Ontology type: schema:ScholarlyArticle
2006-07-13
AUTHORSA Delannoy, E Delabesse, V Lhéritier, S Castaigne, F Rigal-Huguet, E Raffoux, F Garban, O Legrand, S Bologna, V Dubruille, P Turlure, O Reman, M Delain, F Isnard, D Coso, P Raby, A Buzyn, S Caillères, S Darre, C Fohrer, A Sonet, C Bilhou-Nabera, M-C Béné, H Dombret, P Berthaud, X Thomas
ABSTRACTAcute lymphoblastic leukemia (ALL) in the elderly is characterized by its ominous prognosis. On the other hand, imatinib has demonstrated remarkable, although transient, activity in relapsed and refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL), which prompted us to assess the use of imatinib in previously untreated elderly patients. ALL patients aged 55 years or older were given steroids during 1 week. Ph+ve cases were then offered a chemotherapy-based induction followed by a consolidation phase with imatinib and steroids during 2 months. Patients in complete response (CR) after consolidation were given 10 maintenance blocks of alternating chemotherapy, including two additional 2-month blocks of imatinib. Thirty patients were included in this study and are compared with 21 historical controls. Out of 29 assessable patients, 21 (72%, confidence interval (CI): 53–87%) were in CR after induction chemotherapy vs 6/21 (29%, CI: 11–52%) in controls (P=0.003). Five additional CRs were obtained after salvage with imatinib and four after salvage with additional chemotherapy in the control group. Overall survival (OS) is 66% at 1 year vs 43% in the control group (P=0.005). The 1-year relapse-free survival is 58 vs 11% (P=0.0003). The use of imatinib in elderly patients with Ph+ ALL is very likely to improve outcome, including OS. More... »
PAGES1526-1532
http://scigraph.springernature.com/pub.10.1038/sj.leu.2404320
DOIhttp://dx.doi.org/10.1038/sj.leu.2404320
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1038945339
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16838024
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Combined Chemotherapy Protocols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Benzamides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Imatinib Mesylate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methylprednisolone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Philadelphia Chromosome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Piperazines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pyrimidines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital de Jolimont, Haine-Saint-Paul, Belgium",
"id": "http://www.grid.ac/institutes/grid.413908.7",
"name": [
"Department of Hematology, H\u00f4pital de Jolimont, Haine-Saint-Paul, Belgium"
],
"type": "Organization"
},
"familyName": "Delannoy",
"givenName": "A",
"id": "sg:person.01356023612.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356023612.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, CHU Paris-Necker, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, CHU Paris-Necker, Paris, France"
],
"type": "Organization"
},
"familyName": "Delabesse",
"givenName": "E",
"id": "sg:person.01315504000.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315504000.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital E Herriot, Lyon, France",
"id": "http://www.grid.ac/institutes/grid.412180.e",
"name": [
"Department of Hematology, H\u00f4pital E Herriot, Lyon, France"
],
"type": "Organization"
},
"familyName": "Lh\u00e9ritier",
"givenName": "V",
"id": "sg:person.0663562516.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663562516.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital A Mignot, Versailles, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, H\u00f4pital A Mignot, Versailles, France"
],
"type": "Organization"
},
"familyName": "Castaigne",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital Purpan, Toulouse, France",
"id": "http://www.grid.ac/institutes/grid.414282.9",
"name": [
"Department of Hematology, H\u00f4pital Purpan, Toulouse, France"
],
"type": "Organization"
},
"familyName": "Rigal-Huguet",
"givenName": "F",
"id": "sg:person.01055667712.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055667712.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital Saint-Louis, Paris, France",
"id": "http://www.grid.ac/institutes/grid.413328.f",
"name": [
"Department of Hematology, H\u00f4pital Saint-Louis, Paris, France"
],
"type": "Organization"
},
"familyName": "Raffoux",
"givenName": "E",
"id": "sg:person.01241622025.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241622025.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital Michallon, Grenoble, France",
"id": "http://www.grid.ac/institutes/grid.413746.3",
"name": [
"Department of Hematology, H\u00f4pital Michallon, Grenoble, France"
],
"type": "Organization"
},
"familyName": "Garban",
"givenName": "F",
"id": "sg:person.01366260561.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366260561.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4tel-Dieu, Paris, France",
"id": "http://www.grid.ac/institutes/grid.411394.a",
"name": [
"Department of Hematology, H\u00f4tel-Dieu, Paris, France"
],
"type": "Organization"
},
"familyName": "Legrand",
"givenName": "O",
"id": "sg:person.0752753564.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752753564.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, CHU Nancy Brabois, Nancy, France",
"id": "http://www.grid.ac/institutes/grid.410527.5",
"name": [
"Department of Hematology, CHU Nancy Brabois, Nancy, France"
],
"type": "Organization"
},
"familyName": "Bologna",
"givenName": "S",
"id": "sg:person.0600754152.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600754152.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4tel-Dieu, Nantes, France",
"id": "http://www.grid.ac/institutes/grid.277151.7",
"name": [
"Department of Hematology, H\u00f4tel-Dieu, Nantes, France"
],
"type": "Organization"
},
"familyName": "Dubruille",
"givenName": "V",
"id": "sg:person.01152406105.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152406105.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital Dupuytren, Limoges, France",
"id": "http://www.grid.ac/institutes/grid.412212.6",
"name": [
"Department of Hematology, H\u00f4pital Dupuytren, Limoges, France"
],
"type": "Organization"
},
"familyName": "Turlure",
"givenName": "P",
"id": "sg:person.01050653075.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050653075.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, CHU de Caen, Caen, France",
"id": "http://www.grid.ac/institutes/grid.411149.8",
"name": [
"Department of Hematology, CHU de Caen, Caen, France"
],
"type": "Organization"
},
"familyName": "Reman",
"givenName": "O",
"id": "sg:person.0735534523.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735534523.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital Bretonneau, Tours, France",
"id": "http://www.grid.ac/institutes/grid.411777.3",
"name": [
"Department of Hematology, H\u00f4pital Bretonneau, Tours, France"
],
"type": "Organization"
},
"familyName": "Delain",
"givenName": "M",
"id": "sg:person.0774655407.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774655407.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital Saint-Antoine, Paris, France",
"id": "http://www.grid.ac/institutes/grid.412370.3",
"name": [
"Department of Hematology, H\u00f4pital Saint-Antoine, Paris, France"
],
"type": "Organization"
},
"familyName": "Isnard",
"givenName": "F",
"id": "sg:person.010506014074.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010506014074.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Institut Paoli Calmettes, Marseille, France",
"id": "http://www.grid.ac/institutes/grid.418443.e",
"name": [
"Department of Hematology, Institut Paoli Calmettes, Marseille, France"
],
"type": "Organization"
},
"familyName": "Coso",
"givenName": "D",
"id": "sg:person.01335532730.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335532730.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital L Pasteur, Colmar, France",
"id": "http://www.grid.ac/institutes/grid.477063.1",
"name": [
"Department of Hematology, H\u00f4pital L Pasteur, Colmar, France"
],
"type": "Organization"
},
"familyName": "Raby",
"givenName": "P",
"id": "sg:person.0702305407.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702305407.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, CHU Paris-Necker, Paris, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, CHU Paris-Necker, Paris, France"
],
"type": "Organization"
},
"familyName": "Buzyn",
"givenName": "A",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, CH d'Aix, Aix-en-Provence, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, CH d'Aix, Aix-en-Provence, France"
],
"type": "Organization"
},
"familyName": "Caill\u00e8res",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital C Huriez, Lille, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, H\u00f4pital C Huriez, Lille, France"
],
"type": "Organization"
},
"familyName": "Darre",
"givenName": "S",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital de Hautepierre, Strasbourg, France",
"id": "http://www.grid.ac/institutes/grid.412201.4",
"name": [
"Department of Hematology, H\u00f4pital de Hautepierre, Strasbourg, France"
],
"type": "Organization"
},
"familyName": "Fohrer",
"givenName": "C",
"id": "sg:person.01156224135.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156224135.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Cliniques Universitaires de Godinne, Yvoir, Belgium",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Cliniques Universitaires de Godinne, Yvoir, Belgium"
],
"type": "Organization"
},
"familyName": "Sonet",
"givenName": "A",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, CHU du Haut-Lev\u00eaque, Bordeaux, France",
"id": "http://www.grid.ac/institutes/grid.42399.35",
"name": [
"Department of Hematology, CHU du Haut-Lev\u00eaque, Bordeaux, France"
],
"type": "Organization"
},
"familyName": "Bilhou-Nabera",
"givenName": "C",
"id": "sg:person.01242274170.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242274170.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, CHU Nancy Brabois, Nancy, France",
"id": "http://www.grid.ac/institutes/grid.410527.5",
"name": [
"Department of Hematology, CHU Nancy Brabois, Nancy, France"
],
"type": "Organization"
},
"familyName": "B\u00e9n\u00e9",
"givenName": "M-C",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital Saint-Louis, Paris, France",
"id": "http://www.grid.ac/institutes/grid.413328.f",
"name": [
"Department of Hematology, H\u00f4pital Saint-Louis, Paris, France"
],
"type": "Organization"
},
"familyName": "Dombret",
"givenName": "H",
"id": "sg:person.01036301740.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036301740.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Novartis Pharma, Rueil Malmaison, France",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Novartis Pharma, Rueil Malmaison, France"
],
"type": "Organization"
},
"familyName": "Berthaud",
"givenName": "P",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, H\u00f4pital E Herriot, Lyon, France",
"id": "http://www.grid.ac/institutes/grid.412180.e",
"name": [
"Department of Hematology, H\u00f4pital E Herriot, Lyon, France"
],
"type": "Organization"
},
"familyName": "Thomas",
"givenName": "X",
"id": "sg:person.01271000165.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271000165.93"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/sj.leu.2403683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011922060",
"https://doi.org/10.1038/sj.leu.2403683"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-07-13",
"datePublishedReg": "2006-07-13",
"description": "Acute lymphoblastic leukemia (ALL) in the elderly is characterized by its ominous prognosis. On the other hand, imatinib has demonstrated remarkable, although transient, activity in relapsed and refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL), which prompted us to assess the use of imatinib in previously untreated elderly patients. ALL patients aged 55 years or older were given steroids during 1 week. Ph+ve cases were then offered a chemotherapy-based induction followed by a consolidation phase with imatinib and steroids during 2 months. Patients in complete response (CR) after consolidation were given 10 maintenance blocks of alternating chemotherapy, including two additional 2-month blocks of imatinib. Thirty patients were included in this study and are compared with 21 historical controls. Out of 29 assessable patients, 21 (72%, confidence interval (CI): 53\u201387%) were in CR after induction chemotherapy vs 6/21 (29%, CI: 11\u201352%) in controls (P=0.003). Five additional CRs were obtained after salvage with imatinib and four after salvage with additional chemotherapy in the control group. Overall survival (OS) is 66% at 1 year vs 43% in the control group (P=0.005). The 1-year relapse-free survival is 58 vs 11% (P=0.0003). The use of imatinib in elderly patients with Ph+ ALL is very likely to improve outcome, including OS.",
"genre": "article",
"id": "sg:pub.10.1038/sj.leu.2404320",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1097065",
"issn": [
"0887-6924",
"1476-5551"
],
"name": "Leukemia",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "20"
}
],
"keywords": [
"acute lymphoblastic leukemia",
"Philadelphia-positive acute lymphoblastic leukemia",
"use of imatinib",
"complete response",
"elderly patients",
"overall survival",
"lymphoblastic leukemia",
"control group",
"untreated elderly patients",
"additional complete response",
"relapse-free survival",
"assessable patients",
"induction chemotherapy",
"additional chemotherapy",
"ominous prognosis",
"historical controls",
"patients",
"imatinib",
"chemotherapy",
"leukemia",
"steroids",
"salvage",
"consolidation phase",
"survival",
"outcomes",
"methylprednisolone",
"prognosis",
"group",
"years",
"weeks",
"months",
"control",
"study",
"induction",
"use",
"response",
"activity",
"cases",
"block",
"consolidation",
"hand",
"results",
"phase"
],
"name": "Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: results of the GRAALL AFR09 study",
"pagination": "1526-1532",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1038945339"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/sj.leu.2404320"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16838024"
]
}
],
"sameAs": [
"https://doi.org/10.1038/sj.leu.2404320",
"https://app.dimensions.ai/details/publication/pub.1038945339"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:06",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_419.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/sj.leu.2404320"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404320'
This table displays all metadata directly associated to this object as RDF triples.
387 TRIPLES
22 PREDICATES
83 URIs
74 LITERALS
20 BLANK NODES