Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-05

AUTHORS

E K Grand, A J Chase, C Heath, A Rahemtulla, N C P Cross

ABSTRACT

The t(4;14)(p16.3;q32), associated with 10-20% of cases of multiple myeloma (MM), deregulates the expression of MMSET and FGFR3. To assess the potential of FGFR3 as a drug target, we evaluated the effects of selective inhibitors on MM and control cell lines. SU5402 and PD173074 specifically inhibited the growth of the two t(4;14)-positive MM lines, KMS-11 and OPM-2. Importantly, inhibition was still observed in the presence of IL-6, a growth factor known to play an important role in MM. Both compounds induced a dose-dependent reduction in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation. In contrast, no inhibition was seen with either compound against t(4;14)-negative cell lines or NCI-H929, a t(4;14)-positive, FGFR3-negative MM cell line. FGFR3 is thus a plausible candidate for targeted therapy in a subset of MM patients. More... »

PAGES

962

Journal

TITLE

Leukemia

ISSUE

5

VOLUME

18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/sj.leu.2403347

DOI

http://dx.doi.org/10.1038/sj.leu.2403347

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053511457

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15029211


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