α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-04

AUTHORS

W Berrettini, X Yuan, F Tozzi, K Song, C Francks, H Chilcoat, D Waterworth, P Muglia, V Mooser

ABSTRACT

Twin studies indicate that additive genetic effects explain most of the variance in nicotine dependence (ND), a construct emphasizing habitual heavy smoking despite adverse consequences, tolerance and withdrawal. To detect ND alleles, we assessed cigarettes per day (CPD) regularly smoked, in two European populations via whole genome association techniques. In these approximately 7500 persons, a common haplotype in the CHRNA3-CHRNA5 nicotinic receptor subunit gene cluster was associated with CPD (nominal P=6.9 x 10(-5)). In a third set of European populations (n= approximately 7500) which had been genotyped for approximately 6000 SNPs in approximately 2000 genes, an allele in the same haplotype was associated with CPD (nominal P=2.6 x 10(-6)). These results (in three independent populations of European origin, totaling approximately 15 000 individuals) suggest that a common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to ND. More... »

PAGES

368

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.mp.4002154

DOI

http://dx.doi.org/10.1038/sj.mp.4002154

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18227835


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