Immune reconstitution after allogeneic stem cell transplantation with reduced-intensity conditioning regimens View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-08

AUTHORS

M Jiménez, G Ercilla, C Martínez

ABSTRACT

Reduced-intensity conditioning (RIC) regimens have been increasingly used as an alternative to conventional myeloablative conditioning (MAC) regimens for elderly patients, for patients medically infirm to qualify for conventional allogeneic stem cell transplantation (SCT), and for disorders in which traditional MAC-SCT are associated with high rates of non-relapse mortality. One of the theoretical advantages of RIC-SCT is that it might lend to better immune reconstitution after transplantation due to less damage of the thymus, allowing regeneration of naive T cells derived from prethymic donor stem cells, and due to the proliferation of immunologically competent host T cells that survive the conditioning regimen. Although limited, studies comparing immune recovery following RIC and MAC-SCT have been insightful. One of the main difficulties of these studies is the current spectrum of RIC protocols, which vary considerably in myeloablative and immunosuppressive potential, resulting in apparently contradictory findings. In spite of this, most reports have shown significant quantitative and/or qualitative differences in T- and B-cell reconstitution after RIC-SCT in comparison with conventional SCT. This paper will review current knowledge of immune reconstitution following RIC-SCT. More... »

PAGES

2404681

References to SciGraph publications

  • 2001-08. Immune reconstitution following allogeneic stem cell transplantation in recipients conditioned by low intensity vs myeloablative regimen in BONE MARROW TRANSPLANTATION
  • 2001-09. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism in BONE MARROW TRANSPLANTATION
  • 2003-09. Immune reconstitution following reduced-intensity transplantation with cladribine, busulfan, and antithymocyte globulin: serial comparison with conventional myeloablative transplantation in BONE MARROW TRANSPLANTATION
  • 2004-04. Third EBMT/AMGEN Workshop on reduced-intensity conditioning allogeneic haemopoietic stem cell transplants (RIC-HSCT), and panel consensus in BONE MARROW TRANSPLANTATION
  • 1986. Changes in the Human Thymus During Aging in THE HUMAN THYMUS
  • 2005-01. Impact of plasmacytoid dendritic cells on outcome after reduced-intensity conditioning allogeneic stem cell transplantation in LEUKEMIA
  • 2005-01. Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age>55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning in LEUKEMIA
  • 2003-11. Infectious complications following allogeneic HLA-identical sibling transplantation with antithymocyte globulin-based reduced intensity preparative regimen in LEUKEMIA
  • 2002-08. Chimerism and minimal residual disease monitoring after reduced intensity conditioning (RIC) allogeneic transplantation in LEUKEMIA
  • 1998-03. Dendritic cells and the control of immunity in NATURE
  • 2003-07. A comparison of T-, B- and NK-cell reconstitution following conventional or nonmyeloablative conditioning and transplantation with bone marrow or peripheral blood stem cells from human leucocyte antigen identical sibling donors in BONE MARROW TRANSPLANTATION
  • 1984-09. The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor in NATURE
  • 2006-01. Kinetics of dendritic cell chimerism and T cell chimerism in allogeneic hematopoietic stem cell recipients in BONE MARROW TRANSPLANTATION
  • 2003-11. Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients in BONE MARROW TRANSPLANTATION
  • 1998-12. Changes in thymic function with age and during the treatment of HIV infection in NATURE
  • 2005-01. Dendritic cell-mediated T cell polarization in SEMINARS IN IMMUNOPATHOLOGY
  • 1988-09. Deletion of the human T-cell receptor δ-gene by a site-specific recombination in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.leu.2404681

    DOI

    http://dx.doi.org/10.1038/sj.leu.2404681

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035713417

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17525730


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