Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein (SAPAP) is Expressed Differentially in Phencyclidine-Treated Rats and is Increased in the Nucleus Accumbens of ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-04-28

AUTHORS

Yasuo Kajimoto, Osamu Shirakawa, Xian-Hao Lin, Takeshi Hashimoto, Noboru Kitamura, Naoya Murakami, Toru Takumi, Kiyoshi Maeda

ABSTRACT

Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia. Therefore, PCP-treated animals can provide a model for schizophrenia. Using differential display, we identified a gene regulated by the delayed action of PCP in rat nucleus accumbens (NAcs). Sequence analysis showed that the cDNA clone obtained was identical to rat synapse-associated protein 90/postsynaptic density-95-associated protein 1 (SAPAP1). Quantitative reverse transcriptase (RT)-PCR analysis showed that SAPAP1 mRNA had increased significantly in rat NAc (P<0.0001) and hippocampus (P<0.01) 24 h after a PCP (10 mg/kg) injection as compared to the controls. Immunoquantification using an anti-SAPAP1 antibody indicated that immunoreactivity for SAPAP1 increased significantly (P<0.05) in the NAcs of unmedicated patients with schizophrenia, as compared to the control subjects and medicated patients with schizophrenia. Our findings support the hypothesis that there is abnormal glutamatergic neurotransmission in schizophrenia and show evidence of abnormalities in the intracellular signal transduction via N-methyl-D-aspartate (NMDA) receptors. More... »

PAGES

1831-1839

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.npp.1300212

DOI

http://dx.doi.org/10.1038/sj.npp.1300212

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021799720

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12784099


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antipsychotic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Northern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Excitatory Amino Acid Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleus Accumbens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phencyclidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SAP90-PSD95 Associated Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizophrenia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kajimoto", 
        "givenName": "Yasuo", 
        "id": "sg:person.01046322514.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046322514.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shirakawa", 
        "givenName": "Osamu", 
        "id": "sg:person.0767255517.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767255517.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Xian-Hao", 
        "id": "sg:person.01110020710.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110020710.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hashimoto", 
        "givenName": "Takeshi", 
        "id": "sg:person.01253502103.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253502103.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry and Neurology, Kobe General City Hospital, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Psychiatry and Neurology, Kobe General City Hospital, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitamura", 
        "givenName": "Noboru", 
        "id": "sg:person.0637745217.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637745217.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychiatry, Kobe Rosai Hospital, The Labour Welfare Corporation, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415418.d", 
          "name": [
            "Department of Psychiatry, Kobe Rosai Hospital, The Labour Welfare Corporation, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murakami", 
        "givenName": "Naoya", 
        "id": "sg:person.01162551114.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162551114.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience, Osaka Bioscience Institute (OBI), Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410805.8", 
          "name": [
            "Department of Neuroscience, Osaka Bioscience Institute (OBI), Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takumi", 
        "givenName": "Toru", 
        "id": "sg:person.0733100424.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733100424.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maeda", 
        "givenName": "Kiyoshi", 
        "id": "sg:person.01013751772.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013751772.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1016/s0893-133x(97)00036-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024306761", 
          "https://doi.org/10.1016/s0893-133x(97)00036-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/227680a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010419937", 
          "https://doi.org/10.1038/227680a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01276429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038636375", 
          "https://doi.org/10.1007/bf01276429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041999900", 
          "https://doi.org/10.1038/sj.mp.4000454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00421917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031454673", 
          "https://doi.org/10.1007/bf00421917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35039075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048210298", 
          "https://doi.org/10.1038/35039075"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-04-28", 
    "datePublishedReg": "2003-04-28", 
    "description": "Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia. Therefore, PCP-treated animals can provide a model for schizophrenia. Using differential display, we identified a gene regulated by the delayed action of PCP in rat nucleus accumbens (NAcs). Sequence analysis showed that the cDNA clone obtained was identical to rat synapse-associated protein 90/postsynaptic density-95-associated protein 1 (SAPAP1). Quantitative reverse transcriptase (RT)-PCR analysis showed that SAPAP1 mRNA had increased significantly in rat NAc (P<0.0001) and hippocampus (P<0.01) 24\u2009h after a PCP (10\u2009mg/kg) injection as compared to the controls. Immunoquantification using an anti-SAPAP1 antibody indicated that immunoreactivity for SAPAP1 increased significantly (P<0.05) in the NAcs of unmedicated patients with schizophrenia, as compared to the control subjects and medicated patients with schizophrenia. Our findings support the hypothesis that there is abnormal glutamatergic neurotransmission in schizophrenia and show evidence of abnormalities in the intracellular signal transduction via N-methyl-D-aspartate (NMDA) receptors.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.npp.1300212", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "keywords": [
      "nucleus accumbens", 
      "PCP-treated animals", 
      "action of PCP", 
      "abnormal glutamatergic neurotransmission", 
      "rat nucleus accumbens", 
      "evidence of abnormalities", 
      "glutamatergic neurotransmission", 
      "control subjects", 
      "unmedicated patients", 
      "aspartate receptors", 
      "PCP injection", 
      "psychotomimetic states", 
      "schizophrenia", 
      "patients", 
      "rat NAc", 
      "quantitative reverse transcriptase", 
      "intracellular signal transduction", 
      "accumbens", 
      "reverse transcriptase", 
      "protein 1", 
      "phencyclidine", 
      "NAC", 
      "neurotransmission", 
      "rats", 
      "immunoreactivity", 
      "abnormalities", 
      "signal transduction", 
      "antibodies", 
      "receptors", 
      "injection", 
      "synapse", 
      "SAPAP1", 
      "differential display", 
      "animals", 
      "subjects", 
      "immunoquantification", 
      "transcriptase", 
      "PCP", 
      "mRNA", 
      "findings", 
      "evidence", 
      "methyl", 
      "control", 
      "action", 
      "protein", 
      "sequence analysis", 
      "transduction", 
      "genes", 
      "clones", 
      "hypothesis", 
      "cDNA clones", 
      "analysis", 
      "model", 
      "state", 
      "display", 
      "protein 90/postsynaptic density-95-associated protein 1", 
      "postsynaptic density-95-associated protein 1", 
      "density-95-associated protein 1", 
      "SAPAP1 mRNA", 
      "anti-SAPAP1 antibody", 
      "Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein", 
      "Protein 90/Postsynaptic Density-95-Associated Protein", 
      "Postsynaptic Density-95-Associated Protein", 
      "Density-95-Associated Protein"
    ], 
    "name": "Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein (SAPAP) is Expressed Differentially in Phencyclidine-Treated Rats and is Increased in the Nucleus Accumbens of Patients with Schizophrenia", 
    "pagination": "1831-1839", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021799720"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.npp.1300212"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12784099"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.npp.1300212", 
      "https://app.dimensions.ai/details/publication/pub.1021799720"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_375.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.npp.1300212"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300212'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300212'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300212'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300212'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      22 PREDICATES      120 URIs      106 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.npp.1300212 schema:about N040b0441ff2d432fb82a94e6909ad957
2 N08535ce323474c809519fdae9ada7908
3 N27ecf7e28b5a4c4d86c669499b83f051
4 N2b16616a69614b8f99021232c4552c1e
5 N2d185f9b670f4196b421f2cc94d5c694
6 N349a83f571a642ee876c966b0612195e
7 N47045a144d0d4b69a7f0328f0b62a37a
8 N56ac6163f2dd4ed0be33aa51f96a1b88
9 N6ad56100e52b4c0c836d754a188cee92
10 N6e1917e48c2f465b93e2610b8714fc85
11 N72f5985d7b08414ca31fd0bd9b68f48a
12 N8c3695ba8e7d4f8da906949889e1e983
13 N8f3496cfd0fb4653b041108b403d7051
14 N946169a3d9454912869bed480ed7f672
15 N99bb15155ab24a00835275e6e49152ff
16 N9c26de8033814973871747243ee3f1e9
17 N9defc6540f4346d486a9fc5abda4519c
18 Na10a1a480b2a48818f704f261286a6a2
19 Nad004a7d431c4afcb0f0cde65f134c5b
20 Nd1da654072484bd79921c731710ad185
21 Nd7720811710d4728b7746f6ff997a15d
22 Ne1dfe21a07254cf484430dc5550e4316
23 Nf961da618dfb4a0d9ae754965e9fc5aa
24 Nffdc77522731489bb5bf82f6ec35c78a
25 anzsrc-for:11
26 anzsrc-for:1103
27 schema:author N6915072c69bb49abbd7673c0a3805bb5
28 schema:citation sg:pub.10.1007/bf00421917
29 sg:pub.10.1007/bf01276429
30 sg:pub.10.1016/s0893-133x(97)00036-5
31 sg:pub.10.1038/227680a0
32 sg:pub.10.1038/35039075
33 sg:pub.10.1038/sj.mp.4000454
34 schema:datePublished 2003-04-28
35 schema:datePublishedReg 2003-04-28
36 schema:description Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia. Therefore, PCP-treated animals can provide a model for schizophrenia. Using differential display, we identified a gene regulated by the delayed action of PCP in rat nucleus accumbens (NAcs). Sequence analysis showed that the cDNA clone obtained was identical to rat synapse-associated protein 90/postsynaptic density-95-associated protein 1 (SAPAP1). Quantitative reverse transcriptase (RT)-PCR analysis showed that SAPAP1 mRNA had increased significantly in rat NAc (P<0.0001) and hippocampus (P<0.01) 24 h after a PCP (10 mg/kg) injection as compared to the controls. Immunoquantification using an anti-SAPAP1 antibody indicated that immunoreactivity for SAPAP1 increased significantly (P<0.05) in the NAcs of unmedicated patients with schizophrenia, as compared to the control subjects and medicated patients with schizophrenia. Our findings support the hypothesis that there is abnormal glutamatergic neurotransmission in schizophrenia and show evidence of abnormalities in the intracellular signal transduction via N-methyl-D-aspartate (NMDA) receptors.
37 schema:genre article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N6304ad3fe81e40d9ba4a96576f8705a3
41 Na4d15a50fa7143a88396dbe2aa518cc4
42 sg:journal.1099176
43 schema:keywords Density-95-Associated Protein
44 NAC
45 PCP
46 PCP injection
47 PCP-treated animals
48 Postsynaptic Density-95-Associated Protein
49 Protein 90/Postsynaptic Density-95-Associated Protein
50 SAPAP1
51 SAPAP1 mRNA
52 Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein
53 abnormal glutamatergic neurotransmission
54 abnormalities
55 accumbens
56 action
57 action of PCP
58 analysis
59 animals
60 anti-SAPAP1 antibody
61 antibodies
62 aspartate receptors
63 cDNA clones
64 clones
65 control
66 control subjects
67 density-95-associated protein 1
68 differential display
69 display
70 evidence
71 evidence of abnormalities
72 findings
73 genes
74 glutamatergic neurotransmission
75 hypothesis
76 immunoquantification
77 immunoreactivity
78 injection
79 intracellular signal transduction
80 mRNA
81 methyl
82 model
83 neurotransmission
84 nucleus accumbens
85 patients
86 phencyclidine
87 postsynaptic density-95-associated protein 1
88 protein
89 protein 1
90 protein 90/postsynaptic density-95-associated protein 1
91 psychotomimetic states
92 quantitative reverse transcriptase
93 rat NAc
94 rat nucleus accumbens
95 rats
96 receptors
97 reverse transcriptase
98 schizophrenia
99 sequence analysis
100 signal transduction
101 state
102 subjects
103 synapse
104 transcriptase
105 transduction
106 unmedicated patients
107 schema:name Synapse-Associated Protein 90/Postsynaptic Density-95-Associated Protein (SAPAP) is Expressed Differentially in Phencyclidine-Treated Rats and is Increased in the Nucleus Accumbens of Patients with Schizophrenia
108 schema:pagination 1831-1839
109 schema:productId N0d5a82ffef1d48b68542334f3119f8be
110 Nde2a66a956f4451c8a25acfd228be311
111 Ne21ba4bb59eb4f4a81a06d62cd45d866
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021799720
113 https://doi.org/10.1038/sj.npp.1300212
114 schema:sdDatePublished 2021-12-01T19:15
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher N1bd62823375b4dcbb16c64b0578053a1
117 schema:url https://doi.org/10.1038/sj.npp.1300212
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N040b0441ff2d432fb82a94e6909ad957 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Excitatory Amino Acid Antagonists
123 rdf:type schema:DefinedTerm
124 N0641e1238c794d10accb08bd941b6ec1 rdf:first sg:person.01013751772.06
125 rdf:rest rdf:nil
126 N08535ce323474c809519fdae9ada7908 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Reverse Transcriptase Polymerase Chain Reaction
128 rdf:type schema:DefinedTerm
129 N0d5a82ffef1d48b68542334f3119f8be schema:name doi
130 schema:value 10.1038/sj.npp.1300212
131 rdf:type schema:PropertyValue
132 N1bd62823375b4dcbb16c64b0578053a1 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N27ecf7e28b5a4c4d86c669499b83f051 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name RNA, Messenger
136 rdf:type schema:DefinedTerm
137 N2b16616a69614b8f99021232c4552c1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Blotting, Northern
139 rdf:type schema:DefinedTerm
140 N2d185f9b670f4196b421f2cc94d5c694 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Gene Expression Regulation
142 rdf:type schema:DefinedTerm
143 N349a83f571a642ee876c966b0612195e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Blotting, Western
145 rdf:type schema:DefinedTerm
146 N46cb205f9dac4471972fe59a257104be rdf:first sg:person.01110020710.78
147 rdf:rest N67ca37d3d30446cda4e9f267991d0d70
148 N47045a144d0d4b69a7f0328f0b62a37a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Schizophrenia
150 rdf:type schema:DefinedTerm
151 N56ac6163f2dd4ed0be33aa51f96a1b88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Middle Aged
153 rdf:type schema:DefinedTerm
154 N6304ad3fe81e40d9ba4a96576f8705a3 schema:volumeNumber 28
155 rdf:type schema:PublicationVolume
156 N67ca37d3d30446cda4e9f267991d0d70 rdf:first sg:person.01253502103.93
157 rdf:rest Nc9c582e06eda4b31becab01e2ffdd926
158 N6915072c69bb49abbd7673c0a3805bb5 rdf:first sg:person.01046322514.01
159 rdf:rest Nd8e348e8f08c48c0b34868a0a4e0d072
160 N6ad56100e52b4c0c836d754a188cee92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Rats
162 rdf:type schema:DefinedTerm
163 N6e1917e48c2f465b93e2610b8714fc85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Disease Models, Animal
165 rdf:type schema:DefinedTerm
166 N6ed9993b714e4c61b24ffdf9ee2fac4a rdf:first sg:person.01162551114.04
167 rdf:rest Nf5bb895c70744735800bb743942566fd
168 N72f5985d7b08414ca31fd0bd9b68f48a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Rats, Sprague-Dawley
170 rdf:type schema:DefinedTerm
171 N8c3695ba8e7d4f8da906949889e1e983 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Nerve Tissue Proteins
173 rdf:type schema:DefinedTerm
174 N8f3496cfd0fb4653b041108b403d7051 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name SAP90-PSD95 Associated Proteins
176 rdf:type schema:DefinedTerm
177 N946169a3d9454912869bed480ed7f672 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Aged
179 rdf:type schema:DefinedTerm
180 N99bb15155ab24a00835275e6e49152ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Female
182 rdf:type schema:DefinedTerm
183 N9c26de8033814973871747243ee3f1e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Male
185 rdf:type schema:DefinedTerm
186 N9defc6540f4346d486a9fc5abda4519c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Humans
188 rdf:type schema:DefinedTerm
189 Na10a1a480b2a48818f704f261286a6a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Antipsychotic Agents
191 rdf:type schema:DefinedTerm
192 Na4d15a50fa7143a88396dbe2aa518cc4 schema:issueNumber 10
193 rdf:type schema:PublicationIssue
194 Nad004a7d431c4afcb0f0cde65f134c5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Immunohistochemistry
196 rdf:type schema:DefinedTerm
197 Nc9c582e06eda4b31becab01e2ffdd926 rdf:first sg:person.0637745217.49
198 rdf:rest N6ed9993b714e4c61b24ffdf9ee2fac4a
199 Nd1da654072484bd79921c731710ad185 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Nucleus Accumbens
201 rdf:type schema:DefinedTerm
202 Nd7720811710d4728b7746f6ff997a15d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Animals
204 rdf:type schema:DefinedTerm
205 Nd8e348e8f08c48c0b34868a0a4e0d072 rdf:first sg:person.0767255517.34
206 rdf:rest N46cb205f9dac4471972fe59a257104be
207 Nde2a66a956f4451c8a25acfd228be311 schema:name pubmed_id
208 schema:value 12784099
209 rdf:type schema:PropertyValue
210 Ne1dfe21a07254cf484430dc5550e4316 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Aged, 80 and over
212 rdf:type schema:DefinedTerm
213 Ne21ba4bb59eb4f4a81a06d62cd45d866 schema:name dimensions_id
214 schema:value pub.1021799720
215 rdf:type schema:PropertyValue
216 Nf5bb895c70744735800bb743942566fd rdf:first sg:person.0733100424.34
217 rdf:rest N0641e1238c794d10accb08bd941b6ec1
218 Nf961da618dfb4a0d9ae754965e9fc5aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Adult
220 rdf:type schema:DefinedTerm
221 Nffdc77522731489bb5bf82f6ec35c78a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Phencyclidine
223 rdf:type schema:DefinedTerm
224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical and Health Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
228 schema:name Clinical Sciences
229 rdf:type schema:DefinedTerm
230 sg:journal.1099176 schema:issn 0893-133X
231 1740-634X
232 schema:name Neuropsychopharmacology
233 schema:publisher Springer Nature
234 rdf:type schema:Periodical
235 sg:person.01013751772.06 schema:affiliation grid-institutes:grid.31432.37
236 schema:familyName Maeda
237 schema:givenName Kiyoshi
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013751772.06
239 rdf:type schema:Person
240 sg:person.01046322514.01 schema:affiliation grid-institutes:grid.31432.37
241 schema:familyName Kajimoto
242 schema:givenName Yasuo
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046322514.01
244 rdf:type schema:Person
245 sg:person.01110020710.78 schema:affiliation grid-institutes:grid.31432.37
246 schema:familyName Lin
247 schema:givenName Xian-Hao
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110020710.78
249 rdf:type schema:Person
250 sg:person.01162551114.04 schema:affiliation grid-institutes:grid.415418.d
251 schema:familyName Murakami
252 schema:givenName Naoya
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162551114.04
254 rdf:type schema:Person
255 sg:person.01253502103.93 schema:affiliation grid-institutes:grid.31432.37
256 schema:familyName Hashimoto
257 schema:givenName Takeshi
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253502103.93
259 rdf:type schema:Person
260 sg:person.0637745217.49 schema:affiliation grid-institutes:None
261 schema:familyName Kitamura
262 schema:givenName Noboru
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637745217.49
264 rdf:type schema:Person
265 sg:person.0733100424.34 schema:affiliation grid-institutes:grid.410805.8
266 schema:familyName Takumi
267 schema:givenName Toru
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733100424.34
269 rdf:type schema:Person
270 sg:person.0767255517.34 schema:affiliation grid-institutes:grid.31432.37
271 schema:familyName Shirakawa
272 schema:givenName Osamu
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767255517.34
274 rdf:type schema:Person
275 sg:pub.10.1007/bf00421917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031454673
276 https://doi.org/10.1007/bf00421917
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/bf01276429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038636375
279 https://doi.org/10.1007/bf01276429
280 rdf:type schema:CreativeWork
281 sg:pub.10.1016/s0893-133x(97)00036-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024306761
282 https://doi.org/10.1016/s0893-133x(97)00036-5
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/227680a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419937
285 https://doi.org/10.1038/227680a0
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/35039075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048210298
288 https://doi.org/10.1038/35039075
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/sj.mp.4000454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041999900
291 https://doi.org/10.1038/sj.mp.4000454
292 rdf:type schema:CreativeWork
293 grid-institutes:None schema:alternateName Department of Psychiatry and Neurology, Kobe General City Hospital, Kobe, Japan
294 schema:name Department of Psychiatry and Neurology, Kobe General City Hospital, Kobe, Japan
295 rdf:type schema:Organization
296 grid-institutes:grid.31432.37 schema:alternateName Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan
297 schema:name Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan
298 rdf:type schema:Organization
299 grid-institutes:grid.410805.8 schema:alternateName Department of Neuroscience, Osaka Bioscience Institute (OBI), Osaka, Japan
300 schema:name Department of Neuroscience, Osaka Bioscience Institute (OBI), Osaka, Japan
301 rdf:type schema:Organization
302 grid-institutes:grid.415418.d schema:alternateName Department of Psychiatry, Kobe Rosai Hospital, The Labour Welfare Corporation, Kobe, Japan
303 schema:name Department of Psychiatry, Kobe Rosai Hospital, The Labour Welfare Corporation, Kobe, Japan
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...