Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-09-01

AUTHORS

C Exner, J Hebebrand, H Remschmidt, C Wewetzer, A Ziegler, S Herpertz, U Schweiger, W F Blum, G Preibisch, G Heldmaier, M Klingenspor

ABSTRACT

Semi-starvation induced hyperactivity (SIH) occurs in rodents upon caloric restriction. We hypothesized that SIH is triggered by the decline in leptin secretion associated with food restriction. To test this hypothesis, rats, which had established a stable level of activity, were treated with leptin or vehicle via implanted minipumps concomitantly to initiation of food restriction for 7 days. In a second experiment treatment was initiated after SIH had already set in. In contrast to the vehicle-treated rats, which increased their baseline activity level by 300%, the development of SIH was suppressed by leptin. Furthermore, leptin was able to stop SIH, after it had set in. These results underscore the assumed major role of leptin in the adaptation to semi-starvation. Because SIH has been viewed as a model for anorexia nervosa, we also assessed subjective ratings of motor restlessness in 30 patients with this eating disorder in the emaciated state associated with hypoleptinemia and after increments in leptin secretion brought upon by therapeutically induced weight gain. Hypoleptinemic patients ranked their motor restlessness higher than upon attainment of their maximal leptin level during inpatient treatment. Thus, hypoleptinemia might also contribute to the hyperactivity frequently associated with anorexia nervosa. More... »

PAGES

476-481

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.mp.4000771

DOI

http://dx.doi.org/10.1038/sj.mp.4000771

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046305209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11032380


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