Ontology type: schema:ScholarlyArticle Open Access: True
2006-09
AUTHORSA Delannoy, E Delabesse, V Lhéritier, S Castaigne, F Rigal-Huguet, E Raffoux, F Garban, O Legrand, S Bologna, V Dubruille, P Turlure, O Reman, M Delain, F Isnard, D Coso, P Raby, A Buzyn, S Caillères, S Darre, C Fohrer, A Sonet, C Bilhou-Nabera, M-C Béné, H Dombret, P Berthaud, X Thomas
ABSTRACTAcute lymphoblastic leukemia (ALL) in the elderly is characterized by its ominous prognosis. On the other hand, imatinib has demonstrated remarkable, although transient, activity in relapsed and refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL), which prompted us to assess the use of imatinib in previously untreated elderly patients. ALL patients aged 55 years or older were given steroids during 1 week. Ph+ve cases were then offered a chemotherapy-based induction followed by a consolidation phase with imatinib and steroids during 2 months. Patients in complete response (CR) after consolidation were given 10 maintenance blocks of alternating chemotherapy, including two additional 2-month blocks of imatinib. Thirty patients were included in this study and are compared with 21 historical controls. Out of 29 assessable patients, 21 (72%, confidence interval (CI): 53-87%) were in CR after induction chemotherapy vs 6/21 (29%, CI: 11-52%) in controls (P=0.003). Five additional CRs were obtained after salvage with imatinib and four after salvage with additional chemotherapy in the control group. Overall survival (OS) is 66% at 1 year vs 43% in the control group (P=0.005). The 1-year relapse-free survival is 58 vs 11% (P=0.0003). The use of imatinib in elderly patients with Ph+ ALL is very likely to improve outcome, including OS. More... »
PAGES2404320
http://scigraph.springernature.com/pub.10.1038/sj.leu.2404320
DOIhttp://dx.doi.org/10.1038/sj.leu.2404320
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1038945339
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16838024
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Combined Chemotherapy Protocols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Benzamides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Imatinib Mesylate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methylprednisolone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Philadelphia Chromosome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Piperazines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pyrimidines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "H\u00f4pital de Jolimont",
"id": "https://www.grid.ac/institutes/grid.413908.7",
"name": [
"Department of Hematology, H\u00f4pital de Jolimont, Haine-Saint-Paul, Belgium"
],
"type": "Organization"
},
"familyName": "Delannoy",
"givenName": "A",
"id": "sg:person.01356023612.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356023612.38"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, CHU Paris-Necker, Paris, France"
],
"type": "Organization"
},
"familyName": "Delabesse",
"givenName": "E",
"id": "sg:person.01315504000.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315504000.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital \u00c9douard-Herriot",
"id": "https://www.grid.ac/institutes/grid.412180.e",
"name": [
"Department of Hematology, H\u00f4pital E Herriot, Lyon, France"
],
"type": "Organization"
},
"familyName": "Lh\u00e9ritier",
"givenName": "V",
"id": "sg:person.0663562516.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663562516.30"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, H\u00f4pital A Mignot, Versailles, France"
],
"type": "Organization"
},
"familyName": "Castaigne",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Purpan",
"id": "https://www.grid.ac/institutes/grid.414282.9",
"name": [
"Department of Hematology, H\u00f4pital Purpan, Toulouse, France"
],
"type": "Organization"
},
"familyName": "Rigal-Huguet",
"givenName": "F",
"id": "sg:person.01055667712.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055667712.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint-Louis",
"id": "https://www.grid.ac/institutes/grid.413328.f",
"name": [
"Department of Hematology, H\u00f4pital Saint-Louis, Paris, France"
],
"type": "Organization"
},
"familyName": "Raffoux",
"givenName": "E",
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Albert Michallon",
"id": "https://www.grid.ac/institutes/grid.413746.3",
"name": [
"Department of Hematology, H\u00f4pital Michallon, Grenoble, France"
],
"type": "Organization"
},
"familyName": "Garban",
"givenName": "F",
"id": "sg:person.01366260561.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366260561.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4tel-Dieu de Paris",
"id": "https://www.grid.ac/institutes/grid.411394.a",
"name": [
"Department of Hematology, H\u00f4tel-Dieu, Paris, France"
],
"type": "Organization"
},
"familyName": "Legrand",
"givenName": "O",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nancy",
"id": "https://www.grid.ac/institutes/grid.410527.5",
"name": [
"Department of Hematology, CHU Nancy Brabois, Nancy, France"
],
"type": "Organization"
},
"familyName": "Bologna",
"givenName": "S",
"id": "sg:person.0600754152.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600754152.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nantes",
"id": "https://www.grid.ac/institutes/grid.277151.7",
"name": [
"Department of Hematology, H\u00f4tel-Dieu, Nantes, France"
],
"type": "Organization"
},
"familyName": "Dubruille",
"givenName": "V",
"id": "sg:person.01152406105.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152406105.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Universitaire Dupuytren",
"id": "https://www.grid.ac/institutes/grid.412212.6",
"name": [
"Department of Hematology, H\u00f4pital Dupuytren, Limoges, France"
],
"type": "Organization"
},
"familyName": "Turlure",
"givenName": "P",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Caen",
"id": "https://www.grid.ac/institutes/grid.411149.8",
"name": [
"Department of Hematology, CHU de Caen, Caen, France"
],
"type": "Organization"
},
"familyName": "Reman",
"givenName": "O",
"id": "sg:person.0735534523.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735534523.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Bretonneau Hospital",
"id": "https://www.grid.ac/institutes/grid.411777.3",
"name": [
"Department of Hematology, H\u00f4pital Bretonneau, Tours, France"
],
"type": "Organization"
},
"familyName": "Delain",
"givenName": "M",
"id": "sg:person.0774655407.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774655407.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint-Antoine",
"id": "https://www.grid.ac/institutes/grid.412370.3",
"name": [
"Department of Hematology, H\u00f4pital Saint-Antoine, Paris, France"
],
"type": "Organization"
},
"familyName": "Isnard",
"givenName": "F",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute Paoli-Calmettes",
"id": "https://www.grid.ac/institutes/grid.418443.e",
"name": [
"Department of Hematology, Institut Paoli Calmettes, Marseille, France"
],
"type": "Organization"
},
"familyName": "Coso",
"givenName": "D",
"id": "sg:person.01335532730.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335532730.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hopitaux Civils de Colmar",
"id": "https://www.grid.ac/institutes/grid.477063.1",
"name": [
"Department of Hematology, H\u00f4pital L Pasteur, Colmar, France"
],
"type": "Organization"
},
"familyName": "Raby",
"givenName": "P",
"id": "sg:person.0702305407.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702305407.07"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, CHU Paris-Necker, Paris, France"
],
"type": "Organization"
},
"familyName": "Buzyn",
"givenName": "A",
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, CH d'Aix, Aix-en-Provence, France"
],
"type": "Organization"
},
"familyName": "Caill\u00e8res",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, H\u00f4pital C Huriez, Lille, France"
],
"type": "Organization"
},
"familyName": "Darre",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital d'Hautepierre",
"id": "https://www.grid.ac/institutes/grid.412201.4",
"name": [
"Department of Hematology, H\u00f4pital de Hautepierre, Strasbourg, France"
],
"type": "Organization"
},
"familyName": "Fohrer",
"givenName": "C",
"id": "sg:person.01156224135.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156224135.41"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, Cliniques Universitaires de Godinne, Yvoir, Belgium"
],
"type": "Organization"
},
"familyName": "Sonet",
"givenName": "A",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Bordeaux",
"id": "https://www.grid.ac/institutes/grid.42399.35",
"name": [
"Department of Hematology, CHU du Haut-Lev\u00eaque, Bordeaux, France"
],
"type": "Organization"
},
"familyName": "Bilhou-Nabera",
"givenName": "C",
"id": "sg:person.01242274170.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242274170.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire de Nancy",
"id": "https://www.grid.ac/institutes/grid.410527.5",
"name": [
"Department of Hematology, CHU Nancy Brabois, Nancy, France"
],
"type": "Organization"
},
"familyName": "B\u00e9n\u00e9",
"givenName": "M-C",
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital Saint-Louis",
"id": "https://www.grid.ac/institutes/grid.413328.f",
"name": [
"Department of Hematology, H\u00f4pital Saint-Louis, Paris, France"
],
"type": "Organization"
},
"familyName": "Dombret",
"givenName": "H",
"id": "sg:person.01036301740.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036301740.76"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Hematology, Novartis Pharma, Rueil Malmaison, France"
],
"type": "Organization"
},
"familyName": "Berthaud",
"givenName": "P",
"type": "Person"
},
{
"affiliation": {
"alternateName": "H\u00f4pital \u00c9douard-Herriot",
"id": "https://www.grid.ac/institutes/grid.412180.e",
"name": [
"Department of Hematology, H\u00f4pital E Herriot, Lyon, France"
],
"type": "Organization"
},
"familyName": "Thomas",
"givenName": "X",
"id": "sg:person.01271000165.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271000165.93"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1182/blood.v99.3.863",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001902996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2004-04-1389",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005287265"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2002-02-0360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011457668"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011922060",
"https://doi.org/10.1038/sj.leu.2403683"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2403683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011922060",
"https://doi.org/10.1038/sj.leu.2403683"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/10428190210180",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025172729"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2001-12-0181",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037468135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2003-08-2958",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048680812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2002-03-0704",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052893055"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/01621459.1958.10501452",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058299418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/10245330400001983",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058357892"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074699260",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082877385",
"type": "CreativeWork"
}
],
"datePublished": "2006-09",
"datePublishedReg": "2006-09-01",
"description": "Acute lymphoblastic leukemia (ALL) in the elderly is characterized by its ominous prognosis. On the other hand, imatinib has demonstrated remarkable, although transient, activity in relapsed and refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL), which prompted us to assess the use of imatinib in previously untreated elderly patients. ALL patients aged 55 years or older were given steroids during 1 week. Ph+ve cases were then offered a chemotherapy-based induction followed by a consolidation phase with imatinib and steroids during 2 months. Patients in complete response (CR) after consolidation were given 10 maintenance blocks of alternating chemotherapy, including two additional 2-month blocks of imatinib. Thirty patients were included in this study and are compared with 21 historical controls. Out of 29 assessable patients, 21 (72%, confidence interval (CI): 53-87%) were in CR after induction chemotherapy vs 6/21 (29%, CI: 11-52%) in controls (P=0.003). Five additional CRs were obtained after salvage with imatinib and four after salvage with additional chemotherapy in the control group. Overall survival (OS) is 66% at 1 year vs 43% in the control group (P=0.005). The 1-year relapse-free survival is 58 vs 11% (P=0.0003). The use of imatinib in elderly patients with Ph+ ALL is very likely to improve outcome, including OS.",
"genre": "research_article",
"id": "sg:pub.10.1038/sj.leu.2404320",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1097065",
"issn": [
"0887-6924",
"1476-5551"
],
"name": "Leukemia",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "20"
}
],
"name": "Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: results of the GRAALL AFR09 study",
"pagination": "2404320",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b983f0f0ce3c61168c641a1006b6981458f656074165a2a74451cf8c3884157b"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16838024"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8704895"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.leu.2404320"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1038945339"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.leu.2404320",
"https://app.dimensions.ai/details/publication/pub.1038945339"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:13",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53998_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/2404320"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
This table displays all metadata directly associated to this object as RDF triples.
379 TRIPLES
21 PREDICATES
54 URIs
34 LITERALS
22 BLANK NODES