Improvement of criteria for refractory cytopenia with multilineage dysplasia according to the WHO classification based on prognostic significance of morphological ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02-01

AUTHORS

A Matsuda, U Germing, I Jinnai, M Iwanaga, M Misumi, A Kuendgen, C Strupp, Y Miyazaki, H Tsushima, M Sakai, M Bessho, N Gattermann, C Aul, M Tomonaga

ABSTRACT

In the criteria of refractory cytopenia with multilineage dysplasia (RCMD) according to the WHO (World Health Organization) classification, the frequency threshold concerning dysplasia of each lineage was defined as 10%. To predict overall survival (OS) and leukemia-free survival (LFS) for patients with refractory anemia (RA) according to the French-American-British (FAB) classification, we investigated prognostic factors based on the morphological features of 100 Japanese and 87 German FAB-RA patients, excluding 5q-syndrome. In the univariate analysis of all patients, pseudo-Pelger–Huet anomalies ⩾10% (Pelger+), micromegakaryocytes ⩾10% (mMgk+), dysgranulopoiesis (dys G) ⩾10% and dysmegakaryopoiesis (dys Mgk) ⩾40% were unfavorable prognostic factors for OS and LFS (OS; P<0.001, LFS; P<0.001). The prognostic effects of the morphological features were similar in both Japanese and German patients. However, dys Mgk ⩾10% was not correlated with OS and LFS. In the multivariate analysis, mMgk+ and dys Mgk⩾40% were adverse prognostic factors for OS for all patients, and dys G ⩾10% and dys Mgk⩾40% were adverse prognostic factors for LFS for all patients. On the basis of the present analysis, we propose the following modified morphological criteria for RCMD. Modified RCMD should be defined as FAB-RA, excluding 5q-syndrome with dys G ⩾10%, dys Mgk⩾40% or mMgk+. More... »

PAGES

678-686

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2404571

DOI

http://dx.doi.org/10.1038/sj.leu.2404571

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17268513


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44 dies
45 dysgranulopoiesis
46 dysmegakaryopoiesis
47 dysplasia
48 effect
49 factors
50 features
51 frequency threshold
52 improvement
53 improvement of criteria
54 leukemia-free survival
55 lineages
56 morphological criteria
57 morphological features
58 multilineage dysplasia
59 multivariate analysis
60 overall survival
61 patients
62 present analysis
63 prognostic effect
64 prognostic factors
65 prognostic significance
66 pseudo-Pelger
67 refractory anemia
68 refractory cytopenia
69 significance
70 survival
71 threshold
72 unfavorable prognostic factor
73 univariate analysis
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