Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-05-22

AUTHORS

Keishi Makino, Hiroaki Kuwahara, Norio Masuko, Yasuyuki Nishiyama, Tetsurou Morisaki, Ji-ichiro Sasaki, Mitsuyoshi Nakao, Akira Kuwano, Motomi Nakata, Yukitaka Ushio, Hideyuki Saya

ABSTRACT

We have cloned a cDNA for a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein, termed NE-dlg (neuronal and endocrine dlg). Northern blot analysis revealed that the gene is highly expressed in neuronal and endocrine tissues. Fluorescence in situ hybridization (FISH) and radiation hybrid mapping studies localized the NE-dlg gene to chromosome Xq13. We also found that the NE-dlg gene encoded a 100 kDa protein. Immunolocalization studies using an NE-dlg antibody showed that the protein tended to be expressed in non-proliferating cells, such as neurons, cells in Langerhans islets of the pancreas, myocytes of the heart muscles, and the prickle and functional layer cells of the esophageal epithelium. Proliferative cells, including various cultured cancer cell lines and basal cells in the esophageal epithelium, showed little expression of the NE-dlg protein. In addition, yeast two-hybrid screening and in vitro binding assays revealed that the NE-dlg interacted with the carboxyl-terminal region of the APC tumor suppressor protein. These data suggest that NE-dlg negatively regulates cell proliferation through its interaction with the APC protein. More... »

PAGES

2425-2433

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201087

DOI

http://dx.doi.org/10.1038/sj.onc.1201087

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023395602

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9188857


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenomatous Polyposis Coli Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Complementary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Discs Large Homolog 1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insect Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X Chromosome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurosurgery, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
            "Department of Neurosurgery, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Makino", 
        "givenName": "Keishi", 
        "id": "sg:person.0705067031.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705067031.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuwahara", 
        "givenName": "Hiroaki", 
        "id": "sg:person.01153457265.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153457265.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masuko", 
        "givenName": "Norio", 
        "id": "sg:person.01221572465.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221572465.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishiyama", 
        "givenName": "Yasuyuki", 
        "id": "sg:person.01125636236.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125636236.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morisaki", 
        "givenName": "Tetsurou", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasaki", 
        "givenName": "Ji-ichiro", 
        "id": "sg:person.015403014262.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015403014262.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakao", 
        "givenName": "Mitsuyoshi", 
        "id": "sg:person.01114700370.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114700370.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hygiene Ehime, University School of Medicine, 791-02, Ehime, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Hygiene Ehime, University School of Medicine, 791-02, Ehime, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuwano", 
        "givenName": "Akira", 
        "id": "sg:person.01222137751.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222137751.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biomedical R&D Department, Sumitomo Electric Industries, Ltd, 244, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410799.2", 
          "name": [
            "Biomedical R&D Department, Sumitomo Electric Industries, Ltd, 244, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakata", 
        "givenName": "Motomi", 
        "id": "sg:person.0774756565.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774756565.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neurosurgery, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Neurosurgery, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ushio", 
        "givenName": "Yukitaka", 
        "id": "sg:person.01367570261.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367570261.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saya", 
        "givenName": "Hideyuki", 
        "id": "sg:person.0704677621.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704677621.52"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1997-05-22", 
    "datePublishedReg": "1997-05-22", 
    "description": "We have cloned a cDNA for a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein, termed NE-dlg (neuronal and endocrine dlg). Northern blot analysis revealed that the gene is highly expressed in neuronal and endocrine tissues. Fluorescence in situ hybridization (FISH) and radiation hybrid mapping studies localized the NE-dlg gene to chromosome Xq13. We also found that the NE-dlg gene encoded a 100\u2009kDa protein. Immunolocalization studies using an NE-dlg antibody showed that the protein tended to be expressed in non-proliferating cells, such as neurons, cells in Langerhans islets of the pancreas, myocytes of the heart muscles, and the prickle and functional layer cells of the esophageal epithelium. Proliferative cells, including various cultured cancer cell lines and basal cells in the esophageal epithelium, showed little expression of the NE-dlg protein. In addition, yeast two-hybrid screening and in vitro binding assays revealed that the NE-dlg interacted with the carboxyl-terminal region of the APC tumor suppressor protein. These data suggest that NE-dlg negatively regulates cell proliferation through its interaction with the APC protein.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1201087", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "20", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "large tumor suppressor protein", 
      "tumor suppressor protein", 
      "novel human homolog", 
      "suppressor protein", 
      "human homolog", 
      "APC protein", 
      "APC tumor suppressor protein", 
      "two-hybrid screening", 
      "carboxyl-terminal region", 
      "Northern blot analysis", 
      "cultured cancer cell lines", 
      "chromosome Xq13", 
      "Immunolocalization studies", 
      "non-proliferating cells", 
      "cancer cell lines", 
      "protein", 
      "genes", 
      "Drosophila", 
      "situ hybridization", 
      "blot analysis", 
      "cell proliferation", 
      "homolog", 
      "cell lines", 
      "proliferative cells", 
      "little expression", 
      "mapping studies", 
      "binding assays", 
      "cells", 
      "endocrine tissues", 
      "esophageal epithelium", 
      "basal cells", 
      "layer cells", 
      "cloning", 
      "cDNA", 
      "yeast", 
      "Xq13", 
      "hybridization", 
      "epithelium", 
      "expression", 
      "heart muscle", 
      "proliferation", 
      "assays", 
      "fluorescence", 
      "tissue", 
      "myocytes", 
      "Langerhans islets", 
      "islets", 
      "lines", 
      "neurons", 
      "interaction", 
      "characterization", 
      "region", 
      "muscle", 
      "antibodies", 
      "screening", 
      "study", 
      "addition", 
      "analysis", 
      "pancreas", 
      "data"
    ], 
    "name": "Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein", 
    "pagination": "2425-2433", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023395602"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1201087"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9188857"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1201087", 
      "https://app.dimensions.ai/details/publication/pub.1023395602"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_279.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1201087"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201087'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201087'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201087'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201087'


 

This table displays all metadata directly associated to this object as RDF triples.

290 TRIPLES      20 PREDICATES      108 URIs      99 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1201087 schema:about N0c5f217520c14c2eb0237d6e23e4c723
2 N0e1a8f150758464e9b557e7ae171e61f
3 N1ee7ca7d7894444bb029e9c4f0ee4573
4 N2695dcbc760c49ffa63b72a74a839685
5 N3e30a36d673040109cf25001673f7630
6 N41ad8e5feaf340dca21b2b46fa52624e
7 N4313e3a244fa4919a2a3cc18847b5d83
8 N4e4b7d985e8c40b89b58d2c1d5334e63
9 N5774506759eb4bfb91f19986c6cbb10e
10 N5d6b33a33a374168b184bc421275bffa
11 N5f449ffb539e424295dbb00bb616f42e
12 N9be426f0282146c6916f1d120caa6900
13 Na8c98180d5b145c48761c417e91c3801
14 Nb91b9341583b4621ae104c2d70e47455
15 Nc7089b010a854fa79139807210aec58f
16 Nd4f3542d454b4ae092c7482cd0034538
17 Ne27021806d99479281cc5cf97583d438
18 Ne43bf6a6750c464eaf19308b62c31844
19 Ne85a9178f137492aa38d3eb4610679c0
20 Ne8e28416f46d4340bb18c2eea5bca799
21 Nea8c701a0791463984b6e7cae251aed8
22 Nf9b85b5503df4239b84951b7f47c7da8
23 anzsrc-for:11
24 anzsrc-for:1103
25 anzsrc-for:1112
26 schema:author Ncd545e61d1b540c2834bb8cba37b5ad4
27 schema:datePublished 1997-05-22
28 schema:datePublishedReg 1997-05-22
29 schema:description We have cloned a cDNA for a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein, termed NE-dlg (neuronal and endocrine dlg). Northern blot analysis revealed that the gene is highly expressed in neuronal and endocrine tissues. Fluorescence in situ hybridization (FISH) and radiation hybrid mapping studies localized the NE-dlg gene to chromosome Xq13. We also found that the NE-dlg gene encoded a 100‚ÄČkDa protein. Immunolocalization studies using an NE-dlg antibody showed that the protein tended to be expressed in non-proliferating cells, such as neurons, cells in Langerhans islets of the pancreas, myocytes of the heart muscles, and the prickle and functional layer cells of the esophageal epithelium. Proliferative cells, including various cultured cancer cell lines and basal cells in the esophageal epithelium, showed little expression of the NE-dlg protein. In addition, yeast two-hybrid screening and in vitro binding assays revealed that the NE-dlg interacted with the carboxyl-terminal region of the APC tumor suppressor protein. These data suggest that NE-dlg negatively regulates cell proliferation through its interaction with the APC protein.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N3da7ec11939847a49c6668b4e846e0af
33 Naf7e826e4a1848669f1eada0d63997c3
34 sg:journal.1097543
35 schema:keywords APC protein
36 APC tumor suppressor protein
37 Drosophila
38 Immunolocalization studies
39 Langerhans islets
40 Northern blot analysis
41 Xq13
42 addition
43 analysis
44 antibodies
45 assays
46 basal cells
47 binding assays
48 blot analysis
49 cDNA
50 cancer cell lines
51 carboxyl-terminal region
52 cell lines
53 cell proliferation
54 cells
55 characterization
56 chromosome Xq13
57 cloning
58 cultured cancer cell lines
59 data
60 endocrine tissues
61 epithelium
62 esophageal epithelium
63 expression
64 fluorescence
65 genes
66 heart muscle
67 homolog
68 human homolog
69 hybridization
70 interaction
71 islets
72 large tumor suppressor protein
73 layer cells
74 lines
75 little expression
76 mapping studies
77 muscle
78 myocytes
79 neurons
80 non-proliferating cells
81 novel human homolog
82 pancreas
83 proliferation
84 proliferative cells
85 protein
86 region
87 screening
88 situ hybridization
89 study
90 suppressor protein
91 tissue
92 tumor suppressor protein
93 two-hybrid screening
94 yeast
95 schema:name Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein
96 schema:pagination 2425-2433
97 schema:productId N4dd02ff4a5294337b0324cd08f635004
98 Nd57239ff379d4a5db574029b1d938fde
99 Ndccd497276c149ebacd89a91c1143820
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023395602
101 https://doi.org/10.1038/sj.onc.1201087
102 schema:sdDatePublished 2022-10-01T06:30
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Na9d64c224413473dad9a5f11574cfe78
105 schema:url https://doi.org/10.1038/sj.onc.1201087
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N0c5f217520c14c2eb0237d6e23e4c723 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Cytoskeletal Proteins
111 rdf:type schema:DefinedTerm
112 N0e1a8f150758464e9b557e7ae171e61f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name DNA, Complementary
114 rdf:type schema:DefinedTerm
115 N1ee7ca7d7894444bb029e9c4f0ee4573 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Transcription Factors
117 rdf:type schema:DefinedTerm
118 N2695dcbc760c49ffa63b72a74a839685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Amino Acid Sequence
120 rdf:type schema:DefinedTerm
121 N3affe9d23ffa447da0dd0ee717875b2c rdf:first sg:person.01221572465.41
122 rdf:rest N9bb1ddb24085415fb5e077ae07477a1a
123 N3ce84f88fee641268007f63d96eec912 rdf:first sg:person.0704677621.52
124 rdf:rest rdf:nil
125 N3da7ec11939847a49c6668b4e846e0af schema:volumeNumber 14
126 rdf:type schema:PublicationVolume
127 N3e30a36d673040109cf25001673f7630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Molecular Sequence Data
129 rdf:type schema:DefinedTerm
130 N40623a1f39014d69933a7697c9f2c381 rdf:first sg:person.0774756565.41
131 rdf:rest N5e9e3206e6da435d91b71d2256f3c786
132 N41ad8e5feaf340dca21b2b46fa52624e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Insect Proteins
134 rdf:type schema:DefinedTerm
135 N4313e3a244fa4919a2a3cc18847b5d83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Genes, Tumor Suppressor
137 rdf:type schema:DefinedTerm
138 N4dd02ff4a5294337b0324cd08f635004 schema:name doi
139 schema:value 10.1038/sj.onc.1201087
140 rdf:type schema:PropertyValue
141 N4e4b7d985e8c40b89b58d2c1d5334e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adaptor Proteins, Signal Transducing
143 rdf:type schema:DefinedTerm
144 N5204c93c268944c0b217dae189bce03f schema:affiliation grid-institutes:grid.274841.c
145 schema:familyName Morisaki
146 schema:givenName Tetsurou
147 rdf:type schema:Person
148 N5774506759eb4bfb91f19986c6cbb10e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Humans
150 rdf:type schema:DefinedTerm
151 N5c10f968a5f24771854a6c4c82c501c8 rdf:first sg:person.01222137751.38
152 rdf:rest N40623a1f39014d69933a7697c9f2c381
153 N5d6b33a33a374168b184bc421275bffa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Drosophila Proteins
155 rdf:type schema:DefinedTerm
156 N5e9e3206e6da435d91b71d2256f3c786 rdf:first sg:person.01367570261.50
157 rdf:rest N3ce84f88fee641268007f63d96eec912
158 N5f449ffb539e424295dbb00bb616f42e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Proteins
160 rdf:type schema:DefinedTerm
161 N62305993c79c443495f54e3948d6b0b2 rdf:first sg:person.01114700370.80
162 rdf:rest N5c10f968a5f24771854a6c4c82c501c8
163 N7b4c7a65cad84d018a691a314be7ac0e rdf:first sg:person.015403014262.45
164 rdf:rest N62305993c79c443495f54e3948d6b0b2
165 N9bb1ddb24085415fb5e077ae07477a1a rdf:first sg:person.01125636236.44
166 rdf:rest Nc0b2a2a356084a0493c1f5d4ea315192
167 N9be426f0282146c6916f1d120caa6900 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Base Sequence
169 rdf:type schema:DefinedTerm
170 Na8c98180d5b145c48761c417e91c3801 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Tumor Suppressor Proteins
172 rdf:type schema:DefinedTerm
173 Na9d64c224413473dad9a5f11574cfe78 schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 Na9dc9c34924e412cbff4e3eacc70664e rdf:first sg:person.01153457265.74
176 rdf:rest N3affe9d23ffa447da0dd0ee717875b2c
177 Naf7e826e4a1848669f1eada0d63997c3 schema:issueNumber 20
178 rdf:type schema:PublicationIssue
179 Nb91b9341583b4621ae104c2d70e47455 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name X Chromosome
181 rdf:type schema:DefinedTerm
182 Nc0b2a2a356084a0493c1f5d4ea315192 rdf:first N5204c93c268944c0b217dae189bce03f
183 rdf:rest N7b4c7a65cad84d018a691a314be7ac0e
184 Nc7089b010a854fa79139807210aec58f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name RNA, Messenger
186 rdf:type schema:DefinedTerm
187 Ncd545e61d1b540c2834bb8cba37b5ad4 rdf:first sg:person.0705067031.93
188 rdf:rest Na9dc9c34924e412cbff4e3eacc70664e
189 Nd4f3542d454b4ae092c7482cd0034538 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Nuclear Proteins
191 rdf:type schema:DefinedTerm
192 Nd57239ff379d4a5db574029b1d938fde schema:name pubmed_id
193 schema:value 9188857
194 rdf:type schema:PropertyValue
195 Ndccd497276c149ebacd89a91c1143820 schema:name dimensions_id
196 schema:value pub.1023395602
197 rdf:type schema:PropertyValue
198 Ne27021806d99479281cc5cf97583d438 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name In Situ Hybridization, Fluorescence
200 rdf:type schema:DefinedTerm
201 Ne43bf6a6750c464eaf19308b62c31844 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Membrane Proteins
203 rdf:type schema:DefinedTerm
204 Ne85a9178f137492aa38d3eb4610679c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Adenomatous Polyposis Coli Protein
206 rdf:type schema:DefinedTerm
207 Ne8e28416f46d4340bb18c2eea5bca799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Discs Large Homolog 1 Protein
209 rdf:type schema:DefinedTerm
210 Nea8c701a0791463984b6e7cae251aed8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Cell Division
212 rdf:type schema:DefinedTerm
213 Nf9b85b5503df4239b84951b7f47c7da8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Chromosome Mapping
215 rdf:type schema:DefinedTerm
216 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
217 schema:name Medical and Health Sciences
218 rdf:type schema:DefinedTerm
219 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
220 schema:name Clinical Sciences
221 rdf:type schema:DefinedTerm
222 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
223 schema:name Oncology and Carcinogenesis
224 rdf:type schema:DefinedTerm
225 sg:journal.1097543 schema:issn 0950-9232
226 1476-5594
227 schema:name Oncogene
228 schema:publisher Springer Nature
229 rdf:type schema:Periodical
230 sg:person.01114700370.80 schema:affiliation grid-institutes:grid.274841.c
231 schema:familyName Nakao
232 schema:givenName Mitsuyoshi
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114700370.80
234 rdf:type schema:Person
235 sg:person.01125636236.44 schema:affiliation grid-institutes:grid.274841.c
236 schema:familyName Nishiyama
237 schema:givenName Yasuyuki
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125636236.44
239 rdf:type schema:Person
240 sg:person.01153457265.74 schema:affiliation grid-institutes:grid.274841.c
241 schema:familyName Kuwahara
242 schema:givenName Hiroaki
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153457265.74
244 rdf:type schema:Person
245 sg:person.01221572465.41 schema:affiliation grid-institutes:grid.274841.c
246 schema:familyName Masuko
247 schema:givenName Norio
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221572465.41
249 rdf:type schema:Person
250 sg:person.01222137751.38 schema:affiliation grid-institutes:grid.26999.3d
251 schema:familyName Kuwano
252 schema:givenName Akira
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222137751.38
254 rdf:type schema:Person
255 sg:person.01367570261.50 schema:affiliation grid-institutes:grid.274841.c
256 schema:familyName Ushio
257 schema:givenName Yukitaka
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367570261.50
259 rdf:type schema:Person
260 sg:person.015403014262.45 schema:affiliation grid-institutes:grid.274841.c
261 schema:familyName Sasaki
262 schema:givenName Ji-ichiro
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015403014262.45
264 rdf:type schema:Person
265 sg:person.0704677621.52 schema:affiliation grid-institutes:grid.274841.c
266 schema:familyName Saya
267 schema:givenName Hideyuki
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704677621.52
269 rdf:type schema:Person
270 sg:person.0705067031.93 schema:affiliation grid-institutes:grid.274841.c
271 schema:familyName Makino
272 schema:givenName Keishi
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705067031.93
274 rdf:type schema:Person
275 sg:person.0774756565.41 schema:affiliation grid-institutes:grid.410799.2
276 schema:familyName Nakata
277 schema:givenName Motomi
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774756565.41
279 rdf:type schema:Person
280 grid-institutes:grid.26999.3d schema:alternateName Department of Hygiene Ehime, University School of Medicine, 791-02, Ehime, Japan
281 schema:name Department of Hygiene Ehime, University School of Medicine, 791-02, Ehime, Japan
282 rdf:type schema:Organization
283 grid-institutes:grid.274841.c schema:alternateName Department of Neurosurgery, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan
284 Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan
285 schema:name Department of Neurosurgery, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan
286 Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo Kumamoto 860, Japan
287 rdf:type schema:Organization
288 grid-institutes:grid.410799.2 schema:alternateName Biomedical R&D Department, Sumitomo Electric Industries, Ltd, 244, Yokohama, Japan
289 schema:name Biomedical R&D Department, Sumitomo Electric Industries, Ltd, 244, Yokohama, Japan
290 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...