The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04-24

AUTHORS

Daniel Gallahan, Robert Callahan

ABSTRACT

The INT3 gene is frequently rearranged in mouse mammary tumor virus (MMTV)-induced mammary tumors of the CzechII mouse strain. We have completed the nucleotide sequence of the normal 6.5 Kb INT3 RNA and defined the intron/exon boundaries of the gene. The open reading frame of INT3 RNA should encode a 200 kd protein which shares 60% homology with the mouse homologue of Drosophila NOTCH. INT3 is unique among other members of the NOTCH family by containing 29 instead of 36 EGF-like repeats in the extracellular domain of the gene product. Five novel EGF-like repeats have been created as consequence of apparent small deletions which have occurred within the coding region for the extracellular domain during evolution. Nucleotide sequence analysis of host-viral junction fragments from nine independent MMTV-induced mammary tumors containing a rearranged INT3 gene reveals that all of the integration events occur within a 174 bp region 3′ of the sequences encoding the LIN12 repeats in the INT3 extracellular domain and 5′ of the sequences encoding the transmembrane domain. Therefore, the only tumorigenic INT3 mutations resulting from MMTV proviral insertions are those which results in the expression of the intracellular domain. This strongly suggests that MMTV-induced activation of INT3 is manifest in the absence of the regulatory action of the extracellular domain, including the LIN12 repeat sequences, leaving the expressed intracellular domain constitutively free to function in its role in mammary tumorigenesis. More... »

PAGES

1883-1890

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1201035

DOI

http://dx.doi.org/10.1038/sj.onc.1201035

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010498766

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9150355


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Primers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Tumor Virus, Mouse", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multigene Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutagenesis, Insertional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Notch4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Notch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repetitive Sequences, Nucleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retroviridae Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Virus Infections", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "SRA Technologies, Inc, Life Sciences, 4 Research Court, 20850, Rockville, MD, USA", 
            "Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gallahan", 
        "givenName": "Daniel", 
        "id": "sg:person.01035371524.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035371524.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Callahan", 
        "givenName": "Robert", 
        "id": "sg:person.0721143124.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721143124.20"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1997-04-24", 
    "datePublishedReg": "1997-04-24", 
    "description": "The INT3 gene is frequently rearranged in mouse mammary tumor virus (MMTV)-induced mammary tumors of the CzechII mouse strain. We have completed the nucleotide sequence of the normal 6.5\u2009Kb INT3 RNA and defined the intron/exon boundaries of the gene. The open reading frame of INT3 RNA should encode a 200\u2009kd protein which shares 60% homology with the mouse homologue of Drosophila NOTCH. INT3 is unique among other members of the NOTCH family by containing 29 instead of 36 EGF-like repeats in the extracellular domain of the gene product. Five novel EGF-like repeats have been created as consequence of apparent small deletions which have occurred within the coding region for the extracellular domain during evolution. Nucleotide sequence analysis of host-viral junction fragments from nine independent MMTV-induced mammary tumors containing a rearranged INT3 gene reveals that all of the integration events occur within a 174\u2009bp region 3\u2032 of the sequences encoding the LIN12 repeats in the INT3 extracellular domain and 5\u2032 of the sequences encoding the transmembrane domain. Therefore, the only tumorigenic INT3 mutations resulting from MMTV proviral insertions are those which results in the expression of the intracellular domain. This strongly suggests that MMTV-induced activation of INT3 is manifest in the absence of the regulatory action of the extracellular domain, including the LIN12 repeat sequences, leaving the expressed intracellular domain constitutively free to function in its role in mammary tumorigenesis.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.onc.1201035", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "16", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "EGF-like repeats", 
      "extracellular domain", 
      "Int3 gene", 
      "intracellular domain", 
      "intron/exon boundaries", 
      "MMTV proviral insertion", 
      "Notch gene family", 
      "open reading frame", 
      "Nucleotide sequence analysis", 
      "Drosophila Notch", 
      "gene family", 
      "transmembrane domain", 
      "mouse homologue", 
      "reading frame", 
      "mouse mammary tumor virus", 
      "nucleotide sequence", 
      "Notch family", 
      "gene products", 
      "integration events", 
      "exon boundaries", 
      "proviral insertion", 
      "unique member", 
      "sequence analysis", 
      "kD protein", 
      "mammary tumor virus", 
      "genes", 
      "repeats", 
      "tumor virus", 
      "small deletions", 
      "junction fragments", 
      "RNA", 
      "sequence", 
      "Int3", 
      "mouse strains", 
      "mammary tumorigenesis", 
      "region 3", 
      "domain", 
      "mammary tumors", 
      "family", 
      "homologues", 
      "homology", 
      "protein", 
      "regulatory action", 
      "members", 
      "deletion", 
      "tumorigenesis", 
      "mutations", 
      "expression", 
      "MMTV", 
      "fragments", 
      "activation", 
      "Notch", 
      "strains", 
      "evolution", 
      "virus", 
      "role", 
      "insertion", 
      "absence", 
      "region", 
      "frame", 
      "consequences", 
      "tumors", 
      "events", 
      "action", 
      "analysis", 
      "products", 
      "boundaries"
    ], 
    "name": "The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)", 
    "pagination": "1883-1890", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010498766"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1201035"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9150355"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1201035", 
      "https://app.dimensions.ai/details/publication/pub.1010498766"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_281.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.onc.1201035"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201035'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201035'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201035'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1201035'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      20 PREDICATES      118 URIs      109 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1201035 schema:about N04fdbd5385ce49bdb17f9b7b6321e40f
2 N19c061e2cf954035b812d93183a09c1e
3 N1b0677fd8f7a4a7381d0e350df5168a3
4 N1d8e9fb31da9445681d33c3dbdf74ea7
5 N336bc3aad2684a03be8c13e1edd8c6e0
6 N3478748c83a54303852ee03fab6a848c
7 N38c657834317459892f2ca427db779dc
8 N4930601da8b34246bbfae2f310378e82
9 N49ee49b1123f4fccaaf6cc1304631a76
10 N4f74b848b00c4fa283c0c95f220ad3fb
11 N58e7babd1c784fbfb30f1556792de086
12 N65cc52b792f5488ebf340a2985048075
13 N8497e7cc4e974fbfa1cab7b7238d859b
14 N855ae4a7e5684b25bb375c82d77f4ba6
15 N8acac53ed5e94495802eb4f5d59ef5d1
16 N98b04f5aca0b43b6a4c450b8e8351d16
17 Na437230b0c3048609ef642913e615c35
18 Nb17d99f35eed4d7bb8979c99b6ab637c
19 Nb28c17a207504df6a50e3d5e7d55b954
20 Nce418e6991534317a013e25e8b78b35e
21 Ndbcb82988a2e446089c28351fd0ff1f3
22 Ndf22ab4ab9ed4d469ed568c65b93534f
23 Ndf26f03f5174411fbe0fe6e181812901
24 Ne302e6dd9b0a4a6d8e5044f6548e0fb8
25 Nf5069e7107594c33a7fdfed5726f8a7a
26 anzsrc-for:11
27 anzsrc-for:1103
28 anzsrc-for:1112
29 schema:author N8e539a12bf5d44f5b6df902130775a9a
30 schema:datePublished 1997-04-24
31 schema:datePublishedReg 1997-04-24
32 schema:description The INT3 gene is frequently rearranged in mouse mammary tumor virus (MMTV)-induced mammary tumors of the CzechII mouse strain. We have completed the nucleotide sequence of the normal 6.5 Kb INT3 RNA and defined the intron/exon boundaries of the gene. The open reading frame of INT3 RNA should encode a 200 kd protein which shares 60% homology with the mouse homologue of Drosophila NOTCH. INT3 is unique among other members of the NOTCH family by containing 29 instead of 36 EGF-like repeats in the extracellular domain of the gene product. Five novel EGF-like repeats have been created as consequence of apparent small deletions which have occurred within the coding region for the extracellular domain during evolution. Nucleotide sequence analysis of host-viral junction fragments from nine independent MMTV-induced mammary tumors containing a rearranged INT3 gene reveals that all of the integration events occur within a 174 bp region 3′ of the sequences encoding the LIN12 repeats in the INT3 extracellular domain and 5′ of the sequences encoding the transmembrane domain. Therefore, the only tumorigenic INT3 mutations resulting from MMTV proviral insertions are those which results in the expression of the intracellular domain. This strongly suggests that MMTV-induced activation of INT3 is manifest in the absence of the regulatory action of the extracellular domain, including the LIN12 repeat sequences, leaving the expressed intracellular domain constitutively free to function in its role in mammary tumorigenesis.
33 schema:genre article
34 schema:isAccessibleForFree false
35 schema:isPartOf N149ec9dbbc7346baae3da0cbd39c7019
36 N2de86845edd94fd9bebf127bb3f4560f
37 sg:journal.1097543
38 schema:keywords Drosophila Notch
39 EGF-like repeats
40 Int3
41 Int3 gene
42 MMTV
43 MMTV proviral insertion
44 Notch
45 Notch family
46 Notch gene family
47 Nucleotide sequence analysis
48 RNA
49 absence
50 action
51 activation
52 analysis
53 boundaries
54 consequences
55 deletion
56 domain
57 events
58 evolution
59 exon boundaries
60 expression
61 extracellular domain
62 family
63 fragments
64 frame
65 gene family
66 gene products
67 genes
68 homologues
69 homology
70 insertion
71 integration events
72 intracellular domain
73 intron/exon boundaries
74 junction fragments
75 kD protein
76 mammary tumor virus
77 mammary tumorigenesis
78 mammary tumors
79 members
80 mouse homologue
81 mouse mammary tumor virus
82 mouse strains
83 mutations
84 nucleotide sequence
85 open reading frame
86 products
87 protein
88 proviral insertion
89 reading frame
90 region
91 region 3
92 regulatory action
93 repeats
94 role
95 sequence
96 sequence analysis
97 small deletions
98 strains
99 transmembrane domain
100 tumor virus
101 tumorigenesis
102 tumors
103 unique member
104 virus
105 schema:name The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
106 schema:pagination 1883-1890
107 schema:productId N06291b0c640f4fe9989eff2dafb295e3
108 N32c7794a65f442669f933e273738554d
109 N6237f8387b924bc08a91c9cb3e91fca7
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010498766
111 https://doi.org/10.1038/sj.onc.1201035
112 schema:sdDatePublished 2022-12-01T06:21
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher Ne79ad5cedde84d059a898dee327f2c83
115 schema:url https://doi.org/10.1038/sj.onc.1201035
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N04fdbd5385ce49bdb17f9b7b6321e40f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mutagenesis, Insertional
121 rdf:type schema:DefinedTerm
122 N06291b0c640f4fe9989eff2dafb295e3 schema:name doi
123 schema:value 10.1038/sj.onc.1201035
124 rdf:type schema:PropertyValue
125 N149ec9dbbc7346baae3da0cbd39c7019 schema:issueNumber 16
126 rdf:type schema:PublicationIssue
127 N19c061e2cf954035b812d93183a09c1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Mice
129 rdf:type schema:DefinedTerm
130 N1b0677fd8f7a4a7381d0e350df5168a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Repetitive Sequences, Nucleic Acid
132 rdf:type schema:DefinedTerm
133 N1d8e9fb31da9445681d33c3dbdf74ea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Receptor, Notch4
135 rdf:type schema:DefinedTerm
136 N2de86845edd94fd9bebf127bb3f4560f schema:volumeNumber 14
137 rdf:type schema:PublicationVolume
138 N32c7794a65f442669f933e273738554d schema:name dimensions_id
139 schema:value pub.1010498766
140 rdf:type schema:PropertyValue
141 N336bc3aad2684a03be8c13e1edd8c6e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Mammary Neoplasms, Experimental
143 rdf:type schema:DefinedTerm
144 N3478748c83a54303852ee03fab6a848c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Multigene Family
146 rdf:type schema:DefinedTerm
147 N38c657834317459892f2ca427db779dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Base Sequence
149 rdf:type schema:DefinedTerm
150 N3abc92555fe040b4b56c955a8460722b rdf:first sg:person.0721143124.20
151 rdf:rest rdf:nil
152 N4930601da8b34246bbfae2f310378e82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Receptors, Cell Surface
154 rdf:type schema:DefinedTerm
155 N49ee49b1123f4fccaaf6cc1304631a76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Cloning, Molecular
157 rdf:type schema:DefinedTerm
158 N4f74b848b00c4fa283c0c95f220ad3fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name DNA Primers
160 rdf:type schema:DefinedTerm
161 N58e7babd1c784fbfb30f1556792de086 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Molecular Sequence Data
163 rdf:type schema:DefinedTerm
164 N6237f8387b924bc08a91c9cb3e91fca7 schema:name pubmed_id
165 schema:value 9150355
166 rdf:type schema:PropertyValue
167 N65cc52b792f5488ebf340a2985048075 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Tumor Virus Infections
169 rdf:type schema:DefinedTerm
170 N8497e7cc4e974fbfa1cab7b7238d859b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Recombinant Proteins
172 rdf:type schema:DefinedTerm
173 N855ae4a7e5684b25bb375c82d77f4ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Proto-Oncogene Proteins
175 rdf:type schema:DefinedTerm
176 N8acac53ed5e94495802eb4f5d59ef5d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Drosophila
178 rdf:type schema:DefinedTerm
179 N8e539a12bf5d44f5b6df902130775a9a rdf:first sg:person.01035371524.50
180 rdf:rest N3abc92555fe040b4b56c955a8460722b
181 N98b04f5aca0b43b6a4c450b8e8351d16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Sequence Homology, Amino Acid
183 rdf:type schema:DefinedTerm
184 Na437230b0c3048609ef642913e615c35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Proto-Oncogenes
186 rdf:type schema:DefinedTerm
187 Nb17d99f35eed4d7bb8979c99b6ab637c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Receptors, Notch
189 rdf:type schema:DefinedTerm
190 Nb28c17a207504df6a50e3d5e7d55b954 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Rats
192 rdf:type schema:DefinedTerm
193 Nce418e6991534317a013e25e8b78b35e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Retroviridae Infections
195 rdf:type schema:DefinedTerm
196 Ndbcb82988a2e446089c28351fd0ff1f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Polymerase Chain Reaction
198 rdf:type schema:DefinedTerm
199 Ndf22ab4ab9ed4d469ed568c65b93534f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Amino Acid Sequence
201 rdf:type schema:DefinedTerm
202 Ndf26f03f5174411fbe0fe6e181812901 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mammary Tumor Virus, Mouse
204 rdf:type schema:DefinedTerm
205 Ne302e6dd9b0a4a6d8e5044f6548e0fb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Female
207 rdf:type schema:DefinedTerm
208 Ne79ad5cedde84d059a898dee327f2c83 schema:name Springer Nature - SN SciGraph project
209 rdf:type schema:Organization
210 Nf5069e7107594c33a7fdfed5726f8a7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Animals
212 rdf:type schema:DefinedTerm
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
217 schema:name Clinical Sciences
218 rdf:type schema:DefinedTerm
219 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
220 schema:name Oncology and Carcinogenesis
221 rdf:type schema:DefinedTerm
222 sg:journal.1097543 schema:issn 0950-9232
223 1476-5594
224 schema:name Oncogene
225 schema:publisher Springer Nature
226 rdf:type schema:Periodical
227 sg:person.01035371524.50 schema:affiliation grid-institutes:grid.48336.3a
228 schema:familyName Gallahan
229 schema:givenName Daniel
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035371524.50
231 rdf:type schema:Person
232 sg:person.0721143124.20 schema:affiliation grid-institutes:grid.48336.3a
233 schema:familyName Callahan
234 schema:givenName Robert
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721143124.20
236 rdf:type schema:Person
237 grid-institutes:grid.48336.3a schema:alternateName Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, 20892, Bethesda, Maryland, USA
238 schema:name Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, 20892, Bethesda, Maryland, USA
239 SRA Technologies, Inc, Life Sciences, 4 Research Court, 20850, Rockville, MD, USA
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...