Gene structure of the human MET proto-oncogene View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-09

AUTHORS

Fuh-Mei Duh, Stephen W Scherer, Lap-Chee Tsui, Michael I Lerman, Berton Zbar, Laura Schmidt

ABSTRACT

By direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions. By homology search in the database of the Washington University Genome Sequence Center (GSC), we identified one additional exon. These 20 exons, together with a previously reported exon, bring the total exon number of MET to 21. Oligonucleotide primers were designed to amplify each exon and adjacent intronic sequences to permit examination of each exon for mutations. By restriction mapping, we assembled a 110 kb genomic contig that covered almost the entire MET proto-oncogene. This information is relevant for the screening of recently reported mutations of the MET gene which cause hereditary papillary renal carcinomas and for the search for additional mutations of the same gene which may play a role in the pathogenesis of common human carcinomas including carcinomas of the breast, ovary and pancreas. More... »

PAGES

1201338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201338

DOI

http://dx.doi.org/10.1038/sj.onc.1201338

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022580175

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9380410


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