Prognostic significance of allelic losses in primary melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-04

AUTHORS

Eugene Healy, Christine Belgaid, Minoru Takata, David Harrison, Ning Wen Zhu, D Andrew R Burd, Howard S Rigby, John NS Matthews, Jonathan L Rees

ABSTRACT

Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine whether allelic loss is of prognostic importance in melanoma, disease-free survival was related to loss of heterozygosity on 6q, 9p and 10q in 83 individuals with sporadic primary cutaneous melanoma. Loss of chromosome arms 6q and 10q were each significantly associated with a poorer clinical outcome (P=0.013 and P=0.001 respectively). In a subgroup of 41 subjects whose primary tumours were allelotyped, the fractional allelic loss (FAL) at 39 autosomal arms also significantly correlated with disease-free survival (P=0.013), with an increase in FAL associated with a poorer outcome; this association remained significant when controlled for tumour thickness (P=0.035). In addition, a greater proportion of cells were immunopositive for Ki67 antigen, p53 and p21WAF1 protein in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was significantly associated with improved survival (P=0.041). More... »

PAGES

2213

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.onc.1200203

DOI

http://dx.doi.org/10.1038/sj.onc.1200203

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034323004

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9619830


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p21", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ki-67 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Newcastle University", 
          "id": "https://www.grid.ac/institutes/grid.1006.7", 
          "name": [
            "Department of Dermatology, University of Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Healy", 
        "givenName": "Eugene", 
        "id": "sg:person.01121650553.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121650553.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Newcastle University", 
          "id": "https://www.grid.ac/institutes/grid.1006.7", 
          "name": [
            "Department of Dermatology, University of Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belgaid", 
        "givenName": "Christine", 
        "id": "sg:person.01044401723.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044401723.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kanazawa University", 
          "id": "https://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Dermatology, University of Newcastle upon Tyne, UK", 
            "Current address: Department of Dermatology, Kanazawa University School of Medicine, Kanazawa 920, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takata", 
        "givenName": "Minoru", 
        "id": "sg:person.01130542072.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130542072.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Newcastle University", 
          "id": "https://www.grid.ac/institutes/grid.1006.7", 
          "name": [
            "Department of Dermatology, University of Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrison", 
        "givenName": "David", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Frenchay Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415059.c", 
          "name": [
            "Department of Plastic Surgery, Frenchay Hospital, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Ning Wen", 
        "id": "sg:person.01054622055.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054622055.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Frenchay Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415059.c", 
          "name": [
            "Department of Plastic Surgery, Frenchay Hospital, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burd", 
        "givenName": "D Andrew R", 
        "id": "sg:person.01126576355.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126576355.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Frenchay Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415059.c", 
          "name": [
            "Department of Pathology, Frenchay Hospital, Bristol, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rigby", 
        "givenName": "Howard S", 
        "id": "sg:person.0714021345.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714021345.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Newcastle University", 
          "id": "https://www.grid.ac/institutes/grid.1006.7", 
          "name": [
            "Department of Statistics, University of Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matthews", 
        "givenName": "John NS", 
        "id": "sg:person.015216577112.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015216577112.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Newcastle University", 
          "id": "https://www.grid.ac/institutes/grid.1006.7", 
          "name": [
            "Department of Dermatology, University of Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rees", 
        "givenName": "Jonathan L", 
        "id": "sg:person.01242207604.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242207604.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-1-4899-3115-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109705857", 
          "https://doi.org/10.1007/978-1-4899-3115-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4899-3115-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1109705857", 
          "https://doi.org/10.1007/978-1-4899-3115-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-04", 
    "datePublishedReg": "1998-04-01", 
    "description": "Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine whether allelic loss is of prognostic importance in melanoma, disease-free survival was related to loss of heterozygosity on 6q, 9p and 10q in 83 individuals with sporadic primary cutaneous melanoma. Loss of chromosome arms 6q and 10q were each significantly associated with a poorer clinical outcome (P=0.013 and P=0.001 respectively). In a subgroup of 41 subjects whose primary tumours were allelotyped, the fractional allelic loss (FAL) at 39 autosomal arms also significantly correlated with disease-free survival (P=0.013), with an increase in FAL associated with a poorer outcome; this association remained significant when controlled for tumour thickness (P=0.035). In addition, a greater proportion of cells were immunopositive for Ki67 antigen, p53 and p21WAF1 protein in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was significantly associated with improved survival (P=0.041).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.onc.1200203", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "17", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Prognostic significance of allelic losses in primary melanoma", 
    "pagination": "2213", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a3801dd2569971621167ce73557ee3585ae5e25a20e1fa999fcb0351ebe0d695"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9619830"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.onc.1200203"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034323004"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.onc.1200203", 
      "https://app.dimensions.ai/details/publication/pub.1034323004"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54017_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/1200203"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1200203'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1200203'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1200203'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.onc.1200203'


 

This table displays all metadata directly associated to this object as RDF triples.

205 TRIPLES      21 PREDICATES      47 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.onc.1200203 schema:about N13cee6248f0f4eb2a8b9dc8178c46be3
2 N163eac43145d4fb09d2f6601a48f34e2
3 N17a4c4113cbd4bb8ad90659c0cf9bbcc
4 N1ceacbb7a90545319d3f60c08472b0c8
5 N2340101f60d24dc6a3a125c62cd2ee0d
6 N2e358181cef34ff9bc46752078efae8b
7 N4d6c68ceea6f415893afbde525308c15
8 N5b616ff24d2a4868a0a940db65921a37
9 N716a5d47daaf41bfae82e196435f367e
10 N7cb7fa08b51747afbb62fb95ae877380
11 Nabc1d5fd680047b7b0d5c8395fe37a0a
12 Nac7a68c6777c404f9397309ebcdbd4fe
13 Ncbe7072dc9f5448ab9c7e1207f4ae91d
14 Nd1ee08ffcdae4357aee94eb37f2c9fbe
15 Nd53ecfabf6aa41a38a991a1279ee9daf
16 Ndaf41398d628490481a28ecb65b424dd
17 Ne3b40710389145529f42ccfe5f21bf79
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N3f0894aedb704ebc90294bd869492e38
21 schema:citation sg:pub.10.1007/978-1-4899-3115-3
22 schema:datePublished 1998-04
23 schema:datePublishedReg 1998-04-01
24 schema:description Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine whether allelic loss is of prognostic importance in melanoma, disease-free survival was related to loss of heterozygosity on 6q, 9p and 10q in 83 individuals with sporadic primary cutaneous melanoma. Loss of chromosome arms 6q and 10q were each significantly associated with a poorer clinical outcome (P=0.013 and P=0.001 respectively). In a subgroup of 41 subjects whose primary tumours were allelotyped, the fractional allelic loss (FAL) at 39 autosomal arms also significantly correlated with disease-free survival (P=0.013), with an increase in FAL associated with a poorer outcome; this association remained significant when controlled for tumour thickness (P=0.035). In addition, a greater proportion of cells were immunopositive for Ki67 antigen, p53 and p21WAF1 protein in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was significantly associated with improved survival (P=0.041).
25 schema:genre research_article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf Na2bcfb3dffa2428e8df7dfe836f54293
29 Nca77b1e4ebd1456a866c242b714bffa9
30 sg:journal.1097543
31 schema:name Prognostic significance of allelic losses in primary melanoma
32 schema:pagination 2213
33 schema:productId N07dea4039f69489695fd179e58002d5d
34 N4105fdf830904dbca513f0549c62c397
35 N51d8264ec61649308098db9ded52e72b
36 N581eb8866ee14fe295fac0af0ec6aa07
37 Nf3d82d622f674bc2a391668a3f87367a
38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034323004
39 https://doi.org/10.1038/sj.onc.1200203
40 schema:sdDatePublished 2019-04-11T12:16
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher N9f09481af69c4fb2971b8adf8ce958d0
43 schema:url https://www.nature.com/articles/1200203
44 sgo:license sg:explorer/license/
45 sgo:sdDataset articles
46 rdf:type schema:ScholarlyArticle
47 N046a2fdebcc447658931e690420591ab rdf:first sg:person.01130542072.35
48 rdf:rest N2e3e2ed565614f659fa3216211addf74
49 N07dea4039f69489695fd179e58002d5d schema:name nlm_unique_id
50 schema:value 8711562
51 rdf:type schema:PropertyValue
52 N13cee6248f0f4eb2a8b9dc8178c46be3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
53 schema:name Cyclins
54 rdf:type schema:DefinedTerm
55 N163eac43145d4fb09d2f6601a48f34e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name Tumor Suppressor Protein p53
57 rdf:type schema:DefinedTerm
58 N17a4c4113cbd4bb8ad90659c0cf9bbcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Ki-67 Antigen
60 rdf:type schema:DefinedTerm
61 N1ceacbb7a90545319d3f60c08472b0c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Biomarkers, Tumor
63 rdf:type schema:DefinedTerm
64 N2340101f60d24dc6a3a125c62cd2ee0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Chromosomes, Human, Pair 6
66 rdf:type schema:DefinedTerm
67 N2e358181cef34ff9bc46752078efae8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Chromosomes, Human, Pair 9
69 rdf:type schema:DefinedTerm
70 N2e3e2ed565614f659fa3216211addf74 rdf:first Nece3412fe61143e88cf090d2f083c36c
71 rdf:rest N3837a5f0376147b0bdee22696e2bb143
72 N3837a5f0376147b0bdee22696e2bb143 rdf:first sg:person.01054622055.41
73 rdf:rest N75453078aa574dafa65d4896196a93e9
74 N3f0894aedb704ebc90294bd869492e38 rdf:first sg:person.01121650553.12
75 rdf:rest N8164d9480c4246d3ae57bcb966c0736e
76 N4105fdf830904dbca513f0549c62c397 schema:name pubmed_id
77 schema:value 9619830
78 rdf:type schema:PropertyValue
79 N4d6c68ceea6f415893afbde525308c15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Melanoma
81 rdf:type schema:DefinedTerm
82 N51d8264ec61649308098db9ded52e72b schema:name dimensions_id
83 schema:value pub.1034323004
84 rdf:type schema:PropertyValue
85 N581eb8866ee14fe295fac0af0ec6aa07 schema:name readcube_id
86 schema:value a3801dd2569971621167ce73557ee3585ae5e25a20e1fa999fcb0351ebe0d695
87 rdf:type schema:PropertyValue
88 N5b616ff24d2a4868a0a940db65921a37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Skin Neoplasms
90 rdf:type schema:DefinedTerm
91 N6898e684f6684539bbc4b3f89ac5743f rdf:first sg:person.015216577112.88
92 rdf:rest Ndf3c8c561e4d4d0da1ae22683a61ab86
93 N716a5d47daaf41bfae82e196435f367e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Risk Assessment
95 rdf:type schema:DefinedTerm
96 N75453078aa574dafa65d4896196a93e9 rdf:first sg:person.01126576355.60
97 rdf:rest N9408299d23404d3d8313ae2b53d7c2a1
98 N7cb7fa08b51747afbb62fb95ae877380 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Prognosis
100 rdf:type schema:DefinedTerm
101 N8164d9480c4246d3ae57bcb966c0736e rdf:first sg:person.01044401723.51
102 rdf:rest N046a2fdebcc447658931e690420591ab
103 N9408299d23404d3d8313ae2b53d7c2a1 rdf:first sg:person.0714021345.11
104 rdf:rest N6898e684f6684539bbc4b3f89ac5743f
105 N9f09481af69c4fb2971b8adf8ce958d0 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Na2bcfb3dffa2428e8df7dfe836f54293 schema:volumeNumber 16
108 rdf:type schema:PublicationVolume
109 Nabc1d5fd680047b7b0d5c8395fe37a0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Chromosome Deletion
111 rdf:type schema:DefinedTerm
112 Nac7a68c6777c404f9397309ebcdbd4fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Loss of Heterozygosity
114 rdf:type schema:DefinedTerm
115 Nca77b1e4ebd1456a866c242b714bffa9 schema:issueNumber 17
116 rdf:type schema:PublicationIssue
117 Ncbe7072dc9f5448ab9c7e1207f4ae91d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 Nd1ee08ffcdae4357aee94eb37f2c9fbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Alleles
122 rdf:type schema:DefinedTerm
123 Nd53ecfabf6aa41a38a991a1279ee9daf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Chromosomes, Human, Pair 10
125 rdf:type schema:DefinedTerm
126 Ndaf41398d628490481a28ecb65b424dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Cyclin-Dependent Kinase Inhibitor p21
128 rdf:type schema:DefinedTerm
129 Ndf3c8c561e4d4d0da1ae22683a61ab86 rdf:first sg:person.01242207604.07
130 rdf:rest rdf:nil
131 Ne3b40710389145529f42ccfe5f21bf79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Disease-Free Survival
133 rdf:type schema:DefinedTerm
134 Nece3412fe61143e88cf090d2f083c36c schema:affiliation https://www.grid.ac/institutes/grid.1006.7
135 schema:familyName Harrison
136 schema:givenName David
137 rdf:type schema:Person
138 Nf3d82d622f674bc2a391668a3f87367a schema:name doi
139 schema:value 10.1038/sj.onc.1200203
140 rdf:type schema:PropertyValue
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
145 schema:name Oncology and Carcinogenesis
146 rdf:type schema:DefinedTerm
147 sg:journal.1097543 schema:issn 0950-9232
148 1476-5594
149 schema:name Oncogene
150 rdf:type schema:Periodical
151 sg:person.01044401723.51 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
152 schema:familyName Belgaid
153 schema:givenName Christine
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044401723.51
155 rdf:type schema:Person
156 sg:person.01054622055.41 schema:affiliation https://www.grid.ac/institutes/grid.415059.c
157 schema:familyName Zhu
158 schema:givenName Ning Wen
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054622055.41
160 rdf:type schema:Person
161 sg:person.01121650553.12 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
162 schema:familyName Healy
163 schema:givenName Eugene
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121650553.12
165 rdf:type schema:Person
166 sg:person.01126576355.60 schema:affiliation https://www.grid.ac/institutes/grid.415059.c
167 schema:familyName Burd
168 schema:givenName D Andrew R
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126576355.60
170 rdf:type schema:Person
171 sg:person.01130542072.35 schema:affiliation https://www.grid.ac/institutes/grid.9707.9
172 schema:familyName Takata
173 schema:givenName Minoru
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130542072.35
175 rdf:type schema:Person
176 sg:person.01242207604.07 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
177 schema:familyName Rees
178 schema:givenName Jonathan L
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242207604.07
180 rdf:type schema:Person
181 sg:person.015216577112.88 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
182 schema:familyName Matthews
183 schema:givenName John NS
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015216577112.88
185 rdf:type schema:Person
186 sg:person.0714021345.11 schema:affiliation https://www.grid.ac/institutes/grid.415059.c
187 schema:familyName Rigby
188 schema:givenName Howard S
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714021345.11
190 rdf:type schema:Person
191 sg:pub.10.1007/978-1-4899-3115-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109705857
192 https://doi.org/10.1007/978-1-4899-3115-3
193 rdf:type schema:CreativeWork
194 https://www.grid.ac/institutes/grid.1006.7 schema:alternateName Newcastle University
195 schema:name Department of Dermatology, University of Newcastle upon Tyne, UK
196 Department of Statistics, University of Newcastle upon Tyne, UK
197 rdf:type schema:Organization
198 https://www.grid.ac/institutes/grid.415059.c schema:alternateName Frenchay Hospital
199 schema:name Department of Pathology, Frenchay Hospital, Bristol, UK
200 Department of Plastic Surgery, Frenchay Hospital, Bristol, UK
201 rdf:type schema:Organization
202 https://www.grid.ac/institutes/grid.9707.9 schema:alternateName Kanazawa University
203 schema:name Current address: Department of Dermatology, Kanazawa University School of Medicine, Kanazawa 920, Japan
204 Department of Dermatology, University of Newcastle upon Tyne, UK
205 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...