Loss of protein kinase C function induces an apoptotic response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-04

AUTHORS

Richard DH Whelan, Peter J Parker

ABSTRACT

A correlation has been observed between the dephosphorylation and downregulation of cPKC and the induction of apoptosis. This relationship is shown to be causal in COS cells where expression of dominant negative PKC alpha is shown to induce apoptosis. This response is rescued by co-expression of wild-type PKC alpha. The results demonstrate that PKC provides a survival signal that can be supplied by PKC alpha alone. More... »

PAGES

1201725

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201725

DOI

http://dx.doi.org/10.1038/sj.onc.1201725

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030663090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9591777


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COS Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoenzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cancer Research UK", 
          "id": "https://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whelan", 
        "givenName": "Richard DH", 
        "id": "sg:person.016240206362.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016240206362.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK", 
          "id": "https://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parker", 
        "givenName": "Peter J", 
        "id": "sg:person.01111564441.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-04", 
    "datePublishedReg": "1998-04-01", 
    "description": "A correlation has been observed between the dephosphorylation and downregulation of cPKC and the induction of apoptosis. This relationship is shown to be causal in COS cells where expression of dominant negative PKC alpha is shown to induce apoptosis. This response is rescued by co-expression of wild-type PKC alpha. The results demonstrate that PKC provides a survival signal that can be supplied by PKC alpha alone.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1201725", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "15", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Loss of protein kinase C function induces an apoptotic response", 
    "pagination": "1201725", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "92131d9f92c6e0c160bc9ae792a6ba352ed88550b16e63b37235d6ede5b09c44"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9591777"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1201725"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030663090"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1201725", 
      "https://app.dimensions.ai/details/publication/pub.1030663090"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118324_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1201725"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201725'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201725'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201725'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201725'


 

This table displays all metadata directly associated to this object as RDF triples.

108 TRIPLES      20 PREDICATES      37 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1201725 schema:about N0d938f35b1004013bba7c6f8143cf812
2 N20afc0c23ee74c4eb002327192a672a0
3 N3d56ba186d0d4f6fa365d67b6d190d92
4 N4282fd230cf044ec9d2adccaefd19c3d
5 N5a7f579cd9a84e8d93d7c6efc839ab14
6 N636c6b777d45415883c601e9131432b4
7 N6b61b71a71e64d3f9401ca492cd057ad
8 Na12ec40570a14b2f85b1be3fc94feb38
9 anzsrc-for:06
10 anzsrc-for:0604
11 schema:author Nc50ee6f13357426cb2808f9e32190b48
12 schema:datePublished 1998-04
13 schema:datePublishedReg 1998-04-01
14 schema:description A correlation has been observed between the dephosphorylation and downregulation of cPKC and the induction of apoptosis. This relationship is shown to be causal in COS cells where expression of dominant negative PKC alpha is shown to induce apoptosis. This response is rescued by co-expression of wild-type PKC alpha. The results demonstrate that PKC provides a survival signal that can be supplied by PKC alpha alone.
15 schema:genre research_article
16 schema:inLanguage en
17 schema:isAccessibleForFree true
18 schema:isPartOf N1c35c648a6b6421db9de075fc5442c8d
19 N58a49d1a7b444244b1f36aa291c34fda
20 sg:journal.1097543
21 schema:name Loss of protein kinase C function induces an apoptotic response
22 schema:pagination 1201725
23 schema:productId N00bbd09fba15480bad94b5fac56b9c7c
24 N201454f3a0124beeb32197eed6189b7e
25 N40b8c46306df4c01a38583e669dae019
26 Nbd38bd8ea117416d87a71135c629103a
27 Nee14973456aa40e89b9151f6adc34fce
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030663090
29 https://doi.org/10.1038/sj.onc.1201725
30 schema:sdDatePublished 2019-04-11T12:05
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N70a7ea518ac54759b9b7ac738c37966f
33 schema:url http://www.nature.com/articles/1201725
34 sgo:license sg:explorer/license/
35 sgo:sdDataset articles
36 rdf:type schema:ScholarlyArticle
37 N00bbd09fba15480bad94b5fac56b9c7c schema:name nlm_unique_id
38 schema:value 8711562
39 rdf:type schema:PropertyValue
40 N0d938f35b1004013bba7c6f8143cf812 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
41 schema:name Protein Kinase C
42 rdf:type schema:DefinedTerm
43 N1c35c648a6b6421db9de075fc5442c8d schema:volumeNumber 16
44 rdf:type schema:PublicationVolume
45 N201454f3a0124beeb32197eed6189b7e schema:name dimensions_id
46 schema:value pub.1030663090
47 rdf:type schema:PropertyValue
48 N20afc0c23ee74c4eb002327192a672a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
49 schema:name Isoenzymes
50 rdf:type schema:DefinedTerm
51 N2162c598dadd42fea9ac1fbc38ea94fb rdf:first sg:person.01111564441.81
52 rdf:rest rdf:nil
53 N3d56ba186d0d4f6fa365d67b6d190d92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Phosphorylation
55 rdf:type schema:DefinedTerm
56 N40b8c46306df4c01a38583e669dae019 schema:name doi
57 schema:value 10.1038/sj.onc.1201725
58 rdf:type schema:PropertyValue
59 N4282fd230cf044ec9d2adccaefd19c3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name COS Cells
61 rdf:type schema:DefinedTerm
62 N58a49d1a7b444244b1f36aa291c34fda schema:issueNumber 15
63 rdf:type schema:PublicationIssue
64 N5a7f579cd9a84e8d93d7c6efc839ab14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Tumor Cells, Cultured
66 rdf:type schema:DefinedTerm
67 N636c6b777d45415883c601e9131432b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Humans
69 rdf:type schema:DefinedTerm
70 N6b61b71a71e64d3f9401ca492cd057ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Apoptosis
72 rdf:type schema:DefinedTerm
73 N70a7ea518ac54759b9b7ac738c37966f schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 Na12ec40570a14b2f85b1be3fc94feb38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Animals
77 rdf:type schema:DefinedTerm
78 Nbd38bd8ea117416d87a71135c629103a schema:name pubmed_id
79 schema:value 9591777
80 rdf:type schema:PropertyValue
81 Nc50ee6f13357426cb2808f9e32190b48 rdf:first sg:person.016240206362.86
82 rdf:rest N2162c598dadd42fea9ac1fbc38ea94fb
83 Nee14973456aa40e89b9151f6adc34fce schema:name readcube_id
84 schema:value 92131d9f92c6e0c160bc9ae792a6ba352ed88550b16e63b37235d6ede5b09c44
85 rdf:type schema:PropertyValue
86 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
87 schema:name Biological Sciences
88 rdf:type schema:DefinedTerm
89 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
90 schema:name Genetics
91 rdf:type schema:DefinedTerm
92 sg:journal.1097543 schema:issn 0950-9232
93 1476-5594
94 schema:name Oncogene
95 rdf:type schema:Periodical
96 sg:person.01111564441.81 schema:affiliation https://www.grid.ac/institutes/grid.11485.39
97 schema:familyName Parker
98 schema:givenName Peter J
99 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111564441.81
100 rdf:type schema:Person
101 sg:person.016240206362.86 schema:affiliation https://www.grid.ac/institutes/grid.11485.39
102 schema:familyName Whelan
103 schema:givenName Richard DH
104 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016240206362.86
105 rdf:type schema:Person
106 https://www.grid.ac/institutes/grid.11485.39 schema:alternateName Cancer Research UK
107 schema:name Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
108 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...