Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-06

AUTHORS

Friederike Müeller-Pillasch, Ulrike Lacher, Christine Wallrapp, Anne Micha, Frank Zimmerhackl, Horst Hameister, Gabor Varga, Helmut Friess, Markus Büchler, Hans Günther Beger, Maya R Vila, Guido Adler, Thomas M Gress

ABSTRACT

In a previous large scale screen for differentially expressed genes in pancreatic cancer, we identified a gene highly overexpressed in cancer encoding a novel protein with four K-homologous (KH) domains. KH-domains are found in a subset of RNA-binding proteins, including pre-mRNA-binding (hnRNP) K protein and the fragile X mental retardation gene product (FMR1). By fluorescence in situ hybridization (FISH) the identified gene named koc (KH domain containing protein overexpressed in cancer) was assigned to chromosome 7p11.5. Two pseudogenes were localised on chromosome 6 and 11. The cloned koc cDNA has a 250 bp 5'-UTR, a 1740 bp ORF and a 2168 bp 3'-UTR. The AU-rich 3'-untranslated region of koc contains eight AUUUA and four AUUUUUA reiterated motifs. The deduced koc protein with 580 amino-acids has a relative molecular mass (Mr) of approximately 65,000 (65 K). The koc transcript is highly overexpressed in pancreatic cancer cell lines and in pancreatic cancer tissue as compared to both, normal pancreas and chronic pancreatitis tissue. High levels of expression were as well found in tissue samples of other human tumours. As the KH domain has been shown to be involved in the regulation of RNA synthesis and metabolism, we speculate that koc may assume a role in the regulation of tumour cell proliferation by interfering with transcriptional and or posttranscriptional processes. However, the precise role of koc in human tumour cells is unknown and remains to be elucidated. More... »

PAGES

1201110

Journal

TITLE

Oncogene

ISSUE

22

VOLUME

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201110

DOI

http://dx.doi.org/10.1038/sj.onc.1201110

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025232291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9178771


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