Loss of protein kinase C function induces an apoptotic response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-04

AUTHORS

Richard DH Whelan, Peter J Parker

ABSTRACT

A correlation has been observed between the dephosphorylation and downregulation of cPKC and the induction of apoptosis. This relationship is shown to be causal in COS cells where expression of dominant negative PKC alpha is shown to induce apoptosis. This response is rescued by co-expression of wild-type PKC alpha. The results demonstrate that PKC provides a survival signal that can be supplied by PKC alpha alone. More... »

PAGES

1201725

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201725

DOI

http://dx.doi.org/10.1038/sj.onc.1201725

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030663090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9591777


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