COMT haplotypes suggest P2 promoter region relevance for schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-09

AUTHORS

M A Palmatier, A J Pakstis, W Speed, P Paschou, D Goldman, A Odunsi, F Okonofua, S Kajuna, N Karoma, S Kungulilo, E Grigorenko, O V Zhukova, B Bonne-Tamir, R-B Lu, J Parnas, J R Kidd, M M C DeMille, K K Kidd

ABSTRACT

A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599). Subsequently, this haplotype was shown to be associated with lower levels of COMT cDNA derived from normal cortical brain tissue, most likely due to cis-acting element(s). As a first step toward evaluating whether this haplotype may be relevant to schizophrenia in populations other than Ashkenazi Jews, we have studied this haplotype in 38 populations representing all major regions of the world. Adding to our previous data on four polymorphic sites in the COMT gene, including the Val158Met polymorphism, we have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism, yielding seven-site haplotype frequencies for normal individuals in the 38 globally distributed populations, including a sample of Ashkenazi Jews. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. The three-site, schizophrenia-associated haplotype frequencies range from 0% in South America to 37.1% in Southwest Asia, despite the fact that schizophrenia occurs at roughly equal frequency around the world. Assuming that the published associations found between the exon 4 Val158Met SNP and schizophrenia are due to linkage disequilibrium, these new haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain. The previously described HindIII restriction site polymorphism, located within the P2 promoter, varies within all populations and may provide essential information in future studies of schizophrenia. More... »

PAGES

859

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.mp.4001496

DOI

http://dx.doi.org/10.1038/sj.mp.4001496

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023614467

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15098000


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catechol O-Methyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Databases, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linkage Disequilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizophrenia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palmatier", 
        "givenName": "M A", 
        "id": "sg:person.0720747234.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720747234.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pakstis", 
        "givenName": "A J", 
        "id": "sg:person.01147776341.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147776341.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Speed", 
        "givenName": "W", 
        "id": "sg:person.01306046677.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306046677.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paschou", 
        "givenName": "P", 
        "id": "sg:person.01140305107.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140305107.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute On Alcohol Abuse and Alcoholism", 
          "id": "https://www.grid.ac/institutes/grid.420085.b", 
          "name": [
            "Neurogenetics Laboratory, NIAAA, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldman", 
        "givenName": "D", 
        "id": "sg:person.01136132215.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136132215.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roswell Park Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.240614.5", 
          "name": [
            "Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Odunsi", 
        "givenName": "A", 
        "id": "sg:person.01112344567.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112344567.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Benin", 
          "id": "https://www.grid.ac/institutes/grid.413068.8", 
          "name": [
            "Department of Obstetrics and Gynecology, Faculty of Medicine, University of Benin, Benin City, Nigeria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okonofua", 
        "givenName": "F", 
        "id": "sg:person.01172073213.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172073213.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hubert Kairuki Memorial University", 
          "id": "https://www.grid.ac/institutes/grid.442446.4", 
          "name": [
            "The Hubert Kairuki Memorial University, Dar es Salaam, Tanzania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kajuna", 
        "givenName": "S", 
        "id": "sg:person.01055371677.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055371677.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hubert Kairuki Memorial University", 
          "id": "https://www.grid.ac/institutes/grid.442446.4", 
          "name": [
            "The Hubert Kairuki Memorial University, Dar es Salaam, Tanzania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karoma", 
        "givenName": "N", 
        "id": "sg:person.01210504246.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210504246.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Muhimbili University of Health and Allied Sciences", 
          "id": "https://www.grid.ac/institutes/grid.25867.3e", 
          "name": [
            "Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kungulilo", 
        "givenName": "S", 
        "id": "sg:person.0761573441.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761573441.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Child Study Center and Department of Psychology, Yale University, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grigorenko", 
        "givenName": "E", 
        "id": "sg:person.01207514351.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207514351.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "NI Vavilov Institute of General Genetics RAS, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhukova", 
        "givenName": "O V", 
        "id": "sg:person.0701061605.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701061605.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tel Aviv University", 
          "id": "https://www.grid.ac/institutes/grid.12136.37", 
          "name": [
            "Department of Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonne-Tamir", 
        "givenName": "B", 
        "id": "sg:person.01234671475.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234671475.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "R-B", 
        "id": "sg:person.015365121757.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015365121757.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hvidovre Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411905.8", 
          "name": [
            "Copenhagen University, Psychiatry Department, Hvidovre Hospital, Hvidovre, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parnas", 
        "givenName": "J", 
        "id": "sg:person.01137730505.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137730505.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kidd", 
        "givenName": "J R", 
        "id": "sg:person.01216111541.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216111541.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeMille", 
        "givenName": "M M C", 
        "id": "sg:person.013011036320.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013011036320.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kidd", 
        "givenName": "K K", 
        "id": "sg:person.013056040102.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013056040102.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000022963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000671633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1994.63030972.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004013672", 
          "https://doi.org/10.1038/sj.mp.4000638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004013672", 
          "https://doi.org/10.1038/sj.mp.4000638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10425179809034076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004516334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genom.3.022502.103141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005798963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006024273", 
          "https://doi.org/10.1038/sj.mp.4000738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006024273", 
          "https://doi.org/10.1038/sj.mp.4000738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00556-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006445004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00556-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006445004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.20023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009821158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(02)01416-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012184547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(99)00281-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017312019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.20021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020724705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023912309", 
          "https://doi.org/10.1038/sj.mp.4000752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4000752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023912309", 
          "https://doi.org/10.1038/sj.mp.4000752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddg302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027646207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.10286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030201731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.20037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033559956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.111134598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037067248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1995.9003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038103610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1469-1809.1999.6320167.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038109558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.4.1416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040748948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.56.10.940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041035362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-8628(200021)97:1<23::aid-ajmg5>3.0.co;2-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041675272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1994.tb19083.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043596244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-002-0809-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043738924", 
          "https://doi.org/10.1007/s00439-002-0809-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-002-0809-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043738924", 
          "https://doi.org/10.1007/s00439-002-0809-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046066622", 
          "https://doi.org/10.1038/sj.npp.1300218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.npp.1300218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046066622", 
          "https://doi.org/10.1038/sj.npp.1300218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4838(95)00071-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050463737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(99)00098-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050927062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00013a008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055157149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2003-45130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057426481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/344514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058640476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/344514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058640476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/376578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058669925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/376578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058669925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/380206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058672607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077358164", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jhered.a111613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082413162"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-09", 
    "datePublishedReg": "2004-09-01", 
    "description": "A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599). Subsequently, this haplotype was shown to be associated with lower levels of COMT cDNA derived from normal cortical brain tissue, most likely due to cis-acting element(s). As a first step toward evaluating whether this haplotype may be relevant to schizophrenia in populations other than Ashkenazi Jews, we have studied this haplotype in 38 populations representing all major regions of the world. Adding to our previous data on four polymorphic sites in the COMT gene, including the Val158Met polymorphism, we have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism, yielding seven-site haplotype frequencies for normal individuals in the 38 globally distributed populations, including a sample of Ashkenazi Jews. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. The three-site, schizophrenia-associated haplotype frequencies range from 0% in South America to 37.1% in Southwest Asia, despite the fact that schizophrenia occurs at roughly equal frequency around the world. Assuming that the published associations found between the exon 4 Val158Met SNP and schizophrenia are due to linkage disequilibrium, these new haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain. The previously described HindIII restriction site polymorphism, located within the P2 promoter, varies within all populations and may provide essential information in future studies of schizophrenia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.mp.4001496", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2707590", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2707591", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2436384", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2549644", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2443054", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2405382", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1115540", 
        "issn": [
          "1359-4184", 
          "1476-5578"
        ], 
        "name": "Molecular Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "COMT haplotypes suggest P2 promoter region relevance for schizophrenia", 
    "pagination": "859", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "70818d7120c1d14251fb45f83422968bc7a495e5873c72ef73b35a9c826273a5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15098000"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9607835"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.mp.4001496"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023614467"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.mp.4001496", 
      "https://app.dimensions.ai/details/publication/pub.1023614467"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118344_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/4001496"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001496'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001496'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001496'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001496'


 

This table displays all metadata directly associated to this object as RDF triples.

369 TRIPLES      21 PREDICATES      72 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.mp.4001496 schema:about N25272ae49799452bbf6803b4e64663f2
2 N2b775350aa054181872b9d170dea2584
3 N5f505c1fdc8a47c79c5debcc6e476ba9
4 N6deece31430f4e1d8cd52c8b3fca0e23
5 N7c2c77f433ff4ee0a7b81c552241a98e
6 N84462fc1a65b4f8386347b08edd939b1
7 N97824d81b72a45ec997f162661b38d81
8 Nab739ac4553844e48e046612e72e303e
9 Nbb41f166a1164bf2889ac765152df02f
10 Nf00fca8f59e3494db55bedfd9d86c8ee
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N5e67f605a82646fd8ff52619b9a71342
14 schema:citation sg:pub.10.1007/s00439-002-0809-0
15 sg:pub.10.1038/sj.mp.4000638
16 sg:pub.10.1038/sj.mp.4000738
17 sg:pub.10.1038/sj.mp.4000752
18 sg:pub.10.1038/sj.npp.1300218
19 https://app.dimensions.ai/details/publication/pub.1077358164
20 https://doi.org/10.1001/archpsyc.56.10.940
21 https://doi.org/10.1002/(sici)1096-8628(200021)97:1<23::aid-ajmg5>3.0.co;2-k
22 https://doi.org/10.1002/ajmg.b.20021
23 https://doi.org/10.1002/ajmg.b.20023
24 https://doi.org/10.1002/ajmg.b.20037
25 https://doi.org/10.1002/syn.10286
26 https://doi.org/10.1006/geno.1995.9003
27 https://doi.org/10.1016/0167-4838(95)00071-2
28 https://doi.org/10.1016/s0006-3223(02)01416-6
29 https://doi.org/10.1016/s0006-3223(99)00098-0
30 https://doi.org/10.1016/s0006-3223(99)00281-4
31 https://doi.org/10.1016/s0306-4522(02)00556-0
32 https://doi.org/10.1021/bi00013a008
33 https://doi.org/10.1046/j.1469-1809.1999.6320167.x
34 https://doi.org/10.1046/j.1471-4159.1994.63030972.x
35 https://doi.org/10.1055/s-2003-45130
36 https://doi.org/10.1073/pnas.111134598
37 https://doi.org/10.1073/pnas.88.4.1416
38 https://doi.org/10.1086/344514
39 https://doi.org/10.1086/376578
40 https://doi.org/10.1086/380206
41 https://doi.org/10.1093/hmg/ddg302
42 https://doi.org/10.1093/oxfordjournals.jhered.a111613
43 https://doi.org/10.1111/j.1432-1033.1994.tb19083.x
44 https://doi.org/10.1146/annurev.genom.3.022502.103141
45 https://doi.org/10.1159/000022963
46 https://doi.org/10.3109/10425179809034076
47 schema:datePublished 2004-09
48 schema:datePublishedReg 2004-09-01
49 schema:description A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599). Subsequently, this haplotype was shown to be associated with lower levels of COMT cDNA derived from normal cortical brain tissue, most likely due to cis-acting element(s). As a first step toward evaluating whether this haplotype may be relevant to schizophrenia in populations other than Ashkenazi Jews, we have studied this haplotype in 38 populations representing all major regions of the world. Adding to our previous data on four polymorphic sites in the COMT gene, including the Val158Met polymorphism, we have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism, yielding seven-site haplotype frequencies for normal individuals in the 38 globally distributed populations, including a sample of Ashkenazi Jews. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. The three-site, schizophrenia-associated haplotype frequencies range from 0% in South America to 37.1% in Southwest Asia, despite the fact that schizophrenia occurs at roughly equal frequency around the world. Assuming that the published associations found between the exon 4 Val158Met SNP and schizophrenia are due to linkage disequilibrium, these new haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain. The previously described HindIII restriction site polymorphism, located within the P2 promoter, varies within all populations and may provide essential information in future studies of schizophrenia.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf Nd8cb0aca559948f0b6078e686739e486
54 Ne1f79ceff3a642aa8ddd773cb7a5e4d0
55 sg:journal.1115540
56 schema:name COMT haplotypes suggest P2 promoter region relevance for schizophrenia
57 schema:pagination 859
58 schema:productId N3305f05e7b5e44519ec91726167df6a4
59 N4bc2713a07d7471d903a9524731bb6e8
60 N4ceba14da58f4b43afd8597f6d854a79
61 N5c07d020ef1443f58f579a6828c1f2ff
62 Nb236f371c79f41ae9c5c2003c8ec1639
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023614467
64 https://doi.org/10.1038/sj.mp.4001496
65 schema:sdDatePublished 2019-04-11T12:07
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N12f5694659a2405b9b7ba8b627811133
68 schema:url https://www.nature.com/articles/4001496
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N12f5694659a2405b9b7ba8b627811133 schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N16cf65889e9f45dc91cf1f0bb2e03c52 rdf:first sg:person.01207514351.67
75 rdf:rest Nc5c5d16900334955a4fc16f90a642903
76 N25272ae49799452bbf6803b4e64663f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Catechol O-Methyltransferase
78 rdf:type schema:DefinedTerm
79 N26c169c400144d688445243b94362159 rdf:first sg:person.01147776341.54
80 rdf:rest N714a0da02da8495f8c3a4c4917b8d2d1
81 N2b775350aa054181872b9d170dea2584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Genetic Predisposition to Disease
83 rdf:type schema:DefinedTerm
84 N313d7176535c411985be2cf9911ed2e0 rdf:first sg:person.015365121757.32
85 rdf:rest N3507daa4bd444d82ba800331fbd44ba1
86 N3305f05e7b5e44519ec91726167df6a4 schema:name readcube_id
87 schema:value 70818d7120c1d14251fb45f83422968bc7a495e5873c72ef73b35a9c826273a5
88 rdf:type schema:PropertyValue
89 N3507daa4bd444d82ba800331fbd44ba1 rdf:first sg:person.01137730505.12
90 rdf:rest Ncc8877af8ace482b8e4abb96eaec1162
91 N3eb9f159df584250ba4122f111db2482 schema:name NI Vavilov Institute of General Genetics RAS, Moscow, Russia
92 rdf:type schema:Organization
93 N4bc2713a07d7471d903a9524731bb6e8 schema:name nlm_unique_id
94 schema:value 9607835
95 rdf:type schema:PropertyValue
96 N4ceba14da58f4b43afd8597f6d854a79 schema:name pubmed_id
97 schema:value 15098000
98 rdf:type schema:PropertyValue
99 N505da1ac7fd44f07b38daa1e925ab656 rdf:first sg:person.013056040102.90
100 rdf:rest rdf:nil
101 N5c07d020ef1443f58f579a6828c1f2ff schema:name dimensions_id
102 schema:value pub.1023614467
103 rdf:type schema:PropertyValue
104 N5e67f605a82646fd8ff52619b9a71342 rdf:first sg:person.0720747234.41
105 rdf:rest N26c169c400144d688445243b94362159
106 N5f505c1fdc8a47c79c5debcc6e476ba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Databases, Genetic
108 rdf:type schema:DefinedTerm
109 N6deece31430f4e1d8cd52c8b3fca0e23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Genetic Variation
111 rdf:type schema:DefinedTerm
112 N714a0da02da8495f8c3a4c4917b8d2d1 rdf:first sg:person.01306046677.16
113 rdf:rest Na12e0bc485d24bd9878128dd8072b22a
114 N7c2c77f433ff4ee0a7b81c552241a98e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N7e5b841aae18484eabffb6bef76b89c6 rdf:first sg:person.0761573441.44
118 rdf:rest N16cf65889e9f45dc91cf1f0bb2e03c52
119 N84462fc1a65b4f8386347b08edd939b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Haplotypes
121 rdf:type schema:DefinedTerm
122 N908c683dbbe34d59bb097673c11061ad rdf:first sg:person.01234671475.72
123 rdf:rest N313d7176535c411985be2cf9911ed2e0
124 N97824d81b72a45ec997f162661b38d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Promoter Regions, Genetic
126 rdf:type schema:DefinedTerm
127 Na12e0bc485d24bd9878128dd8072b22a rdf:first sg:person.01140305107.04
128 rdf:rest Nacd87ed7865541ff9b72d1e8268b559b
129 Nab739ac4553844e48e046612e72e303e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Linkage Disequilibrium
131 rdf:type schema:DefinedTerm
132 Nacd87ed7865541ff9b72d1e8268b559b rdf:first sg:person.01136132215.07
133 rdf:rest Nccd7f2c91cff4e6387584285a778d9ea
134 Nb236f371c79f41ae9c5c2003c8ec1639 schema:name doi
135 schema:value 10.1038/sj.mp.4001496
136 rdf:type schema:PropertyValue
137 Nbb41f166a1164bf2889ac765152df02f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Gene Frequency
139 rdf:type schema:DefinedTerm
140 Nbce9141ca35847fead10542ca2ba671d rdf:first sg:person.01210504246.50
141 rdf:rest N7e5b841aae18484eabffb6bef76b89c6
142 Nc5c5d16900334955a4fc16f90a642903 rdf:first sg:person.0701061605.68
143 rdf:rest N908c683dbbe34d59bb097673c11061ad
144 Nc6abdd6b949145228e19b1d901ca5788 rdf:first sg:person.013011036320.73
145 rdf:rest N505da1ac7fd44f07b38daa1e925ab656
146 Ncc8877af8ace482b8e4abb96eaec1162 rdf:first sg:person.01216111541.41
147 rdf:rest Nc6abdd6b949145228e19b1d901ca5788
148 Nccd7f2c91cff4e6387584285a778d9ea rdf:first sg:person.01112344567.33
149 rdf:rest Nfd497f287d134155a08a0530ae1dbfba
150 Nd8cb0aca559948f0b6078e686739e486 schema:volumeNumber 9
151 rdf:type schema:PublicationVolume
152 Ne01b3e121cad44a28b9911e0d4f75857 schema:name Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
153 rdf:type schema:Organization
154 Ne1f79ceff3a642aa8ddd773cb7a5e4d0 schema:issueNumber 9
155 rdf:type schema:PublicationIssue
156 Nee2ca9a730104c99a632018cfcce08c2 rdf:first sg:person.01055371677.11
157 rdf:rest Nbce9141ca35847fead10542ca2ba671d
158 Nf00fca8f59e3494db55bedfd9d86c8ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Schizophrenia
160 rdf:type schema:DefinedTerm
161 Nfd497f287d134155a08a0530ae1dbfba rdf:first sg:person.01172073213.95
162 rdf:rest Nee2ca9a730104c99a632018cfcce08c2
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
167 schema:name Clinical Sciences
168 rdf:type schema:DefinedTerm
169 sg:grant.2405382 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.mp.4001496
170 rdf:type schema:MonetaryGrant
171 sg:grant.2436384 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.mp.4001496
172 rdf:type schema:MonetaryGrant
173 sg:grant.2443054 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.mp.4001496
174 rdf:type schema:MonetaryGrant
175 sg:grant.2549644 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.mp.4001496
176 rdf:type schema:MonetaryGrant
177 sg:grant.2707590 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.mp.4001496
178 rdf:type schema:MonetaryGrant
179 sg:grant.2707591 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.mp.4001496
180 rdf:type schema:MonetaryGrant
181 sg:journal.1115540 schema:issn 1359-4184
182 1476-5578
183 schema:name Molecular Psychiatry
184 rdf:type schema:Periodical
185 sg:person.01055371677.11 schema:affiliation https://www.grid.ac/institutes/grid.442446.4
186 schema:familyName Kajuna
187 schema:givenName S
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055371677.11
189 rdf:type schema:Person
190 sg:person.01112344567.33 schema:affiliation https://www.grid.ac/institutes/grid.240614.5
191 schema:familyName Odunsi
192 schema:givenName A
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112344567.33
194 rdf:type schema:Person
195 sg:person.01136132215.07 schema:affiliation https://www.grid.ac/institutes/grid.420085.b
196 schema:familyName Goldman
197 schema:givenName D
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136132215.07
199 rdf:type schema:Person
200 sg:person.01137730505.12 schema:affiliation https://www.grid.ac/institutes/grid.411905.8
201 schema:familyName Parnas
202 schema:givenName J
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137730505.12
204 rdf:type schema:Person
205 sg:person.01140305107.04 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
206 schema:familyName Paschou
207 schema:givenName P
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140305107.04
209 rdf:type schema:Person
210 sg:person.01147776341.54 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
211 schema:familyName Pakstis
212 schema:givenName A J
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147776341.54
214 rdf:type schema:Person
215 sg:person.01172073213.95 schema:affiliation https://www.grid.ac/institutes/grid.413068.8
216 schema:familyName Okonofua
217 schema:givenName F
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172073213.95
219 rdf:type schema:Person
220 sg:person.01207514351.67 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
221 schema:familyName Grigorenko
222 schema:givenName E
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207514351.67
224 rdf:type schema:Person
225 sg:person.01210504246.50 schema:affiliation https://www.grid.ac/institutes/grid.442446.4
226 schema:familyName Karoma
227 schema:givenName N
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210504246.50
229 rdf:type schema:Person
230 sg:person.01216111541.41 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
231 schema:familyName Kidd
232 schema:givenName J R
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216111541.41
234 rdf:type schema:Person
235 sg:person.01234671475.72 schema:affiliation https://www.grid.ac/institutes/grid.12136.37
236 schema:familyName Bonne-Tamir
237 schema:givenName B
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234671475.72
239 rdf:type schema:Person
240 sg:person.013011036320.73 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
241 schema:familyName DeMille
242 schema:givenName M M C
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013011036320.73
244 rdf:type schema:Person
245 sg:person.013056040102.90 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
246 schema:familyName Kidd
247 schema:givenName K K
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013056040102.90
249 rdf:type schema:Person
250 sg:person.01306046677.16 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
251 schema:familyName Speed
252 schema:givenName W
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306046677.16
254 rdf:type schema:Person
255 sg:person.015365121757.32 schema:affiliation Ne01b3e121cad44a28b9911e0d4f75857
256 schema:familyName Lu
257 schema:givenName R-B
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015365121757.32
259 rdf:type schema:Person
260 sg:person.0701061605.68 schema:affiliation N3eb9f159df584250ba4122f111db2482
261 schema:familyName Zhukova
262 schema:givenName O V
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701061605.68
264 rdf:type schema:Person
265 sg:person.0720747234.41 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
266 schema:familyName Palmatier
267 schema:givenName M A
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720747234.41
269 rdf:type schema:Person
270 sg:person.0761573441.44 schema:affiliation https://www.grid.ac/institutes/grid.25867.3e
271 schema:familyName Kungulilo
272 schema:givenName S
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761573441.44
274 rdf:type schema:Person
275 sg:pub.10.1007/s00439-002-0809-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043738924
276 https://doi.org/10.1007/s00439-002-0809-0
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/sj.mp.4000638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004013672
279 https://doi.org/10.1038/sj.mp.4000638
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/sj.mp.4000738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006024273
282 https://doi.org/10.1038/sj.mp.4000738
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/sj.mp.4000752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023912309
285 https://doi.org/10.1038/sj.mp.4000752
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/sj.npp.1300218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046066622
288 https://doi.org/10.1038/sj.npp.1300218
289 rdf:type schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1077358164 schema:CreativeWork
291 https://doi.org/10.1001/archpsyc.56.10.940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041035362
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1002/(sici)1096-8628(200021)97:1<23::aid-ajmg5>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1041675272
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1002/ajmg.b.20021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020724705
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/ajmg.b.20023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009821158
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/ajmg.b.20037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033559956
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/syn.10286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030201731
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1006/geno.1995.9003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038103610
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/0167-4838(95)00071-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050463737
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/s0006-3223(02)01416-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012184547
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s0006-3223(99)00098-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050927062
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s0006-3223(99)00281-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017312019
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s0306-4522(02)00556-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006445004
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1021/bi00013a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055157149
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1046/j.1469-1809.1999.6320167.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038109558
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1046/j.1471-4159.1994.63030972.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430937
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1055/s-2003-45130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057426481
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.111134598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037067248
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1073/pnas.88.4.1416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040748948
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1086/344514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058640476
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1086/376578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058669925
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1086/380206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058672607
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/hmg/ddg302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027646207
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/oxfordjournals.jhered.a111613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082413162
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1432-1033.1994.tb19083.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043596244
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1146/annurev.genom.3.022502.103141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005798963
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1159/000022963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000671633
342 rdf:type schema:CreativeWork
343 https://doi.org/10.3109/10425179809034076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004516334
344 rdf:type schema:CreativeWork
345 https://www.grid.ac/institutes/grid.12136.37 schema:alternateName Tel Aviv University
346 schema:name Department of Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.240614.5 schema:alternateName Roswell Park Cancer Institute
349 schema:name Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA
350 rdf:type schema:Organization
351 https://www.grid.ac/institutes/grid.25867.3e schema:alternateName Muhimbili University of Health and Allied Sciences
352 schema:name Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.411905.8 schema:alternateName Hvidovre Hospital
355 schema:name Copenhagen University, Psychiatry Department, Hvidovre Hospital, Hvidovre, Denmark
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.413068.8 schema:alternateName University of Benin
358 schema:name Department of Obstetrics and Gynecology, Faculty of Medicine, University of Benin, Benin City, Nigeria
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.420085.b schema:alternateName National Institute On Alcohol Abuse and Alcoholism
361 schema:name Neurogenetics Laboratory, NIAAA, Rockville, MD, USA
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.442446.4 schema:alternateName Hubert Kairuki Memorial University
364 schema:name The Hubert Kairuki Memorial University, Dar es Salaam, Tanzania
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
367 schema:name Child Study Center and Department of Psychology, Yale University, New Haven, CT, USA
368 Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
369 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...