_id
68 schema:value pub.1051610015
69 rdf:type schema:PropertyValue
70 N5020f24afca34cccad0c46c155fb4a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name PTEN Phosphohydrolase
72 rdf:type schema:DefinedTerm
73 N526342433494475ca0ac2d24e9e75805 rdf:first sg:person.0745542377.36
74 rdf:rest rdf:nil
75 N59596ec37339437bab31b2d6c30ab448 schema:name doi
76 schema:value 10.1038/sj.onc.1201940
77 rdf:type schema:PropertyValue
78 N5cf7b1416607447da64180fe2ba59a21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Female
80 rdf:type schema:DefinedTerm
81 N622db8701dfd476289d429a5bf67a323 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Chromosomes, Human, Pair 10
83 rdf:type schema:DefinedTerm
84 N7ae368e37e7b456ebf1368a651e75ab2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Carcinoma in Situ
86 rdf:type schema:DefinedTerm
87 N839abd198f09447992aa67b48ebcd37f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Protein Tyrosine Phosphatases
89 rdf:type schema:DefinedTerm
90 N92138ddb582849e7b4bdfb3bdf642cc0 schema:name pubmed_id
91 schema:value 9671321
92 rdf:type schema:PropertyValue
93 N98c3bd6446094ba3933eec64559fce90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Tumor Suppressor Proteins
95 rdf:type schema:DefinedTerm
96 N9b0b475a662f4bc6bce4d5e5941c30ea rdf:first sg:person.012504154737.41
97 rdf:rest N2bdf0559041e43b5b11694d83d8d904c
98 N9c3fb4d6e7134dccaee92f0b1cc5e7ae rdf:first sg:person.0712316337.97
99 rdf:rest N526342433494475ca0ac2d24e9e75805
100 Na8c7319013504b4e82c7f11667d24dbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Phosphoric Monoester Hydrolases
102 rdf:type schema:DefinedTerm
103 Nab85e7ca951c4a479866c60059ca67db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Disease Progression
105 rdf:type schema:DefinedTerm
106 Ne5d7b5dd9b834403b956d27b7c0a8216 rdf:first sg:person.0760461320.97
107 rdf:rest N9b0b475a662f4bc6bce4d5e5941c30ea
108 Ne78d98b91f5546488733a937f6dd0540 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Carcinoma, Ductal, Breast
110 rdf:type schema:DefinedTerm
111 Nf232564d5e964a40b5a2affc264b500b schema:name nlm_unique_id
112 schema:value 8711562
113 rdf:type schema:PropertyValue
114 Nfb5e8518b3f54bebb4a62289269a9b99 schema:volumeNumber 17
115 rdf:type schema:PublicationVolume
116 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
117 schema:name Medical and Health Sciences
118 rdf:type schema:DefinedTerm
119 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
120 schema:name Oncology and Carcinogenesis
121 rdf:type schema:DefinedTerm
122 sg:journal.1097543 schema:issn 0950-9232
123 1476-5594
124 schema:name Oncogene
125 rdf:type schema:Periodical
126 sg:person.01112011460.11 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
127 schema:familyName Parsons
128 schema:givenName Ramon
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112011460.11
130 rdf:type schema:Person
131 sg:person.012504154737.41 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
132 schema:familyName Terry
133 schema:givenName Mary Beth
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012504154737.41
135 rdf:type schema:Person
136 sg:person.0712316337.97 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
137 schema:familyName Bose
138 schema:givenName Shikha
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712316337.97
140 rdf:type schema:Person
141 sg:person.0745542377.36 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
142 schema:familyName Wang
143 schema:givenName Steven I
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745542377.36
145 rdf:type schema:Person
146 sg:person.0760461320.97 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
147 schema:familyName Hibshoosh
148 schema:givenName Hanina
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760461320.97
150 rdf:type schema:Person
151 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
152 schema:name Department of Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
153 Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
154 Department of Pathology, Medicine and Epidemiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
155 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...