Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-05

AUTHORS

W-C Chou, J-L Tang, S-J Wu, W Tsay, M Yao, S-Y Huang, K-C Huang, C-Y Chen, C-F Huang, H-F Tien

ABSTRACT

To explore the validity and prognostic significance of minimal residual disease detection by quantitative polymerase chain reaction (qPCR) in patients of acute myeloid leukemia (AML) bearing Nucleophosmin (NPM1) mutations, we quantified mutants in 194 bone marrow samples from 38 patients with a median follow-up time of 20.6 months. Following induction chemotherapy, a median of 2.78 log decline in mutant copy number was observed. Relapse was always accompanied by significant increase of mutant numbers (P<0.001). After achieving complete remission (CR), the mutant copy number was significantly higher in patients with subsequent relapse than in those remaining in continuous CR (P<0.001). Presence of detectable mutants after treatment predicted relapse if no further chemotherapy was administered. Furthermore, the patients with any rise of mutant signals during serial follow-up had 3.2-fold increase of relapse risk compared to those with persistently low or undetectable signals (P<0.001). Patients who could achieve mutant reduction to <0.1% of internal control had significantly longer overall survival (OS) (P=0.004) and relapse-free survival (RFS) (P<0.001). Failure to achieve 2 logs of reduction after consolidation predicted shorter OS (P=0.01) and RFS (P=0.001). In conclusion, qPCR monitoring may have prognostic impact in AML patients with NPM1 mutations. More... »

PAGES

2404637

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2404637

DOI

http://dx.doi.org/10.1038/sj.leu.2404637

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045479680

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17361227


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm, Residual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan", 
            "Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chou", 
        "givenName": "W-C", 
        "id": "sg:person.01061277343.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061277343.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "J-L", 
        "id": "sg:person.011336406464.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011336406464.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "S-J", 
        "id": "sg:person.01363730643.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363730643.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsay", 
        "givenName": "W", 
        "id": "sg:person.0721210172.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721210172.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "M", 
        "id": "sg:person.0646462116.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646462116.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "S-Y", 
        "id": "sg:person.012155533514.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155533514.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Family Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "K-C", 
        "id": "sg:person.016440556640.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016440556640.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "C-Y", 
        "id": "sg:person.01175525743.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175525743.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "C-F", 
        "id": "sg:person.01365321011.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365321011.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taiwan University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412094.a", 
          "name": [
            "Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tien", 
        "givenName": "H-F", 
        "id": "sg:person.013177614042.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013177614042.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood-2005-08-3167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001126578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006184192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.9.2651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009800834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-01-0195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010459142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-05-2168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013848437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-01-0178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014214168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014224898", 
          "https://doi.org/10.1038/sj.leu.2404149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014224898", 
          "https://doi.org/10.1038/sj.leu.2404149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa041974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020502159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-05-2174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022325658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-05-2164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031737858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-07-012252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034533794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-06-2248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036438078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-03-0880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038155124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040786175", 
          "https://doi.org/10.1038/sj.leu.2403809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040786175", 
          "https://doi.org/10.1038/sj.leu.2403809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040786175", 
          "https://doi.org/10.1038/sj.leu.2403809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-03-007013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040935883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v100.1.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042949004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02982571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043329204", 
          "https://doi.org/10.1007/bf02982571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02982571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043329204", 
          "https://doi.org/10.1007/bf02982571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-02-0560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046903111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.03.166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203515"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-05", 
    "datePublishedReg": "2007-05-01", 
    "description": "To explore the validity and prognostic significance of minimal residual disease detection by quantitative polymerase chain reaction (qPCR) in patients of acute myeloid leukemia (AML) bearing Nucleophosmin (NPM1) mutations, we quantified mutants in 194 bone marrow samples from 38 patients with a median follow-up time of 20.6 months. Following induction chemotherapy, a median of 2.78 log decline in mutant copy number was observed. Relapse was always accompanied by significant increase of mutant numbers (P<0.001). After achieving complete remission (CR), the mutant copy number was significantly higher in patients with subsequent relapse than in those remaining in continuous CR (P<0.001). Presence of detectable mutants after treatment predicted relapse if no further chemotherapy was administered. Furthermore, the patients with any rise of mutant signals during serial follow-up had 3.2-fold increase of relapse risk compared to those with persistently low or undetectable signals (P<0.001). Patients who could achieve mutant reduction to <0.1% of internal control had significantly longer overall survival (OS) (P=0.004) and relapse-free survival (RFS) (P<0.001). Failure to achieve 2 logs of reduction after consolidation predicted shorter OS (P=0.01) and RFS (P=0.001). In conclusion, qPCR monitoring may have prognostic impact in AML patients with NPM1 mutations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/sj.leu.2404637", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations", 
    "pagination": "2404637", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d8a3862281978576dd047020fae6210f88b90431abc5ae68070cd216198aef44"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17361227"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8704895"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2404637"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045479680"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2404637", 
      "https://app.dimensions.ai/details/publication/pub.1045479680"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/2404637"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404637'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404637'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404637'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404637'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      62 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2404637 schema:about N0ac430b0f1044baaa3fd8807fcf5635c
2 N11d003d43db44f76b6e1681a171b43fc
3 N13c88e0625fb4a10b96a5637909cb148
4 N3980b6092998459293a69dac70f8cc5f
5 N3f244126267146b99548cf833861918d
6 N508f6cfb5c6c412b9e9acc39d7f8c0d5
7 N537f8f6bb8ee49d8a3bbacee48e91ff1
8 N5eb8a3554532496aa352f0c1df626c15
9 N63657ae4f4d446e794eb36fc03ed652b
10 N6ecc2124d17744aa8316d7373b6f082b
11 N773fd5dbc18c49d4b121c30569dbc5b3
12 Ncecab71ac1f24d9cad340276ae33619c
13 Ne539fdb60d7b48a0a08487adfc8964ac
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N1379abf8bb104e24b19ce9b8dc7fa161
17 schema:citation sg:pub.10.1007/bf02982571
18 sg:pub.10.1038/sj.leu.2403809
19 sg:pub.10.1038/sj.leu.2404149
20 https://doi.org/10.1056/nejmoa041974
21 https://doi.org/10.1158/0008-5472.can-05-4316
22 https://doi.org/10.1182/blood-2002-01-0195
23 https://doi.org/10.1182/blood-2003-03-0880
24 https://doi.org/10.1182/blood-2005-01-0178
25 https://doi.org/10.1182/blood-2005-02-0560
26 https://doi.org/10.1182/blood-2005-05-2164
27 https://doi.org/10.1182/blood-2005-05-2168
28 https://doi.org/10.1182/blood-2005-05-2174
29 https://doi.org/10.1182/blood-2005-06-2248
30 https://doi.org/10.1182/blood-2005-08-3167
31 https://doi.org/10.1182/blood-2006-03-007013
32 https://doi.org/10.1182/blood-2006-07-012252
33 https://doi.org/10.1182/blood.v100.1.59
34 https://doi.org/10.1182/blood.v98.9.2651
35 https://doi.org/10.1200/jco.2003.03.166
36 https://doi.org/10.1200/jco.2003.04.036
37 schema:datePublished 2007-05
38 schema:datePublishedReg 2007-05-01
39 schema:description To explore the validity and prognostic significance of minimal residual disease detection by quantitative polymerase chain reaction (qPCR) in patients of acute myeloid leukemia (AML) bearing Nucleophosmin (NPM1) mutations, we quantified mutants in 194 bone marrow samples from 38 patients with a median follow-up time of 20.6 months. Following induction chemotherapy, a median of 2.78 log decline in mutant copy number was observed. Relapse was always accompanied by significant increase of mutant numbers (P<0.001). After achieving complete remission (CR), the mutant copy number was significantly higher in patients with subsequent relapse than in those remaining in continuous CR (P<0.001). Presence of detectable mutants after treatment predicted relapse if no further chemotherapy was administered. Furthermore, the patients with any rise of mutant signals during serial follow-up had 3.2-fold increase of relapse risk compared to those with persistently low or undetectable signals (P<0.001). Patients who could achieve mutant reduction to <0.1% of internal control had significantly longer overall survival (OS) (P=0.004) and relapse-free survival (RFS) (P<0.001). Failure to achieve 2 logs of reduction after consolidation predicted shorter OS (P=0.01) and RFS (P=0.001). In conclusion, qPCR monitoring may have prognostic impact in AML patients with NPM1 mutations.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N26ecce93a752495fa61cf225e746380b
44 N83003faf4e974b4bb4035aa346249bdb
45 sg:journal.1097065
46 schema:name Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations
47 schema:pagination 2404637
48 schema:productId N0b2e21ecb6f74182bbaa930ba08a3568
49 N43b80a44cd774a79aa05454d9ad97553
50 N5adcfefa3bba417c9e0916acb1672a1d
51 Nc46e9a1103674e2dae7a4eebc579b3e2
52 Nd6f9305c4df346f099e97d70ee0db0ce
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045479680
54 https://doi.org/10.1038/sj.leu.2404637
55 schema:sdDatePublished 2019-04-10T18:08
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N95278378f6b9452a80fa0a55f44e826f
58 schema:url http://www.nature.com/articles/2404637
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N0ac430b0f1044baaa3fd8807fcf5635c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Middle Aged
64 rdf:type schema:DefinedTerm
65 N0b2e21ecb6f74182bbaa930ba08a3568 schema:name readcube_id
66 schema:value d8a3862281978576dd047020fae6210f88b90431abc5ae68070cd216198aef44
67 rdf:type schema:PropertyValue
68 N11d003d43db44f76b6e1681a171b43fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Female
70 rdf:type schema:DefinedTerm
71 N1379abf8bb104e24b19ce9b8dc7fa161 rdf:first sg:person.01061277343.50
72 rdf:rest N49609bbe9041493792722b01fa8259f8
73 N13c88e0625fb4a10b96a5637909cb148 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Male
75 rdf:type schema:DefinedTerm
76 N1c6881c640c84fccb79f393b40e711d2 rdf:first sg:person.01365321011.16
77 rdf:rest N6cd2dcc2ce5f4792b868211cc52b8d9e
78 N26ecce93a752495fa61cf225e746380b schema:issueNumber 5
79 rdf:type schema:PublicationIssue
80 N3440a95845a1459f9056347d0e32e2cd rdf:first sg:person.012155533514.10
81 rdf:rest N6a7fa4bb79304d81b37af433b41e4e2d
82 N3980b6092998459293a69dac70f8cc5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Adolescent
84 rdf:type schema:DefinedTerm
85 N3f244126267146b99548cf833861918d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Nuclear Proteins
87 rdf:type schema:DefinedTerm
88 N43b80a44cd774a79aa05454d9ad97553 schema:name pubmed_id
89 schema:value 17361227
90 rdf:type schema:PropertyValue
91 N47395e9289e34432a86708a480dca539 rdf:first sg:person.0646462116.10
92 rdf:rest N3440a95845a1459f9056347d0e32e2cd
93 N49609bbe9041493792722b01fa8259f8 rdf:first sg:person.011336406464.70
94 rdf:rest Na29acf86e0934d678da610c6874c72a1
95 N508f6cfb5c6c412b9e9acc39d7f8c0d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N537f8f6bb8ee49d8a3bbacee48e91ff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Aged, 80 and over
100 rdf:type schema:DefinedTerm
101 N5adcfefa3bba417c9e0916acb1672a1d schema:name doi
102 schema:value 10.1038/sj.leu.2404637
103 rdf:type schema:PropertyValue
104 N5eb8a3554532496aa352f0c1df626c15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Mutation
106 rdf:type schema:DefinedTerm
107 N63657ae4f4d446e794eb36fc03ed652b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Neoplasm, Residual
109 rdf:type schema:DefinedTerm
110 N6a7fa4bb79304d81b37af433b41e4e2d rdf:first sg:person.016440556640.94
111 rdf:rest Ne0f82316dbe14ad6976aa9527dcab700
112 N6cd2dcc2ce5f4792b868211cc52b8d9e rdf:first sg:person.013177614042.37
113 rdf:rest rdf:nil
114 N6ecc2124d17744aa8316d7373b6f082b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Leukemia, Myeloid, Acute
116 rdf:type schema:DefinedTerm
117 N773fd5dbc18c49d4b121c30569dbc5b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adult
119 rdf:type schema:DefinedTerm
120 N775c8c9129c54e1ba0319100b88ed465 rdf:first sg:person.0721210172.02
121 rdf:rest N47395e9289e34432a86708a480dca539
122 N83003faf4e974b4bb4035aa346249bdb schema:volumeNumber 21
123 rdf:type schema:PublicationVolume
124 N95278378f6b9452a80fa0a55f44e826f schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 Na29acf86e0934d678da610c6874c72a1 rdf:first sg:person.01363730643.29
127 rdf:rest N775c8c9129c54e1ba0319100b88ed465
128 Nc46e9a1103674e2dae7a4eebc579b3e2 schema:name nlm_unique_id
129 schema:value 8704895
130 rdf:type schema:PropertyValue
131 Ncecab71ac1f24d9cad340276ae33619c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Aged
133 rdf:type schema:DefinedTerm
134 Nd6f9305c4df346f099e97d70ee0db0ce schema:name dimensions_id
135 schema:value pub.1045479680
136 rdf:type schema:PropertyValue
137 Ne0f82316dbe14ad6976aa9527dcab700 rdf:first sg:person.01175525743.45
138 rdf:rest N1c6881c640c84fccb79f393b40e711d2
139 Ne539fdb60d7b48a0a08487adfc8964ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Polymerase Chain Reaction
141 rdf:type schema:DefinedTerm
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
146 schema:name Oncology and Carcinogenesis
147 rdf:type schema:DefinedTerm
148 sg:journal.1097065 schema:issn 0887-6924
149 1476-5551
150 schema:name Leukemia
151 rdf:type schema:Periodical
152 sg:person.01061277343.50 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
153 schema:familyName Chou
154 schema:givenName W-C
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061277343.50
156 rdf:type schema:Person
157 sg:person.011336406464.70 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
158 schema:familyName Tang
159 schema:givenName J-L
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011336406464.70
161 rdf:type schema:Person
162 sg:person.01175525743.45 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
163 schema:familyName Chen
164 schema:givenName C-Y
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175525743.45
166 rdf:type schema:Person
167 sg:person.012155533514.10 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
168 schema:familyName Huang
169 schema:givenName S-Y
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012155533514.10
171 rdf:type schema:Person
172 sg:person.013177614042.37 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
173 schema:familyName Tien
174 schema:givenName H-F
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013177614042.37
176 rdf:type schema:Person
177 sg:person.01363730643.29 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
178 schema:familyName Wu
179 schema:givenName S-J
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363730643.29
181 rdf:type schema:Person
182 sg:person.01365321011.16 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
183 schema:familyName Huang
184 schema:givenName C-F
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365321011.16
186 rdf:type schema:Person
187 sg:person.016440556640.94 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
188 schema:familyName Huang
189 schema:givenName K-C
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016440556640.94
191 rdf:type schema:Person
192 sg:person.0646462116.10 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
193 schema:familyName Yao
194 schema:givenName M
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646462116.10
196 rdf:type schema:Person
197 sg:person.0721210172.02 schema:affiliation https://www.grid.ac/institutes/grid.412094.a
198 schema:familyName Tsay
199 schema:givenName W
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721210172.02
201 rdf:type schema:Person
202 sg:pub.10.1007/bf02982571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043329204
203 https://doi.org/10.1007/bf02982571
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/sj.leu.2403809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040786175
206 https://doi.org/10.1038/sj.leu.2403809
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/sj.leu.2404149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014224898
209 https://doi.org/10.1038/sj.leu.2404149
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1056/nejmoa041974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020502159
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1158/0008-5472.can-05-4316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006184192
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1182/blood-2002-01-0195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010459142
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1182/blood-2003-03-0880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038155124
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1182/blood-2005-01-0178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014214168
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1182/blood-2005-02-0560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046903111
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1182/blood-2005-05-2164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031737858
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1182/blood-2005-05-2168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013848437
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1182/blood-2005-05-2174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022325658
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1182/blood-2005-06-2248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036438078
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1182/blood-2005-08-3167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001126578
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1182/blood-2006-03-007013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040935883
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1182/blood-2006-07-012252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034533794
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1182/blood.v100.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042949004
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1182/blood.v98.9.2651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009800834
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1200/jco.2003.03.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203486
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1200/jco.2003.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203515
244 rdf:type schema:CreativeWork
245 https://www.grid.ac/institutes/grid.412094.a schema:alternateName National Taiwan University Hospital
246 schema:name Department of Family Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
247 Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
248 Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...