Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-07

AUTHORS

Marielle Cavrois, India Leclercq, Olivier Gout, Antoine Gessain, Simon Wain-Hobson, Eric Wattel

ABSTRACT

The pattern of HTLV-1 replication was assessed through PCR amplification of the 3' proviral integration sites in patients with TSP/HAM at different times. Integration sites were sequenced and oligonucleotides specific for the flanking sequences were synthesized. Together with HTLV-1 LTR specific primers, clonotypic nested PCR was performed on peripheral blood from two patients. The frequencies of five clones studied ranged from 1/300 to 1/1500 PBMCs while four clones persisted for more than 1-5 years. It would seem that Tax driven expansion of T cells may persist for considerable periods of time in TSP/HAM despite strong cellular immunity. This may provide a background for the accumulation of subsequent mutations leading to malignancy. More... »

PAGES

1201906

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201906

DOI

http://dx.doi.org/10.1038/sj.onc.1201906

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041069693

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9671316


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Human T-lymphotropic virus 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes, Mononuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligodeoxyribonucleotides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paraparesis, Tropical Spastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Latency", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut pour la Recherche sur le Cancer de Lille", 
          "id": "https://www.grid.ac/institutes/grid.420223.5", 
          "name": [
            "Unit\u00e9 124 INSERM, Institut de Recherche sur le Cancer de Lille, France", 
            "Current address: Institute of Human Virology, Medical Biotechnology Center, University of Maryland, 725 West Lombard Street, Baltimore, Maryland 21201, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cavrois", 
        "givenName": "Marielle", 
        "id": "sg:person.01026561715.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026561715.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut pour la Recherche sur le Cancer de Lille", 
          "id": "https://www.grid.ac/institutes/grid.420223.5", 
          "name": [
            "Unit\u00e9 124 INSERM, Institut de Recherche sur le Cancer de Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leclercq", 
        "givenName": "India", 
        "id": "sg:person.0615356226.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615356226.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "F\u00e9d\u00e9ration de Neurologie, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gout", 
        "givenName": "Olivier", 
        "id": "sg:person.01302231233.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302231233.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit\u00e9 d'Epid\u00e9miologie des Virus Oncog\u00e8nes, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gessain", 
        "givenName": "Antoine", 
        "id": "sg:person.01055521174.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055521174.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 de Retrovirologie Mol\u00e9culaire, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wain-Hobson", 
        "givenName": "Simon", 
        "id": "sg:person.055642406.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Oscar Lambret", 
          "id": "https://www.grid.ac/institutes/grid.452351.4", 
          "name": [
            "Unit\u00e9 124 INSERM, Institut de Recherche sur le Cancer de Lille, France", 
            "Unit\u00e9 d'Oncogen\u00e8se Virale, Centre Oscar Lambret, Lille, France", 
            "Service des Maladies du Sang, CHU, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wattel", 
        "givenName": "Eric", 
        "id": "sg:person.0700626202.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700626202.51"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-07", 
    "datePublishedReg": "1998-07-01", 
    "description": "The pattern of HTLV-1 replication was assessed through PCR amplification of the 3' proviral integration sites in patients with TSP/HAM at different times. Integration sites were sequenced and oligonucleotides specific for the flanking sequences were synthesized. Together with HTLV-1 LTR specific primers, clonotypic nested PCR was performed on peripheral blood from two patients. The frequencies of five clones studied ranged from 1/300 to 1/1500 PBMCs while four clones persisted for more than 1-5 years. It would seem that Tax driven expansion of T cells may persist for considerable periods of time in TSP/HAM despite strong cellular immunity. This may provide a background for the accumulation of subsequent mutations leading to malignancy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1201906", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy", 
    "pagination": "1201906", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c3a43a594a6b78bbd8de5b9d638b8ae3d21a167ee3bacb20a81da2da7de81d52"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9671316"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1201906"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041069693"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1201906", 
      "https://app.dimensions.ai/details/publication/pub.1041069693"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118346_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1201906"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201906'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201906'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201906'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201906'


 

This table displays all metadata directly associated to this object as RDF triples.

162 TRIPLES      20 PREDICATES      40 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1201906 schema:about N0e24c9adca7b42ca962804d0c376b8ea
2 N1a5129bf5ff34468928be7419b846aae
3 N27cfff7dd301490799d97719669b9671
4 N2d61030938d24c0b8f86401ae90240cb
5 N4526204c382e4f4a9b892f14d02d3a43
6 N4caf90b0d8364941a15e9dd578b775db
7 N58d63332c5454f39aa253fc02a062404
8 N78a8e47a3df94ccf8d0865b001fa1b81
9 N802c1b7e958c4142ac61ad86637d243e
10 N896c680714d841b39bf6cba7b83c34d6
11 Na598f67b3596489ebfbc6242610dde2d
12 anzsrc-for:11
13 anzsrc-for:1107
14 schema:author Ncd0f6a1bbda04df38c8a1022823af64a
15 schema:datePublished 1998-07
16 schema:datePublishedReg 1998-07-01
17 schema:description The pattern of HTLV-1 replication was assessed through PCR amplification of the 3' proviral integration sites in patients with TSP/HAM at different times. Integration sites were sequenced and oligonucleotides specific for the flanking sequences were synthesized. Together with HTLV-1 LTR specific primers, clonotypic nested PCR was performed on peripheral blood from two patients. The frequencies of five clones studied ranged from 1/300 to 1/1500 PBMCs while four clones persisted for more than 1-5 years. It would seem that Tax driven expansion of T cells may persist for considerable periods of time in TSP/HAM despite strong cellular immunity. This may provide a background for the accumulation of subsequent mutations leading to malignancy.
18 schema:genre research_article
19 schema:inLanguage en
20 schema:isAccessibleForFree true
21 schema:isPartOf N4480728c477c4e7393dc4840bc23b229
22 Nb52f8a4475ae4f25a8653adeef37cd18
23 sg:journal.1097543
24 schema:name Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy
25 schema:pagination 1201906
26 schema:productId N046450d0fc2f46fbb7dc1d7ca0498d6d
27 N2f7afcd9910b4fb78b58af873a0ddc56
28 N4b984ac434d64795a5da898937727c83
29 Nc155482afbf8481181976b7629063d5c
30 Nd0d4374964c54e76bc03e3dd87f34c94
31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041069693
32 https://doi.org/10.1038/sj.onc.1201906
33 schema:sdDatePublished 2019-04-11T12:07
34 schema:sdLicense https://scigraph.springernature.com/explorer/license/
35 schema:sdPublisher N66ecc3c2b2534bb9b1373857b4675704
36 schema:url http://www.nature.com/articles/1201906
37 sgo:license sg:explorer/license/
38 sgo:sdDataset articles
39 rdf:type schema:ScholarlyArticle
40 N046450d0fc2f46fbb7dc1d7ca0498d6d schema:name doi
41 schema:value 10.1038/sj.onc.1201906
42 rdf:type schema:PropertyValue
43 N063d4088c692420196dbae244705a80b rdf:first sg:person.0615356226.07
44 rdf:rest Ne82e67d769ce448fb999fca2a889910a
45 N0e24c9adca7b42ca962804d0c376b8ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
46 schema:name Humans
47 rdf:type schema:DefinedTerm
48 N1a5129bf5ff34468928be7419b846aae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
49 schema:name Oligodeoxyribonucleotides
50 rdf:type schema:DefinedTerm
51 N25977f826171402493b32a6c7e552254 rdf:first sg:person.0700626202.51
52 rdf:rest rdf:nil
53 N27cfff7dd301490799d97719669b9671 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Leukocytes, Mononuclear
55 rdf:type schema:DefinedTerm
56 N2d61030938d24c0b8f86401ae90240cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Virus Latency
58 rdf:type schema:DefinedTerm
59 N2f7afcd9910b4fb78b58af873a0ddc56 schema:name dimensions_id
60 schema:value pub.1041069693
61 rdf:type schema:PropertyValue
62 N4480728c477c4e7393dc4840bc23b229 schema:volumeNumber 17
63 rdf:type schema:PublicationVolume
64 N4526204c382e4f4a9b892f14d02d3a43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Base Sequence
66 rdf:type schema:DefinedTerm
67 N492414eea5964e3eaec67df1081c8e2a rdf:first sg:person.01055521174.17
68 rdf:rest N741b874ed7f24cca982ea311b759c74a
69 N4b984ac434d64795a5da898937727c83 schema:name nlm_unique_id
70 schema:value 8711562
71 rdf:type schema:PropertyValue
72 N4caf90b0d8364941a15e9dd578b775db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Middle Aged
74 rdf:type schema:DefinedTerm
75 N58d63332c5454f39aa253fc02a062404 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Paraparesis, Tropical Spastic
77 rdf:type schema:DefinedTerm
78 N66ecc3c2b2534bb9b1373857b4675704 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N741b874ed7f24cca982ea311b759c74a rdf:first sg:person.055642406.07
81 rdf:rest N25977f826171402493b32a6c7e552254
82 N78a8e47a3df94ccf8d0865b001fa1b81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Human T-lymphotropic virus 1
84 rdf:type schema:DefinedTerm
85 N802c1b7e958c4142ac61ad86637d243e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Female
87 rdf:type schema:DefinedTerm
88 N896c680714d841b39bf6cba7b83c34d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Molecular Sequence Data
90 rdf:type schema:DefinedTerm
91 Na598f67b3596489ebfbc6242610dde2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Adult
93 rdf:type schema:DefinedTerm
94 Nb52f8a4475ae4f25a8653adeef37cd18 schema:issueNumber 1
95 rdf:type schema:PublicationIssue
96 Nc155482afbf8481181976b7629063d5c schema:name readcube_id
97 schema:value c3a43a594a6b78bbd8de5b9d638b8ae3d21a167ee3bacb20a81da2da7de81d52
98 rdf:type schema:PropertyValue
99 Ncd0f6a1bbda04df38c8a1022823af64a rdf:first sg:person.01026561715.82
100 rdf:rest N063d4088c692420196dbae244705a80b
101 Nd0d4374964c54e76bc03e3dd87f34c94 schema:name pubmed_id
102 schema:value 9671316
103 rdf:type schema:PropertyValue
104 Ne82e67d769ce448fb999fca2a889910a rdf:first sg:person.01302231233.16
105 rdf:rest N492414eea5964e3eaec67df1081c8e2a
106 Nfa8472e5222e4c9bade9c648bb393e41 schema:name Unité d'Epidémiologie des Virus Oncogènes, Paris, France
107 rdf:type schema:Organization
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
112 schema:name Immunology
113 rdf:type schema:DefinedTerm
114 sg:journal.1097543 schema:issn 0950-9232
115 1476-5594
116 schema:name Oncogene
117 rdf:type schema:Periodical
118 sg:person.01026561715.82 schema:affiliation https://www.grid.ac/institutes/grid.420223.5
119 schema:familyName Cavrois
120 schema:givenName Marielle
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026561715.82
122 rdf:type schema:Person
123 sg:person.01055521174.17 schema:affiliation Nfa8472e5222e4c9bade9c648bb393e41
124 schema:familyName Gessain
125 schema:givenName Antoine
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055521174.17
127 rdf:type schema:Person
128 sg:person.01302231233.16 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
129 schema:familyName Gout
130 schema:givenName Olivier
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302231233.16
132 rdf:type schema:Person
133 sg:person.055642406.07 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
134 schema:familyName Wain-Hobson
135 schema:givenName Simon
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07
137 rdf:type schema:Person
138 sg:person.0615356226.07 schema:affiliation https://www.grid.ac/institutes/grid.420223.5
139 schema:familyName Leclercq
140 schema:givenName India
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615356226.07
142 rdf:type schema:Person
143 sg:person.0700626202.51 schema:affiliation https://www.grid.ac/institutes/grid.452351.4
144 schema:familyName Wattel
145 schema:givenName Eric
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700626202.51
147 rdf:type schema:Person
148 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
149 schema:name Fédération de Neurologie, Hôpital de la Pitié Salpêtrière, Paris, France
150 rdf:type schema:Organization
151 https://www.grid.ac/institutes/grid.420223.5 schema:alternateName Institut pour la Recherche sur le Cancer de Lille
152 schema:name Current address: Institute of Human Virology, Medical Biotechnology Center, University of Maryland, 725 West Lombard Street, Baltimore, Maryland 21201, USA
153 Unité 124 INSERM, Institut de Recherche sur le Cancer de Lille, France
154 rdf:type schema:Organization
155 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
156 schema:name Unité de Retrovirologie Moléculaire, Institut Pasteur, Paris, France
157 rdf:type schema:Organization
158 https://www.grid.ac/institutes/grid.452351.4 schema:alternateName Centre Oscar Lambret
159 schema:name Service des Maladies du Sang, CHU, Lille, France
160 Unité 124 INSERM, Institut de Recherche sur le Cancer de Lille, France
161 Unité d'Oncogenèse Virale, Centre Oscar Lambret, Lille, France
162 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...