Ontology type: schema:ScholarlyArticle
2006-07-13
AUTHORSA Delannoy, E Delabesse, V Lhéritier, S Castaigne, F Rigal-Huguet, E Raffoux, F Garban, O Legrand, S Bologna, V Dubruille, P Turlure, O Reman, M Delain, F Isnard, D Coso, P Raby, A Buzyn, S Caillères, S Darre, C Fohrer, A Sonet, C Bilhou-Nabera, M-C Béné, H Dombret, P Berthaud, X Thomas
ABSTRACTAcute lymphoblastic leukemia (ALL) in the elderly is characterized by its ominous prognosis. On the other hand, imatinib has demonstrated remarkable, although transient, activity in relapsed and refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL), which prompted us to assess the use of imatinib in previously untreated elderly patients. ALL patients aged 55 years or older were given steroids during 1 week. Ph+ve cases were then offered a chemotherapy-based induction followed by a consolidation phase with imatinib and steroids during 2 months. Patients in complete response (CR) after consolidation were given 10 maintenance blocks of alternating chemotherapy, including two additional 2-month blocks of imatinib. Thirty patients were included in this study and are compared with 21 historical controls. Out of 29 assessable patients, 21 (72%, confidence interval (CI): 53–87%) were in CR after induction chemotherapy vs 6/21 (29%, CI: 11–52%) in controls (P=0.003). Five additional CRs were obtained after salvage with imatinib and four after salvage with additional chemotherapy in the control group. Overall survival (OS) is 66% at 1 year vs 43% in the control group (P=0.005). The 1-year relapse-free survival is 58 vs 11% (P=0.0003). The use of imatinib in elderly patients with Ph+ ALL is very likely to improve outcome, including OS. More... »
PAGES1526-1532
http://scigraph.springernature.com/pub.10.1038/sj.leu.2404320
DOIhttp://dx.doi.org/10.1038/sj.leu.2404320
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16838024
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