Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-05

AUTHORS

Berndt Enholm, Karri Paavonen, Ari Ristimäki, Vijay Kumar, Yuji Gunji, Juha Klefstrom, Laura Kivinen, Marikki Laiho, Birgitta Olofsson, Vladimir Joukov, Ulf Eriksson, Kari Alitalo

ABSTRACT

The vascular endothelial growth factor (VEGF) family has recently been expanded by the isolation of two additional growth factors, VEGF-B and VEGF-C. Here we compare the regulation of steady-state levels of VEGF, VEGF-B and VEGF-C mRNAs in cultured cells by a variety of stimuli implicated in angiogenesis and endothelial cell physiology. Hypoxia, Ras oncoprotein and mutant p53 tumor suppressor, which are potent inducers of VEGF mRNA did not increase VEGF-B or VEGF-C mRNA levels. Serum and its component growth factors, platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) as well as transforming growth factor-beta (TGF-beta) and the tumor promoter phorbol myristate 12,13-acetate (PMA) stimulated VEGF-C, but not VEGF-B mRNA expression. Interestingly, these growth factors and hypoxia simultaneously downregulated the mRNA of another endothelial cell specific ligand, angiopoietin-1. Serum induction of VEGF-C mRNA occurred independently of protein synthesis; with an increase of the mRNA half-life from 3.5 h to 5.5-6 h, whereas VEGF-B mRNA was very stable (T 1/2>8 h). Our results reveal that the three VEGF genes are regulated in a strikingly different manner, suggesting that they serve distinct, although perhaps overlapping functions in vivo. More... »

PAGES

1201090

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201090

DOI

http://dx.doi.org/10.1038/sj.onc.1201090

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009788098

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9188862


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