Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-04-29

AUTHORS

R Tang, A-M Faussat, P Majdak, J-Y Perrot, D Chaoui, O Legrand, J-P Marie

ABSTRACT

The multidrug resistance (MDR) phenotype, induced by the overexpression of several ABC transporters or by antiapoptotic mechanisms, has been identified as the major cause of drug resistance in the treatment of patients with acute myeloid leukemia (AML). In this study, we have shown that valproic acid (VPA) (a histone deacetylase inhibitor) can inhibit the proliferation of both P-glycoprotein (P-gp)- and MDR-associated protein 1 (MRP1)-positive and -negative cells. VPA also induced apoptosis of P-gp-positive cells. VPA induced apoptosis in K562 cells led to decrease in Flip (FLICE/caspase-8 inhibitory protein) expression with Flip cleavage, which could not be observed in HL60 cells. In HL60/MRP cell line, which proved to be resistant to apoptosis by VPA, we observed an abnormal expression of apoptotic regulatory proteins, overexpression of Bcl-2 and absence of Bax. Also, the Bcl-2 antagonist HA14-1 rapidly restored apoptosis in this cell line. Cotreatment with cytosine arabinoside induced very strong apoptosis in both K562/DOX and HL60/DNR cell lines. VPA also induced apoptosis in AML patient cells expressing P-gp and/or MRP1. Our findings show VPA as an interesting drug that should be tested in clinical trials for overcoming the MDR phenotype in AML patients. More... »

PAGES

1246-1251

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2403390

DOI

http://dx.doi.org/10.1038/sj.leu.2403390

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016032644

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15116123


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ATP Binding Cassette Transporter, Subfamily B, Member 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CASP8 and FADD-Like Apoptosis Regulating Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytarabine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Evaluation, Preclinical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Multiple", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Synergism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multidrug Resistance-Associated Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Valproic Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "R", 
        "id": "sg:person.010467152312.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010467152312.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faussat", 
        "givenName": "A-M", 
        "id": "sg:person.015436354754.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015436354754.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Majdak", 
        "givenName": "P", 
        "id": "sg:person.0725554173.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725554173.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire d\u2019H\u00e9matologie Biologique, H\u00f4tel Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "Laboratoire d\u2019H\u00e9matologie Biologique, H\u00f4tel Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perrot", 
        "givenName": "J-Y", 
        "id": "sg:person.0632736606.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632736606.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaoui", 
        "givenName": "D", 
        "id": "sg:person.01163646352.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163646352.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Legrand", 
        "givenName": "O", 
        "id": "sg:person.0752753564.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752753564.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411394.a", 
          "name": [
            "Laboratotoire INSERM E0355, H\u00f4tel Dieu, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marie", 
        "givenName": "J-P", 
        "id": "sg:person.016247574432.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016247574432.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35106079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033914466", 
          "https://doi.org/10.1038/35106079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029160422", 
          "https://doi.org/10.1038/sj.leu.2402092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048649414", 
          "https://doi.org/10.1038/sj.onc.1203176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030001451", 
          "https://doi.org/10.1038/sj.onc.1204269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044821987", 
          "https://doi.org/10.1038/sj.leu.2402535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014646894", 
          "https://doi.org/10.1038/nrd772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016878939", 
          "https://doi.org/10.1038/sj.leu.2403112"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-04-29", 
    "datePublishedReg": "2004-04-29", 
    "description": "The multidrug resistance (MDR) phenotype, induced by the overexpression of several ABC transporters or by antiapoptotic mechanisms, has been identified as the major cause of drug resistance in the treatment of patients with acute myeloid leukemia (AML). In this study, we have shown that valproic acid (VPA) (a histone deacetylase inhibitor) can inhibit the proliferation of both P-glycoprotein (P-gp)- and MDR-associated protein 1 (MRP1)-positive and -negative cells. VPA also induced apoptosis of P-gp-positive cells. VPA induced apoptosis in K562 cells led to decrease in Flip (FLICE/caspase-8 inhibitory protein) expression with Flip cleavage, which could not be observed in HL60 cells. In HL60/MRP cell line, which proved to be resistant to apoptosis by VPA, we observed an abnormal expression of apoptotic regulatory proteins, overexpression of Bcl-2 and absence of Bax. Also, the Bcl-2 antagonist HA14-1 rapidly restored apoptosis in this cell line. Cotreatment with cytosine arabinoside induced very strong apoptosis in both K562/DOX and HL60/DNR cell lines. VPA also induced apoptosis in AML patient cells expressing P-gp and/or MRP1. Our findings show VPA as an interesting drug that should be tested in clinical trials for overcoming the MDR phenotype in AML patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/sj.leu.2403390", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097065", 
        "issn": [
          "0887-6924", 
          "1476-5551"
        ], 
        "name": "Leukemia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "acute myeloid leukemia", 
      "valproic acid", 
      "cell lines", 
      "acute myeloid leukemia cells", 
      "treatment of patients", 
      "K562/DOX", 
      "AML patient cells", 
      "myeloid leukemia cells", 
      "gp-positive cells", 
      "multidrug resistance phenotype", 
      "AML patients", 
      "clinical trials", 
      "myeloid leukemia", 
      "interesting drug", 
      "MDR phenotype", 
      "apoptotic regulatory proteins", 
      "drug resistance", 
      "abnormal expression", 
      "major cause", 
      "antiapoptotic mechanisms", 
      "leukemia cells", 
      "FLIP expression", 
      "protein 1", 
      "patient cells", 
      "Bcl-2", 
      "negative cells", 
      "patients", 
      "apoptosis", 
      "strong apoptosis", 
      "K562 cells", 
      "resistance phenotype", 
      "GPs", 
      "HL60 cells", 
      "MRP1", 
      "cells", 
      "Bcl-2 antagonist HA14-1", 
      "HA14-1", 
      "proliferation", 
      "overexpression", 
      "phenotype", 
      "leukemia", 
      "expression", 
      "regulatory proteins", 
      "MDR", 
      "trials", 
      "absence of Bax", 
      "drugs", 
      "ABC transporters", 
      "treatment", 
      "Bax", 
      "cause", 
      "glycoprotein", 
      "DOX", 
      "FLIP cleavage", 
      "acid", 
      "findings", 
      "transporters", 
      "lines", 
      "absence", 
      "study", 
      "protein", 
      "resistance", 
      "mechanism", 
      "cytosine", 
      "cleavage", 
      "HL60/MRP cell line", 
      "MRP cell line", 
      "antagonist HA14-1", 
      "HL60/DNR cell lines", 
      "DNR cell lines"
    ], 
    "name": "Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1", 
    "pagination": "1246-1251", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016032644"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/sj.leu.2403390"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15116123"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/sj.leu.2403390", 
      "https://app.dimensions.ai/details/publication/pub.1016032644"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_393.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/sj.leu.2403390"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403390'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403390'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403390'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403390'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      22 PREDICATES      121 URIs      106 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/sj.leu.2403390 schema:about N10c966cdaed940bb848a3c344e27a632
2 N170a2c8948964cc19cf0779819c5e503
3 N2f3fca9f56fd4e78a0c7dd3477f83952
4 N368d22fac3ea44c6932a27f0776e9219
5 N3fb8c2b6fc9f4907907b6d20c4da35d5
6 N6b10f49e0a4c4c31aa235acbdd8aa0d2
7 N7458b78534ae4c8c912579c44e554f65
8 N7e7fd7047ed44ebe90068e2d61c4803d
9 N8b734924fb3f477ba0cf47f0dca29337
10 N8ebeee0dee214ac1b24a3030079c1a9e
11 N92828cbb63994600a5bad3c409ce3122
12 Nad204d363abc4018be0d16b4485ae9f4
13 Nc41da73192be470681fce1e050eea4b9
14 Nd68f096f76f74c43901e927083e83a03
15 Nd7430352437a4c649880ecffade47de5
16 Ne5575e7446fa466787648a4627ed179b
17 Nf1274a8928b94342901852e521f1eeb2
18 Nfa6c5193553940e5a214e27a825d0ea5
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Ne97b05a82c22468f848711b262e3fd7f
22 schema:citation sg:pub.10.1038/35106079
23 sg:pub.10.1038/nrd772
24 sg:pub.10.1038/sj.leu.2402092
25 sg:pub.10.1038/sj.leu.2402535
26 sg:pub.10.1038/sj.leu.2403112
27 sg:pub.10.1038/sj.onc.1203176
28 sg:pub.10.1038/sj.onc.1204269
29 schema:datePublished 2004-04-29
30 schema:datePublishedReg 2004-04-29
31 schema:description The multidrug resistance (MDR) phenotype, induced by the overexpression of several ABC transporters or by antiapoptotic mechanisms, has been identified as the major cause of drug resistance in the treatment of patients with acute myeloid leukemia (AML). In this study, we have shown that valproic acid (VPA) (a histone deacetylase inhibitor) can inhibit the proliferation of both P-glycoprotein (P-gp)- and MDR-associated protein 1 (MRP1)-positive and -negative cells. VPA also induced apoptosis of P-gp-positive cells. VPA induced apoptosis in K562 cells led to decrease in Flip (FLICE/caspase-8 inhibitory protein) expression with Flip cleavage, which could not be observed in HL60 cells. In HL60/MRP cell line, which proved to be resistant to apoptosis by VPA, we observed an abnormal expression of apoptotic regulatory proteins, overexpression of Bcl-2 and absence of Bax. Also, the Bcl-2 antagonist HA14-1 rapidly restored apoptosis in this cell line. Cotreatment with cytosine arabinoside induced very strong apoptosis in both K562/DOX and HL60/DNR cell lines. VPA also induced apoptosis in AML patient cells expressing P-gp and/or MRP1. Our findings show VPA as an interesting drug that should be tested in clinical trials for overcoming the MDR phenotype in AML patients.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N7de91efb3ee7483080bf469d0e1cea1d
36 Nb640115e46bf430f98bda6b8ff4b744b
37 sg:journal.1097065
38 schema:keywords ABC transporters
39 AML patient cells
40 AML patients
41 Bax
42 Bcl-2
43 Bcl-2 antagonist HA14-1
44 DNR cell lines
45 DOX
46 FLIP cleavage
47 FLIP expression
48 GPs
49 HA14-1
50 HL60 cells
51 HL60/DNR cell lines
52 HL60/MRP cell line
53 K562 cells
54 K562/DOX
55 MDR
56 MDR phenotype
57 MRP cell line
58 MRP1
59 abnormal expression
60 absence
61 absence of Bax
62 acid
63 acute myeloid leukemia
64 acute myeloid leukemia cells
65 antagonist HA14-1
66 antiapoptotic mechanisms
67 apoptosis
68 apoptotic regulatory proteins
69 cause
70 cell lines
71 cells
72 cleavage
73 clinical trials
74 cytosine
75 drug resistance
76 drugs
77 expression
78 findings
79 glycoprotein
80 gp-positive cells
81 interesting drug
82 leukemia
83 leukemia cells
84 lines
85 major cause
86 mechanism
87 multidrug resistance phenotype
88 myeloid leukemia
89 myeloid leukemia cells
90 negative cells
91 overexpression
92 patient cells
93 patients
94 phenotype
95 proliferation
96 protein
97 protein 1
98 regulatory proteins
99 resistance
100 resistance phenotype
101 strong apoptosis
102 study
103 transporters
104 treatment
105 treatment of patients
106 trials
107 valproic acid
108 schema:name Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1
109 schema:pagination 1246-1251
110 schema:productId N011648ebb9294f9895009e411e86e646
111 N9edcd1f2858c4427b53abb990bb967a5
112 Nf8692fd0cada497fb74753536b22e712
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016032644
114 https://doi.org/10.1038/sj.leu.2403390
115 schema:sdDatePublished 2022-01-01T18:14
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher Ncf79c9defaa2406d9d3252ce3e4cf866
118 schema:url https://doi.org/10.1038/sj.leu.2403390
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N011648ebb9294f9895009e411e86e646 schema:name dimensions_id
123 schema:value pub.1016032644
124 rdf:type schema:PropertyValue
125 N0c1ed919dc19468f8335668c63deea70 rdf:first sg:person.016247574432.21
126 rdf:rest rdf:nil
127 N10c966cdaed940bb848a3c344e27a632 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Drug Resistance, Multiple
129 rdf:type schema:DefinedTerm
130 N170a2c8948964cc19cf0779819c5e503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Acute Disease
132 rdf:type schema:DefinedTerm
133 N25e1f3b7bc594600a94992a620bcc92c rdf:first sg:person.0725554173.96
134 rdf:rest Nf6025ab61f6d4e039ebf3aa42e689437
135 N2d99602906e84b2d802ba12bbd9780c4 rdf:first sg:person.01163646352.37
136 rdf:rest Nd79035a33ea24bcfade61134cb223093
137 N2da512363d7e471ea6b047f8b42abde8 rdf:first sg:person.015436354754.08
138 rdf:rest N25e1f3b7bc594600a94992a620bcc92c
139 N2f3fca9f56fd4e78a0c7dd3477f83952 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Intracellular Signaling Peptides and Proteins
141 rdf:type schema:DefinedTerm
142 N368d22fac3ea44c6932a27f0776e9219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Multidrug Resistance-Associated Proteins
144 rdf:type schema:DefinedTerm
145 N3fb8c2b6fc9f4907907b6d20c4da35d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Division
147 rdf:type schema:DefinedTerm
148 N6b10f49e0a4c4c31aa235acbdd8aa0d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Leukemia, Myeloid
150 rdf:type schema:DefinedTerm
151 N7458b78534ae4c8c912579c44e554f65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name CASP8 and FADD-Like Apoptosis Regulating Protein
153 rdf:type schema:DefinedTerm
154 N7de91efb3ee7483080bf469d0e1cea1d schema:volumeNumber 18
155 rdf:type schema:PublicationVolume
156 N7e7fd7047ed44ebe90068e2d61c4803d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cell Line, Tumor
158 rdf:type schema:DefinedTerm
159 N8b734924fb3f477ba0cf47f0dca29337 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Valproic Acid
161 rdf:type schema:DefinedTerm
162 N8ebeee0dee214ac1b24a3030079c1a9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Carrier Proteins
164 rdf:type schema:DefinedTerm
165 N92828cbb63994600a5bad3c409ce3122 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Cytarabine
167 rdf:type schema:DefinedTerm
168 N9edcd1f2858c4427b53abb990bb967a5 schema:name pubmed_id
169 schema:value 15116123
170 rdf:type schema:PropertyValue
171 Nad204d363abc4018be0d16b4485ae9f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Apoptosis
173 rdf:type schema:DefinedTerm
174 Nb640115e46bf430f98bda6b8ff4b744b schema:issueNumber 7
175 rdf:type schema:PublicationIssue
176 Nc41da73192be470681fce1e050eea4b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Drug Synergism
178 rdf:type schema:DefinedTerm
179 Ncf79c9defaa2406d9d3252ce3e4cf866 schema:name Springer Nature - SN SciGraph project
180 rdf:type schema:Organization
181 Nd68f096f76f74c43901e927083e83a03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Drug Evaluation, Preclinical
183 rdf:type schema:DefinedTerm
184 Nd7430352437a4c649880ecffade47de5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name ATP Binding Cassette Transporter, Subfamily B, Member 1
186 rdf:type schema:DefinedTerm
187 Nd79035a33ea24bcfade61134cb223093 rdf:first sg:person.0752753564.08
188 rdf:rest N0c1ed919dc19468f8335668c63deea70
189 Ne5575e7446fa466787648a4627ed179b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Enzyme Inhibitors
191 rdf:type schema:DefinedTerm
192 Ne97b05a82c22468f848711b262e3fd7f rdf:first sg:person.010467152312.87
193 rdf:rest N2da512363d7e471ea6b047f8b42abde8
194 Nf1274a8928b94342901852e521f1eeb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Humans
196 rdf:type schema:DefinedTerm
197 Nf6025ab61f6d4e039ebf3aa42e689437 rdf:first sg:person.0632736606.03
198 rdf:rest N2d99602906e84b2d802ba12bbd9780c4
199 Nf8692fd0cada497fb74753536b22e712 schema:name doi
200 schema:value 10.1038/sj.leu.2403390
201 rdf:type schema:PropertyValue
202 Nfa6c5193553940e5a214e27a825d0ea5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Tumor Cells, Cultured
204 rdf:type schema:DefinedTerm
205 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
206 schema:name Medical and Health Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
209 schema:name Oncology and Carcinogenesis
210 rdf:type schema:DefinedTerm
211 sg:journal.1097065 schema:issn 0887-6924
212 1476-5551
213 schema:name Leukemia
214 schema:publisher Springer Nature
215 rdf:type schema:Periodical
216 sg:person.010467152312.87 schema:affiliation grid-institutes:grid.411394.a
217 schema:familyName Tang
218 schema:givenName R
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010467152312.87
220 rdf:type schema:Person
221 sg:person.01163646352.37 schema:affiliation grid-institutes:grid.411394.a
222 schema:familyName Chaoui
223 schema:givenName D
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163646352.37
225 rdf:type schema:Person
226 sg:person.015436354754.08 schema:affiliation grid-institutes:grid.411394.a
227 schema:familyName Faussat
228 schema:givenName A-M
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015436354754.08
230 rdf:type schema:Person
231 sg:person.016247574432.21 schema:affiliation grid-institutes:grid.411394.a
232 schema:familyName Marie
233 schema:givenName J-P
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016247574432.21
235 rdf:type schema:Person
236 sg:person.0632736606.03 schema:affiliation grid-institutes:grid.411394.a
237 schema:familyName Perrot
238 schema:givenName J-Y
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632736606.03
240 rdf:type schema:Person
241 sg:person.0725554173.96 schema:affiliation grid-institutes:grid.411394.a
242 schema:familyName Majdak
243 schema:givenName P
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725554173.96
245 rdf:type schema:Person
246 sg:person.0752753564.08 schema:affiliation grid-institutes:grid.411394.a
247 schema:familyName Legrand
248 schema:givenName O
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752753564.08
250 rdf:type schema:Person
251 sg:pub.10.1038/35106079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033914466
252 https://doi.org/10.1038/35106079
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nrd772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014646894
255 https://doi.org/10.1038/nrd772
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/sj.leu.2402092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029160422
258 https://doi.org/10.1038/sj.leu.2402092
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/sj.leu.2402535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044821987
261 https://doi.org/10.1038/sj.leu.2402535
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/sj.leu.2403112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016878939
264 https://doi.org/10.1038/sj.leu.2403112
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/sj.onc.1203176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048649414
267 https://doi.org/10.1038/sj.onc.1203176
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/sj.onc.1204269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030001451
270 https://doi.org/10.1038/sj.onc.1204269
271 rdf:type schema:CreativeWork
272 grid-institutes:grid.411394.a schema:alternateName Laboratoire d’Hématologie Biologique, Hôtel Dieu, Paris, France
273 Laboratotoire INSERM E0355, Hôtel Dieu, Paris, France
274 schema:name Laboratoire d’Hématologie Biologique, Hôtel Dieu, Paris, France
275 Laboratotoire INSERM E0355, Hôtel Dieu, Paris, France
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...