Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-09

AUTHORS

C Graux, J Cools, L Michaux, P Vandenberghe, A Hagemeijer

ABSTRACT

For long, T-cell acute lymphoblastic leukemia (T-ALL) remained in the shadow of precursor B-ALL because it was more seldom, and showed a normal karyotype in more than 50% of cases. The last decennia, intense research has been carried out on different fronts. On one side, development of normal thymocyte and its regulation mechanisms have been studied in multiple mouse models and subsequently validated. On the other side, molecular cytogenetics (fluorescence in situ hybridization) and mutation analysis revealed cytogenetically cryptic aberrations in almost all cases of T-ALL. Also, expression microarray analysis disclosed gene expression signatures that recapitulate specific stages of thymocyte development. Investigations are still very much actual, fed by the discovery of new genetic aberrations. In this review, we present a summary of the current cytogenetic changes associated with T-ALL. The genes deregulated by translocations or mutations appear to encode proteins that are also implicated in T-cell development, which prompted us to review the 'normal' and 'leukemogenic' functions of these transcription regulators. To conclude, we show that the paradigm of multistep leukemogenesis is very much applicable to T-ALL and that the different genetic insults collaborate to maintain self-renewal capacity, and induce proliferation and differentiation arrest of T-lymphoblasts. They also open perspectives for targeted therapies. More... »

PAGES

2404302

References to SciGraph publications

  • 2001-06. The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice in ONCOGENE
  • 2005-11. Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2000-08. SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression in NATURE IMMUNOLOGY
  • 2006-01. Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias in LEUKEMIA
  • 1999-01. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus in NATURE
  • 2006-05. The MLL recombinome of acute leukemias in LEUKEMIA
  • 1998-10. Multiple negative elements contribute to repression of the HOX11 proto-oncogene in ONCOGENE
  • 2001-10. A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia in LEUKEMIA
  • 2004-05. An overview of the basic helix-loop-helix proteins in GENOME BIOLOGY
  • 2005-08. G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia in ONCOGENE
  • 2005-02. e6-a2 BCR-ABL1 fusion in T-cell acute lymphoblastic leukemia in LEUKEMIA
  • 1999-11. The role of Homeobox genes in normal hematopoiesis and hematological malignancies in LEUKEMIA
  • 2005-03. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 1999. True in LEUKEMIA
  • 1994-04. Hox11 controls the genesis of the spleen in NATURE
  • 2003-05. Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG) in LEUKEMIA
  • 2003-06. Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development in LEUKEMIA
  • 2003-05. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells in NATURE
  • 1998. Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatric cases. in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2002-01. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia in NATURE GENETICS
  • 2005-03. NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance in LEUKEMIA
  • 2005-03. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias in LEUKEMIA
  • 2002-11. Disruption of the RanBP17/Hox11L2 region by recombination with the TCRδ locus in acute lymphoblastic leukemias with t(5;14)(q34;q11) in LEUKEMIA
  • 1995-02. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL in NATURE
  • 2000-08. Intertwining proteins in thymocyte development and cancer in NATURE IMMUNOLOGY
  • 1983-04. Somatic generation of antibody diversity in NATURE
  • 2005-11. CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes in LEUKEMIA
  • 1995-11. Altered Hox expression and segmental identity in Mll-mutant mice in NATURE
  • 2004-10. Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia in NATURE GENETICS
  • 2002-10. Development of αβ T cells in the human thymus in NATURE REVIEWS IMMUNOLOGY
  • 1997-01. HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.leu.2404302

    DOI

    http://dx.doi.org/10.1038/sj.leu.2404302

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007087640

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16826225


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Lineage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Aberrations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Homeobox", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia-Lymphoma, Adult T-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Tyrosine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Antigen, T-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thymus Gland", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Cliniques Universitaires Saint-Luc", 
              "id": "https://www.grid.ac/institutes/grid.48769.34", 
              "name": [
                "Department of Hematology, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Graux", 
            "givenName": "C", 
            "id": "sg:person.01257427235.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257427235.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Flanders Institute for Biotechnology", 
              "id": "https://www.grid.ac/institutes/grid.11486.3a", 
              "name": [
                "Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cools", 
            "givenName": "J", 
            "id": "sg:person.01367254577.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367254577.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Center for Human Genetics, University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Michaux", 
            "givenName": "L", 
            "id": "sg:person.01313166747.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313166747.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Center for Human Genetics, University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vandenberghe", 
            "givenName": "P", 
            "id": "sg:person.01253026177.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253026177.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "KU Leuven", 
              "id": "https://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Center for Human Genetics, University of Leuven, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hagemeijer", 
            "givenName": "A", 
            "id": "sg:person.01102221607.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102221607.57"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.leu.2402892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000009864", 
              "https://doi.org/10.1038/sj.leu.2402892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000009864", 
              "https://doi.org/10.1038/sj.leu.2402892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000203970", 
              "https://doi.org/10.1038/sj.leu.2403657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000203970", 
              "https://doi.org/10.1038/sj.leu.2403657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000325804", 
              "https://doi.org/10.1038/ng1425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000325804", 
              "https://doi.org/10.1038/ng1425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.2002.03850.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001696989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-04-1640", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001723076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.10.4804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003471963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-10-3900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005658770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra023001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005718906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-08-2438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006819700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.17.1.369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007112233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007131623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007176814", 
              "https://doi.org/10.1038/nri913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007176814", 
              "https://doi.org/10.1038/nri913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.05096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007366802", 
              "https://doi.org/10.1532/ijh97.05096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.05096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007366802", 
              "https://doi.org/10.1532/ijh97.05096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90292-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007711944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/385454a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008345653", 
              "https://doi.org/10.1038/385454a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008537155", 
              "https://doi.org/10.1038/sj.onc.1202078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008537155", 
              "https://doi.org/10.1038/sj.onc.1202078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80238-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008803131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00067-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008852336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(02)00032-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009156234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009567652", 
              "https://doi.org/10.1038/sj.leu.2403595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009567652", 
              "https://doi.org/10.1038/sj.leu.2403595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1044-5323(02)00065-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009572917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.23.021704.115747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009632362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-09-2913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010170710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.189.2.289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010331178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-01-0168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010704620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m209870200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011504518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/16.9.2408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012161439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012844405", 
              "https://doi.org/10.1038/sj.leu.2404008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012844405", 
              "https://doi.org/10.1038/sj.leu.2404008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.3.996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014057026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-9525(93)90209-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014683468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-11-3944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015484622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90289-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015652035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.23.11045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016446367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.172.9.5230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016497452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra052603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017360868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/16.11.3145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017509311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.17.12.7317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017547530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.22.012703.104753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017591971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424763", 
              "https://doi.org/10.1038/ni1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424763", 
              "https://doi.org/10.1038/ni1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1088547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018519577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/368747a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018774944", 
              "https://doi.org/10.1038/368747a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.17.2651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019160542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373432a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019482424", 
              "https://doi.org/10.1038/373432a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.15.7075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019671936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1034/j.1600-065x.2003.00013.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020028066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020235924", 
              "https://doi.org/10.1038/sj.leu.2402947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020235924", 
              "https://doi.org/10.1038/sj.leu.2402947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2004.07.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021173850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021413855", 
              "https://doi.org/10.1038/sj.leu.2404150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021413855", 
              "https://doi.org/10.1038/sj.leu.2404150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00741-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021817762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-5699(00)01744-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021847408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(02)00013-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022313571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(02)00013-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022313571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.9.5.2124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022896452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2004.05.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023684149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024497082", 
              "https://doi.org/10.1038/nature01587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024497082", 
              "https://doi.org/10.1038/nature01587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.7.3497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024581792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(00)00223-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024743252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/302575a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025246621", 
              "https://doi.org/10.1038/302575a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025508855", 
              "https://doi.org/10.1038/sj.leu.2401562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025508855", 
              "https://doi.org/10.1038/sj.leu.2401562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.06.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025556779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1050>3.0.co;2-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025639138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.2001.02586.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026537939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80054-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026877657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-12-4897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026983792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.12.8240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027289033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.176.5.1303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027295946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027750442", 
              "https://doi.org/10.1038/sj.onc.1204519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027750442", 
              "https://doi.org/10.1038/sj.onc.1204519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028468408", 
              "https://doi.org/10.1038/ng765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028468408", 
              "https://doi.org/10.1038/ng765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-03-0717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029898791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030084985", 
              "https://doi.org/10.1038/77881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030084985", 
              "https://doi.org/10.1038/77881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(02)00018-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030156052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.8.4107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030726927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90571-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030827577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.11090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031208881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032111723", 
              "https://doi.org/10.1038/sj.leu.2402671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032111723", 
              "https://doi.org/10.1038/sj.leu.2402671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergencyto.2005.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032513554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-09-2857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033109926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033156851", 
              "https://doi.org/10.1038/16476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033156851", 
              "https://doi.org/10.1038/16476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(97)01133-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033178806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1102160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033243130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-10-3221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033966736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/378505a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034280981", 
              "https://doi.org/10.1038/378505a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-06-2267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034400971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(03)00305-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034607211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.leukres.2004.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035272721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(02)00330-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035438570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2004.01.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035937353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2003.11.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037431643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403654", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037899461", 
              "https://doi.org/10.1038/sj.leu.2403654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403654", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037899461", 
              "https://doi.org/10.1038/sj.leu.2403654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.24.021605.090612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039207381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039524982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.174.4.867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039872673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.4.473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040333965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90404-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040542003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.20-5-364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040942278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(99)00038-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041076025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2004-5-6-226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041078460", 
              "https://doi.org/10.1186/gb-2004-5-6-226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1468-0734.2002.00069.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041513396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.24.10128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042593812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.13.3714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042631731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042917486", 
              "https://doi.org/10.1038/sj.leu.2402249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042917486", 
              "https://doi.org/10.1038/sj.leu.2402249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-05-1495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043030836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2003-07-2577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044326253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044704381", 
              "https://doi.org/10.1038/sj.leu.2403891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044704381", 
              "https://doi.org/10.1038/sj.leu.2403891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044803804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2001-11-0093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044993471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.2870030602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045866171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046329016", 
              "https://doi.org/10.1038/77819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046329016", 
              "https://doi.org/10.1038/77819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(02)00264-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047540455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.17.8.4782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047935175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.15.1.433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048560775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048979489", 
              "https://doi.org/10.1038/sj.onc.1208727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048979489", 
              "https://doi.org/10.1038/sj.onc.1208727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048979489", 
              "https://doi.org/10.1038/sj.onc.1208727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2004.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049337123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.2.655-664.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049628527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90111-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050537171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.183.5.2283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050837486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(04)15542-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051150833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.24.11416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051789765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052292788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.12.6939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052482451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052579019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0925-5710(98)00015-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054664140", 
              "https://doi.org/10.1016/s0925-5710(98)00015-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj/leu/2401562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056650536", 
              "https://doi.org/10.1038/sj/leu/2401562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1676542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062499466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5340.1059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062558563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5341.1309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062558683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.13.9.5620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062713584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074362856", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.1.191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074511226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074517587", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074608453", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074628563", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074641659", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075301786", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076569046", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077093338", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077853380", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07535.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078477442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078782349", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079010052", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082407074", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082414891", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082432373", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082432603", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082461551", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082559420", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082599627", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082626616", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082662173", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082670828", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082769692", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00439.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082877715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082885870", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082895236", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083008472", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083033962", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083157825", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083274036", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083288694", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2006-09", 
        "datePublishedReg": "2006-09-01", 
        "description": "For long, T-cell acute lymphoblastic leukemia (T-ALL) remained in the shadow of precursor B-ALL because it was more seldom, and showed a normal karyotype in more than 50% of cases. The last decennia, intense research has been carried out on different fronts. On one side, development of normal thymocyte and its regulation mechanisms have been studied in multiple mouse models and subsequently validated. On the other side, molecular cytogenetics (fluorescence in situ hybridization) and mutation analysis revealed cytogenetically cryptic aberrations in almost all cases of T-ALL. Also, expression microarray analysis disclosed gene expression signatures that recapitulate specific stages of thymocyte development. Investigations are still very much actual, fed by the discovery of new genetic aberrations. In this review, we present a summary of the current cytogenetic changes associated with T-ALL. The genes deregulated by translocations or mutations appear to encode proteins that are also implicated in T-cell development, which prompted us to review the 'normal' and 'leukemogenic' functions of these transcription regulators. To conclude, we show that the paradigm of multistep leukemogenesis is very much applicable to T-ALL and that the different genetic insults collaborate to maintain self-renewal capacity, and induce proliferation and differentiation arrest of T-lymphoblasts. They also open perspectives for targeted therapies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.leu.2404302", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1097065", 
            "issn": [
              "0887-6924", 
              "1476-5551"
            ], 
            "name": "Leukemia", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast", 
        "pagination": "2404302", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "21c31d6da42bf9df5a1d50afeca4d4ee1e9bfb64caeeadc22417cc6432fb527c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16826225"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8704895"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.leu.2404302"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007087640"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.leu.2404302", 
          "https://app.dimensions.ai/details/publication/pub.1007087640"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:10", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53977_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/2404302"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404302'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404302'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404302'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2404302'


     

    This table displays all metadata directly associated to this object as RDF triples.

    619 TRIPLES      21 PREDICATES      197 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.leu.2404302 schema:about N130b6361cbc242e9a536c120cc5d23a8
    2 N284f9a647cde45b2adc94376bd09716a
    3 N3c677a43304d43c786b5d34beb81c9c9
    4 N5287961e4d2b4bf0ac165d69de70c87a
    5 N5341fdbe35d6432bab11601a8063a6d4
    6 N7f62fcdf7fae4f169f9223f2e8c072b1
    7 Nacf49b8858f149aea00d7ea0d8aef044
    8 Nb5f4af76c1e448459b519d1a791b2361
    9 Nf2080e86c6bf44249bc2d022e9f82734
    10 Nf44ba90d176c4565b239d100fd9f6643
    11 anzsrc-for:06
    12 anzsrc-for:0604
    13 schema:author Ne2b737e02ca94d5aaf54c677c891745a
    14 schema:citation sg:pub.10.1016/s0925-5710(98)00015-2
    15 sg:pub.10.1038/16476
    16 sg:pub.10.1038/302575a0
    17 sg:pub.10.1038/368747a0
    18 sg:pub.10.1038/373432a0
    19 sg:pub.10.1038/378505a0
    20 sg:pub.10.1038/385454a0
    21 sg:pub.10.1038/77819
    22 sg:pub.10.1038/77881
    23 sg:pub.10.1038/nature01587
    24 sg:pub.10.1038/ng1425
    25 sg:pub.10.1038/ng765
    26 sg:pub.10.1038/ni1164
    27 sg:pub.10.1038/nri913
    28 sg:pub.10.1038/sj.leu.2401562
    29 sg:pub.10.1038/sj.leu.2402249
    30 sg:pub.10.1038/sj.leu.2402671
    31 sg:pub.10.1038/sj.leu.2402892
    32 sg:pub.10.1038/sj.leu.2402947
    33 sg:pub.10.1038/sj.leu.2403595
    34 sg:pub.10.1038/sj.leu.2403654
    35 sg:pub.10.1038/sj.leu.2403657
    36 sg:pub.10.1038/sj.leu.2403891
    37 sg:pub.10.1038/sj.leu.2404008
    38 sg:pub.10.1038/sj.leu.2404150
    39 sg:pub.10.1038/sj.onc.1202078
    40 sg:pub.10.1038/sj.onc.1204519
    41 sg:pub.10.1038/sj.onc.1208727
    42 sg:pub.10.1038/sj/leu/2401562
    43 sg:pub.10.1186/gb-2004-5-6-226
    44 sg:pub.10.1532/ijh97.05096
    45 https://app.dimensions.ai/details/publication/pub.1074362856
    46 https://app.dimensions.ai/details/publication/pub.1074517587
    47 https://app.dimensions.ai/details/publication/pub.1074608453
    48 https://app.dimensions.ai/details/publication/pub.1074628563
    49 https://app.dimensions.ai/details/publication/pub.1074641659
    50 https://app.dimensions.ai/details/publication/pub.1075301786
    51 https://app.dimensions.ai/details/publication/pub.1076569046
    52 https://app.dimensions.ai/details/publication/pub.1077093338
    53 https://app.dimensions.ai/details/publication/pub.1077853380
    54 https://app.dimensions.ai/details/publication/pub.1078782349
    55 https://app.dimensions.ai/details/publication/pub.1079010052
    56 https://app.dimensions.ai/details/publication/pub.1082407074
    57 https://app.dimensions.ai/details/publication/pub.1082414891
    58 https://app.dimensions.ai/details/publication/pub.1082432373
    59 https://app.dimensions.ai/details/publication/pub.1082432603
    60 https://app.dimensions.ai/details/publication/pub.1082461551
    61 https://app.dimensions.ai/details/publication/pub.1082559420
    62 https://app.dimensions.ai/details/publication/pub.1082599627
    63 https://app.dimensions.ai/details/publication/pub.1082626616
    64 https://app.dimensions.ai/details/publication/pub.1082662173
    65 https://app.dimensions.ai/details/publication/pub.1082670828
    66 https://app.dimensions.ai/details/publication/pub.1082769692
    67 https://app.dimensions.ai/details/publication/pub.1082885870
    68 https://app.dimensions.ai/details/publication/pub.1082895236
    69 https://app.dimensions.ai/details/publication/pub.1083008472
    70 https://app.dimensions.ai/details/publication/pub.1083033962
    71 https://app.dimensions.ai/details/publication/pub.1083157825
    72 https://app.dimensions.ai/details/publication/pub.1083274036
    73 https://app.dimensions.ai/details/publication/pub.1083288694
    74 https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1050>3.0.co;2-y
    75 https://doi.org/10.1002/cncr.11090
    76 https://doi.org/10.1002/gcc.20088
    77 https://doi.org/10.1002/gcc.2870030602
    78 https://doi.org/10.1002/j.1460-2075.1990.tb07535.x
    79 https://doi.org/10.1002/j.1460-2075.1996.tb00439.x
    80 https://doi.org/10.1016/0092-8674(89)90404-2
    81 https://doi.org/10.1016/0092-8674(91)90111-b
    82 https://doi.org/10.1016/0092-8674(94)90289-5
    83 https://doi.org/10.1016/0092-8674(94)90292-5
    84 https://doi.org/10.1016/0092-8674(94)90571-1
    85 https://doi.org/10.1016/0168-9525(93)90209-z
    86 https://doi.org/10.1016/j.bbrc.2003.11.030
    87 https://doi.org/10.1016/j.bbrc.2004.06.038
    88 https://doi.org/10.1016/j.cancergencyto.2005.04.002
    89 https://doi.org/10.1016/j.ccr.2004.05.023
    90 https://doi.org/10.1016/j.cub.2004.01.023
    91 https://doi.org/10.1016/j.cub.2004.07.012
    92 https://doi.org/10.1016/j.cub.2004.07.021
    93 https://doi.org/10.1016/j.leukres.2004.05.013
    94 https://doi.org/10.1016/s0140-6736(04)15542-6
    95 https://doi.org/10.1016/s0167-5699(00)01744-8
    96 https://doi.org/10.1016/s0168-9525(97)01133-5
    97 https://doi.org/10.1016/s0952-7915(00)00223-5
    98 https://doi.org/10.1016/s0959-437x(02)00013-8
    99 https://doi.org/10.1016/s0959-437x(99)00038-6
    100 https://doi.org/10.1016/s1044-5323(02)00065-9
    101 https://doi.org/10.1016/s1074-7613(00)00067-4
    102 https://doi.org/10.1016/s1074-7613(00)80054-0
    103 https://doi.org/10.1016/s1074-7613(00)80238-1
    104 https://doi.org/10.1016/s1074-7613(02)00264-9
    105 https://doi.org/10.1016/s1074-7613(02)00330-8
    106 https://doi.org/10.1016/s1097-2765(02)00741-4
    107 https://doi.org/10.1016/s1535-6108(02)00018-1
    108 https://doi.org/10.1016/s1535-6108(02)00032-6
    109 https://doi.org/10.1016/s1535-6108(03)00305-2
    110 https://doi.org/10.1034/j.1600-065x.2003.00013.x
    111 https://doi.org/10.1038/sj.emboj.7600017
    112 https://doi.org/10.1046/j.1365-2141.2001.02586.x
    113 https://doi.org/10.1046/j.1365-2141.2002.03850.x
    114 https://doi.org/10.1046/j.1468-0734.2002.00069.x
    115 https://doi.org/10.1056/nejmra023001
    116 https://doi.org/10.1056/nejmra052603
    117 https://doi.org/10.1073/pnas.86.24.10128
    118 https://doi.org/10.1073/pnas.88.24.11416
    119 https://doi.org/10.1073/pnas.91.23.11045
    120 https://doi.org/10.1073/pnas.92.15.7075
    121 https://doi.org/10.1073/pnas.93.10.4804
    122 https://doi.org/10.1073/pnas.96.3.996
    123 https://doi.org/10.1073/pnas.97.7.3497
    124 https://doi.org/10.1074/jbc.m209870200
    125 https://doi.org/10.1084/jem.174.4.867
    126 https://doi.org/10.1084/jem.176.5.1303
    127 https://doi.org/10.1084/jem.183.5.2283
    128 https://doi.org/10.1084/jem.189.2.289
    129 https://doi.org/10.1093/emboj/16.11.3145
    130 https://doi.org/10.1093/emboj/16.9.2408
    131 https://doi.org/10.1093/emboj/17.13.3714
    132 https://doi.org/10.1093/emboj/cdg567
    133 https://doi.org/10.1101/gad.12.17.2651
    134 https://doi.org/10.1101/gad.12.4.473
    135 https://doi.org/10.1126/science.1088547
    136 https://doi.org/10.1126/science.1102160
    137 https://doi.org/10.1126/science.1676542
    138 https://doi.org/10.1126/science.278.5340.1059
    139 https://doi.org/10.1126/science.278.5341.1309
    140 https://doi.org/10.1128/mcb.13.9.5620
    141 https://doi.org/10.1128/mcb.16.8.4107
    142 https://doi.org/10.1128/mcb.17.12.7317
    143 https://doi.org/10.1128/mcb.17.8.4782
    144 https://doi.org/10.1128/mcb.18.12.6939
    145 https://doi.org/10.1128/mcb.19.12.8240
    146 https://doi.org/10.1128/mcb.23.2.655-664.2003
    147 https://doi.org/10.1128/mcb.9.5.2124
    148 https://doi.org/10.1146/annurev.immunol.15.1.433
    149 https://doi.org/10.1146/annurev.immunol.17.1.369
    150 https://doi.org/10.1146/annurev.immunol.22.012703.104753
    151 https://doi.org/10.1146/annurev.immunol.23.021704.115747
    152 https://doi.org/10.1146/annurev.immunol.24.021605.090612
    153 https://doi.org/10.1158/0008-5472.can-03-1871
    154 https://doi.org/10.1182/blood-2001-11-0093
    155 https://doi.org/10.1182/blood-2002-03-0717
    156 https://doi.org/10.1182/blood-2002-08-2438
    157 https://doi.org/10.1182/blood-2002-09-2857
    158 https://doi.org/10.1182/blood-2002-09-2913
    159 https://doi.org/10.1182/blood-2002-10-3221
    160 https://doi.org/10.1182/blood-2003-05-1495
    161 https://doi.org/10.1182/blood-2003-07-2577
    162 https://doi.org/10.1182/blood-2003-11-3944
    163 https://doi.org/10.1182/blood-2004-01-0168
    164 https://doi.org/10.1182/blood-2004-10-3900
    165 https://doi.org/10.1182/blood-2004-12-4897
    166 https://doi.org/10.1182/blood-2005-04-1640
    167 https://doi.org/10.1182/blood-2005-06-2267
    168 https://doi.org/10.1200/jco.1999.17.1.191
    169 https://doi.org/10.1242/dev.01074
    170 https://doi.org/10.1634/stemcells.20-5-364
    171 https://doi.org/10.4049/jimmunol.172.9.5230
    172 schema:datePublished 2006-09
    173 schema:datePublishedReg 2006-09-01
    174 schema:description For long, T-cell acute lymphoblastic leukemia (T-ALL) remained in the shadow of precursor B-ALL because it was more seldom, and showed a normal karyotype in more than 50% of cases. The last decennia, intense research has been carried out on different fronts. On one side, development of normal thymocyte and its regulation mechanisms have been studied in multiple mouse models and subsequently validated. On the other side, molecular cytogenetics (fluorescence in situ hybridization) and mutation analysis revealed cytogenetically cryptic aberrations in almost all cases of T-ALL. Also, expression microarray analysis disclosed gene expression signatures that recapitulate specific stages of thymocyte development. Investigations are still very much actual, fed by the discovery of new genetic aberrations. In this review, we present a summary of the current cytogenetic changes associated with T-ALL. The genes deregulated by translocations or mutations appear to encode proteins that are also implicated in T-cell development, which prompted us to review the 'normal' and 'leukemogenic' functions of these transcription regulators. To conclude, we show that the paradigm of multistep leukemogenesis is very much applicable to T-ALL and that the different genetic insults collaborate to maintain self-renewal capacity, and induce proliferation and differentiation arrest of T-lymphoblasts. They also open perspectives for targeted therapies.
    175 schema:genre research_article
    176 schema:inLanguage en
    177 schema:isAccessibleForFree true
    178 schema:isPartOf N014ca955725f41dab217aab78a281370
    179 N0f40b38a5899425ab71bf3dc461b364c
    180 sg:journal.1097065
    181 schema:name Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast
    182 schema:pagination 2404302
    183 schema:productId N2c211c3768c64f34a3e23a4485265141
    184 N5c49e79a88824f0e95a43db6ae5a7297
    185 Nd052b258f13945b68b47d275671faae7
    186 Nd61ef349e42c4b8d996c4ab80776ca7f
    187 Ne84f149ea8064797bdc3053efa0b7b6a
    188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007087640
    189 https://doi.org/10.1038/sj.leu.2404302
    190 schema:sdDatePublished 2019-04-11T12:10
    191 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    192 schema:sdPublisher N13d0f62e435a409b94a0e0ffbf4684fd
    193 schema:url http://www.nature.com/articles/2404302
    194 sgo:license sg:explorer/license/
    195 sgo:sdDataset articles
    196 rdf:type schema:ScholarlyArticle
    197 N014ca955725f41dab217aab78a281370 schema:issueNumber 9
    198 rdf:type schema:PublicationIssue
    199 N0f40b38a5899425ab71bf3dc461b364c schema:volumeNumber 20
    200 rdf:type schema:PublicationVolume
    201 N130b6361cbc242e9a536c120cc5d23a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Cell Lineage
    203 rdf:type schema:DefinedTerm
    204 N13d0f62e435a409b94a0e0ffbf4684fd schema:name Springer Nature - SN SciGraph project
    205 rdf:type schema:Organization
    206 N161fc239164546159f7efe841a6b2311 rdf:first sg:person.01313166747.19
    207 rdf:rest N400bb4cd007848c3bc52c68390f06ae7
    208 N284f9a647cde45b2adc94376bd09716a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Signal Transduction
    210 rdf:type schema:DefinedTerm
    211 N2c211c3768c64f34a3e23a4485265141 schema:name doi
    212 schema:value 10.1038/sj.leu.2404302
    213 rdf:type schema:PropertyValue
    214 N3c677a43304d43c786b5d34beb81c9c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Lymphocytes
    216 rdf:type schema:DefinedTerm
    217 N400bb4cd007848c3bc52c68390f06ae7 rdf:first sg:person.01253026177.70
    218 rdf:rest Ndd1f8693fbf64da5abbf7d17819fe3b1
    219 N5287961e4d2b4bf0ac165d69de70c87a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Receptors, Antigen, T-Cell
    221 rdf:type schema:DefinedTerm
    222 N5341fdbe35d6432bab11601a8063a6d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Protein-Tyrosine Kinases
    224 rdf:type schema:DefinedTerm
    225 N5c49e79a88824f0e95a43db6ae5a7297 schema:name dimensions_id
    226 schema:value pub.1007087640
    227 rdf:type schema:PropertyValue
    228 N7f62fcdf7fae4f169f9223f2e8c072b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Chromosome Aberrations
    230 rdf:type schema:DefinedTerm
    231 N89226023c3da466f9bbd5ed458d4c1f4 rdf:first sg:person.01367254577.12
    232 rdf:rest N161fc239164546159f7efe841a6b2311
    233 Nacf49b8858f149aea00d7ea0d8aef044 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Genes, Homeobox
    235 rdf:type schema:DefinedTerm
    236 Nb5f4af76c1e448459b519d1a791b2361 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Humans
    238 rdf:type schema:DefinedTerm
    239 Nd052b258f13945b68b47d275671faae7 schema:name nlm_unique_id
    240 schema:value 8704895
    241 rdf:type schema:PropertyValue
    242 Nd61ef349e42c4b8d996c4ab80776ca7f schema:name readcube_id
    243 schema:value 21c31d6da42bf9df5a1d50afeca4d4ee1e9bfb64caeeadc22417cc6432fb527c
    244 rdf:type schema:PropertyValue
    245 Ndd1f8693fbf64da5abbf7d17819fe3b1 rdf:first sg:person.01102221607.57
    246 rdf:rest rdf:nil
    247 Ne2b737e02ca94d5aaf54c677c891745a rdf:first sg:person.01257427235.50
    248 rdf:rest N89226023c3da466f9bbd5ed458d4c1f4
    249 Ne84f149ea8064797bdc3053efa0b7b6a schema:name pubmed_id
    250 schema:value 16826225
    251 rdf:type schema:PropertyValue
    252 Nf2080e86c6bf44249bc2d022e9f82734 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name Leukemia-Lymphoma, Adult T-Cell
    254 rdf:type schema:DefinedTerm
    255 Nf44ba90d176c4565b239d100fd9f6643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Thymus Gland
    257 rdf:type schema:DefinedTerm
    258 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    259 schema:name Biological Sciences
    260 rdf:type schema:DefinedTerm
    261 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    262 schema:name Genetics
    263 rdf:type schema:DefinedTerm
    264 sg:journal.1097065 schema:issn 0887-6924
    265 1476-5551
    266 schema:name Leukemia
    267 rdf:type schema:Periodical
    268 sg:person.01102221607.57 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    269 schema:familyName Hagemeijer
    270 schema:givenName A
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102221607.57
    272 rdf:type schema:Person
    273 sg:person.01253026177.70 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    274 schema:familyName Vandenberghe
    275 schema:givenName P
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253026177.70
    277 rdf:type schema:Person
    278 sg:person.01257427235.50 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
    279 schema:familyName Graux
    280 schema:givenName C
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257427235.50
    282 rdf:type schema:Person
    283 sg:person.01313166747.19 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
    284 schema:familyName Michaux
    285 schema:givenName L
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313166747.19
    287 rdf:type schema:Person
    288 sg:person.01367254577.12 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
    289 schema:familyName Cools
    290 schema:givenName J
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367254577.12
    292 rdf:type schema:Person
    293 sg:pub.10.1016/s0925-5710(98)00015-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054664140
    294 https://doi.org/10.1016/s0925-5710(98)00015-2
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/16476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033156851
    297 https://doi.org/10.1038/16476
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/302575a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025246621
    300 https://doi.org/10.1038/302575a0
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/368747a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018774944
    303 https://doi.org/10.1038/368747a0
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/373432a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019482424
    306 https://doi.org/10.1038/373432a0
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/378505a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034280981
    309 https://doi.org/10.1038/378505a0
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/385454a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008345653
    312 https://doi.org/10.1038/385454a0
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/77819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046329016
    315 https://doi.org/10.1038/77819
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/77881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030084985
    318 https://doi.org/10.1038/77881
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nature01587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024497082
    321 https://doi.org/10.1038/nature01587
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/ng1425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000325804
    324 https://doi.org/10.1038/ng1425
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/ng765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028468408
    327 https://doi.org/10.1038/ng765
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/ni1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424763
    330 https://doi.org/10.1038/ni1164
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/nri913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007176814
    333 https://doi.org/10.1038/nri913
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/sj.leu.2401562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025508855
    336 https://doi.org/10.1038/sj.leu.2401562
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/sj.leu.2402249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042917486
    339 https://doi.org/10.1038/sj.leu.2402249
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/sj.leu.2402671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032111723
    342 https://doi.org/10.1038/sj.leu.2402671
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/sj.leu.2402892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000009864
    345 https://doi.org/10.1038/sj.leu.2402892
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/sj.leu.2402947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020235924
    348 https://doi.org/10.1038/sj.leu.2402947
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/sj.leu.2403595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009567652
    351 https://doi.org/10.1038/sj.leu.2403595
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/sj.leu.2403654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037899461
    354 https://doi.org/10.1038/sj.leu.2403654
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/sj.leu.2403657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000203970
    357 https://doi.org/10.1038/sj.leu.2403657
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/sj.leu.2403891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044704381
    360 https://doi.org/10.1038/sj.leu.2403891
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/sj.leu.2404008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012844405
    363 https://doi.org/10.1038/sj.leu.2404008
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/sj.leu.2404150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021413855
    366 https://doi.org/10.1038/sj.leu.2404150
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/sj.onc.1202078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008537155
    369 https://doi.org/10.1038/sj.onc.1202078
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/sj.onc.1204519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027750442
    372 https://doi.org/10.1038/sj.onc.1204519
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/sj.onc.1208727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048979489
    375 https://doi.org/10.1038/sj.onc.1208727
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/sj/leu/2401562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056650536
    378 https://doi.org/10.1038/sj/leu/2401562
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1186/gb-2004-5-6-226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041078460
    381 https://doi.org/10.1186/gb-2004-5-6-226
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1532/ijh97.05096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007366802
    384 https://doi.org/10.1532/ijh97.05096
    385 rdf:type schema:CreativeWork
    386 https://app.dimensions.ai/details/publication/pub.1074362856 schema:CreativeWork
    387 https://app.dimensions.ai/details/publication/pub.1074517587 schema:CreativeWork
    388 https://app.dimensions.ai/details/publication/pub.1074608453 schema:CreativeWork
    389 https://app.dimensions.ai/details/publication/pub.1074628563 schema:CreativeWork
    390 https://app.dimensions.ai/details/publication/pub.1074641659 schema:CreativeWork
    391 https://app.dimensions.ai/details/publication/pub.1075301786 schema:CreativeWork
    392 https://app.dimensions.ai/details/publication/pub.1076569046 schema:CreativeWork
    393 https://app.dimensions.ai/details/publication/pub.1077093338 schema:CreativeWork
    394 https://app.dimensions.ai/details/publication/pub.1077853380 schema:CreativeWork
    395 https://app.dimensions.ai/details/publication/pub.1078782349 schema:CreativeWork
    396 https://app.dimensions.ai/details/publication/pub.1079010052 schema:CreativeWork
    397 https://app.dimensions.ai/details/publication/pub.1082407074 schema:CreativeWork
    398 https://app.dimensions.ai/details/publication/pub.1082414891 schema:CreativeWork
    399 https://app.dimensions.ai/details/publication/pub.1082432373 schema:CreativeWork
    400 https://app.dimensions.ai/details/publication/pub.1082432603 schema:CreativeWork
    401 https://app.dimensions.ai/details/publication/pub.1082461551 schema:CreativeWork
    402 https://app.dimensions.ai/details/publication/pub.1082559420 schema:CreativeWork
    403 https://app.dimensions.ai/details/publication/pub.1082599627 schema:CreativeWork
    404 https://app.dimensions.ai/details/publication/pub.1082626616 schema:CreativeWork
    405 https://app.dimensions.ai/details/publication/pub.1082662173 schema:CreativeWork
    406 https://app.dimensions.ai/details/publication/pub.1082670828 schema:CreativeWork
    407 https://app.dimensions.ai/details/publication/pub.1082769692 schema:CreativeWork
    408 https://app.dimensions.ai/details/publication/pub.1082885870 schema:CreativeWork
    409 https://app.dimensions.ai/details/publication/pub.1082895236 schema:CreativeWork
    410 https://app.dimensions.ai/details/publication/pub.1083008472 schema:CreativeWork
    411 https://app.dimensions.ai/details/publication/pub.1083033962 schema:CreativeWork
    412 https://app.dimensions.ai/details/publication/pub.1083157825 schema:CreativeWork
    413 https://app.dimensions.ai/details/publication/pub.1083274036 schema:CreativeWork
    414 https://app.dimensions.ai/details/publication/pub.1083288694 schema:CreativeWork
    415 https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1050>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1025639138
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1002/cncr.11090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031208881
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1002/gcc.20088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007131623
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1002/gcc.2870030602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045866171
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1002/j.1460-2075.1990.tb07535.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078477442
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1002/j.1460-2075.1996.tb00439.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082877715
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/0092-8674(89)90404-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040542003
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/0092-8674(91)90111-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1050537171
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/0092-8674(94)90289-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015652035
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/0092-8674(94)90292-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007711944
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/0092-8674(94)90571-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030827577
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/0168-9525(93)90209-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1014683468
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.bbrc.2003.11.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037431643
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/j.bbrc.2004.06.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025556779
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/j.cancergencyto.2005.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032513554
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/j.ccr.2004.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023684149
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.cub.2004.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035937353
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/j.cub.2004.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049337123
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/j.cub.2004.07.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021173850
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.leukres.2004.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035272721
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/s0140-6736(04)15542-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051150833
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/s0167-5699(00)01744-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021847408
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/s0168-9525(97)01133-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033178806
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/s0952-7915(00)00223-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024743252
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/s0959-437x(02)00013-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022313571
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/s0959-437x(99)00038-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041076025
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/s1044-5323(02)00065-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009572917
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/s1074-7613(00)00067-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008852336
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/s1074-7613(00)80054-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026877657
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/s1074-7613(00)80238-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008803131
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/s1074-7613(02)00264-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047540455
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/s1074-7613(02)00330-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035438570
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/s1097-2765(02)00741-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021817762
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1016/s1535-6108(02)00018-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030156052
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1016/s1535-6108(02)00032-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009156234
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1016/s1535-6108(03)00305-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034607211
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1034/j.1600-065x.2003.00013.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020028066
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1038/sj.emboj.7600017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044803804
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1046/j.1365-2141.2001.02586.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026537939
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1046/j.1365-2141.2002.03850.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001696989
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1046/j.1468-0734.2002.00069.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041513396
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1056/nejmra023001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005718906
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1056/nejmra052603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017360868
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1073/pnas.86.24.10128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042593812
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1073/pnas.88.24.11416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051789765
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1073/pnas.91.23.11045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016446367
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1073/pnas.92.15.7075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019671936
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1073/pnas.93.10.4804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003471963
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1073/pnas.96.3.996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014057026
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1073/pnas.97.7.3497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024581792
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1074/jbc.m209870200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011504518
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1084/jem.174.4.867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039872673
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1084/jem.176.5.1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027295946
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1084/jem.183.5.2283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050837486
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1084/jem.189.2.289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010331178
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1093/emboj/16.11.3145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017509311
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1093/emboj/16.9.2408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012161439
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1093/emboj/17.13.3714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042631731
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1093/emboj/cdg567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052579019
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1101/gad.12.17.2651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019160542
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1101/gad.12.4.473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040333965
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1126/science.1088547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018519577
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1126/science.1102160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033243130
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1126/science.1676542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062499466
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1126/science.278.5340.1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062558563
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1126/science.278.5341.1309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062558683
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1128/mcb.13.9.5620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062713584
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1128/mcb.16.8.4107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030726927
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1128/mcb.17.12.7317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017547530
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1128/mcb.17.8.4782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047935175
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1128/mcb.18.12.6939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052482451
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1128/mcb.19.12.8240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027289033
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1128/mcb.23.2.655-664.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049628527
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1128/mcb.9.5.2124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022896452
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1146/annurev.immunol.15.1.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048560775
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1146/annurev.immunol.17.1.369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007112233
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1146/annurev.immunol.22.012703.104753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017591971
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1146/annurev.immunol.23.021704.115747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009632362
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1146/annurev.immunol.24.021605.090612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039207381
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1158/0008-5472.can-03-1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039524982
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1182/blood-2001-11-0093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044993471
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1182/blood-2002-03-0717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029898791
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1182/blood-2002-08-2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006819700
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1182/blood-2002-09-2857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033109926
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1182/blood-2002-09-2913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010170710
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1182/blood-2002-10-3221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033966736
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1182/blood-2003-05-1495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043030836
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1182/blood-2003-07-2577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044326253
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1182/blood-2003-11-3944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015484622
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1182/blood-2004-01-0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010704620
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1182/blood-2004-10-3900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005658770
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1182/blood-2004-12-4897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026983792
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1182/blood-2005-04-1640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001723076
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1182/blood-2005-06-2267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034400971
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1200/jco.1999.17.1.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074511226
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1242/dev.01074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052292788
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1634/stemcells.20-5-364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040942278
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.4049/jimmunol.172.9.5230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016497452
    610 rdf:type schema:CreativeWork
    611 https://www.grid.ac/institutes/grid.11486.3a schema:alternateName Flanders Institute for Biotechnology
    612 schema:name Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Leuven, Belgium
    613 rdf:type schema:Organization
    614 https://www.grid.ac/institutes/grid.48769.34 schema:alternateName Cliniques Universitaires Saint-Luc
    615 schema:name Department of Hematology, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium
    616 rdf:type schema:Organization
    617 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
    618 schema:name Center for Human Genetics, University of Leuven, Leuven, Belgium
    619 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...