Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-11-16

AUTHORS

K Yui, K Goto, S Ikemoto, T Ishiguro, B Angrist, G E Duncan, B B Sheitman, J A Lieberman, S H Bracha, S F Ali

ABSTRACT

A number of consistent clinical observations provide direction for the hypothesis that pathological sensitization of neuronal systems may be an important factor for relapse or the onset of stimulant-induced psychosis (eg, methamphetamine or amphetamine psychosis, cocaine psychosis and phencyclidine psychosis) and schizophrenia. First, psychotic symptoms can be produced in normal subjects by stimulants. Secondly, a large portion of schizophrenic patients exhibit exacerbation of psychotic symptoms in response to stimulants at doses which would not be psychotogenic in normal subjects. Lastly, the ability of stress to precipitate the onset and relapse of schizophrenia is well documented. In this regard, acute responses to stimulants provide useful information for relapse prediction of schizophrenia and substance abuse. This paper addresses the nature and role of pathological sensitization in relapse of stimulant- and phencyclidine-induced psychosis and schizophrenia, and its relation to pathophysiology of schizophrenia. More... »

PAGES

512-523

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.mp.4000575

DOI

http://dx.doi.org/10.1038/sj.mp.4000575

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014397979

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10578232


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