Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-05-14

AUTHORS

R Halaban, E Cheng, Y Zhang, C E Mandigo, M R Miglarese

ABSTRACT

Compared to normal melanocytes, melanoma cell lines exhibit overexpression of hyperphosphorylated retinoblastoma tumor suppressor protein (Rb) or a marked decrease in, or lack of, expression of Rb. Hyperphosphorylation of Rb results in increased E2F-mediated transactivation of target genes and cell cycle progression. Using a combination of gene disruption and ectopic expression in growth factor-dependent mouse melanocytes, we studied the roles of E2F1 and the p16INK4A and p21WAF1/CIP1 CKIs (cyclin dependent kinase inhibitors) in the acquisition of TPA (12-O-tetradecanoyl phorbol-13-acetate)-independent growth in culture, a hallmark of melanomas. Surprisingly, melanocytes from p16INK4A- or p21WAF1/CIP1-null mice remained TPA-dependent, and disruption of p21WAF1/CIP1 accelerated cell death in the absence of this mitogen. Disruption of E2F1 had the most profound effect on melanocyte growth, resulting in a fourfold decrease in growth rate in the presence of TPA. Furthermore, enforced overexpression of the DNA-binding-defective E2F1E132 mutant conferred TPA-independence upon melanocytes and was associated with sequestration of Rb and constitutive expression of E2F1 target genes, including p21WAF1/CIP1. We conclude that neutralization of Rb by E2F1E132, but not the disruption of p16INK4A or p21WAF1/CIP1, resulted in the accumulation of free E2F and cell cycle progression. Thus, mechanisms other than the loss of p16INK4A or p21WAF1/CIP1 that activate E2F may play an important role in melanomas. More... »

PAGES

2489-2501

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201773

DOI

http://dx.doi.org/10.1038/sj.onc.1201773

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027113387

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9627115


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p21", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "E2F Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "E2F1 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutagenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Biosynthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma-Binding Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetradecanoylphorbol Acetate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor DP1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halaban", 
        "givenName": "R", 
        "id": "sg:person.053601122.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053601122.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "E", 
        "id": "sg:person.01271010511.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271010511.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Y", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mandigo", 
        "givenName": "C E", 
        "id": "sg:person.01076014770.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076014770.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmaceutical Division, Institute of Bone and Joint Disorders and Cancer Research, Bayer Corporation, 06516, West Haven, CT", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
            "Pharmaceutical Division, Institute of Bone and Joint Disorders and Cancer Research, Bayer Corporation, 06516, West Haven, CT"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miglarese", 
        "givenName": "M R", 
        "id": "sg:person.0657553015.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657553015.25"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-05-14", 
    "datePublishedReg": "1998-05-14", 
    "description": "Compared to normal melanocytes, melanoma cell lines exhibit overexpression of hyperphosphorylated retinoblastoma tumor suppressor protein (Rb) or a marked decrease in, or lack of, expression of Rb. Hyperphosphorylation of Rb results in increased E2F-mediated transactivation of target genes and cell cycle progression. Using a combination of gene disruption and ectopic expression in growth factor-dependent mouse melanocytes, we studied the roles of E2F1 and the p16INK4A and p21WAF1/CIP1 CKIs (cyclin dependent kinase inhibitors) in the acquisition of TPA (12-O-tetradecanoyl phorbol-13-acetate)-independent growth in culture, a hallmark of melanomas. Surprisingly, melanocytes from p16INK4A- or p21WAF1/CIP1-null mice remained TPA-dependent, and disruption of p21WAF1/CIP1 accelerated cell death in the absence of this mitogen. Disruption of E2F1 had the most profound effect on melanocyte growth, resulting in a fourfold decrease in growth rate in the presence of TPA. Furthermore, enforced overexpression of the DNA-binding-defective E2F1E132 mutant conferred TPA-independence upon melanocytes and was associated with sequestration of Rb and constitutive expression of E2F1 target genes, including p21WAF1/CIP1. We conclude that neutralization of Rb by E2F1E132, but not the disruption of p16INK4A or p21WAF1/CIP1, resulted in the accumulation of free E2F and cell cycle progression. Thus, mechanisms other than the loss of p16INK4A or p21WAF1/CIP1 that activate E2F may play an important role in melanomas.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1201773", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "19", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "keywords": [
      "p21WAF1/CIP1", 
      "cell cycle progression", 
      "mouse melanocytes", 
      "target genes", 
      "cycle progression", 
      "retinoblastoma tumor suppressor protein", 
      "E2F-mediated transactivation", 
      "cell cycle constraints", 
      "tumor suppressor protein", 
      "role of E2F1", 
      "deletion of p16INK4A", 
      "free E2F", 
      "expression of Rb", 
      "gene disruption", 
      "suppressor protein", 
      "ectopic expression", 
      "hallmark of melanoma", 
      "tetradecanoyl phorbol 13", 
      "loss of p16INK4a", 
      "constitutive expression", 
      "melanoma cell lines", 
      "cell death", 
      "normal melanocytes", 
      "independent growth", 
      "melanocyte growth", 
      "CIP1", 
      "E2F", 
      "cell lines", 
      "phorbol 13", 
      "E2F1", 
      "genes", 
      "melanocytes", 
      "presence of TPA", 
      "overexpression", 
      "p16INK4a", 
      "expression", 
      "RBS results", 
      "growth rate", 
      "disruption", 
      "profound effect", 
      "important role", 
      "mutants", 
      "CKI", 
      "transactivation", 
      "fourfold decrease", 
      "TPA", 
      "protein", 
      "growth", 
      "deletion", 
      "hyperphosphorylation", 
      "mitogen", 
      "role", 
      "progression", 
      "Rb", 
      "hallmark", 
      "accumulation", 
      "sequestration", 
      "mechanism", 
      "mice", 
      "lines", 
      "cycle constraints", 
      "melanoma", 
      "absence", 
      "culture", 
      "release", 
      "death", 
      "loss", 
      "decrease", 
      "presence", 
      "acquisition", 
      "combination", 
      "lack", 
      "effect", 
      "neutralization", 
      "results", 
      "rate", 
      "constraints"
    ], 
    "name": "Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1", 
    "pagination": "2489-2501", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027113387"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1201773"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9627115"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1201773", 
      "https://app.dimensions.ai/details/publication/pub.1027113387"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_284.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1201773"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201773'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201773'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201773'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201773'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      20 PREDICATES      127 URIs      118 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1201773 schema:about N080819b95ea34ed69f2c3300ee90905e
2 N4be731feb2724849b6d8a4735fb71132
3 N51dcc08ffd534ea89de9a67eaab15e29
4 N55cb39972e704f2194bdb5a4f043a312
5 N55f7b1ed034e4b67b9827a58fae708eb
6 N5eb53f0f0b0047f195756b88dd46e647
7 N6728264379f8405581b7a68d83c35a4a
8 N68ee60784079485e9e8898b974521baa
9 N6d664a959a3f4c2b82cbd2cc7bfa63ae
10 N77666974d41d4fdb9dc535f18b9dc322
11 N77f44d102da04785b182566078986562
12 N7b716df75a064915b46b9cf851920def
13 N852bd45351604f2c81c05236cd369eaf
14 N8bdbff1448d0490ca7445c87774a0183
15 N9642d8917db84fad98df90d807815de2
16 N99d448a53e6e4b89837c2f1c55b7c051
17 Nacec1b84d5ee40369a35c9dd8522a144
18 Nbab3121040af430591b4a2c70dbdcbd6
19 Nd2e3ccf2c4964942b03cc4f60c80422b
20 Nd53384d95a1a47919a77a1893c5b01c2
21 Ne981cc92a5c347c49c9c1c0f06df1774
22 Nebd62a5c66e44a11b9e839f5b6c8da00
23 Nf083e33c3d24453db2772f4253129e61
24 Nfbc99bdbeffe4d5ab4c89c98817e2241
25 anzsrc-for:11
26 anzsrc-for:1103
27 anzsrc-for:1112
28 schema:author N83704c1918f24895996bbbca186ef590
29 schema:datePublished 1998-05-14
30 schema:datePublishedReg 1998-05-14
31 schema:description Compared to normal melanocytes, melanoma cell lines exhibit overexpression of hyperphosphorylated retinoblastoma tumor suppressor protein (Rb) or a marked decrease in, or lack of, expression of Rb. Hyperphosphorylation of Rb results in increased E2F-mediated transactivation of target genes and cell cycle progression. Using a combination of gene disruption and ectopic expression in growth factor-dependent mouse melanocytes, we studied the roles of E2F1 and the p16INK4A and p21WAF1/CIP1 CKIs (cyclin dependent kinase inhibitors) in the acquisition of TPA (12-O-tetradecanoyl phorbol-13-acetate)-independent growth in culture, a hallmark of melanomas. Surprisingly, melanocytes from p16INK4A- or p21WAF1/CIP1-null mice remained TPA-dependent, and disruption of p21WAF1/CIP1 accelerated cell death in the absence of this mitogen. Disruption of E2F1 had the most profound effect on melanocyte growth, resulting in a fourfold decrease in growth rate in the presence of TPA. Furthermore, enforced overexpression of the DNA-binding-defective E2F1E132 mutant conferred TPA-independence upon melanocytes and was associated with sequestration of Rb and constitutive expression of E2F1 target genes, including p21WAF1/CIP1. We conclude that neutralization of Rb by E2F1E132, but not the disruption of p16INK4A or p21WAF1/CIP1, resulted in the accumulation of free E2F and cell cycle progression. Thus, mechanisms other than the loss of p16INK4A or p21WAF1/CIP1 that activate E2F may play an important role in melanomas.
32 schema:genre article
33 schema:isAccessibleForFree false
34 schema:isPartOf N45b4c41b32f84165bf7f7952aa5233ff
35 N79778b537db64f7f823a4f88d41f5aff
36 sg:journal.1097543
37 schema:keywords CIP1
38 CKI
39 E2F
40 E2F-mediated transactivation
41 E2F1
42 RBS results
43 Rb
44 TPA
45 absence
46 accumulation
47 acquisition
48 cell cycle constraints
49 cell cycle progression
50 cell death
51 cell lines
52 combination
53 constitutive expression
54 constraints
55 culture
56 cycle constraints
57 cycle progression
58 death
59 decrease
60 deletion
61 deletion of p16INK4A
62 disruption
63 ectopic expression
64 effect
65 expression
66 expression of Rb
67 fourfold decrease
68 free E2F
69 gene disruption
70 genes
71 growth
72 growth rate
73 hallmark
74 hallmark of melanoma
75 hyperphosphorylation
76 important role
77 independent growth
78 lack
79 lines
80 loss
81 loss of p16INK4a
82 mechanism
83 melanocyte growth
84 melanocytes
85 melanoma
86 melanoma cell lines
87 mice
88 mitogen
89 mouse melanocytes
90 mutants
91 neutralization
92 normal melanocytes
93 overexpression
94 p16INK4a
95 p21WAF1/CIP1
96 phorbol 13
97 presence
98 presence of TPA
99 profound effect
100 progression
101 protein
102 rate
103 release
104 results
105 retinoblastoma tumor suppressor protein
106 role
107 role of E2F1
108 sequestration
109 suppressor protein
110 target genes
111 tetradecanoyl phorbol 13
112 transactivation
113 tumor suppressor protein
114 schema:name Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1
115 schema:pagination 2489-2501
116 schema:productId N01c23a0a37f945d9a15459ac06d16588
117 N78e891078a1b4a9baaf8161b9aa5a253
118 Na046e6fd89e74d7cad4e0a84bc6b9084
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027113387
120 https://doi.org/10.1038/sj.onc.1201773
121 schema:sdDatePublished 2022-09-02T15:49
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher Nad10edbd324341189e3512ed8386780d
124 schema:url https://doi.org/10.1038/sj.onc.1201773
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N01c23a0a37f945d9a15459ac06d16588 schema:name pubmed_id
129 schema:value 9627115
130 rdf:type schema:PropertyValue
131 N080819b95ea34ed69f2c3300ee90905e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mutagenesis
133 rdf:type schema:DefinedTerm
134 N45b4c41b32f84165bf7f7952aa5233ff schema:volumeNumber 16
135 rdf:type schema:PublicationVolume
136 N4be731feb2724849b6d8a4735fb71132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name E2F1 Transcription Factor
138 rdf:type schema:DefinedTerm
139 N4ffe28d0df3b4baab2a9a3cdc460da2f rdf:first sg:person.0657553015.25
140 rdf:rest rdf:nil
141 N51dcc08ffd534ea89de9a67eaab15e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Mice, Nude
143 rdf:type schema:DefinedTerm
144 N55cb39972e704f2194bdb5a4f043a312 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name DNA-Binding Proteins
146 rdf:type schema:DefinedTerm
147 N55f7b1ed034e4b67b9827a58fae708eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cell Survival
149 rdf:type schema:DefinedTerm
150 N5bc095fa21e74442aa1213d53dd68be2 rdf:first sg:person.01076014770.67
151 rdf:rest N4ffe28d0df3b4baab2a9a3cdc460da2f
152 N5eb53f0f0b0047f195756b88dd46e647 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Retinoblastoma Protein
154 rdf:type schema:DefinedTerm
155 N6728264379f8405581b7a68d83c35a4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Tetradecanoylphorbol Acetate
157 rdf:type schema:DefinedTerm
158 N68ee60784079485e9e8898b974521baa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cyclin-Dependent Kinase Inhibitor p21
160 rdf:type schema:DefinedTerm
161 N6d664a959a3f4c2b82cbd2cc7bfa63ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Gene Expression Regulation
163 rdf:type schema:DefinedTerm
164 N77666974d41d4fdb9dc535f18b9dc322 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 N77f44d102da04785b182566078986562 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Transcription Factor DP1
169 rdf:type schema:DefinedTerm
170 N78e891078a1b4a9baaf8161b9aa5a253 schema:name doi
171 schema:value 10.1038/sj.onc.1201773
172 rdf:type schema:PropertyValue
173 N79778b537db64f7f823a4f88d41f5aff schema:issueNumber 19
174 rdf:type schema:PublicationIssue
175 N7b716df75a064915b46b9cf851920def schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Melanocytes
177 rdf:type schema:DefinedTerm
178 N83704c1918f24895996bbbca186ef590 rdf:first sg:person.053601122.01
179 rdf:rest Ndc3bf55c01804a4bb3eb88041d5ebaec
180 N852bd45351604f2c81c05236cd369eaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Protein Biosynthesis
182 rdf:type schema:DefinedTerm
183 N8bdbff1448d0490ca7445c87774a0183 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Mice
185 rdf:type schema:DefinedTerm
186 N9642d8917db84fad98df90d807815de2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Transcription Factors
188 rdf:type schema:DefinedTerm
189 N99d448a53e6e4b89837c2f1c55b7c051 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Recombinant Fusion Proteins
191 rdf:type schema:DefinedTerm
192 N9ba438e41bc146a689be7c8408a69f3d schema:affiliation grid-institutes:grid.47100.32
193 schema:familyName Zhang
194 schema:givenName Y
195 rdf:type schema:Person
196 Na046e6fd89e74d7cad4e0a84bc6b9084 schema:name dimensions_id
197 schema:value pub.1027113387
198 rdf:type schema:PropertyValue
199 Nacec1b84d5ee40369a35c9dd8522a144 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Retinoblastoma-Binding Protein 1
201 rdf:type schema:DefinedTerm
202 Nad10edbd324341189e3512ed8386780d schema:name Springer Nature - SN SciGraph project
203 rdf:type schema:Organization
204 Nb3f99a5fc5a94467b4b23f729be79292 rdf:first N9ba438e41bc146a689be7c8408a69f3d
205 rdf:rest N5bc095fa21e74442aa1213d53dd68be2
206 Nbab3121040af430591b4a2c70dbdcbd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Cell Cycle
208 rdf:type schema:DefinedTerm
209 Nd2e3ccf2c4964942b03cc4f60c80422b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Cyclin-Dependent Kinase Inhibitor p16
211 rdf:type schema:DefinedTerm
212 Nd53384d95a1a47919a77a1893c5b01c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Carrier Proteins
214 rdf:type schema:DefinedTerm
215 Ndc3bf55c01804a4bb3eb88041d5ebaec rdf:first sg:person.01271010511.94
216 rdf:rest Nb3f99a5fc5a94467b4b23f729be79292
217 Ne981cc92a5c347c49c9c1c0f06df1774 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Cell Cycle Proteins
219 rdf:type schema:DefinedTerm
220 Nebd62a5c66e44a11b9e839f5b6c8da00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Animals
222 rdf:type schema:DefinedTerm
223 Nf083e33c3d24453db2772f4253129e61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Cyclins
225 rdf:type schema:DefinedTerm
226 Nfbc99bdbeffe4d5ab4c89c98817e2241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name E2F Transcription Factors
228 rdf:type schema:DefinedTerm
229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
230 schema:name Medical and Health Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
233 schema:name Clinical Sciences
234 rdf:type schema:DefinedTerm
235 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
236 schema:name Oncology and Carcinogenesis
237 rdf:type schema:DefinedTerm
238 sg:journal.1097543 schema:issn 0950-9232
239 1476-5594
240 schema:name Oncogene
241 schema:publisher Springer Nature
242 rdf:type schema:Periodical
243 sg:person.01076014770.67 schema:affiliation grid-institutes:grid.47100.32
244 schema:familyName Mandigo
245 schema:givenName C E
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076014770.67
247 rdf:type schema:Person
248 sg:person.01271010511.94 schema:affiliation grid-institutes:grid.47100.32
249 schema:familyName Cheng
250 schema:givenName E
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271010511.94
252 rdf:type schema:Person
253 sg:person.053601122.01 schema:affiliation grid-institutes:grid.47100.32
254 schema:familyName Halaban
255 schema:givenName R
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053601122.01
257 rdf:type schema:Person
258 sg:person.0657553015.25 schema:affiliation grid-institutes:None
259 schema:familyName Miglarese
260 schema:givenName M R
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657553015.25
262 rdf:type schema:Person
263 grid-institutes:None schema:alternateName Pharmaceutical Division, Institute of Bone and Joint Disorders and Cancer Research, Bayer Corporation, 06516, West Haven, CT
264 schema:name Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
265 Pharmaceutical Division, Institute of Bone and Joint Disorders and Cancer Research, Bayer Corporation, 06516, West Haven, CT
266 rdf:type schema:Organization
267 grid-institutes:grid.47100.32 schema:alternateName Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
268 schema:name Department of Dermatology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...