HLA-identical sibling allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning compared to autologous peripheral blood stem cell transplantation ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-11-23

AUTHORS

A-L Herr, M Labopin, D Blaise, N Milpied, M Potter, M Michallet, W Heit, F Ferrara, J Esteve, W Arcese, G Ehninger, J M Rowe, G Kobbe, A Rosselet, D Bunjes, B Rio, M Brune, A Nagler, N C Gorin, F Frassoni, V Rocha

ABSTRACT

We conducted a retrospective registry-based analysis to compare the outcome of 361 allogeneic human leukocyte antigen (HLA)-identical peripheral blood stem cell transplants (PBSCT) with reduced intensity conditioning (RIC) to that of 1369 autologous (auto) PBSCT in patients aged 50 years or older with de novo acute myeloid leukemia (AML), performed from 1997 until 2003 and reported to the European Group for Blood and Marrow Transplantation. Median age was 58 and 57 years in the RIC and auto groups, respectively. RIC patients had more advanced disease at the time of transplant. At a median follow-up of 24 months for RIC and 16 months for auto, multivariate analysis showed a lower risk for relapse (RR 0.77, P=0.013) without increased non-relapse mortality (NRM) in RIC patients (RR 1.26, P=0.28). Moreover, leukemia-free survival (RR 1.22, P=0.02) and overall survival (OS) (RR 1.32, P=0.005) were superior in the RIC group. In patients in 1st (CR), fewer relapses were counterbalanced by significantly increased NRM. Therefore, there was no survival advantage in this subgroup. In patients in 2nd or subsequent CR, LFS and OS were superior in the RIC group. RIC transplants show encouraging results in this older patient population with de novo AML. More... »

PAGES

129-135

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2404461

DOI

http://dx.doi.org/10.1038/sj.leu.2404461

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049155895

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17128198


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397 grid-institutes:grid.418443.e schema:alternateName Institut Paoli Calmettes, Marseille, France
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406 grid-institutes:grid.8515.9 schema:alternateName Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
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