Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-06

AUTHORS

Jürgen Braunger, Lothar Schleithoff, Ansgar S Schulz, Heidi Kessler, Reiner Lammers, Axel Ullrich, Claus R Bartram, Johannes WG Janssen

ABSTRACT

Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) method. Three putative Ufo substrates were identified: phospholipase Cγ1 (PLCγ), as well as p85α and p85β subunits of phosphatidylinositol 3′-kinase (PI3-kinase). Subsequently, chimeric EGFR/Ufo receptors consisting of the extracellular domains of the epidermal growth factor receptor (EGFR) and the transmembrane and intracellular moiety of Ufo were engineered. Using different far-Western blot analyses and coimmunoprecipitation assays, receptor binding of PLCγ and p85 proteins as well as GRB2, c-src and lck was examined in vitro and in vivo. Competitive inhibition of substrate binding and mutagenesis experiments with EGFR/Ufo constructs revealed C-terminal tyrosine 821 (EILpYVNMDEG) as a docking site for multiple effectors, namely PLCγ, p85 proteins, GRB2, c-src and lck. Tyrosine 779 (DGLpYALMSRC) demonstrated an additional, but lower binding affinity for the p85 proteins in vitro. In addition, binding of PLCγ occurred through tyrosine 866 (AGRpYVLCPST). Moreover, our in vivo data indicate that further direct or indirect binding sites for PLCγ, GRB2, c-src and lck on the human Ufo receptor may exist. More... »

PAGES

2619-2631

Journal

TITLE

Oncogene

ISSUE

22

VOLUME

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201123

DOI

http://dx.doi.org/10.1038/sj.onc.1201123

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001331316

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9178760


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