Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: results of the ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07-13

AUTHORS

A Delannoy, E Delabesse, V Lhéritier, S Castaigne, F Rigal-Huguet, E Raffoux, F Garban, O Legrand, S Bologna, V Dubruille, P Turlure, O Reman, M Delain, F Isnard, D Coso, P Raby, A Buzyn, S Caillères, S Darre, C Fohrer, A Sonet, C Bilhou-Nabera, M-C Béné, H Dombret, P Berthaud, X Thomas

ABSTRACT

Acute lymphoblastic leukemia (ALL) in the elderly is characterized by its ominous prognosis. On the other hand, imatinib has demonstrated remarkable, although transient, activity in relapsed and refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL), which prompted us to assess the use of imatinib in previously untreated elderly patients. ALL patients aged 55 years or older were given steroids during 1 week. Ph+ve cases were then offered a chemotherapy-based induction followed by a consolidation phase with imatinib and steroids during 2 months. Patients in complete response (CR) after consolidation were given 10 maintenance blocks of alternating chemotherapy, including two additional 2-month blocks of imatinib. Thirty patients were included in this study and are compared with 21 historical controls. Out of 29 assessable patients, 21 (72%, confidence interval (CI): 53–87%) were in CR after induction chemotherapy vs 6/21 (29%, CI: 11–52%) in controls (P=0.003). Five additional CRs were obtained after salvage with imatinib and four after salvage with additional chemotherapy in the control group. Overall survival (OS) is 66% at 1 year vs 43% in the control group (P=0.005). The 1-year relapse-free survival is 58 vs 11% (P=0.0003). The use of imatinib in elderly patients with Ph+ ALL is very likely to improve outcome, including OS. More... »

PAGES

1526-1532

Journal

TITLE

Leukemia

ISSUE

9

VOLUME

20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2404320

DOI

http://dx.doi.org/10.1038/sj.leu.2404320

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038945339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16838024


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371 schema:name Department of Hematology, Hôpital Michallon, Grenoble, France
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373 grid-institutes:grid.413908.7 schema:alternateName Department of Hematology, Hôpital de Jolimont, Haine-Saint-Paul, Belgium
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376 grid-institutes:grid.414282.9 schema:alternateName Department of Hematology, Hôpital Purpan, Toulouse, France
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379 grid-institutes:grid.418443.e schema:alternateName Department of Hematology, Institut Paoli Calmettes, Marseille, France
380 schema:name Department of Hematology, Institut Paoli Calmettes, Marseille, France
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382 grid-institutes:grid.42399.35 schema:alternateName Department of Hematology, CHU du Haut-Levêque, Bordeaux, France
383 schema:name Department of Hematology, CHU du Haut-Levêque, Bordeaux, France
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385 grid-institutes:grid.477063.1 schema:alternateName Department of Hematology, Hôpital L Pasteur, Colmar, France
386 schema:name Department of Hematology, Hôpital L Pasteur, Colmar, France
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