Effects of Nicotine Nasal Spray on Cognitive Function in Schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-03

AUTHORS

Robert C Smith, Jessy Warner-Cohen, Melissa Matute, Erin Butler, Erin Kelly, Sumathi Vaidhyanathaswamy, Alea Khan

ABSTRACT

Schizophrenics have among the highest rates of cigarette smoking. Some studies indicate that cigarette smoking or nicotine may ameliorate some of the cognitive or theoretically related neurophysiological deficits seen in schizophrenic patients. This study investigated the effects of nicotine nasal spray on measures of attention, verbal memory, and visual-spatial memory in schizophrenic patients who were chronic smokers, using a double-blind placebo-controlled pre-post experimental design. Compared to placebo, active nicotine spray significantly decreased reaction time on the Conner's CPT and improved scores on a measure purported to reflect spatial working memory on a dot task. There were trends for the increased number of hits and decreased number of errors in pre-post comparisons on the CPT task in the active nicotine session. There were no effects of active nicotine nasal spray on verbal memory. Our results suggest that nicotine may modestly enhance attention and spatial working memory in schizophrenic patients who are cigarette smokers and have been abstinent overnight. More... »

PAGES

637

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.npp.1300881

DOI

http://dx.doi.org/10.1038/sj.npp.1300881

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034297969

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16160711


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