Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-07

AUTHORS

Chi-Hua Chen, John Suckling, Cinly Ooi, Cynthia H Y Fu, Steve C R Williams, Nicholas D Walsh, Martina T Mitterschiffthaler, Emilio Merlo Pich, Ed Bullmore

ABSTRACT

The amygdala plays a central role in various aspects of affect processing and mood regulation by its rich anatomical connections to other limbic and cortical regions. It is plausible that depressive disorders, and response to antidepressant drugs, may reflect changes in the physiological coupling between the amygdala and other components of affect-related large-scale brain systems. We explored this hypothesis by mapping the functional coupling of right and left amygdalae in functional magnetic resonance imaging data acquired from 19 patients with major depressive disorder and 19 healthy volunteers, each scanned twice (at baseline and 8 weeks later) during performance of an implicit facial affect processing task. Between scanning sessions, the patients received treatment with an antidepressant drug, fluoxetine 20 mg/day. We found that the amygdala was positively coupled bilaterally with medial temporal and ventral occipital regions, and negatively coupled with the anterior cingulate cortex. Antidepressant treatment was associated with significantly increased coupling between the amygdala and right frontal and cingulate cortex, striatum, and thalamus. Treatment-related increases in functional coupling to frontal and other regions were greater for the left amygdala than for the right amygdala. These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico-limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala. More... »

PAGES

1301593

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.npp.1301593

DOI

http://dx.doi.org/10.1038/sj.npp.1301593

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034841070

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17987064


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amygdala", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antidepressive Agents, Second-Generation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Depressive Disorder, Major", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Facial Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluoxetine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Functional Laterality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Image Processing, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Psychiatric Status Rating Scales", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Social Perception", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Chi-Hua", 
        "id": "sg:person.01015265243.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015265243.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suckling", 
        "givenName": "John", 
        "id": "sg:person.01354663052.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354663052.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ooi", 
        "givenName": "Cinly", 
        "id": "sg:person.0602243135.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602243135.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Cynthia H Y", 
        "id": "sg:person.0712502437.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712502437.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Centre for Neuroimaging Science, Institute of Psychiatry, King's College, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Steve C R", 
        "id": "sg:person.013236156002.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013236156002.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Centre for Neuroimaging Science, Institute of Psychiatry, King's College, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walsh", 
        "givenName": "Nicholas D", 
        "id": "sg:person.01000504665.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000504665.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Centre for Neuroimaging Science, Institute of Psychiatry, King's College, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitterschiffthaler", 
        "givenName": "Martina T", 
        "id": "sg:person.0732371465.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732371465.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Psychiatry Centre for Excellence in Drug Discovery, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline SpA, Verona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pich", 
        "givenName": "Emilio Merlo", 
        "id": "sg:person.010243476465.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010243476465.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK", 
            "Clinical Unit Cambridge, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline R&D, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bullmore", 
        "givenName": "Ed", 
        "id": "sg:person.012155772042.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155772042.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nn1366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000081399", 
          "https://doi.org/10.1038/nn1366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000081399", 
          "https://doi.org/10.1038/nn1366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(00)01036-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001115534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/30976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001367794", 
          "https://doi.org/10.1038/30976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/30976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001367794", 
          "https://doi.org/10.1038/30976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.902620208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002150444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2004.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002418093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003374955", 
          "https://doi.org/10.1038/nrn1589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003374955", 
          "https://doi.org/10.1038/nrn1589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-0173(99)00023-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003474647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004719924", 
          "https://doi.org/10.1038/sj.npp.1300725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004719924", 
          "https://doi.org/10.1038/sj.npp.1300725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.61.9.877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006624257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.2001.0978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008623590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1162/089892901753294338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009245783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2003.09.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009360401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/46286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009957018", 
          "https://doi.org/10.1038/46286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/46286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009957018", 
          "https://doi.org/10.1038/46286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113206", 
          "https://doi.org/10.1038/nrn1704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113206", 
          "https://doi.org/10.1038/nrn1704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113206", 
          "https://doi.org/10.1038/nrn1704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.24.1.167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011665436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.2000.0544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011726668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00446-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012600362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00446-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012600362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(99)00266-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013683137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014324826", 
          "https://doi.org/10.1038/nrn1629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014324826", 
          "https://doi.org/10.1038/nrn1629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(96)00155-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014613031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb07098.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014828163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2004.10.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016013935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(96)00097-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016302304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2004.06.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016762056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017259369", 
          "https://doi.org/10.1038/nrn1825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017259369", 
          "https://doi.org/10.1038/nrn1825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(02)01314-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017618156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-8119(03)00202-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019860370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1053-8119(03)00202-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019860370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(01)01263-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020254412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nimg.1997.0291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021428113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mri.2003.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022449519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.460020107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022711595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/10.3.220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023328661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(00)01020-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025489906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-4388(96)80077-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027414877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb07094.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027603461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.23.1.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028571621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.1985.01790350045009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028866135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)91357-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030454821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(91)91357-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030454821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2006.01.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030496570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb09292.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031552597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1999.tb09292.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031552597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-3057(01)00687-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032033133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2006.09.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033731130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-4388(00)00203-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034381661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ne.09.030186.002041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035901217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(02)01817-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036044416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(02)01817-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036044416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(85)90530-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036430016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(85)90530-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036430016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/10.3.295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039102640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.1.325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040003324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-4388(02)00301-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041964588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.23.1.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042824373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2005.08.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043774467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2005.08.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043774467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2005.02.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044232627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-4388(99)80031-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047468346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pneurobio.2004.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047679642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(02)00653-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048101444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cercor/bhi016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049616524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.20027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049619679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050890022", 
          "https://doi.org/10.1038/nn1463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050890022", 
          "https://doi.org/10.1038/nn1463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050890022", 
          "https://doi.org/10.1038/nn1463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(03)00347-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050919477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(03)00347-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050919477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0924-977x(02)00102-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051378003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0924-977x(02)00102-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051378003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0361-9230(99)00245-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053243576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/scnp.2002.35223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057077632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1059115395", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/42.750253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061170735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.158.6.899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063493912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.160.1.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063494956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.156.5.675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074458877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076847051", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.12-09-03628.1992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076870765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.14-02-00655.1994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082746387"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-07", 
    "datePublishedReg": "2008-07-01", 
    "description": "The amygdala plays a central role in various aspects of affect processing and mood regulation by its rich anatomical connections to other limbic and cortical regions. It is plausible that depressive disorders, and response to antidepressant drugs, may reflect changes in the physiological coupling between the amygdala and other components of affect-related large-scale brain systems. We explored this hypothesis by mapping the functional coupling of right and left amygdalae in functional magnetic resonance imaging data acquired from 19 patients with major depressive disorder and 19 healthy volunteers, each scanned twice (at baseline and 8 weeks later) during performance of an implicit facial affect processing task. Between scanning sessions, the patients received treatment with an antidepressant drug, fluoxetine 20 mg/day. We found that the amygdala was positively coupled bilaterally with medial temporal and ventral occipital regions, and negatively coupled with the anterior cingulate cortex. Antidepressant treatment was associated with significantly increased coupling between the amygdala and right frontal and cingulate cortex, striatum, and thalamus. Treatment-related increases in functional coupling to frontal and other regions were greater for the left amygdala than for the right amygdala. These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico-limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.npp.1301593", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2762165", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "name": "Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication", 
    "pagination": "1301593", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a5f81c72d171eb9c22ca742cf73a71bb280c4d5555229a9444065f19026042f4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17987064"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8904907"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.npp.1301593"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034841070"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.npp.1301593", 
      "https://app.dimensions.ai/details/publication/pub.1034841070"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1301593"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1301593'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1301593'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1301593'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1301593'


 

This table displays all metadata directly associated to this object as RDF triples.

419 TRIPLES      21 PREDICATES      116 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.npp.1301593 schema:about N13a189f54aab489fb33fbda5c3fb1d8f
2 N1a6dd9b2a6ce449695f559ff4081e666
3 N2034cbd2d7294782b8c85ec1c12f2788
4 N21cf97cb6b924d6a89a15fc1007ef87e
5 N3fb28dd12d964dfd9454e787c2643c63
6 N44ef2fd536a046d198612ffe7ca452be
7 N4735b52b96444ac794c485152b3cef64
8 N55824dcfd50143a185665182142e0da1
9 N63e02c5817864365afc04259d7070fbf
10 N753c319521a24af6b184f20002bb1bc2
11 N81f48e7e808b428f807348850e10cf57
12 N921fa00058bf4a499136409269a26903
13 Nbcb294c9111b49f5854056261566bb10
14 Nc0c7625ec4b84510b00746deb7478b3f
15 Nca8a8e3a75cf4520b9879969b44e5e75
16 Ne3ffff403d0045c7bc55498e29bce52a
17 Neb0272e60c2b4b239931cebf4d9bceaf
18 anzsrc-for:11
19 anzsrc-for:1109
20 schema:author N4c710d2055d44bed949d5d0800ad5063
21 schema:citation sg:pub.10.1038/30976
22 sg:pub.10.1038/46286
23 sg:pub.10.1038/nn1366
24 sg:pub.10.1038/nn1463
25 sg:pub.10.1038/nrn1589
26 sg:pub.10.1038/nrn1629
27 sg:pub.10.1038/nrn1704
28 sg:pub.10.1038/nrn1825
29 sg:pub.10.1038/sj.npp.1300725
30 https://app.dimensions.ai/details/publication/pub.1059115395
31 https://app.dimensions.ai/details/publication/pub.1076847051
32 https://doi.org/10.1001/archpsyc.1985.01790350045009
33 https://doi.org/10.1001/archpsyc.61.9.877
34 https://doi.org/10.1002/cne.902620208
35 https://doi.org/10.1002/hbm.20027
36 https://doi.org/10.1002/hbm.460020107
37 https://doi.org/10.1006/nimg.1997.0291
38 https://doi.org/10.1006/nimg.2000.0544
39 https://doi.org/10.1006/nimg.2001.0978
40 https://doi.org/10.1016/0006-8993(85)90530-x
41 https://doi.org/10.1016/0006-8993(91)91357-7
42 https://doi.org/10.1016/0006-8993(96)00155-2
43 https://doi.org/10.1016/j.biopsych.2004.10.030
44 https://doi.org/10.1016/j.biopsych.2005.02.021
45 https://doi.org/10.1016/j.biopsych.2006.09.018
46 https://doi.org/10.1016/j.mri.2003.08.026
47 https://doi.org/10.1016/j.neuroimage.2003.09.057
48 https://doi.org/10.1016/j.neuroimage.2004.01.015
49 https://doi.org/10.1016/j.neuroimage.2004.06.030
50 https://doi.org/10.1016/j.neuroimage.2005.08.047
51 https://doi.org/10.1016/j.neuroscience.2006.01.026
52 https://doi.org/10.1016/j.pneurobio.2004.03.006
53 https://doi.org/10.1016/s0006-3223(00)01020-9
54 https://doi.org/10.1016/s0006-3223(00)01036-2
55 https://doi.org/10.1016/s0006-3223(01)01263-x
56 https://doi.org/10.1016/s0006-3223(02)01314-8
57 https://doi.org/10.1016/s0006-3223(02)01817-6
58 https://doi.org/10.1016/s0006-3223(03)00347-0
59 https://doi.org/10.1016/s0006-3223(96)00097-2
60 https://doi.org/10.1016/s0006-3223(99)00266-8
61 https://doi.org/10.1016/s0091-3057(01)00687-6
62 https://doi.org/10.1016/s0165-0173(99)00023-5
63 https://doi.org/10.1016/s0306-4522(02)00446-3
64 https://doi.org/10.1016/s0361-9230(99)00245-2
65 https://doi.org/10.1016/s0896-6273(02)00653-0
66 https://doi.org/10.1016/s0924-977x(02)00102-5
67 https://doi.org/10.1016/s0959-4388(00)00203-8
68 https://doi.org/10.1016/s0959-4388(02)00301-x
69 https://doi.org/10.1016/s0959-4388(96)80077-8
70 https://doi.org/10.1016/s0959-4388(99)80031-2
71 https://doi.org/10.1016/s1053-8119(03)00202-7
72 https://doi.org/10.1053/scnp.2002.35223
73 https://doi.org/10.1073/pnas.97.1.325
74 https://doi.org/10.1093/cercor/10.3.220
75 https://doi.org/10.1093/cercor/10.3.295
76 https://doi.org/10.1093/cercor/bhi016
77 https://doi.org/10.1109/42.750253
78 https://doi.org/10.1111/j.1749-6632.1999.tb09292.x
79 https://doi.org/10.1111/j.1749-6632.2003.tb07094.x
80 https://doi.org/10.1111/j.1749-6632.2003.tb07098.x
81 https://doi.org/10.1136/jnnp.23.1.56
82 https://doi.org/10.1146/annurev.ne.09.030186.002041
83 https://doi.org/10.1146/annurev.neuro.23.1.155
84 https://doi.org/10.1146/annurev.neuro.24.1.167
85 https://doi.org/10.1162/089892901753294338
86 https://doi.org/10.1176/ajp.156.5.675
87 https://doi.org/10.1176/appi.ajp.158.6.899
88 https://doi.org/10.1176/appi.ajp.160.1.64
89 https://doi.org/10.1523/jneurosci.12-09-03628.1992
90 https://doi.org/10.1523/jneurosci.14-02-00655.1994
91 schema:datePublished 2008-07
92 schema:datePublishedReg 2008-07-01
93 schema:description The amygdala plays a central role in various aspects of affect processing and mood regulation by its rich anatomical connections to other limbic and cortical regions. It is plausible that depressive disorders, and response to antidepressant drugs, may reflect changes in the physiological coupling between the amygdala and other components of affect-related large-scale brain systems. We explored this hypothesis by mapping the functional coupling of right and left amygdalae in functional magnetic resonance imaging data acquired from 19 patients with major depressive disorder and 19 healthy volunteers, each scanned twice (at baseline and 8 weeks later) during performance of an implicit facial affect processing task. Between scanning sessions, the patients received treatment with an antidepressant drug, fluoxetine 20 mg/day. We found that the amygdala was positively coupled bilaterally with medial temporal and ventral occipital regions, and negatively coupled with the anterior cingulate cortex. Antidepressant treatment was associated with significantly increased coupling between the amygdala and right frontal and cingulate cortex, striatum, and thalamus. Treatment-related increases in functional coupling to frontal and other regions were greater for the left amygdala than for the right amygdala. These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico-limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala.
94 schema:genre research_article
95 schema:inLanguage en
96 schema:isAccessibleForFree true
97 schema:isPartOf N53519523964e47468395815d43d2b267
98 N6a71d784fdfc4e1fad1fe6d309a9c3b5
99 sg:journal.1099176
100 schema:name Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication
101 schema:pagination 1301593
102 schema:productId N2bb30d5531b841edaea8c251f5e3b0d7
103 N5689e3f9b6744cdc86a759c3eb2bc08a
104 N56cfac5807674ca59b2974d826842675
105 Nd68be1b04d244030a29d850e0870d5e6
106 Nf2fc5133664243b4871ff6a2a1834033
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034841070
108 https://doi.org/10.1038/sj.npp.1301593
109 schema:sdDatePublished 2019-04-10T14:48
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher Nfd38b5cdd0dd44979e59ad387183fd73
112 schema:url http://www.nature.com/articles/1301593
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N0a30ebdd69ef45579b92dcdbe75bc057 rdf:first sg:person.0712502437.19
117 rdf:rest N76e61b0ee8cf43118b369d08f99b85fb
118 N13a189f54aab489fb33fbda5c3fb1d8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Adult
120 rdf:type schema:DefinedTerm
121 N1a6dd9b2a6ce449695f559ff4081e666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Fluoxetine
123 rdf:type schema:DefinedTerm
124 N2034cbd2d7294782b8c85ec1c12f2788 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Social Perception
126 rdf:type schema:DefinedTerm
127 N21cf97cb6b924d6a89a15fc1007ef87e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Functional Laterality
129 rdf:type schema:DefinedTerm
130 N25357af183a440929e0d595029971248 rdf:first sg:person.012155772042.10
131 rdf:rest rdf:nil
132 N2bb30d5531b841edaea8c251f5e3b0d7 schema:name pubmed_id
133 schema:value 17987064
134 rdf:type schema:PropertyValue
135 N3a3a36af0b314a20a03d8a3dd5ce749b rdf:first sg:person.01354663052.50
136 rdf:rest N84f5a630384d410e8b4783c66d41f025
137 N3fb28dd12d964dfd9454e787c2643c63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Male
139 rdf:type schema:DefinedTerm
140 N44ef2fd536a046d198612ffe7ca452be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Middle Aged
142 rdf:type schema:DefinedTerm
143 N4735b52b96444ac794c485152b3cef64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Analysis of Variance
145 rdf:type schema:DefinedTerm
146 N4c710d2055d44bed949d5d0800ad5063 rdf:first sg:person.01015265243.54
147 rdf:rest N3a3a36af0b314a20a03d8a3dd5ce749b
148 N53519523964e47468395815d43d2b267 schema:issueNumber 8
149 rdf:type schema:PublicationIssue
150 N55824dcfd50143a185665182142e0da1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Amygdala
152 rdf:type schema:DefinedTerm
153 N5689e3f9b6744cdc86a759c3eb2bc08a schema:name readcube_id
154 schema:value a5f81c72d171eb9c22ca742cf73a71bb280c4d5555229a9444065f19026042f4
155 rdf:type schema:PropertyValue
156 N56cfac5807674ca59b2974d826842675 schema:name nlm_unique_id
157 schema:value 8904907
158 rdf:type schema:PropertyValue
159 N63e02c5817864365afc04259d7070fbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Image Processing, Computer-Assisted
161 rdf:type schema:DefinedTerm
162 N6a71d784fdfc4e1fad1fe6d309a9c3b5 schema:volumeNumber 33
163 rdf:type schema:PublicationVolume
164 N753c319521a24af6b184f20002bb1bc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Magnetic Resonance Imaging
166 rdf:type schema:DefinedTerm
167 N76e61b0ee8cf43118b369d08f99b85fb rdf:first sg:person.013236156002.26
168 rdf:rest Nc0ce3775be0c4459a67234aee9a223f2
169 N7a9231123924437693d4047254122916 rdf:first sg:person.0732371465.34
170 rdf:rest Nc40210a117934334a369370ea705fca2
171 N81f48e7e808b428f807348850e10cf57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Brain Mapping
173 rdf:type schema:DefinedTerm
174 N84f5a630384d410e8b4783c66d41f025 rdf:first sg:person.0602243135.14
175 rdf:rest N0a30ebdd69ef45579b92dcdbe75bc057
176 N921fa00058bf4a499136409269a26903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Female
178 rdf:type schema:DefinedTerm
179 Na2367df25269490c915bc720b98240db schema:name Psychiatry Centre for Excellence in Drug Discovery, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline SpA, Verona, Italy
180 rdf:type schema:Organization
181 Nbcb294c9111b49f5854056261566bb10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Antidepressive Agents, Second-Generation
183 rdf:type schema:DefinedTerm
184 Nc0c7625ec4b84510b00746deb7478b3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Psychiatric Status Rating Scales
186 rdf:type schema:DefinedTerm
187 Nc0ce3775be0c4459a67234aee9a223f2 rdf:first sg:person.01000504665.58
188 rdf:rest N7a9231123924437693d4047254122916
189 Nc40210a117934334a369370ea705fca2 rdf:first sg:person.010243476465.77
190 rdf:rest N25357af183a440929e0d595029971248
191 Nca8a8e3a75cf4520b9879969b44e5e75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Depressive Disorder, Major
193 rdf:type schema:DefinedTerm
194 Nd68be1b04d244030a29d850e0870d5e6 schema:name doi
195 schema:value 10.1038/sj.npp.1301593
196 rdf:type schema:PropertyValue
197 Ne3ffff403d0045c7bc55498e29bce52a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Humans
199 rdf:type schema:DefinedTerm
200 Neb0272e60c2b4b239931cebf4d9bceaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Facial Expression
202 rdf:type schema:DefinedTerm
203 Nf2fc5133664243b4871ff6a2a1834033 schema:name dimensions_id
204 schema:value pub.1034841070
205 rdf:type schema:PropertyValue
206 Nfd38b5cdd0dd44979e59ad387183fd73 schema:name Springer Nature - SN SciGraph project
207 rdf:type schema:Organization
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
212 schema:name Neurosciences
213 rdf:type schema:DefinedTerm
214 sg:grant.2762165 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.npp.1301593
215 rdf:type schema:MonetaryGrant
216 sg:journal.1099176 schema:issn 0893-133X
217 1740-634X
218 schema:name Neuropsychopharmacology
219 rdf:type schema:Periodical
220 sg:person.01000504665.58 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
221 schema:familyName Walsh
222 schema:givenName Nicholas D
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000504665.58
224 rdf:type schema:Person
225 sg:person.01015265243.54 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
226 schema:familyName Chen
227 schema:givenName Chi-Hua
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015265243.54
229 rdf:type schema:Person
230 sg:person.010243476465.77 schema:affiliation Na2367df25269490c915bc720b98240db
231 schema:familyName Pich
232 schema:givenName Emilio Merlo
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010243476465.77
234 rdf:type schema:Person
235 sg:person.012155772042.10 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
236 schema:familyName Bullmore
237 schema:givenName Ed
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155772042.10
239 rdf:type schema:Person
240 sg:person.013236156002.26 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
241 schema:familyName Williams
242 schema:givenName Steve C R
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013236156002.26
244 rdf:type schema:Person
245 sg:person.01354663052.50 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
246 schema:familyName Suckling
247 schema:givenName John
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354663052.50
249 rdf:type schema:Person
250 sg:person.0602243135.14 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
251 schema:familyName Ooi
252 schema:givenName Cinly
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602243135.14
254 rdf:type schema:Person
255 sg:person.0712502437.19 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
256 schema:familyName Fu
257 schema:givenName Cynthia H Y
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712502437.19
259 rdf:type schema:Person
260 sg:person.0732371465.34 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
261 schema:familyName Mitterschiffthaler
262 schema:givenName Martina T
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732371465.34
264 rdf:type schema:Person
265 sg:pub.10.1038/30976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001367794
266 https://doi.org/10.1038/30976
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/46286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009957018
269 https://doi.org/10.1038/46286
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nn1366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000081399
272 https://doi.org/10.1038/nn1366
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nn1463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050890022
275 https://doi.org/10.1038/nn1463
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nrn1589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003374955
278 https://doi.org/10.1038/nrn1589
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nrn1629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014324826
281 https://doi.org/10.1038/nrn1629
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nrn1704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010113206
284 https://doi.org/10.1038/nrn1704
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nrn1825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017259369
287 https://doi.org/10.1038/nrn1825
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/sj.npp.1300725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004719924
290 https://doi.org/10.1038/sj.npp.1300725
291 rdf:type schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1059115395 schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1076847051 schema:CreativeWork
294 https://doi.org/10.1001/archpsyc.1985.01790350045009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028866135
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1001/archpsyc.61.9.877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006624257
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1002/cne.902620208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002150444
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1002/hbm.20027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049619679
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1002/hbm.460020107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022711595
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1006/nimg.1997.0291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021428113
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1006/nimg.2000.0544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011726668
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1006/nimg.2001.0978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008623590
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/0006-8993(85)90530-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036430016
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/0006-8993(91)91357-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030454821
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/0006-8993(96)00155-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014613031
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.biopsych.2004.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016013935
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.biopsych.2005.02.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044232627
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.biopsych.2006.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033731130
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.mri.2003.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022449519
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.neuroimage.2003.09.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009360401
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.neuroimage.2004.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002418093
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.neuroimage.2004.06.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016762056
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.neuroimage.2005.08.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043774467
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/j.neuroscience.2006.01.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030496570
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.pneurobio.2004.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047679642
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/s0006-3223(00)01020-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025489906
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/s0006-3223(00)01036-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001115534
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/s0006-3223(01)01263-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020254412
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/s0006-3223(02)01314-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017618156
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/s0006-3223(02)01817-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036044416
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/s0006-3223(03)00347-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050919477
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/s0006-3223(96)00097-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016302304
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/s0006-3223(99)00266-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013683137
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/s0091-3057(01)00687-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032033133
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/s0165-0173(99)00023-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003474647
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/s0306-4522(02)00446-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012600362
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/s0361-9230(99)00245-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053243576
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/s0896-6273(02)00653-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048101444
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/s0924-977x(02)00102-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051378003
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/s0959-4388(00)00203-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034381661
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/s0959-4388(02)00301-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041964588
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/s0959-4388(96)80077-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027414877
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/s0959-4388(99)80031-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047468346
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/s1053-8119(03)00202-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019860370
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1053/scnp.2002.35223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057077632
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1073/pnas.97.1.325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040003324
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1093/cercor/10.3.220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023328661
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1093/cercor/10.3.295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039102640
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1093/cercor/bhi016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049616524
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1109/42.750253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061170735
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1111/j.1749-6632.1999.tb09292.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031552597
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1111/j.1749-6632.2003.tb07094.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027603461
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1111/j.1749-6632.2003.tb07098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014828163
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1136/jnnp.23.1.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042824373
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1146/annurev.ne.09.030186.002041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035901217
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1146/annurev.neuro.23.1.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028571621
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1146/annurev.neuro.24.1.167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011665436
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1162/089892901753294338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009245783
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1176/ajp.156.5.675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074458877
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1176/appi.ajp.158.6.899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063493912
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1176/appi.ajp.160.1.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063494956
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1523/jneurosci.12-09-03628.1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076870765
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1523/jneurosci.14-02-00655.1994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082746387
411 rdf:type schema:CreativeWork
412 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
413 schema:name Centre for Neuroimaging Science, Institute of Psychiatry, King's College, London, UK
414 MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK
415 rdf:type schema:Organization
416 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
417 schema:name Clinical Unit Cambridge, Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline R&D, Cambridge, UK
418 Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
419 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...