Reduction of Hypothalamic Vasopressinergic Hyperdrive Contributes to Clinically Relevant Behavioral and Neuroendocrine Effects of Chronic Paroxetine Treatment in a Psychopathological ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-02

AUTHORS

Martin E Keck, Tobias Welt, Marianne B Müller, Manfred Uhr, Frauke Ohl, Alexandra Wigger, Nicola Toschi, Florian Holsboer, Rainer Landgraf

ABSTRACT

The neuroendocrine and behavioral effects of chronic paroxetine treatment were investigated in two rat lines selectively bred for high anxiety-related behavior (HAB) or low anxiety-related behavior (LAB) emotionality. In addition to a characteristic behavioral phenotype with markedly passive stress-coping strategies, HAB rats show a hypothalamic vasopressinergic hyperdrive that is causally related to hypothalamic-pituitary-adrenocortical dysregulation as demonstrated in the combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test. A total of 8 weeks of chronic paroxetine treatment induced a more active coping strategy in the forced swim test in HAB rats only. In contrast, paroxetine-treated LAB rats did not change their swimming behavior. To investigate the neuroendocrine alterations linked to these behavioral changes, a combined DEX/CRH test was performed. In HAB rats, the paroxetine-induced behavioral changes towards more active coping strategies were accompanied by a normalization of the CRH-stimulated increase in corticotropin (ACTH) and corticosterone secretion. Concomitantly, the hypothalamic vasopressinergic hyperdrive was found to be reduced in HAB but not LAB rats, as indicated by a decrease in vasopressin mRNA expression, whereas vasopressin 1a receptor binding was unaffected. These findings provide the first evidence that the vasopressinergic system is likely to be critically involved in the behavioral and neuroendocrine effects of antidepressant drugs. This novel mechanism of action of paroxetine on vasopressin gene regulation renders vasopressinergic neuronal circuits a promising target for the development of more causal antidepressant treatment strategies. More... »

PAGES

1300040

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.npp.1300040

DOI

http://dx.doi.org/10.1038/sj.npp.1300040

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017050478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12589376


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anxiety Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurosecretory Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paroxetine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasopressins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keck", 
        "givenName": "Martin E", 
        "id": "sg:person.01100052127.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100052127.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welt", 
        "givenName": "Tobias", 
        "id": "sg:person.0762231675.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762231675.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "Marianne B", 
        "id": "sg:person.013017360042.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013017360042.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uhr", 
        "givenName": "Manfred", 
        "id": "sg:person.0756334213.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756334213.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohl", 
        "givenName": "Frauke", 
        "id": "sg:person.0655226035.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655226035.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wigger", 
        "givenName": "Alexandra", 
        "id": "sg:person.01331240012.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331240012.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toschi", 
        "givenName": "Nicola", 
        "id": "sg:person.01003335120.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003335120.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holsboer", 
        "givenName": "Florian", 
        "id": "sg:person.01260634025.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260634025.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Psychiatry", 
          "id": "https://www.grid.ac/institutes/grid.419548.5", 
          "name": [
            "Max Planck Institute of Psychiatry, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Landgraf", 
        "givenName": "Rainer", 
        "id": "sg:person.01320043364.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320043364.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0006-8993(83)90945-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001364945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(83)90945-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001364945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(98)00042-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001929382", 
          "https://doi.org/10.1016/s0893-133x(98)00042-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.092012099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003449494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-3057(99)00192-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003514475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-4328(97)00198-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003948543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(96)00509-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004640805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0196-9781(01)00398-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005672182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0735-7044.115.2.429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006713419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0735-7044.115.2.429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006713419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3956(01)00013-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007608445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(00)00159-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008542408", 
          "https://doi.org/10.1016/s0893-133x(00)00159-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.2000.00030.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010854722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.6114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013201640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(99)00169-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014275493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008877-199711000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014365112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008877-199711000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014365112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.300.3.1085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018297760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(00)00677-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020259477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200304000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022569612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004714-200304000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022569612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000127138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023760602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2826.1989.tb00150.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024295756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(97)00054-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025474274", 
          "https://doi.org/10.1016/s0893-133x(97)00054-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027187296", 
          "https://doi.org/10.1038/sj.mp.4000937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027187296", 
          "https://doi.org/10.1038/sj.mp.4000937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.1996.01830020055007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028364156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/frne.1993.1004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028693832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(98)00523-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029623263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)91326-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030195780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)91326-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030195780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.1999.00508.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031596981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1993.tb49921.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033657238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-4328(00)00151-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036710008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(00)00191-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036941710", 
          "https://doi.org/10.1016/s0893-133x(00)00191-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(01)00351-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041352347", 
          "https://doi.org/10.1016/s0893-133x(01)00351-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-4388(00)00146-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041676346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6123(08)61571-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043167008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1390077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045960335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0953-816x.2000.01383.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046335819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(99)02289-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047253683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0028-3908(00)00010-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047557021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/299355a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049462359", 
          "https://doi.org/10.1038/299355a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050371123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(96)13069-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050914146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000126998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053305750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.150.4.656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063482287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.156.6.949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063485835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv-17-2-187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1064244784", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.131.2.1322285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064277760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.140.12.7214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064282849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.141.11.7767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064283463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critrevneurobiol.v10.i1.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068132154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.21-10-03572.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074807699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-05-01513.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075009259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.15-06-04250.1995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082509028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.16-23-07725.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082999411"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-02", 
    "datePublishedReg": "2003-02-01", 
    "description": "The neuroendocrine and behavioral effects of chronic paroxetine treatment were investigated in two rat lines selectively bred for high anxiety-related behavior (HAB) or low anxiety-related behavior (LAB) emotionality. In addition to a characteristic behavioral phenotype with markedly passive stress-coping strategies, HAB rats show a hypothalamic vasopressinergic hyperdrive that is causally related to hypothalamic-pituitary-adrenocortical dysregulation as demonstrated in the combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test. A total of 8 weeks of chronic paroxetine treatment induced a more active coping strategy in the forced swim test in HAB rats only. In contrast, paroxetine-treated LAB rats did not change their swimming behavior. To investigate the neuroendocrine alterations linked to these behavioral changes, a combined DEX/CRH test was performed. In HAB rats, the paroxetine-induced behavioral changes towards more active coping strategies were accompanied by a normalization of the CRH-stimulated increase in corticotropin (ACTH) and corticosterone secretion. Concomitantly, the hypothalamic vasopressinergic hyperdrive was found to be reduced in HAB but not LAB rats, as indicated by a decrease in vasopressin mRNA expression, whereas vasopressin 1a receptor binding was unaffected. These findings provide the first evidence that the vasopressinergic system is likely to be critically involved in the behavioral and neuroendocrine effects of antidepressant drugs. This novel mechanism of action of paroxetine on vasopressin gene regulation renders vasopressinergic neuronal circuits a promising target for the development of more causal antidepressant treatment strategies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.npp.1300040", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Reduction of Hypothalamic Vasopressinergic Hyperdrive Contributes to Clinically Relevant Behavioral and Neuroendocrine Effects of Chronic Paroxetine Treatment in a Psychopathological Rat Model", 
    "pagination": "1300040", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "513c6518aa5789d8d5ab6634ae7c2ab80935d53420b3427113752ba8b0177ae7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12589376"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8904907"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.npp.1300040"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017050478"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.npp.1300040", 
      "https://app.dimensions.ai/details/publication/pub.1017050478"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87117_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/1300040"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300040'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300040'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300040'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.npp.1300040'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      21 PREDICATES      92 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.npp.1300040 schema:about N0e923a3ad371479584ac7c70dc6280e8
2 N230b243a35144398925918e275d620c6
3 N686d69b3219b4657a789d650b1044d29
4 N69f0f55c4b234009a9b6770ea93a3fd2
5 N7cac446c3f7f4223a84f0c4cc467af0e
6 N85755551c60b4c7680d83489aba7e28c
7 N9b94dd80a33943d18136ffd77525c705
8 N9c73b6bcf29b42bba4a8841f1948649e
9 Nab7027f1459d4e55ae9fccef4fba7aaa
10 Naee3c003ae68469e9508ba7d55dab762
11 Nd661b80cc2de4d85ae7f4d491e25c4f3
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author N932a04afc85b49748d3fd4791b932fc6
15 schema:citation sg:pub.10.1016/s0893-133x(00)00159-7
16 sg:pub.10.1016/s0893-133x(00)00191-3
17 sg:pub.10.1016/s0893-133x(01)00351-7
18 sg:pub.10.1016/s0893-133x(97)00054-7
19 sg:pub.10.1016/s0893-133x(98)00042-6
20 sg:pub.10.1038/299355a0
21 sg:pub.10.1038/sj.mp.4000937
22 https://app.dimensions.ai/details/publication/pub.1064244784
23 https://doi.org/10.1001/archpsyc.1996.01830020055007
24 https://doi.org/10.1006/bbrc.2001.6114
25 https://doi.org/10.1006/frne.1993.1004
26 https://doi.org/10.1016/0006-8993(83)90945-9
27 https://doi.org/10.1016/0006-8993(92)91326-a
28 https://doi.org/10.1016/0006-8993(96)00509-4
29 https://doi.org/10.1016/0304-3940(96)13069-x
30 https://doi.org/10.1016/s0006-8993(99)02289-1
31 https://doi.org/10.1016/s0014-2999(00)00677-4
32 https://doi.org/10.1016/s0022-3956(01)00013-9
33 https://doi.org/10.1016/s0024-3205(99)00169-1
34 https://doi.org/10.1016/s0028-3908(00)00010-1
35 https://doi.org/10.1016/s0079-6123(08)61571-x
36 https://doi.org/10.1016/s0091-3057(99)00192-6
37 https://doi.org/10.1016/s0166-4328(00)00151-0
38 https://doi.org/10.1016/s0166-4328(97)00198-8
39 https://doi.org/10.1016/s0196-9781(01)00398-9
40 https://doi.org/10.1016/s0306-4522(98)00523-5
41 https://doi.org/10.1016/s0959-4388(00)00146-x
42 https://doi.org/10.1037/0735-7044.115.2.429
43 https://doi.org/10.1046/j.0953-816x.2000.01383.x
44 https://doi.org/10.1046/j.1460-9568.1999.00508.x
45 https://doi.org/10.1046/j.1460-9568.2000.00030.x
46 https://doi.org/10.1073/pnas.092012099
47 https://doi.org/10.1097/00004714-200304000-00008
48 https://doi.org/10.1097/00008877-199711000-00010
49 https://doi.org/10.1111/j.1365-2826.1989.tb00150.x
50 https://doi.org/10.1111/j.1749-6632.1993.tb49921.x
51 https://doi.org/10.1124/jpet.300.3.1085
52 https://doi.org/10.1159/000126998
53 https://doi.org/10.1159/000127138
54 https://doi.org/10.1172/jci115086
55 https://doi.org/10.1176/ajp.150.4.656
56 https://doi.org/10.1176/ajp.156.6.949
57 https://doi.org/10.1210/edrv-17-2-187
58 https://doi.org/10.1210/endo.131.2.1322285
59 https://doi.org/10.1210/endo.140.12.7214
60 https://doi.org/10.1210/endo.141.11.7767
61 https://doi.org/10.1523/jneurosci.15-06-04250.1995
62 https://doi.org/10.1523/jneurosci.16-23-07725.1996
63 https://doi.org/10.1523/jneurosci.21-10-03572.2001
64 https://doi.org/10.1523/jneurosci.22-05-01513.2002
65 https://doi.org/10.1615/critrevneurobiol.v10.i1.60
66 https://doi.org/10.1677/joe.0.1390077
67 schema:datePublished 2003-02
68 schema:datePublishedReg 2003-02-01
69 schema:description The neuroendocrine and behavioral effects of chronic paroxetine treatment were investigated in two rat lines selectively bred for high anxiety-related behavior (HAB) or low anxiety-related behavior (LAB) emotionality. In addition to a characteristic behavioral phenotype with markedly passive stress-coping strategies, HAB rats show a hypothalamic vasopressinergic hyperdrive that is causally related to hypothalamic-pituitary-adrenocortical dysregulation as demonstrated in the combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) test. A total of 8 weeks of chronic paroxetine treatment induced a more active coping strategy in the forced swim test in HAB rats only. In contrast, paroxetine-treated LAB rats did not change their swimming behavior. To investigate the neuroendocrine alterations linked to these behavioral changes, a combined DEX/CRH test was performed. In HAB rats, the paroxetine-induced behavioral changes towards more active coping strategies were accompanied by a normalization of the CRH-stimulated increase in corticotropin (ACTH) and corticosterone secretion. Concomitantly, the hypothalamic vasopressinergic hyperdrive was found to be reduced in HAB but not LAB rats, as indicated by a decrease in vasopressin mRNA expression, whereas vasopressin 1a receptor binding was unaffected. These findings provide the first evidence that the vasopressinergic system is likely to be critically involved in the behavioral and neuroendocrine effects of antidepressant drugs. This novel mechanism of action of paroxetine on vasopressin gene regulation renders vasopressinergic neuronal circuits a promising target for the development of more causal antidepressant treatment strategies.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N4c016c4dd25c4065a817faab187d410d
74 Nfb6d568f8481485d97908f210ad1cb7a
75 sg:journal.1099176
76 schema:name Reduction of Hypothalamic Vasopressinergic Hyperdrive Contributes to Clinically Relevant Behavioral and Neuroendocrine Effects of Chronic Paroxetine Treatment in a Psychopathological Rat Model
77 schema:pagination 1300040
78 schema:productId N1c0f68d72af345dfb55d7d089e6e35f4
79 N2826d79f11344b89a061ddc104114d84
80 N2e9afcaa76dc4180b2a096c7e0fa2e57
81 N9d62a661e75445bd95d58d76791a7f22
82 Nebdffd35063c443c9b1b87d26db06715
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017050478
84 https://doi.org/10.1038/sj.npp.1300040
85 schema:sdDatePublished 2019-04-11T12:27
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N13354c9b82d444f1a858d1045f0965aa
88 schema:url http://www.nature.com/articles/1300040
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N0e923a3ad371479584ac7c70dc6280e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Male
94 rdf:type schema:DefinedTerm
95 N13354c9b82d444f1a858d1045f0965aa schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N1c0f68d72af345dfb55d7d089e6e35f4 schema:name nlm_unique_id
98 schema:value 8904907
99 rdf:type schema:PropertyValue
100 N230b243a35144398925918e275d620c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Anxiety Disorders
102 rdf:type schema:DefinedTerm
103 N2826d79f11344b89a061ddc104114d84 schema:name readcube_id
104 schema:value 513c6518aa5789d8d5ab6634ae7c2ab80935d53420b3427113752ba8b0177ae7
105 rdf:type schema:PropertyValue
106 N2e9afcaa76dc4180b2a096c7e0fa2e57 schema:name dimensions_id
107 schema:value pub.1017050478
108 rdf:type schema:PropertyValue
109 N4c016c4dd25c4065a817faab187d410d schema:issueNumber 2
110 rdf:type schema:PublicationIssue
111 N67800311bae34502a4b700f908ff43b8 rdf:first sg:person.01260634025.39
112 rdf:rest N932105df02df43649e5a3daf5846312e
113 N686d69b3219b4657a789d650b1044d29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Species Specificity
115 rdf:type schema:DefinedTerm
116 N69f0f55c4b234009a9b6770ea93a3fd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Disease Models, Animal
118 rdf:type schema:DefinedTerm
119 N7cac446c3f7f4223a84f0c4cc467af0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Hypothalamus
121 rdf:type schema:DefinedTerm
122 N8391f1f81aa148109d8a379b15c218a6 rdf:first sg:person.013017360042.00
123 rdf:rest N9247ea8d245f4cf99dc5e969e66c8d6c
124 N85755551c60b4c7680d83489aba7e28c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Neurosecretory Systems
126 rdf:type schema:DefinedTerm
127 N9247ea8d245f4cf99dc5e969e66c8d6c rdf:first sg:person.0756334213.23
128 rdf:rest N9a70a57b589c43b988ee8ed2f9de7e7a
129 N932105df02df43649e5a3daf5846312e rdf:first sg:person.01320043364.13
130 rdf:rest rdf:nil
131 N932a04afc85b49748d3fd4791b932fc6 rdf:first sg:person.01100052127.34
132 rdf:rest Nd8a73bed72a64fb88660469a700498ee
133 N9a70a57b589c43b988ee8ed2f9de7e7a rdf:first sg:person.0655226035.83
134 rdf:rest Nda4b4e323baa44ab81c5ee7ab62954b5
135 N9b94dd80a33943d18136ffd77525c705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Rats
137 rdf:type schema:DefinedTerm
138 N9c73b6bcf29b42bba4a8841f1948649e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Animals
140 rdf:type schema:DefinedTerm
141 N9d62a661e75445bd95d58d76791a7f22 schema:name doi
142 schema:value 10.1038/sj.npp.1300040
143 rdf:type schema:PropertyValue
144 Na8d9cd4b3c344f3bb4a1b7954819350e rdf:first sg:person.01003335120.86
145 rdf:rest N67800311bae34502a4b700f908ff43b8
146 Nab7027f1459d4e55ae9fccef4fba7aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name RNA, Messenger
148 rdf:type schema:DefinedTerm
149 Naee3c003ae68469e9508ba7d55dab762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Paroxetine
151 rdf:type schema:DefinedTerm
152 Nd661b80cc2de4d85ae7f4d491e25c4f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Vasopressins
154 rdf:type schema:DefinedTerm
155 Nd8a73bed72a64fb88660469a700498ee rdf:first sg:person.0762231675.91
156 rdf:rest N8391f1f81aa148109d8a379b15c218a6
157 Nda4b4e323baa44ab81c5ee7ab62954b5 rdf:first sg:person.01331240012.05
158 rdf:rest Na8d9cd4b3c344f3bb4a1b7954819350e
159 Nebdffd35063c443c9b1b87d26db06715 schema:name pubmed_id
160 schema:value 12589376
161 rdf:type schema:PropertyValue
162 Nfb6d568f8481485d97908f210ad1cb7a schema:volumeNumber 28
163 rdf:type schema:PublicationVolume
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
168 schema:name Neurosciences
169 rdf:type schema:DefinedTerm
170 sg:journal.1099176 schema:issn 0893-133X
171 1740-634X
172 schema:name Neuropsychopharmacology
173 rdf:type schema:Periodical
174 sg:person.01003335120.86 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
175 schema:familyName Toschi
176 schema:givenName Nicola
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003335120.86
178 rdf:type schema:Person
179 sg:person.01100052127.34 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
180 schema:familyName Keck
181 schema:givenName Martin E
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100052127.34
183 rdf:type schema:Person
184 sg:person.01260634025.39 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
185 schema:familyName Holsboer
186 schema:givenName Florian
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260634025.39
188 rdf:type schema:Person
189 sg:person.013017360042.00 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
190 schema:familyName Müller
191 schema:givenName Marianne B
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013017360042.00
193 rdf:type schema:Person
194 sg:person.01320043364.13 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
195 schema:familyName Landgraf
196 schema:givenName Rainer
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320043364.13
198 rdf:type schema:Person
199 sg:person.01331240012.05 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
200 schema:familyName Wigger
201 schema:givenName Alexandra
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331240012.05
203 rdf:type schema:Person
204 sg:person.0655226035.83 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
205 schema:familyName Ohl
206 schema:givenName Frauke
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655226035.83
208 rdf:type schema:Person
209 sg:person.0756334213.23 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
210 schema:familyName Uhr
211 schema:givenName Manfred
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756334213.23
213 rdf:type schema:Person
214 sg:person.0762231675.91 schema:affiliation https://www.grid.ac/institutes/grid.419548.5
215 schema:familyName Welt
216 schema:givenName Tobias
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762231675.91
218 rdf:type schema:Person
219 sg:pub.10.1016/s0893-133x(00)00159-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008542408
220 https://doi.org/10.1016/s0893-133x(00)00159-7
221 rdf:type schema:CreativeWork
222 sg:pub.10.1016/s0893-133x(00)00191-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036941710
223 https://doi.org/10.1016/s0893-133x(00)00191-3
224 rdf:type schema:CreativeWork
225 sg:pub.10.1016/s0893-133x(01)00351-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041352347
226 https://doi.org/10.1016/s0893-133x(01)00351-7
227 rdf:type schema:CreativeWork
228 sg:pub.10.1016/s0893-133x(97)00054-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025474274
229 https://doi.org/10.1016/s0893-133x(97)00054-7
230 rdf:type schema:CreativeWork
231 sg:pub.10.1016/s0893-133x(98)00042-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001929382
232 https://doi.org/10.1016/s0893-133x(98)00042-6
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/299355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049462359
235 https://doi.org/10.1038/299355a0
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/sj.mp.4000937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027187296
238 https://doi.org/10.1038/sj.mp.4000937
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1064244784 schema:CreativeWork
241 https://doi.org/10.1001/archpsyc.1996.01830020055007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028364156
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1006/bbrc.2001.6114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013201640
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1006/frne.1993.1004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028693832
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0006-8993(83)90945-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001364945
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0006-8993(92)91326-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1030195780
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0006-8993(96)00509-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004640805
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0304-3940(96)13069-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050914146
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0006-8993(99)02289-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047253683
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s0014-2999(00)00677-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020259477
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0022-3956(01)00013-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007608445
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0024-3205(99)00169-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014275493
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0028-3908(00)00010-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047557021
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0079-6123(08)61571-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043167008
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0091-3057(99)00192-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003514475
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0166-4328(00)00151-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036710008
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0166-4328(97)00198-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003948543
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0196-9781(01)00398-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005672182
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0306-4522(98)00523-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029623263
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0959-4388(00)00146-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041676346
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1037/0735-7044.115.2.429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006713419
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1046/j.0953-816x.2000.01383.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046335819
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1046/j.1460-9568.1999.00508.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031596981
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1046/j.1460-9568.2000.00030.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010854722
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.092012099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003449494
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/00004714-200304000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022569612
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/00008877-199711000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014365112
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1111/j.1365-2826.1989.tb00150.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024295756
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1111/j.1749-6632.1993.tb49921.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033657238
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1124/jpet.300.3.1085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018297760
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1159/000126998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053305750
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1159/000127138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023760602
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1172/jci115086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050371123
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1176/ajp.150.4.656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063482287
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1176/ajp.156.6.949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485835
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1210/edrv-17-2-187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238144
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1210/endo.131.2.1322285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064277760
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1210/endo.140.12.7214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282849
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1210/endo.141.11.7767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064283463
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1523/jneurosci.15-06-04250.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082509028
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1523/jneurosci.16-23-07725.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082999411
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1523/jneurosci.21-10-03572.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074807699
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1523/jneurosci.22-05-01513.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075009259
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1615/critrevneurobiol.v10.i1.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068132154
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1677/joe.0.1390077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045960335
328 rdf:type schema:CreativeWork
329 https://www.grid.ac/institutes/grid.419548.5 schema:alternateName Max Planck Institute of Psychiatry
330 schema:name Max Planck Institute of Psychiatry, Munich, Germany
331 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...