Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-05-29

AUTHORS

Maryann B Flick, Eva Sapi, Peter L Perrotta, M Grey Maher, Ruth Halaban, Darryl Carter, Barry M Kacinski

ABSTRACT

The macrophage colony stimulating factor receptor (CSF-1R), the product of the c-fms proto-oncogene, plays an important role in regulating the normal proliferation and differentiation of macrophages and trophoblasts. However, the abnormal expression of CSF-1R transcripts and protein by human breast carcinomas has been shown to correlate with advanced stage and poor prognosis. Ligand activated CSF-1R dimers transphosphorylate several tyrosines in their cytoplasmic domains which provide recognition sites for various effector proteins in multiple signal transduction pathways. In cells transformed by the c-fms oncogene, one of the major CSF-1R phosphotyrosines, pTyr723 is important for phenotypic expression of anchorage-independent growth and metastasis. In order to investigate the relationship between receptor activation/phosphorylation and cellular phenotypes in vitro and in vivo, we prepared a CSF-1R phosphorylation-state specific antibody raised against a specific phosphopeptide of CSF-1R, which included phosphorylated tyrosine 723. On immunoblots of lysates from cells expressing CSF-1R, this antibody recognizes phosphorylated CSF-1R in CSF-1 stimulated cells but not in unstimulated cells. As an immunohistochemical reagent, this antibody stained 52% of invasive human breast tumors (72% of CSF-1R positive cases) in a sample of 114 cases and 38% of carcinoma in situ. This data represents the first direct evidence of in vivo phosphorylation of CSF-1R in human breast carcinomas. More... »

PAGES

2553-2561

Journal

TITLE

Oncogene

ISSUE

21

VOLUME

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201092

DOI

http://dx.doi.org/10.1038/sj.onc.1201092

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034693094

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9191055


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