DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-10

AUTHORS

Z K Mirnics, K Mirnics, D Terrano, D A Lewis, S S Sisodia, N F Schor

ABSTRACT

Presenilin 1 (PS1) plays a critical role in the nervous system development and PS1 mutations have been associated with familial Alzheimer's disease. PS1-deficient mice exhibit alterations in neural and vascular development and die in late embryogenesis. The present study was aimed at uncovering transcript networks that depend on intact PS1 function in the developing brain. To achieve this, we analyzed the brains of PS1-deficient and control animals at embryonic ages E12.5 and E14.5 using MG_U74Av2 oligonucleotide microarrays by Affymetrix. Based on the microarray data, overall molecular brain development appeared to be comparable between the E12.5 and E14.5 PS1-deficient and control embryos. However, in brains of PS1-deficient mice, we observed significant differences in the expression of genes encoding molecules that are associated with neural differentiation, extracellular matrix, vascular development, Notch-related signaling and lipid metabolism. Many of the expression differences between wild-type and PS1-deficient animals were present at both E12.5 and E14.5, whereas other transcript alterations were characteristic of only one developmental stage. The results suggest that the role of PS1 in development includes influences on a highly co-regulated transcript network; some of the genes participating in this expression network may contribute to the pathophysiology of Alzheimer's disease. More... »

PAGES

863

References to SciGraph publications

  • 2000-03. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2 in NATURE
  • 2000-07. Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells in NATURE CELL BIOLOGY
  • 1996-08. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease in NATURE MEDICINE
  • 1999-09. The Notch-Hes pathway in mammalian neural development in CELL RESEARCH
  • 1999-01. High density synthetic oligonucleotide arrays in NATURE GENETICS
  • 2002-04. γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in? in NATURE REVIEWS NEUROSCIENCE
  • 1998-01. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein in NATURE
  • 1997-05. Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm in NATURE
  • 2002-10. Fast axonal transport misregulation and Alzheimer’s Disease in NEUROMOLECULAR MEDICINE
  • 1999-12. The function of presenilin-1 in amyloid β-peptide generation and brain development in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • 2002-08. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ in CELL DEATH & DIFFERENTIATION
  • 1998. Familial Amyotrophic Lateral Sclerosis and Alzheimer’s Disease in MOLECULAR AND CELLULAR MECHANISMS OF NEURONAL PLASTICITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.mp.4001389

    DOI

    http://dx.doi.org/10.1038/sj.mp.4001389

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049762513

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14515137


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alzheimer Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Developmental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Situ Hybridization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Mutant Strains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pregnancy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Presenilin-1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Pediatric Center for Neuroscience, Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mirnics", 
            "givenName": "Z K", 
            "id": "sg:person.01245165704.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245165704.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.21925.3d", 
              "name": [
                "Departments of Psychiatry and Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mirnics", 
            "givenName": "K", 
            "id": "sg:person.01273606273.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273606273.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Molecular Neurobiology, University of Chicago, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Terrano", 
            "givenName": "D", 
            "id": "sg:person.0664547473.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664547473.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Pittsburgh", 
              "id": "https://www.grid.ac/institutes/grid.21925.3d", 
              "name": [
                "Departments of Psychiatry and Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lewis", 
            "givenName": "D A", 
            "id": "sg:person.0602206326.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602206326.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Molecular Neurobiology, University of Chicago, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sisodia", 
            "givenName": "S S", 
            "id": "sg:person.01365507347.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365507347.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Pediatric Center for Neuroscience, Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schor", 
            "givenName": "N F", 
            "id": "sg:person.01361414304.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361414304.96"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1074/jbc.273.12.6998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000242641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0079-6123(02)36024-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000770486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80861-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000914349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.8.2196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000982033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.2002.8017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002167969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.2002.8017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002167969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m206872200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002318899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.10351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003083282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35005118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003313867", 
              "https://doi.org/10.1038/35005118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35005118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003313867", 
              "https://doi.org/10.1038/35005118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1679/aohc.65.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003992065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1679/aohc.65.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003992065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1679/aohc.65.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003992065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387288a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005421437", 
              "https://doi.org/10.1038/387288a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-0102(02)00057-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005996637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1388-1981(00)00155-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007058583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(02)00491-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007253134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(02)00491-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007253134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-0082(96)00038-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007870352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(99)01664-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008085899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-199412000-00019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008760342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-199412000-00019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008760342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/21.8.1948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009564192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m204446200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010086004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2002.01182.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010164890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.211352598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010645760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.10208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010691091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7290016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011044427", 
              "https://doi.org/10.1038/sj.cr.7290016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7290016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011044427", 
              "https://doi.org/10.1038/sj.cr.7290016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c200711200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011397538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35017105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011766041", 
              "https://doi.org/10.1038/35017105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35017105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011766041", 
              "https://doi.org/10.1038/35017105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.21.11872", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011915800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m008782200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013800958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0736-5748(02)00040-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016150760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0024-3205(01)01221-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016292986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(00)00550-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016968193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.neuro.21.1.479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018039231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-4388(91)90067-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018228801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-4388(91)90067-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018228801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/nmm:2:2:089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018503910", 
              "https://doi.org/10.1385/nmm:2:2:089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00032-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018995634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/nbdi.1998.0183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019915074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(99)80331-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020429302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.14.7932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020504332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80998-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020940452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041433-200302000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024053403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041433-200302000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024053403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041433-200302000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024053403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.47.29729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024098728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.143.3.777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024535567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-2236(00)01987-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024664421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(00)00290-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025412956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0300-9084(97)81506-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025882008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80244-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026276273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)00085-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026770587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-2952(98)00209-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027256879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028181856", 
              "https://doi.org/10.1038/nrn785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028181856", 
              "https://doi.org/10.1038/nrn785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0896-864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028210081", 
              "https://doi.org/10.1038/nm0896-864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-3278(02)00261-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028875752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-3278(02)00261-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028875752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.37.22514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029473554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.051619898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031207419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80458-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033204441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0304-3940(01)02399-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033386682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033534955", 
              "https://doi.org/10.1038/sj.cdd.4401036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033534955", 
              "https://doi.org/10.1038/sj.cdd.4401036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m210179200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034493459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.2001.5329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034581250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000055194.85073.ff", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034907325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000055194.85073.ff", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034907325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1471-4914(01)02067-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035779024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.48.34317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036060190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-4869-0_9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036693815", 
              "https://doi.org/10.1007/978-1-4615-4869-0_9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1995.2871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038921616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040686717", 
              "https://doi.org/10.1038/4447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040686717", 
              "https://doi.org/10.1038/4447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.m200376-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040863270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043605162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3727/000000001783992597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045401515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3727/000000001783992597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045401515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111263200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046092390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m208288200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046681707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80230-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046770250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.12.6959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048157452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-2236(00)01862-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049102782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1357-2725(97)89968-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049294811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.98.4.1930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050455719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m201979200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052995820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.c100758200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053053218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053079917", 
              "https://doi.org/10.1038/34910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053079917", 
              "https://doi.org/10.1038/34910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004060050099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053252297", 
              "https://doi.org/10.1007/s004060050099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi026888g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055196437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi026888g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055196437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi991080q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055217975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi991080q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055217975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1065412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.158.9.1384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063494092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/130.2.294s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074605913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074643438", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074695280", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074721681", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074869192", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.22-14-06029.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075087387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075198131", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082489019", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.7.2.8440409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082807521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083297971", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2003-10", 
        "datePublishedReg": "2003-10-01", 
        "description": "Presenilin 1 (PS1) plays a critical role in the nervous system development and PS1 mutations have been associated with familial Alzheimer's disease. PS1-deficient mice exhibit alterations in neural and vascular development and die in late embryogenesis. The present study was aimed at uncovering transcript networks that depend on intact PS1 function in the developing brain. To achieve this, we analyzed the brains of PS1-deficient and control animals at embryonic ages E12.5 and E14.5 using MG_U74Av2 oligonucleotide microarrays by Affymetrix. Based on the microarray data, overall molecular brain development appeared to be comparable between the E12.5 and E14.5 PS1-deficient and control embryos. However, in brains of PS1-deficient mice, we observed significant differences in the expression of genes encoding molecules that are associated with neural differentiation, extracellular matrix, vascular development, Notch-related signaling and lipid metabolism. Many of the expression differences between wild-type and PS1-deficient animals were present at both E12.5 and E14.5, whereas other transcript alterations were characteristic of only one developmental stage. The results suggest that the role of PS1 in development includes influences on a highly co-regulated transcript network; some of the genes participating in this expression network may contribute to the pathophysiology of Alzheimer's disease.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.mp.4001389", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2388706", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1115540", 
            "issn": [
              "1359-4184", 
              "1476-5578"
            ], 
            "name": "Molecular Psychiatry", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes", 
        "pagination": "863", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ed0d9c7f0b4b4af1334e09268d00e8eb18b94be3ad267dda9635bdd28e70ad9b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "14515137"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9607835"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.mp.4001389"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1049762513"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.mp.4001389", 
          "https://app.dimensions.ai/details/publication/pub.1049762513"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118306_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/4001389"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001389'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001389'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001389'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.mp.4001389'


     

    This table displays all metadata directly associated to this object as RDF triples.

    449 TRIPLES      21 PREDICATES      134 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.mp.4001389 schema:about N002714c2dcf44ac8be3747abc787f243
    2 N0cdbfccfc1774b95ab84daf3474fa8d7
    3 N2ac1e333b6114e94b29a1f30fdb774f3
    4 N3a2e3aac20b04fa891175d9cc9b127c7
    5 N6474d8d146da4fd89d87e53b6145fc3e
    6 N64de2bd86e4d47578b8619db12626e80
    7 N6a1925f8c7a6414eb3e42df4fc0c2378
    8 N6a5784d94fcf427db8c04cb60a4365cd
    9 N6e3123595c784813814d5d4b440e84fb
    10 N964a8553bbc64fc9a2287139d35a838e
    11 Na1ec9de8990a44eabb19e85913955640
    12 Nd559f7d91d804f639cef938e871f7ac9
    13 Ndbcf3c90c01e43f2afcd908015ad8881
    14 Neeb0a15a4fd94b54818636be7ed32969
    15 Nf697b3f44cfe4b459bbc5a81f28938ac
    16 anzsrc-for:11
    17 anzsrc-for:1109
    18 schema:author N01e3e834d9f948dea22ed13f20023d90
    19 schema:citation sg:pub.10.1007/978-1-4615-4869-0_9
    20 sg:pub.10.1007/s004060050099
    21 sg:pub.10.1038/34910
    22 sg:pub.10.1038/35005118
    23 sg:pub.10.1038/35017105
    24 sg:pub.10.1038/387288a0
    25 sg:pub.10.1038/4447
    26 sg:pub.10.1038/nm0896-864
    27 sg:pub.10.1038/nrn785
    28 sg:pub.10.1038/sj.cdd.4401036
    29 sg:pub.10.1038/sj.cr.7290016
    30 sg:pub.10.1385/nmm:2:2:089
    31 https://app.dimensions.ai/details/publication/pub.1074643438
    32 https://app.dimensions.ai/details/publication/pub.1074695280
    33 https://app.dimensions.ai/details/publication/pub.1074721681
    34 https://app.dimensions.ai/details/publication/pub.1074869192
    35 https://app.dimensions.ai/details/publication/pub.1075198131
    36 https://app.dimensions.ai/details/publication/pub.1082489019
    37 https://app.dimensions.ai/details/publication/pub.1083297971
    38 https://doi.org/10.1002/jcp.10208
    39 https://doi.org/10.1002/jnr.10351
    40 https://doi.org/10.1006/bbrc.1995.2871
    41 https://doi.org/10.1006/excr.2001.5329
    42 https://doi.org/10.1006/exnr.2002.8017
    43 https://doi.org/10.1006/nbdi.1998.0183
    44 https://doi.org/10.1016/0959-4388(91)90067-h
    45 https://doi.org/10.1016/s0006-2952(98)00209-3
    46 https://doi.org/10.1016/s0014-5793(99)01664-6
    47 https://doi.org/10.1016/s0024-3205(01)01221-8
    48 https://doi.org/10.1016/s0079-6123(02)36024-2
    49 https://doi.org/10.1016/s0092-8674(00)00032-5
    50 https://doi.org/10.1016/s0092-8674(00)80244-5
    51 https://doi.org/10.1016/s0166-2236(00)01862-2
    52 https://doi.org/10.1016/s0166-2236(00)01987-1
    53 https://doi.org/10.1016/s0168-0102(02)00057-3
    54 https://doi.org/10.1016/s0169-328x(02)00491-6
    55 https://doi.org/10.1016/s0300-9084(97)81506-4
    56 https://doi.org/10.1016/s0301-0082(96)00038-x
    57 https://doi.org/10.1016/s0304-3940(01)02399-0
    58 https://doi.org/10.1016/s0306-4522(00)00550-9
    59 https://doi.org/10.1016/s0378-1119(00)00290-0
    60 https://doi.org/10.1016/s0736-5748(02)00040-0
    61 https://doi.org/10.1016/s0896-6273(00)00085-4
    62 https://doi.org/10.1016/s0896-6273(00)80230-5
    63 https://doi.org/10.1016/s0896-6273(00)80458-4
    64 https://doi.org/10.1016/s0896-6273(00)80861-2
    65 https://doi.org/10.1016/s0896-6273(00)80998-8
    66 https://doi.org/10.1016/s0952-3278(02)00261-2
    67 https://doi.org/10.1016/s0960-9822(99)80331-5
    68 https://doi.org/10.1016/s1357-2725(97)89968-2
    69 https://doi.org/10.1016/s1388-1981(00)00155-4
    70 https://doi.org/10.1016/s1471-4914(01)02067-6
    71 https://doi.org/10.1021/bi026888g
    72 https://doi.org/10.1021/bi991080q
    73 https://doi.org/10.1046/j.1471-4159.2002.01182.x
    74 https://doi.org/10.1073/pnas.051619898
    75 https://doi.org/10.1073/pnas.211352598
    76 https://doi.org/10.1073/pnas.96.12.6959
    77 https://doi.org/10.1073/pnas.96.14.7932
    78 https://doi.org/10.1073/pnas.96.21.11872
    79 https://doi.org/10.1073/pnas.98.4.1930
    80 https://doi.org/10.1074/jbc.271.37.22514
    81 https://doi.org/10.1074/jbc.272.47.29729
    82 https://doi.org/10.1074/jbc.273.12.6998
    83 https://doi.org/10.1074/jbc.274.48.34317
    84 https://doi.org/10.1074/jbc.c100758200
    85 https://doi.org/10.1074/jbc.c200711200
    86 https://doi.org/10.1074/jbc.m008782200
    87 https://doi.org/10.1074/jbc.m111263200
    88 https://doi.org/10.1074/jbc.m201979200
    89 https://doi.org/10.1074/jbc.m204446200
    90 https://doi.org/10.1074/jbc.m206872200
    91 https://doi.org/10.1074/jbc.m208288200
    92 https://doi.org/10.1074/jbc.m210179200
    93 https://doi.org/10.1083/jcb.143.3.777
    94 https://doi.org/10.1093/emboj/18.8.2196
    95 https://doi.org/10.1093/emboj/21.8.1948
    96 https://doi.org/10.1093/jn/130.2.294s
    97 https://doi.org/10.1093/nar/gkg121
    98 https://doi.org/10.1096/fasebj.7.2.8440409
    99 https://doi.org/10.1097/00001756-199412000-00019
    100 https://doi.org/10.1097/00041433-200302000-00007
    101 https://doi.org/10.1126/science.1065412
    102 https://doi.org/10.1146/annurev.neuro.21.1.479
    103 https://doi.org/10.1161/01.atv.0000055194.85073.ff
    104 https://doi.org/10.1176/appi.ajp.158.9.1384
    105 https://doi.org/10.1194/jlr.m200376-jlr200
    106 https://doi.org/10.1523/jneurosci.22-14-06029.2002
    107 https://doi.org/10.1679/aohc.65.27
    108 https://doi.org/10.3727/000000001783992597
    109 schema:datePublished 2003-10
    110 schema:datePublishedReg 2003-10-01
    111 schema:description Presenilin 1 (PS1) plays a critical role in the nervous system development and PS1 mutations have been associated with familial Alzheimer's disease. PS1-deficient mice exhibit alterations in neural and vascular development and die in late embryogenesis. The present study was aimed at uncovering transcript networks that depend on intact PS1 function in the developing brain. To achieve this, we analyzed the brains of PS1-deficient and control animals at embryonic ages E12.5 and E14.5 using MG_U74Av2 oligonucleotide microarrays by Affymetrix. Based on the microarray data, overall molecular brain development appeared to be comparable between the E12.5 and E14.5 PS1-deficient and control embryos. However, in brains of PS1-deficient mice, we observed significant differences in the expression of genes encoding molecules that are associated with neural differentiation, extracellular matrix, vascular development, Notch-related signaling and lipid metabolism. Many of the expression differences between wild-type and PS1-deficient animals were present at both E12.5 and E14.5, whereas other transcript alterations were characteristic of only one developmental stage. The results suggest that the role of PS1 in development includes influences on a highly co-regulated transcript network; some of the genes participating in this expression network may contribute to the pathophysiology of Alzheimer's disease.
    112 schema:genre research_article
    113 schema:inLanguage en
    114 schema:isAccessibleForFree true
    115 schema:isPartOf Need430794a5540be81ff5a7e285538e0
    116 Neede0edd8ce149d1b5341cb0c9c66ff6
    117 sg:journal.1115540
    118 schema:name DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes
    119 schema:pagination 863
    120 schema:productId N1b75f9673fc844b59b53002bf51f1666
    121 N1c1c9e2a99b7423e908a1c75e69eb105
    122 N289a54e3abc04882a2ea661e4b90b65e
    123 N5403997edac14220a56a135edc9b49e7
    124 Ndb53597ea94f48a588877e9f9de912a9
    125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049762513
    126 https://doi.org/10.1038/sj.mp.4001389
    127 schema:sdDatePublished 2019-04-11T12:03
    128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    129 schema:sdPublisher N7a239735d6d540c98be0d0af649d5037
    130 schema:url https://www.nature.com/articles/4001389
    131 sgo:license sg:explorer/license/
    132 sgo:sdDataset articles
    133 rdf:type schema:ScholarlyArticle
    134 N002714c2dcf44ac8be3747abc787f243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Animals
    136 rdf:type schema:DefinedTerm
    137 N01e3e834d9f948dea22ed13f20023d90 rdf:first sg:person.01245165704.16
    138 rdf:rest Ndae42ec6a0f848fa9af7f8a6eb652762
    139 N0cdbfccfc1774b95ab84daf3474fa8d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Male
    141 rdf:type schema:DefinedTerm
    142 N1b75f9673fc844b59b53002bf51f1666 schema:name dimensions_id
    143 schema:value pub.1049762513
    144 rdf:type schema:PropertyValue
    145 N1c1c9e2a99b7423e908a1c75e69eb105 schema:name doi
    146 schema:value 10.1038/sj.mp.4001389
    147 rdf:type schema:PropertyValue
    148 N213402b9a8604b0da7645efd9a4bf1d8 schema:name Pediatric Center for Neuroscience, Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA
    149 rdf:type schema:Organization
    150 N289a54e3abc04882a2ea661e4b90b65e schema:name nlm_unique_id
    151 schema:value 9607835
    152 rdf:type schema:PropertyValue
    153 N2ac1e333b6114e94b29a1f30fdb774f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Mice, Mutant Strains
    155 rdf:type schema:DefinedTerm
    156 N3a2e3aac20b04fa891175d9cc9b127c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Pregnancy
    158 rdf:type schema:DefinedTerm
    159 N4ab6a68587e743ccab249e84472a54dd rdf:first sg:person.01365507347.91
    160 rdf:rest N56c3e2faa95d4c7084309337e6e939d9
    161 N5403997edac14220a56a135edc9b49e7 schema:name readcube_id
    162 schema:value ed0d9c7f0b4b4af1334e09268d00e8eb18b94be3ad267dda9635bdd28e70ad9b
    163 rdf:type schema:PropertyValue
    164 N56c3e2faa95d4c7084309337e6e939d9 rdf:first sg:person.01361414304.96
    165 rdf:rest rdf:nil
    166 N6474d8d146da4fd89d87e53b6145fc3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Alzheimer Disease
    168 rdf:type schema:DefinedTerm
    169 N64de2bd86e4d47578b8619db12626e80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name In Situ Hybridization
    171 rdf:type schema:DefinedTerm
    172 N6a1925f8c7a6414eb3e42df4fc0c2378 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Presenilin-1
    174 rdf:type schema:DefinedTerm
    175 N6a5784d94fcf427db8c04cb60a4365cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Gene Expression Regulation, Developmental
    177 rdf:type schema:DefinedTerm
    178 N6cf141fa319f45e89515a1faf5850007 schema:name Center for Molecular Neurobiology, University of Chicago, Chicago, IL, USA
    179 rdf:type schema:Organization
    180 N6e3123595c784813814d5d4b440e84fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Mice
    182 rdf:type schema:DefinedTerm
    183 N7a239735d6d540c98be0d0af649d5037 schema:name Springer Nature - SN SciGraph project
    184 rdf:type schema:Organization
    185 N957995bc5db94448adff960398770e8e rdf:first sg:person.0602206326.28
    186 rdf:rest N4ab6a68587e743ccab249e84472a54dd
    187 N964a8553bbc64fc9a2287139d35a838e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Transcription, Genetic
    189 rdf:type schema:DefinedTerm
    190 N9fa382b444c4420d94a13a325645b169 rdf:first sg:person.0664547473.43
    191 rdf:rest N957995bc5db94448adff960398770e8e
    192 Na1ec9de8990a44eabb19e85913955640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Membrane Proteins
    194 rdf:type schema:DefinedTerm
    195 Nd559f7d91d804f639cef938e871f7ac9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Female
    197 rdf:type schema:DefinedTerm
    198 Ndae42ec6a0f848fa9af7f8a6eb652762 rdf:first sg:person.01273606273.18
    199 rdf:rest N9fa382b444c4420d94a13a325645b169
    200 Ndb53597ea94f48a588877e9f9de912a9 schema:name pubmed_id
    201 schema:value 14515137
    202 rdf:type schema:PropertyValue
    203 Ndbcf3c90c01e43f2afcd908015ad8881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Brain
    205 rdf:type schema:DefinedTerm
    206 Neeadb3f21daa4f21b9f32fe507d5511f schema:name Pediatric Center for Neuroscience, Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA
    207 rdf:type schema:Organization
    208 Neeb0a15a4fd94b54818636be7ed32969 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Oligonucleotide Array Sequence Analysis
    210 rdf:type schema:DefinedTerm
    211 Need430794a5540be81ff5a7e285538e0 schema:volumeNumber 8
    212 rdf:type schema:PublicationVolume
    213 Neede0edd8ce149d1b5341cb0c9c66ff6 schema:issueNumber 10
    214 rdf:type schema:PublicationIssue
    215 Nf697b3f44cfe4b459bbc5a81f28938ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Brain Chemistry
    217 rdf:type schema:DefinedTerm
    218 Nf782eaaa120c4a2e88586ea5cee41ed5 schema:name Center for Molecular Neurobiology, University of Chicago, Chicago, IL, USA
    219 rdf:type schema:Organization
    220 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    221 schema:name Medical and Health Sciences
    222 rdf:type schema:DefinedTerm
    223 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    224 schema:name Neurosciences
    225 rdf:type schema:DefinedTerm
    226 sg:grant.2388706 http://pending.schema.org/fundedItem sg:pub.10.1038/sj.mp.4001389
    227 rdf:type schema:MonetaryGrant
    228 sg:journal.1115540 schema:issn 1359-4184
    229 1476-5578
    230 schema:name Molecular Psychiatry
    231 rdf:type schema:Periodical
    232 sg:person.01245165704.16 schema:affiliation Neeadb3f21daa4f21b9f32fe507d5511f
    233 schema:familyName Mirnics
    234 schema:givenName Z K
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245165704.16
    236 rdf:type schema:Person
    237 sg:person.01273606273.18 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
    238 schema:familyName Mirnics
    239 schema:givenName K
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273606273.18
    241 rdf:type schema:Person
    242 sg:person.01361414304.96 schema:affiliation N213402b9a8604b0da7645efd9a4bf1d8
    243 schema:familyName Schor
    244 schema:givenName N F
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361414304.96
    246 rdf:type schema:Person
    247 sg:person.01365507347.91 schema:affiliation Nf782eaaa120c4a2e88586ea5cee41ed5
    248 schema:familyName Sisodia
    249 schema:givenName S S
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365507347.91
    251 rdf:type schema:Person
    252 sg:person.0602206326.28 schema:affiliation https://www.grid.ac/institutes/grid.21925.3d
    253 schema:familyName Lewis
    254 schema:givenName D A
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602206326.28
    256 rdf:type schema:Person
    257 sg:person.0664547473.43 schema:affiliation N6cf141fa319f45e89515a1faf5850007
    258 schema:familyName Terrano
    259 schema:givenName D
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664547473.43
    261 rdf:type schema:Person
    262 sg:pub.10.1007/978-1-4615-4869-0_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036693815
    263 https://doi.org/10.1007/978-1-4615-4869-0_9
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1007/s004060050099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053252297
    266 https://doi.org/10.1007/s004060050099
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/34910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053079917
    269 https://doi.org/10.1038/34910
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/35005118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003313867
    272 https://doi.org/10.1038/35005118
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/35017105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011766041
    275 https://doi.org/10.1038/35017105
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/387288a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005421437
    278 https://doi.org/10.1038/387288a0
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/4447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040686717
    281 https://doi.org/10.1038/4447
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nm0896-864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028210081
    284 https://doi.org/10.1038/nm0896-864
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nrn785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028181856
    287 https://doi.org/10.1038/nrn785
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/sj.cdd.4401036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033534955
    290 https://doi.org/10.1038/sj.cdd.4401036
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/sj.cr.7290016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011044427
    293 https://doi.org/10.1038/sj.cr.7290016
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1385/nmm:2:2:089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018503910
    296 https://doi.org/10.1385/nmm:2:2:089
    297 rdf:type schema:CreativeWork
    298 https://app.dimensions.ai/details/publication/pub.1074643438 schema:CreativeWork
    299 https://app.dimensions.ai/details/publication/pub.1074695280 schema:CreativeWork
    300 https://app.dimensions.ai/details/publication/pub.1074721681 schema:CreativeWork
    301 https://app.dimensions.ai/details/publication/pub.1074869192 schema:CreativeWork
    302 https://app.dimensions.ai/details/publication/pub.1075198131 schema:CreativeWork
    303 https://app.dimensions.ai/details/publication/pub.1082489019 schema:CreativeWork
    304 https://app.dimensions.ai/details/publication/pub.1083297971 schema:CreativeWork
    305 https://doi.org/10.1002/jcp.10208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010691091
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1002/jnr.10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003083282
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1006/bbrc.1995.2871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038921616
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1006/excr.2001.5329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034581250
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1006/exnr.2002.8017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002167969
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1006/nbdi.1998.0183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019915074
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/0959-4388(91)90067-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1018228801
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/s0006-2952(98)00209-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027256879
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s0014-5793(99)01664-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008085899
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0024-3205(01)01221-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016292986
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s0079-6123(02)36024-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000770486
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s0092-8674(00)00032-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018995634
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s0092-8674(00)80244-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026276273
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/s0166-2236(00)01862-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049102782
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s0166-2236(00)01987-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024664421
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/s0168-0102(02)00057-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005996637
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/s0169-328x(02)00491-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007253134
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/s0300-9084(97)81506-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025882008
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/s0301-0082(96)00038-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007870352
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/s0304-3940(01)02399-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033386682
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/s0306-4522(00)00550-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016968193
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/s0378-1119(00)00290-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025412956
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/s0736-5748(02)00040-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016150760
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/s0896-6273(00)00085-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026770587
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/s0896-6273(00)80230-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046770250
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/s0896-6273(00)80458-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033204441
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/s0896-6273(00)80861-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000914349
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/s0896-6273(00)80998-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020940452
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s0952-3278(02)00261-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028875752
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/s0960-9822(99)80331-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020429302
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/s1357-2725(97)89968-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049294811
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/s1388-1981(00)00155-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007058583
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/s1471-4914(01)02067-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035779024
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1021/bi026888g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055196437
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1021/bi991080q schema:sameAs https://app.dimensions.ai/details/publication/pub.1055217975
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1046/j.1471-4159.2002.01182.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010164890
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1073/pnas.051619898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031207419
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1073/pnas.211352598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010645760
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1073/pnas.96.12.6959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048157452
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1073/pnas.96.14.7932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020504332
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1073/pnas.96.21.11872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011915800
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1073/pnas.98.4.1930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050455719
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1074/jbc.271.37.22514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029473554
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1074/jbc.272.47.29729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024098728
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1074/jbc.273.12.6998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000242641
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1074/jbc.274.48.34317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060190
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1074/jbc.c100758200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053053218
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1074/jbc.c200711200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011397538
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1074/jbc.m008782200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013800958
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1074/jbc.m111263200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046092390
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1074/jbc.m201979200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052995820
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1074/jbc.m204446200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010086004
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1074/jbc.m206872200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002318899
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1074/jbc.m208288200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046681707
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1074/jbc.m210179200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034493459
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1083/jcb.143.3.777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024535567
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1093/emboj/18.8.2196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000982033
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1093/emboj/21.8.1948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009564192
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1093/jn/130.2.294s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074605913
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1093/nar/gkg121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043605162
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1096/fasebj.7.2.8440409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082807521
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1097/00001756-199412000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008760342
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1097/00041433-200302000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024053403
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1126/science.1065412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445502
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1146/annurev.neuro.21.1.479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018039231
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1161/01.atv.0000055194.85073.ff schema:sameAs https://app.dimensions.ai/details/publication/pub.1034907325
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1176/appi.ajp.158.9.1384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063494092
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1194/jlr.m200376-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040863270
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1523/jneurosci.22-14-06029.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075087387
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1679/aohc.65.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003992065
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.3727/000000001783992597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045401515
    446 rdf:type schema:CreativeWork
    447 https://www.grid.ac/institutes/grid.21925.3d schema:alternateName University of Pittsburgh
    448 schema:name Departments of Psychiatry and Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA
    449 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...