Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-12

AUTHORS

J J M van Dongen, A W Langerak, M Brüggemann, P A S Evans, M Hummel, F L Lavender, E Delabesse, F Davi, E Schuuring, R García-Sanz, J H J M van Krieken, J Droese, D González, C Bastard, H E White, M Spaargaren, M González, A Parreira, J L Smith, G J Morgan, M Kneba, E A Macintyre

ABSTRACT

In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes and the chromosome aberrations t(11;14) and t(14;18). This has resulted in 107 different primers in only 18 multiplex PCR tubes: three VH-JH, two DH-JH, two Ig kappa (IGK), one Ig lambda (IGL), three TCR beta (TCRB), two TCR gamma (TCRG), one TCR delta (TCRD), three BCL1-Ig heavy chain (IGH), and one BCL2-IGH. The PCR products of Ig/TCR genes can be analyzed for clonality assessment by heteroduplex analysis or GeneScanning. The detection rate of clonal rearrangements using the BIOMED-2 primer sets is unprecedentedly high. This is mainly based on the complementarity of the various BIOMED-2 tubes. In particular, combined application of IGH (VH-JH and DH-JH) and IGK tubes can detect virtually all clonal B-cell proliferations, even in B-cell malignancies with high levels of somatic mutations. The contribution of IGL gene rearrangements seems limited. Combined usage of the TCRB and TCRG tubes detects virtually all clonal T-cell populations, whereas the TCRD tube has added value in case of TCRgammadelta(+) T-cell proliferations. The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease. More... »

PAGES

2257

References to SciGraph publications

  • 1999. Unusual Immunoglobulin and T-cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemias in MECHANISMS OF B CELL NEOPLASIA 1998
  • 2003-01. IMGT® databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr in LEUKEMIA
  • 2000-06. Rapid, multifluorescent TCRG Vγ and Jγ typing: application to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations in LEUKEMIA
  • 1998-07. Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease in LEUKEMIA
  • 1992. Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia Patients by Polymerase Chain Reactions in ACUTE LEUKEMIAS
  • 2002-03. Fusion gene transcripts and Ig/TCR gene rearrangements are complementary but infrequent targets for PCR-based detection of minimal residual disease in acute myeloid leukemia in LEUKEMIA
  • 1997-12. Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations in LEUKEMIA
  • 1998-08. Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length in MOLECULAR MEDICINE
  • 1985-07. A uniform deleting element mediates the loss of κ genes in human B cells in NATURE
  • 2001-09. Precursor-B-ALL with DH–JH gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14 in LEUKEMIA
  • 1999-03. γδ T cells, their T cell receptor usage and role in human diseases in SEMINARS IN IMMUNOPATHOLOGY
  • 1999-05. γδ T cells, their T cell receptor usage and role in human diseases in SEMINARS IN IMMUNOPATHOLOGY
  • 1999-10. Easy detection of all T cell receptor gamma (TCRG) gene rearrangements by Southern blot analysis: recommendations for optimal results in LEUKEMIA
  • 1997-12. Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: a new molecular target for detection of minimal residual disease in LEUKEMIA
  • 2001-01. Immunoglobulin lambda isotype gene rearrangements in B cell malignancies in LEUKEMIA
  • 2002-05. Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR in LEUKEMIA
  • 1995-10. Human T-cell receptor variable gene segment families in IMMUNOGENETICS
  • 1999-02. Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease in LEUKEMIA
  • 1999-02. Immunophenotypic and immunogenotypic characteristics of TCRγδ+ T cell acute lymphoblastic leukemia in LEUKEMIA
  • 2002-09. Minimal residual disease (MRD) status prior to allogeneic stem cell transplantation is a powerful predictor for post-transplant outcome in children with ALL in LEUKEMIA
  • 2000-07. T cell receptor gamma (TCRG) gene rearrangements in T cell acute lymphoblastic leukemia reflect ‘end-stage’ recombinations: implications for minimal residual disease monitoring in LEUKEMIA
  • 2000-09. Characterisation of BCL2-JH rearrangements in follicular lymphoma: PCR detection of 3′ BCL2 breakpoints and evidence of a new cluster in LEUKEMIA
  • 1995-10. Nomenclature for T-cell receptor (TCR) gene segments of the immune system in IMMUNOGENETICS
  • 2001-07. Post-induction residual leukemia in childhood acute lymphoblastic leukemia quantified by PCR correlates with in vitro prednisolone resistance in LEUKEMIA
  • 1994-01. The extent of the human germline T-cell receptor V beta gene segment repertoire in IMMUNOGENETICS
  • 1998-02. TCR-gamma gene rearrangement with interstitial deletion within the TRGV2 gene segment is not detected in normal T-lymphocytes in LEUKEMIA
  • 1981-04. Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells in NATURE
  • 1998-10. Structure of Bcl-1 and IgH-CDR3 rearrangements as clonal markers in mantle cell lymphomas in LEUKEMIA
  • 1991. Phenotypic and Functional Characterization of Human TCRγδ+ Intestinal Intraepithelial Lymphocytes in FUNCTION AND SPECIFICITY OF Γ/Δ T CELLS
  • 1999-01. Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets Report of the BIOMED-1 CONCERTED ACTION: Investigation of minimal residual disease in acute leukemia in LEUKEMIA
  • 1983-07. Variable amplification of immunoglobulin λ light-chain genes in human populations in NATURE
  • 1983-04. Somatic generation of antibody diversity in NATURE
  • 2001-09. Real-time quantitative PCR for detection of minimal residual disease before allogeneic stem cell transplantation predicts outcome in children with acute lymphoblastic leukemia in LEUKEMIA
  • 1998-04. Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma in LEUKEMIA
  • 2002-07. T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis in LEUKEMIA
  • 1993-06. Polymorphisms in the Tcrb-V2 gene segments localize the Tcrb orphon genes to human chromosome 9p21 in IMMUNOGENETICS
  • 1988-08. T-cell antigen receptor genes and T-cell recognition in NATURE
  • 2001-02. MRD at the end of induction therapy in childhood acute lymphoblastic leukemia: outcome prediction strongly depends on the therapeutic regimen in LEUKEMIA
  • 1999-06. Detection of T cell receptor beta (TCRB) gene rearrangement patterns in T cell malignancies by Southern blot analysis in LEUKEMIA
  • 2002-04. A competitive PCR-based method using TCRD, TCRG and IGH rearrangements for rapid detection of patients with high levels of minimal residual disease in acute lymphoblastic leukemia in LEUKEMIA
  • 2003-02. False leukemia–lymphoma cell lines: an update on over 500 cell lines in LEUKEMIA
  • 1995-02. Gamma/delta T cells and human skin reactivity to heavy metals in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1997-07. Automated high resolution PCR fragment analysis for identification of clonally rearranged immunoglobulin heavy chain genes in LEUKEMIA
  • Journal

    TITLE

    Leukemia

    ISSUE

    12

    VOLUME

    17

    Related Patents

  • Methods Of Monitoring Conditions By Sequence Analysis
  • Quantification Of Adaptive Immune Cell Genomes In A Complex Mixture Of Cells
  • Monitoring Health And Disease Status Using Clonotype Profiles
  • Quantification Of Adaptive Immune Cell Genomes In A Complex Mixture Of Cells
  • Monitoring Health And Disease Status Using Clonotype Profiles
  • Identification Of Clonal Cells By Repeats In (Eg.) T-Cell Receptor V/D/J Genes
  • Method For Studying V(D)J Combinatory Diversity
  • Detection And Prognosis Of Cervical Cancer
  • Single Cell Analysis By Polymerase Cycling Assembly
  • System And Methods For Massively Parallel Analysis Of Nucleic Acids In Single Cells
  • Isolating Cells Expressing Secreted Proteins
  • Quantification Of Adaptive Immune Cell Genomes In A Complex Mixture Of Cells
  • Measurement Of The Immunological Diversity And Evaluation Of The Effects Of A Treatment Through Studying V(D)J Diversity
  • Diagnosis Of Lymphoid Malignancies And Minimal Residual Disease Detection
  • Sequence Analysis Of Complex Amplicons
  • Recombinant Fusion Proteins And Libraries From Immune Cell Repertoires
  • Methods Of Monitoring Conditions By Sequence Analysis
  • Method For Studying The V(D)J Combinatorial Diversity.
  • Compositions And Method For Measuring And Calibrating Amplification Bias In Multiplexed Pcr Reactions
  • Isolation Of Unknown Rearranged T-Cell Receptors From Single Cells
  • Single Cell Analysis By Polymerase Cycling Assembly
  • Recombinant Fusion Proteins And Libraries From Immune Cell Repertoires
  • Method Of Determining Clonotypes And Clonotype Profiles
  • Method Of Measuring Adaptive Immunity
  • Determining The Replicative History Of Lymphocytes
  • Monitoring Health And Disease Status Using Clonotype Profiles
  • Method Of Measuring Adaptive Immunity
  • Quantification Of Adaptive Immune Cell Genomes In A Complex Mixture Of Cells
  • Use Of The Combinatorial Diversity Of T-Lymphocyte Repertoire As A Prognostic Marker Of Cancer
  • Determining Antigen-Specific T-Cells
  • Determining Paired Immune Receptor Chains From Frequency Matched Subunits
  • Monitoring Health And Disease Status Using Clonotype Profiles
  • Isolation Of Unknown Rearranged T-Cell Receptors From Single Cells
  • Method Of Measuring Adaptive Immunity
  • Method For Genotyping Clonotype Profiles Using Sequence Tags
  • Reprogramming Immortalized B-Cells To Induced Pluripotent Stem Cells
  • Compositions And Method For Measuring And Calibrating Amplification Bias In Multiplexed Pcr Reactions
  • Use Of The Combinatory Diversity Of The Catalogue Of T Lymphocytes As A Cancer Prognostic Marker
  • Recombinant Fusion Proteins And Libraries From Immune Cell Repertoires
  • Quantification Of Adaptive Immune Cell Genomes In A Complex Mixture Of Cells
  • Methods Of Monitoring Conditions By Sequence Analysis
  • Detection And Quantification Of Sample Contamination In Immune Repertoire Analysis
  • Improved Method For The Generation Of Genetically Modified Cells
  • Methods And Kits For Detecting Ige-Expressing B Cells
  • Method Of Identifying Vdj Recombination Products
  • Method Of Analysing A Marker Nucleic Acid Molecule
  • Quantification Of Adaptive Immune Cell Genomes In A Complex Mixture Of Cells
  • Methods For Antibody And Cell Therapeutic Discovery
  • Detection And Prognosis Of Cervical Cancer
  • Method For Improving Detection Of B Cell Immunoglobulin Gene Recombination
  • Recombination Sequence (Rs) Rearrangement Frequency As A Measure Of Central B Cell Tolerance
  • Recombinant Fusion Proteins And Libraries From Immune Cell Repertoires
  • Sequence Analysis Of Complex Amplicons
  • Sox11 Expression In Malignant Lymphomas
  • Method For Generating Clonotype Profiles Using Sequence Tags
  • Rare Clonotypes And Uses Thereof
  • Recombinant Cell Surface Capture Proteins
  • Method Of Sequence Determination Using Sequence Tags
  • Molecular Assay Reagents And Methods
  • Method For Improving Detection Of B Cell Immunoglobulin Gene Recombination
  • Detection And Measurement Of Tissue-Infiltrating Lymphocytes
  • Monitoring Immunoglobulin Heavy Chain Evolution In B-Cell Acute Lymphoblastic Leukemia
  • Methods Of Monitoring Conditions By Sequence Analysis
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.leu.2403202

    DOI

    http://dx.doi.org/10.1038/sj.leu.2403202

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027716225

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14671650


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Aberrations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clone Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Primers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "European Union", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Rearrangement, T-Lymphocyte", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoglobulins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoproliferative Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm, Residual", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Antigen, T-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reference Standards", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Erasmus University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Dongen", 
            "givenName": "J J M", 
            "id": "sg:person.014022412277.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014022412277.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Erasmus University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langerak", 
            "givenName": "A W", 
            "id": "sg:person.011464602664.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464602664.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Schleswig-Holstein", 
              "id": "https://www.grid.ac/institutes/grid.412468.d", 
              "name": [
                "II Medizinische Klinik des Universit\u00e4tsklinikums Schleswig-Holstein, Campus Kiel, Kiel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Br\u00fcggemann", 
            "givenName": "M", 
            "id": "sg:person.0776675364.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776675364.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Leeds", 
              "id": "https://www.grid.ac/institutes/grid.9909.9", 
              "name": [
                "Academic Unit of Haematology and Oncology, University of Leeds, Leeds, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Evans", 
            "givenName": "P A S", 
            "id": "sg:person.013513065422.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013513065422.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Freie Universit\u00e4t Berlin", 
              "id": "https://www.grid.ac/institutes/grid.14095.39", 
              "name": [
                "lnstitute of Pathology, Free University Berlin, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hummel", 
            "givenName": "M", 
            "id": "sg:person.0615736477.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615736477.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Southampton NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.430506.4", 
              "name": [
                "Wessex Immunology Service, Molecular Pathology Unit, Southampton University Hospitals NHS Trust, Southampton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lavender", 
            "givenName": "F L", 
            "id": "sg:person.01146120036.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146120036.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Necker-Enfants Malades Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412134.1", 
              "name": [
                "Laboratoire d'Hematologie and INSERM EMI 210, H\u00f4pital Necker-Enfants Malades, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delabesse", 
            "givenName": "E", 
            "id": "sg:person.01315504000.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315504000.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Department of Hematology, H\u00f4pital Piti\u00e9-Salp\u00e9triere, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davi", 
            "givenName": "F", 
            "id": "sg:person.01240304757.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240304757.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Groningen", 
              "id": "https://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands", 
                "Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schuuring", 
            "givenName": "E", 
            "id": "sg:person.01151001152.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151001152.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario de Salamanca", 
              "id": "https://www.grid.ac/institutes/grid.411258.b", 
              "name": [
                "Servicio de Hematologia, Hospital Universitario de Salamanca, Salamanca, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garc\u00eda-Sanz", 
            "givenName": "R", 
            "id": "sg:person.01210335655.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210335655.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Radboud University Nijmegen Medical Centre", 
              "id": "https://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Krieken", 
            "givenName": "J H J M", 
            "id": "sg:person.013245604437.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245604437.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Schleswig-Holstein", 
              "id": "https://www.grid.ac/institutes/grid.412468.d", 
              "name": [
                "II Medizinische Klinik des Universit\u00e4tsklinikums Schleswig-Holstein, Campus Kiel, Kiel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Droese", 
            "givenName": "J", 
            "id": "sg:person.01102766322.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102766322.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario de Salamanca", 
              "id": "https://www.grid.ac/institutes/grid.411258.b", 
              "name": [
                "Servicio de Hematologia, Hospital Universitario de Salamanca, Salamanca, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonz\u00e1lez", 
            "givenName": "D", 
            "id": "sg:person.01233421047.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233421047.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UniCancer Group", 
              "id": "https://www.grid.ac/institutes/grid.418189.d", 
              "name": [
                "Laboratoire de Genetique Oncologique, Centre Henri Becquerel, Rouen, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bastard", 
            "givenName": "C", 
            "id": "sg:person.01302141257.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302141257.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Southampton NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.430506.4", 
              "name": [
                "Wessex Immunology Service, Molecular Pathology Unit, Southampton University Hospitals NHS Trust, Southampton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "White", 
            "givenName": "H E", 
            "id": "sg:person.01352020050.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352020050.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Academic Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Spaargaren", 
            "givenName": "M", 
            "id": "sg:person.0724422422.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724422422.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Complejo Hospitalario de Salamanca", 
              "id": "https://www.grid.ac/institutes/grid.411258.b", 
              "name": [
                "Servicio de Hematologia, Hospital Universitario de Salamanca, Salamanca, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonz\u00e1lez", 
            "givenName": "M", 
            "id": "sg:person.013023123727.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013023123727.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Portuguese Oncology Institute", 
              "id": "https://www.grid.ac/institutes/grid.418711.a", 
              "name": [
                "Department of Hematology, Instituto Portugu\u00e9s de Oncologia, Lisboa, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parreira", 
            "givenName": "A", 
            "id": "sg:person.0711207571.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711207571.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Southampton NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.430506.4", 
              "name": [
                "Wessex Immunology Service, Molecular Pathology Unit, Southampton University Hospitals NHS Trust, Southampton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "J L", 
            "id": "sg:person.0737266661.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737266661.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Leeds", 
              "id": "https://www.grid.ac/institutes/grid.9909.9", 
              "name": [
                "Academic Unit of Haematology and Oncology, University of Leeds, Leeds, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morgan", 
            "givenName": "G J", 
            "id": "sg:person.015235304437.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015235304437.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Schleswig-Holstein", 
              "id": "https://www.grid.ac/institutes/grid.412468.d", 
              "name": [
                "II Medizinische Klinik des Universit\u00e4tsklinikums Schleswig-Holstein, Campus Kiel, Kiel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kneba", 
            "givenName": "M", 
            "id": "sg:person.01016640613.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016640613.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Necker-Enfants Malades Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412134.1", 
              "name": [
                "Laboratoire d'Hematologie and INSERM EMI 210, H\u00f4pital Necker-Enfants Malades, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Macintyre", 
            "givenName": "E A", 
            "id": "sg:person.012275040134.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012275040134.75"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0009-8981(91)90246-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000134618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0009-8981(91)90246-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000134618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.6.2433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000219698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.172.6.1717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000369550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v99.12.4386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000372558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.172.2.609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000406828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.164.1.315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000536240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(85)80070-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001046047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00163961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001509507", 
              "https://doi.org/10.1007/bf00163961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000245709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001515924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.1993.tb08669.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001670352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0320(19961215)26:4<243::aid-cyto2>3.0.co;2-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001818494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v99.2.716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001875292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.53.1.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001936506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.53.1.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001936506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.16.6146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002215683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0320(20000801)40:4<336::aid-cyto9>3.0.co;2-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002693341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003405116", 
              "https://doi.org/10.1038/sj.leu.2402799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003405116", 
              "https://doi.org/10.1038/sj.leu.2402799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003716668", 
              "https://doi.org/10.1038/sj.leu.2400904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003716668", 
              "https://doi.org/10.1038/sj.leu.2400904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.1993.1217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003751282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004442643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/bchm3.1993.374.7-12.1001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004497483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.2001.02871.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004520106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004563953", 
              "https://doi.org/10.1038/sj.leu.2402144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004563953", 
              "https://doi.org/10.1038/sj.leu.2402144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.53.4.194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004691993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.53.4.194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004691993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/9.10.1503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004730934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1996.0636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004892202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004952160", 
              "https://doi.org/10.1038/sj.leu.2401985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004952160", 
              "https://doi.org/10.1038/sj.leu.2401985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-76492-9_38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005559427", 
              "https://doi.org/10.1007/978-3-642-76492-9_38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2567.1998.00417.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005641787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005735020", 
              "https://doi.org/10.1038/sj.leu.2402387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005735020", 
              "https://doi.org/10.1038/sj.leu.2402387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1092-9134(00)90014-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005955950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830190907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006200826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006931005", 
              "https://doi.org/10.1038/sj.leu.2401540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006931005", 
              "https://doi.org/10.1038/sj.leu.2401540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0625.1993.tb00017.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007802696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/beha.2002.0184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008048548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-4608(96)85244-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008354640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008402343", 
              "https://doi.org/10.1038/sj.leu.2402396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402396", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008402343", 
              "https://doi.org/10.1038/sj.leu.2402396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01262321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008559812", 
              "https://doi.org/10.1007/bf01262321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01262321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008559812", 
              "https://doi.org/10.1007/bf01262321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/290368a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008695588", 
              "https://doi.org/10.1038/290368a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00172176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009083864", 
              "https://doi.org/10.1007/bf00172176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00172176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009083864", 
              "https://doi.org/10.1007/bf00172176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2002-11-3456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009185168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1998.00879.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009690983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1998.00879.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009690983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.24.8624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009758889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010153215", 
              "https://doi.org/10.1038/sj.leu.2401277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010153215", 
              "https://doi.org/10.1038/sj.leu.2401277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012586847", 
              "https://doi.org/10.1038/sj.leu.2401889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012586847", 
              "https://doi.org/10.1038/sj.leu.2401889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.52.2.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014151376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.52.2.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014151376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1997.1141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014181974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014823000", 
              "https://doi.org/10.1038/sj.leu.2401427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014823000", 
              "https://doi.org/10.1038/sj.leu.2401427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-199503000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015451217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-199503000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015451217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1998.00764.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015649878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1998.00764.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015649878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0379-0738(01)00641-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015760573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1991.tb00591.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015839958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199911113412007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016446570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00188805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017319371", 
              "https://doi.org/10.1007/bf00188805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0320(19960615)26:2<148::aid-cyto8>3.0.co;2-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017525401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830220237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017553706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.184.6.2217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018966773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019826116", 
              "https://doi.org/10.1038/sj.leu.2401071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019826116", 
              "https://doi.org/10.1038/sj.leu.2401071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-76591-9_25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020533055", 
              "https://doi.org/10.1007/978-3-642-76591-9_25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-1578(10)60610-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020646902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.53.1.51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022056869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/mp.53.1.51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022056869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-199706000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022134126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-199706000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022134126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.13.4890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022134791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022578009", 
              "https://doi.org/10.1038/sj.leu.2401276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022578009", 
              "https://doi.org/10.1038/sj.leu.2401276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022611760", 
              "https://doi.org/10.1038/sj.leu.2402198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022611760", 
              "https://doi.org/10.1038/sj.leu.2402198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022931353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830240312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023213364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198412063112304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023488026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1999.01757.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024047326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/334395a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024802262", 
              "https://doi.org/10.1038/334395a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024876558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/302575a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025246621", 
              "https://doi.org/10.1038/302575a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830230214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025275362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026799533", 
              "https://doi.org/10.1038/sj.leu.2401245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026799533", 
              "https://doi.org/10.1038/sj.leu.2401245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026859604", 
              "https://doi.org/10.1038/sj.leu.2401765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026859604", 
              "https://doi.org/10.1038/sj.leu.2401765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.85.13.4869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027866661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1711740402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028160221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1711740402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028160221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci113270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028504791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029655664", 
              "https://doi.org/10.1038/sj.leu.2402552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029655664", 
              "https://doi.org/10.1038/sj.leu.2402552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.7.3.250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029897232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.44.11.924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030421714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198711053171904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031358812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcp/95.2.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031378440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/304172a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033446611", 
              "https://doi.org/10.1038/304172a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.1995.tb08938.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034452207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034918434", 
              "https://doi.org/10.1038/sj.leu.2401750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034918434", 
              "https://doi.org/10.1038/sj.leu.2401750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035352523", 
              "https://doi.org/10.1038/sj.leu.2400972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035352523", 
              "https://doi.org/10.1038/sj.leu.2400972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2264(199801)21:1<17::aid-gcc4>3.0.co;2-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035735066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830181223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035751125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.50.10.811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036043611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-8652(199809)59:1<99::aid-ajh21>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036244425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.1990.tb07836.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036827783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830220937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036881884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80592-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036917513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036928822", 
              "https://doi.org/10.1038/sj.leu.2402515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036928822", 
              "https://doi.org/10.1038/sj.leu.2402515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.21.8536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037138218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archderm.136.8.1052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037991920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199809000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038446426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199809000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038446426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038768462", 
              "https://doi.org/10.1038/sj.leu.2402475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038768462", 
              "https://doi.org/10.1038/sj.leu.2402475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63032-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039086076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(98)04058-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039481418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.11.2151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040336011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040343703", 
              "https://doi.org/10.1038/sj.leu.2402206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040343703", 
              "https://doi.org/10.1038/sj.leu.2402206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040475109", 
              "https://doi.org/10.1038/sj.leu.2400736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040475109", 
              "https://doi.org/10.1038/sj.leu.2400736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-291x(85)90390-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040870428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041074612", 
              "https://doi.org/10.1038/sj.leu.2402637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041074612", 
              "https://doi.org/10.1038/sj.leu.2402637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1997.3653179.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041400833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2141.1997.3653179.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041400833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/316260a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042306472", 
              "https://doi.org/10.1038/316260a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1997.0956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042353257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19930701)72:1<231::aid-cncr2820720141>3.0.co;2-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042403823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043492721", 
              "https://doi.org/10.1038/sj.leu.2400887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043492721", 
              "https://doi.org/10.1038/sj.leu.2400887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00815178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044219352", 
              "https://doi.org/10.1007/bf00815178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(87)80472-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044573603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199808273390904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045206858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-60162-0_26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045273127", 
              "https://doi.org/10.1007/978-3-642-60162-0_26"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-60162-0_26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045273127", 
              "https://doi.org/10.1007/978-3-642-60162-0_26"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.1993.tb03141.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045564277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v97.9.2716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045783290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1999.3243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047415795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.167.2.694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047529639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.21.7439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047611732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.1994.tb04913.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047720759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-1759(95)00178-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048885398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-200112000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050155394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-200112000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050155394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-199712000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050477375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00019606-199712000-00006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050477375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-5699(98)01330-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051223592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051322446", 
              "https://doi.org/10.1038/sj.leu.2402019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051322446", 
              "https://doi.org/10.1038/sj.leu.2402019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0009-8981(91)90247-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051565194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0009-8981(91)90247-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051565194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051684187", 
              "https://doi.org/10.1038/sj.leu.2401172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051684187", 
              "https://doi.org/10.1038/sj.leu.2401172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00172175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051709443", 
              "https://doi.org/10.1007/bf00172175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00172175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051709443", 
              "https://doi.org/10.1007/bf00172175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.42.8.840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052081071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.54.5.401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052176926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v98.1.165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052668532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1098-2264(200001)27:1<85::aid-gcc11>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053134854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053321235", 
              "https://doi.org/10.1038/sj.leu.2400903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2400903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053321235", 
              "https://doi.org/10.1038/sj.leu.2400903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002810050052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054514364", 
              "https://doi.org/10.1007/s002810050052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002810050052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054514364", 
              "https://doi.org/10.1007/s002810050052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1023/a:1008207005567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056302586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/4.6.983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059645455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/27.16.e12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059931851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/34.10.978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060011133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.272.5269.1755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062553361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3110950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062591676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6610211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062639178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v97.4.1001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064123465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo.137.11.8895354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064280572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074273855", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074355973", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074362856", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074473241", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074619144", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074664979", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074673676", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074690909", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.1.271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075073834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.170.5.2711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075240060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.171.2.524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075311920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076046313", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076886645", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077606865", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077609435", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077626434", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078044053", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078297690", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078426827", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079210368", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079472482", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079484200", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079550267", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1988.tb03309.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079635214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081364954", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082392764", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082402356", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082421973", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082459365", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082482177", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082516916", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082558278", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082620070", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082623487", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082670869", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082687326", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082695627", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082700455", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082707186", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082719657", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082729400", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082742024", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082778920", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082836376", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082878916", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082881496", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082889471", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082900523", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082910768", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082913018", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082916690", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082989447", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083023704", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083118301", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083152210", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083167205", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083215421", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083230187", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083265289", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03401757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083318163", 
              "https://doi.org/10.1007/bf03401757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083326202", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083354373", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083390219", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2003-12", 
        "datePublishedReg": "2003-12-01", 
        "description": "In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes and the chromosome aberrations t(11;14) and t(14;18). This has resulted in 107 different primers in only 18 multiplex PCR tubes: three VH-JH, two DH-JH, two Ig kappa (IGK), one Ig lambda (IGL), three TCR beta (TCRB), two TCR gamma (TCRG), one TCR delta (TCRD), three BCL1-Ig heavy chain (IGH), and one BCL2-IGH. The PCR products of Ig/TCR genes can be analyzed for clonality assessment by heteroduplex analysis or GeneScanning. The detection rate of clonal rearrangements using the BIOMED-2 primer sets is unprecedentedly high. This is mainly based on the complementarity of the various BIOMED-2 tubes. In particular, combined application of IGH (VH-JH and DH-JH) and IGK tubes can detect virtually all clonal B-cell proliferations, even in B-cell malignancies with high levels of somatic mutations. The contribution of IGL gene rearrangements seems limited. Combined usage of the TCRB and TCRG tubes detects virtually all clonal T-cell populations, whereas the TCRD tube has added value in case of TCRgammadelta(+) T-cell proliferations. The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/sj.leu.2403202", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1097065", 
            "issn": [
              "0887-6924", 
              "1476-5551"
            ], 
            "name": "Leukemia", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936", 
        "pagination": "2257", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8408d128187681ad7f011a0039c11cbee9a12e7747bc06a8afb6cd080410ee1b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "14671650"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8704895"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/sj.leu.2403202"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1027716225"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/sj.leu.2403202", 
          "https://app.dimensions.ai/details/publication/pub.1027716225"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118332_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/2403202"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403202'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403202'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403202'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/sj.leu.2403202'


     

    This table displays all metadata directly associated to this object as RDF triples.

    908 TRIPLES      21 PREDICATES      248 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/sj.leu.2403202 schema:about N240d0c0b18064f5ca39012de15025e95
    2 N2d80aa82258745988e27499cc5754b58
    3 N32f2bcdb2b83484ab07347c5a5e916ed
    4 N5a4107a1415c4bcd8c0de16ff74846c5
    5 N74986117e9d1492a8cb3652ae4c00330
    6 N9a4363abc3164d15b8498fb24e7abc0e
    7 Na8b41358c19f46ccb0c7ea32bb4d5679
    8 Nc16182e73cdb419aa5cb288c7a9542a2
    9 Nc4046819afaa4c0ca44e8673267adc19
    10 Nc489a8a6fd7e460394ee7ae7c0cd7ef6
    11 Nd0c10d9b8f724a8c9a93f0a8703af954
    12 Neb6818bccfb44f94b6f61977a8ee4fe4
    13 Nf4aeaabdb5ed4e36a561515a7b279d50
    14 anzsrc-for:06
    15 anzsrc-for:0604
    16 schema:author Naf5911e6fe7c4be6a7284ff050148c76
    17 schema:citation sg:pub.10.1007/978-3-642-60162-0_26
    18 sg:pub.10.1007/978-3-642-76492-9_38
    19 sg:pub.10.1007/978-3-642-76591-9_25
    20 sg:pub.10.1007/bf00163961
    21 sg:pub.10.1007/bf00172175
    22 sg:pub.10.1007/bf00172176
    23 sg:pub.10.1007/bf00188805
    24 sg:pub.10.1007/bf00815178
    25 sg:pub.10.1007/bf01262321
    26 sg:pub.10.1007/bf03401757
    27 sg:pub.10.1007/s002810050052
    28 sg:pub.10.1038/290368a0
    29 sg:pub.10.1038/302575a0
    30 sg:pub.10.1038/304172a0
    31 sg:pub.10.1038/316260a0
    32 sg:pub.10.1038/334395a0
    33 sg:pub.10.1038/sj.leu.2400736
    34 sg:pub.10.1038/sj.leu.2400887
    35 sg:pub.10.1038/sj.leu.2400903
    36 sg:pub.10.1038/sj.leu.2400904
    37 sg:pub.10.1038/sj.leu.2400972
    38 sg:pub.10.1038/sj.leu.2401071
    39 sg:pub.10.1038/sj.leu.2401172
    40 sg:pub.10.1038/sj.leu.2401245
    41 sg:pub.10.1038/sj.leu.2401276
    42 sg:pub.10.1038/sj.leu.2401277
    43 sg:pub.10.1038/sj.leu.2401427
    44 sg:pub.10.1038/sj.leu.2401540
    45 sg:pub.10.1038/sj.leu.2401750
    46 sg:pub.10.1038/sj.leu.2401765
    47 sg:pub.10.1038/sj.leu.2401889
    48 sg:pub.10.1038/sj.leu.2401985
    49 sg:pub.10.1038/sj.leu.2402019
    50 sg:pub.10.1038/sj.leu.2402144
    51 sg:pub.10.1038/sj.leu.2402198
    52 sg:pub.10.1038/sj.leu.2402206
    53 sg:pub.10.1038/sj.leu.2402387
    54 sg:pub.10.1038/sj.leu.2402396
    55 sg:pub.10.1038/sj.leu.2402475
    56 sg:pub.10.1038/sj.leu.2402515
    57 sg:pub.10.1038/sj.leu.2402552
    58 sg:pub.10.1038/sj.leu.2402637
    59 sg:pub.10.1038/sj.leu.2402799
    60 https://app.dimensions.ai/details/publication/pub.1074273855
    61 https://app.dimensions.ai/details/publication/pub.1074355973
    62 https://app.dimensions.ai/details/publication/pub.1074362856
    63 https://app.dimensions.ai/details/publication/pub.1074473241
    64 https://app.dimensions.ai/details/publication/pub.1074619144
    65 https://app.dimensions.ai/details/publication/pub.1074664979
    66 https://app.dimensions.ai/details/publication/pub.1074673676
    67 https://app.dimensions.ai/details/publication/pub.1074690909
    68 https://app.dimensions.ai/details/publication/pub.1076046313
    69 https://app.dimensions.ai/details/publication/pub.1076886645
    70 https://app.dimensions.ai/details/publication/pub.1077606865
    71 https://app.dimensions.ai/details/publication/pub.1077609435
    72 https://app.dimensions.ai/details/publication/pub.1077626434
    73 https://app.dimensions.ai/details/publication/pub.1078044053
    74 https://app.dimensions.ai/details/publication/pub.1078297690
    75 https://app.dimensions.ai/details/publication/pub.1078426827
    76 https://app.dimensions.ai/details/publication/pub.1079210368
    77 https://app.dimensions.ai/details/publication/pub.1079472482
    78 https://app.dimensions.ai/details/publication/pub.1079484200
    79 https://app.dimensions.ai/details/publication/pub.1079550267
    80 https://app.dimensions.ai/details/publication/pub.1081364954
    81 https://app.dimensions.ai/details/publication/pub.1082392764
    82 https://app.dimensions.ai/details/publication/pub.1082402356
    83 https://app.dimensions.ai/details/publication/pub.1082421973
    84 https://app.dimensions.ai/details/publication/pub.1082459365
    85 https://app.dimensions.ai/details/publication/pub.1082482177
    86 https://app.dimensions.ai/details/publication/pub.1082516916
    87 https://app.dimensions.ai/details/publication/pub.1082558278
    88 https://app.dimensions.ai/details/publication/pub.1082620070
    89 https://app.dimensions.ai/details/publication/pub.1082623487
    90 https://app.dimensions.ai/details/publication/pub.1082670869
    91 https://app.dimensions.ai/details/publication/pub.1082687326
    92 https://app.dimensions.ai/details/publication/pub.1082695627
    93 https://app.dimensions.ai/details/publication/pub.1082700455
    94 https://app.dimensions.ai/details/publication/pub.1082707186
    95 https://app.dimensions.ai/details/publication/pub.1082719657
    96 https://app.dimensions.ai/details/publication/pub.1082729400
    97 https://app.dimensions.ai/details/publication/pub.1082742024
    98 https://app.dimensions.ai/details/publication/pub.1082778920
    99 https://app.dimensions.ai/details/publication/pub.1082836376
    100 https://app.dimensions.ai/details/publication/pub.1082878916
    101 https://app.dimensions.ai/details/publication/pub.1082881496
    102 https://app.dimensions.ai/details/publication/pub.1082889471
    103 https://app.dimensions.ai/details/publication/pub.1082900523
    104 https://app.dimensions.ai/details/publication/pub.1082910768
    105 https://app.dimensions.ai/details/publication/pub.1082913018
    106 https://app.dimensions.ai/details/publication/pub.1082916690
    107 https://app.dimensions.ai/details/publication/pub.1082989447
    108 https://app.dimensions.ai/details/publication/pub.1083023704
    109 https://app.dimensions.ai/details/publication/pub.1083118301
    110 https://app.dimensions.ai/details/publication/pub.1083152210
    111 https://app.dimensions.ai/details/publication/pub.1083167205
    112 https://app.dimensions.ai/details/publication/pub.1083215421
    113 https://app.dimensions.ai/details/publication/pub.1083230187
    114 https://app.dimensions.ai/details/publication/pub.1083265289
    115 https://app.dimensions.ai/details/publication/pub.1083326202
    116 https://app.dimensions.ai/details/publication/pub.1083354373
    117 https://app.dimensions.ai/details/publication/pub.1083390219
    118 https://doi.org/10.1001/archderm.136.8.1052
    119 https://doi.org/10.1002/(sici)1096-8652(199809)59:1<99::aid-ajh21>3.0.co;2-w
    120 https://doi.org/10.1002/(sici)1097-0320(19960615)26:2<148::aid-cyto8>3.0.co;2-c
    121 https://doi.org/10.1002/(sici)1097-0320(19961215)26:4<243::aid-cyto2>3.0.co;2-d
    122 https://doi.org/10.1002/(sici)1098-2264(199801)21:1<17::aid-gcc4>3.0.co;2-b
    123 https://doi.org/10.1002/(sici)1098-2264(200001)27:1<85::aid-gcc11>3.0.co;2-9
    124 https://doi.org/10.1002/1097-0142(19930701)72:1<231::aid-cncr2820720141>3.0.co;2-5
    125 https://doi.org/10.1002/1097-0320(20000801)40:4<336::aid-cyto9>3.0.co;2-0
    126 https://doi.org/10.1002/eji.1830181223
    127 https://doi.org/10.1002/eji.1830190907
    128 https://doi.org/10.1002/eji.1830220237
    129 https://doi.org/10.1002/eji.1830220937
    130 https://doi.org/10.1002/eji.1830230214
    131 https://doi.org/10.1002/eji.1830240312
    132 https://doi.org/10.1002/j.1460-2075.1988.tb03309.x
    133 https://doi.org/10.1002/path.1197
    134 https://doi.org/10.1002/path.1711740402
    135 https://doi.org/10.1006/geno.1993.1217
    136 https://doi.org/10.1006/jmbi.1996.0636
    137 https://doi.org/10.1006/jmbi.1997.0956
    138 https://doi.org/10.1006/jmbi.1997.1141
    139 https://doi.org/10.1006/jmbi.1999.3243
    140 https://doi.org/10.1016/0006-291x(85)90390-0
    141 https://doi.org/10.1016/0009-8981(91)90246-9
    142 https://doi.org/10.1016/0009-8981(91)90247-a
    143 https://doi.org/10.1016/0014-5793(87)80472-6
    144 https://doi.org/10.1016/0022-1759(95)00178-d
    145 https://doi.org/10.1016/0165-4608(96)85244-7
    146 https://doi.org/10.1016/s0002-9440(10)63032-5
    147 https://doi.org/10.1016/s0092-8674(85)80070-2
    148 https://doi.org/10.1016/s0140-6736(98)04058-6
    149 https://doi.org/10.1016/s0167-5699(98)01330-9
    150 https://doi.org/10.1016/s0379-0738(01)00641-7
    151 https://doi.org/10.1016/s1074-7613(00)80592-0
    152 https://doi.org/10.1016/s1092-9134(00)90014-5
    153 https://doi.org/10.1016/s1525-1578(10)60610-1
    154 https://doi.org/10.1023/a:1008207005567
    155 https://doi.org/10.1046/j.1365-2141.1997.3653179.x
    156 https://doi.org/10.1046/j.1365-2141.1998.00764.x
    157 https://doi.org/10.1046/j.1365-2141.1998.00879.x
    158 https://doi.org/10.1046/j.1365-2141.1999.01757.x
    159 https://doi.org/10.1046/j.1365-2141.2001.02871.x
    160 https://doi.org/10.1046/j.1365-2567.1998.00417.x
    161 https://doi.org/10.1053/beha.2002.0184
    162 https://doi.org/10.1056/nejm198412063112304
    163 https://doi.org/10.1056/nejm198711053171904
    164 https://doi.org/10.1056/nejm199808273390904
    165 https://doi.org/10.1056/nejm199911113412007
    166 https://doi.org/10.1073/pnas.82.21.7439
    167 https://doi.org/10.1073/pnas.82.24.8624
    168 https://doi.org/10.1073/pnas.83.13.4890
    169 https://doi.org/10.1073/pnas.85.13.4869
    170 https://doi.org/10.1073/pnas.87.16.6146
    171 https://doi.org/10.1073/pnas.87.21.8536
    172 https://doi.org/10.1073/pnas.90.6.2433
    173 https://doi.org/10.1084/jem.164.1.315
    174 https://doi.org/10.1084/jem.167.2.694
    175 https://doi.org/10.1084/jem.172.2.609
    176 https://doi.org/10.1084/jem.172.6.1717
    177 https://doi.org/10.1084/jem.184.6.2217
    178 https://doi.org/10.1084/jem.188.11.2151
    179 https://doi.org/10.1093/ajcp/95.2.117
    180 https://doi.org/10.1093/hmg/4.6.983
    181 https://doi.org/10.1093/intimm/9.10.1503
    182 https://doi.org/10.1093/nar/27.16.e12
    183 https://doi.org/10.1093/nar/gkg085
    184 https://doi.org/10.1093/rheumatology/34.10.978
    185 https://doi.org/10.1097/00002371-199809000-00004
    186 https://doi.org/10.1097/00019606-199503000-00003
    187 https://doi.org/10.1097/00019606-199706000-00007
    188 https://doi.org/10.1097/00019606-199712000-00006
    189 https://doi.org/10.1097/00019606-200112000-00009
    190 https://doi.org/10.1101/gr.7.3.250
    191 https://doi.org/10.1111/j.1365-2141.1990.tb07836.x
    192 https://doi.org/10.1111/j.1365-2141.1993.tb03141.x
    193 https://doi.org/10.1111/j.1365-2141.1993.tb08669.x
    194 https://doi.org/10.1111/j.1365-2141.1994.tb04913.x
    195 https://doi.org/10.1111/j.1365-2141.1995.tb08938.x
    196 https://doi.org/10.1111/j.1600-0625.1993.tb00017.x
    197 https://doi.org/10.1111/j.1600-065x.1991.tb00591.x
    198 https://doi.org/10.1126/science.272.5269.1755
    199 https://doi.org/10.1126/science.3110950
    200 https://doi.org/10.1126/science.6610211
    201 https://doi.org/10.1136/jcp.42.8.840
    202 https://doi.org/10.1136/jcp.44.11.924
    203 https://doi.org/10.1136/jcp.50.10.811
    204 https://doi.org/10.1136/jcp.54.5.401
    205 https://doi.org/10.1136/mp.52.2.104
    206 https://doi.org/10.1136/mp.53.1.19
    207 https://doi.org/10.1136/mp.53.1.51
    208 https://doi.org/10.1136/mp.53.4.194
    209 https://doi.org/10.1159/000245709
    210 https://doi.org/10.1172/jci113270
    211 https://doi.org/10.1172/jci115044
    212 https://doi.org/10.1182/blood-2002-11-3456
    213 https://doi.org/10.1182/blood.v97.4.1001
    214 https://doi.org/10.1182/blood.v97.9.2716
    215 https://doi.org/10.1182/blood.v98.1.165
    216 https://doi.org/10.1182/blood.v99.12.4386
    217 https://doi.org/10.1182/blood.v99.2.716
    218 https://doi.org/10.1210/endo.137.11.8895354
    219 https://doi.org/10.1515/bchm3.1993.374.7-12.1001
    220 https://doi.org/10.4049/jimmunol.169.1.271
    221 https://doi.org/10.4049/jimmunol.170.5.2711
    222 https://doi.org/10.4049/jimmunol.171.2.524
    223 schema:datePublished 2003-12
    224 schema:datePublishedReg 2003-12-01
    225 schema:description In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes and the chromosome aberrations t(11;14) and t(14;18). This has resulted in 107 different primers in only 18 multiplex PCR tubes: three VH-JH, two DH-JH, two Ig kappa (IGK), one Ig lambda (IGL), three TCR beta (TCRB), two TCR gamma (TCRG), one TCR delta (TCRD), three BCL1-Ig heavy chain (IGH), and one BCL2-IGH. The PCR products of Ig/TCR genes can be analyzed for clonality assessment by heteroduplex analysis or GeneScanning. The detection rate of clonal rearrangements using the BIOMED-2 primer sets is unprecedentedly high. This is mainly based on the complementarity of the various BIOMED-2 tubes. In particular, combined application of IGH (VH-JH and DH-JH) and IGK tubes can detect virtually all clonal B-cell proliferations, even in B-cell malignancies with high levels of somatic mutations. The contribution of IGL gene rearrangements seems limited. Combined usage of the TCRB and TCRG tubes detects virtually all clonal T-cell populations, whereas the TCRD tube has added value in case of TCRgammadelta(+) T-cell proliferations. The BIOMED-2 multiplex tubes can now be used for diagnostic clonality studies as well as for the identification of PCR targets suitable for the detection of minimal residual disease.
    226 schema:genre research_article
    227 schema:inLanguage en
    228 schema:isAccessibleForFree true
    229 schema:isPartOf N4b9f65c4ded24616a0202e5260c0051d
    230 Nb95792effa424f548390156b7f365471
    231 sg:journal.1097065
    232 schema:name Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936
    233 schema:pagination 2257
    234 schema:productId N4619054365fe4f538b169fd129a7a7a8
    235 N60772b90d042477285f2f581f8cf2736
    236 N7509d274e0bf476696fe50fbba97d9e2
    237 Na3c472baf4f44ba3b97e96f85729f462
    238 Ne6b0e258116447a7bbf1446331067c7f
    239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027716225
    240 https://doi.org/10.1038/sj.leu.2403202
    241 schema:sdDatePublished 2019-04-11T12:05
    242 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    243 schema:sdPublisher N18be2c9ec19d417b974a735b0462ff85
    244 schema:url https://www.nature.com/articles/2403202
    245 sgo:license sg:explorer/license/
    246 sgo:sdDataset articles
    247 rdf:type schema:ScholarlyArticle
    248 N092ff8aa9f604becb4e4aaae4de59f13 rdf:first sg:person.01302141257.08
    249 rdf:rest N3cdcdb62072445718a00756b756d5475
    250 N139c103ae9d34b489cf0390f0eadb40f rdf:first sg:person.011464602664.29
    251 rdf:rest N59f2a8aa32cd4ea1820ab9d8889a12bf
    252 N15ba476f1d2b491fb768b003e388c236 rdf:first sg:person.012275040134.75
    253 rdf:rest rdf:nil
    254 N18be2c9ec19d417b974a735b0462ff85 schema:name Springer Nature - SN SciGraph project
    255 rdf:type schema:Organization
    256 N1f65048b4d724a9ea5fce072e07af5ec rdf:first sg:person.01210335655.37
    257 rdf:rest N4a2f6689f13d4ac5966fc5cf57a7c9c8
    258 N240d0c0b18064f5ca39012de15025e95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Receptors, Antigen, T-Cell
    260 rdf:type schema:DefinedTerm
    261 N27e4f22bc9e54398b75a6d6b1ba72a2b rdf:first sg:person.01016640613.58
    262 rdf:rest N15ba476f1d2b491fb768b003e388c236
    263 N2d80aa82258745988e27499cc5754b58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Gene Rearrangement, T-Lymphocyte
    265 rdf:type schema:DefinedTerm
    266 N32f2bcdb2b83484ab07347c5a5e916ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    267 schema:name Humans
    268 rdf:type schema:DefinedTerm
    269 N374025a86ada4fd9926c88fc6d7527be rdf:first sg:person.01151001152.04
    270 rdf:rest N1f65048b4d724a9ea5fce072e07af5ec
    271 N39fd68250db24b34b7d0473090c22d8b rdf:first sg:person.01315504000.41
    272 rdf:rest N720033a2c16c405c89a58a6a07e1b5b1
    273 N3cdcdb62072445718a00756b756d5475 rdf:first sg:person.01352020050.25
    274 rdf:rest N6238b0fe6d9e481abf95344a651ab1b1
    275 N4619054365fe4f538b169fd129a7a7a8 schema:name nlm_unique_id
    276 schema:value 8704895
    277 rdf:type schema:PropertyValue
    278 N4a2f6689f13d4ac5966fc5cf57a7c9c8 rdf:first sg:person.013245604437.70
    279 rdf:rest N9cee7cb7047f4f6b86785f552aeec835
    280 N4b9f65c4ded24616a0202e5260c0051d schema:issueNumber 12
    281 rdf:type schema:PublicationIssue
    282 N59f2a8aa32cd4ea1820ab9d8889a12bf rdf:first sg:person.0776675364.84
    283 rdf:rest Nf53e1dab22d44035854f474dc1a7f10b
    284 N5a4107a1415c4bcd8c0de16ff74846c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    285 schema:name Clone Cells
    286 rdf:type schema:DefinedTerm
    287 N60772b90d042477285f2f581f8cf2736 schema:name doi
    288 schema:value 10.1038/sj.leu.2403202
    289 rdf:type schema:PropertyValue
    290 N6238b0fe6d9e481abf95344a651ab1b1 rdf:first sg:person.0724422422.86
    291 rdf:rest Nac1a2486b1ed4a3895cee44c02d0737e
    292 N635c6a582bdb4439bf5fea48a1df1476 rdf:first sg:person.0737266661.05
    293 rdf:rest N98558d9ffe4745c69ba9c2e94f6b2a50
    294 N720033a2c16c405c89a58a6a07e1b5b1 rdf:first sg:person.01240304757.74
    295 rdf:rest N374025a86ada4fd9926c88fc6d7527be
    296 N74986117e9d1492a8cb3652ae4c00330 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    297 schema:name Reference Standards
    298 rdf:type schema:DefinedTerm
    299 N7509d274e0bf476696fe50fbba97d9e2 schema:name dimensions_id
    300 schema:value pub.1027716225
    301 rdf:type schema:PropertyValue
    302 N7e3db661a1da4c48bce183e7689eb1ba rdf:first sg:person.01146120036.72
    303 rdf:rest N39fd68250db24b34b7d0473090c22d8b
    304 N98558d9ffe4745c69ba9c2e94f6b2a50 rdf:first sg:person.015235304437.41
    305 rdf:rest N27e4f22bc9e54398b75a6d6b1ba72a2b
    306 N9a4363abc3164d15b8498fb24e7abc0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    307 schema:name Polymerase Chain Reaction
    308 rdf:type schema:DefinedTerm
    309 N9cee7cb7047f4f6b86785f552aeec835 rdf:first sg:person.01102766322.41
    310 rdf:rest Nb7b92371a1af4373b24a74c33a92ddb0
    311 Na3c472baf4f44ba3b97e96f85729f462 schema:name readcube_id
    312 schema:value 8408d128187681ad7f011a0039c11cbee9a12e7747bc06a8afb6cd080410ee1b
    313 rdf:type schema:PropertyValue
    314 Na8b41358c19f46ccb0c7ea32bb4d5679 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    315 schema:name Neoplasm, Residual
    316 rdf:type schema:DefinedTerm
    317 Naa01a9a67bfd448aa7b0a46c3f61b10b rdf:first sg:person.0711207571.17
    318 rdf:rest N635c6a582bdb4439bf5fea48a1df1476
    319 Nac1a2486b1ed4a3895cee44c02d0737e rdf:first sg:person.013023123727.43
    320 rdf:rest Naa01a9a67bfd448aa7b0a46c3f61b10b
    321 Naf5911e6fe7c4be6a7284ff050148c76 rdf:first sg:person.014022412277.73
    322 rdf:rest N139c103ae9d34b489cf0390f0eadb40f
    323 Nb7b92371a1af4373b24a74c33a92ddb0 rdf:first sg:person.01233421047.98
    324 rdf:rest N092ff8aa9f604becb4e4aaae4de59f13
    325 Nb95792effa424f548390156b7f365471 schema:volumeNumber 17
    326 rdf:type schema:PublicationVolume
    327 Nc16182e73cdb419aa5cb288c7a9542a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    328 schema:name DNA Primers
    329 rdf:type schema:DefinedTerm
    330 Nc4046819afaa4c0ca44e8673267adc19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    331 schema:name Reproducibility of Results
    332 rdf:type schema:DefinedTerm
    333 Nc489a8a6fd7e460394ee7ae7c0cd7ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    334 schema:name Immunoglobulins
    335 rdf:type schema:DefinedTerm
    336 Nd0c10d9b8f724a8c9a93f0a8703af954 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    337 schema:name Lymphoproliferative Disorders
    338 rdf:type schema:DefinedTerm
    339 Nd5ebce7f9f064f99a9035aece0776501 rdf:first sg:person.0615736477.31
    340 rdf:rest N7e3db661a1da4c48bce183e7689eb1ba
    341 Ne6b0e258116447a7bbf1446331067c7f schema:name pubmed_id
    342 schema:value 14671650
    343 rdf:type schema:PropertyValue
    344 Neb6818bccfb44f94b6f61977a8ee4fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    345 schema:name European Union
    346 rdf:type schema:DefinedTerm
    347 Nf4aeaabdb5ed4e36a561515a7b279d50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    348 schema:name Chromosome Aberrations
    349 rdf:type schema:DefinedTerm
    350 Nf53e1dab22d44035854f474dc1a7f10b rdf:first sg:person.013513065422.97
    351 rdf:rest Nd5ebce7f9f064f99a9035aece0776501
    352 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    353 schema:name Biological Sciences
    354 rdf:type schema:DefinedTerm
    355 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    356 schema:name Genetics
    357 rdf:type schema:DefinedTerm
    358 sg:journal.1097065 schema:issn 0887-6924
    359 1476-5551
    360 schema:name Leukemia
    361 rdf:type schema:Periodical
    362 sg:person.01016640613.58 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
    363 schema:familyName Kneba
    364 schema:givenName M
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016640613.58
    366 rdf:type schema:Person
    367 sg:person.01102766322.41 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
    368 schema:familyName Droese
    369 schema:givenName J
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102766322.41
    371 rdf:type schema:Person
    372 sg:person.01146120036.72 schema:affiliation https://www.grid.ac/institutes/grid.430506.4
    373 schema:familyName Lavender
    374 schema:givenName F L
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146120036.72
    376 rdf:type schema:Person
    377 sg:person.011464602664.29 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
    378 schema:familyName Langerak
    379 schema:givenName A W
    380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464602664.29
    381 rdf:type schema:Person
    382 sg:person.01151001152.04 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
    383 schema:familyName Schuuring
    384 schema:givenName E
    385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151001152.04
    386 rdf:type schema:Person
    387 sg:person.01210335655.37 schema:affiliation https://www.grid.ac/institutes/grid.411258.b
    388 schema:familyName García-Sanz
    389 schema:givenName R
    390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210335655.37
    391 rdf:type schema:Person
    392 sg:person.012275040134.75 schema:affiliation https://www.grid.ac/institutes/grid.412134.1
    393 schema:familyName Macintyre
    394 schema:givenName E A
    395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012275040134.75
    396 rdf:type schema:Person
    397 sg:person.01233421047.98 schema:affiliation https://www.grid.ac/institutes/grid.411258.b
    398 schema:familyName González
    399 schema:givenName D
    400 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233421047.98
    401 rdf:type schema:Person
    402 sg:person.01240304757.74 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    403 schema:familyName Davi
    404 schema:givenName F
    405 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240304757.74
    406 rdf:type schema:Person
    407 sg:person.01302141257.08 schema:affiliation https://www.grid.ac/institutes/grid.418189.d
    408 schema:familyName Bastard
    409 schema:givenName C
    410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302141257.08
    411 rdf:type schema:Person
    412 sg:person.013023123727.43 schema:affiliation https://www.grid.ac/institutes/grid.411258.b
    413 schema:familyName González
    414 schema:givenName M
    415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013023123727.43
    416 rdf:type schema:Person
    417 sg:person.01315504000.41 schema:affiliation https://www.grid.ac/institutes/grid.412134.1
    418 schema:familyName Delabesse
    419 schema:givenName E
    420 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315504000.41
    421 rdf:type schema:Person
    422 sg:person.013245604437.70 schema:affiliation https://www.grid.ac/institutes/grid.10417.33
    423 schema:familyName van Krieken
    424 schema:givenName J H J M
    425 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013245604437.70
    426 rdf:type schema:Person
    427 sg:person.013513065422.97 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
    428 schema:familyName Evans
    429 schema:givenName P A S
    430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013513065422.97
    431 rdf:type schema:Person
    432 sg:person.01352020050.25 schema:affiliation https://www.grid.ac/institutes/grid.430506.4
    433 schema:familyName White
    434 schema:givenName H E
    435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352020050.25
    436 rdf:type schema:Person
    437 sg:person.014022412277.73 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
    438 schema:familyName van Dongen
    439 schema:givenName J J M
    440 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014022412277.73
    441 rdf:type schema:Person
    442 sg:person.015235304437.41 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
    443 schema:familyName Morgan
    444 schema:givenName G J
    445 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015235304437.41
    446 rdf:type schema:Person
    447 sg:person.0615736477.31 schema:affiliation https://www.grid.ac/institutes/grid.14095.39
    448 schema:familyName Hummel
    449 schema:givenName M
    450 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615736477.31
    451 rdf:type schema:Person
    452 sg:person.0711207571.17 schema:affiliation https://www.grid.ac/institutes/grid.418711.a
    453 schema:familyName Parreira
    454 schema:givenName A
    455 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711207571.17
    456 rdf:type schema:Person
    457 sg:person.0724422422.86 schema:affiliation https://www.grid.ac/institutes/grid.5650.6
    458 schema:familyName Spaargaren
    459 schema:givenName M
    460 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724422422.86
    461 rdf:type schema:Person
    462 sg:person.0737266661.05 schema:affiliation https://www.grid.ac/institutes/grid.430506.4
    463 schema:familyName Smith
    464 schema:givenName J L
    465 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737266661.05
    466 rdf:type schema:Person
    467 sg:person.0776675364.84 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
    468 schema:familyName Brüggemann
    469 schema:givenName M
    470 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776675364.84
    471 rdf:type schema:Person
    472 sg:pub.10.1007/978-3-642-60162-0_26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045273127
    473 https://doi.org/10.1007/978-3-642-60162-0_26
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1007/978-3-642-76492-9_38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005559427
    476 https://doi.org/10.1007/978-3-642-76492-9_38
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1007/978-3-642-76591-9_25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020533055
    479 https://doi.org/10.1007/978-3-642-76591-9_25
    480 rdf:type schema:CreativeWork
    481 sg:pub.10.1007/bf00163961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001509507
    482 https://doi.org/10.1007/bf00163961
    483 rdf:type schema:CreativeWork
    484 sg:pub.10.1007/bf00172175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051709443
    485 https://doi.org/10.1007/bf00172175
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1007/bf00172176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009083864
    488 https://doi.org/10.1007/bf00172176
    489 rdf:type schema:CreativeWork
    490 sg:pub.10.1007/bf00188805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017319371
    491 https://doi.org/10.1007/bf00188805
    492 rdf:type schema:CreativeWork
    493 sg:pub.10.1007/bf00815178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044219352
    494 https://doi.org/10.1007/bf00815178
    495 rdf:type schema:CreativeWork
    496 sg:pub.10.1007/bf01262321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008559812
    497 https://doi.org/10.1007/bf01262321
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1007/bf03401757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083318163
    500 https://doi.org/10.1007/bf03401757
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1007/s002810050052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054514364
    503 https://doi.org/10.1007/s002810050052
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/290368a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008695588
    506 https://doi.org/10.1038/290368a0
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/302575a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025246621
    509 https://doi.org/10.1038/302575a0
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1038/304172a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033446611
    512 https://doi.org/10.1038/304172a0
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1038/316260a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042306472
    515 https://doi.org/10.1038/316260a0
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1038/334395a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024802262
    518 https://doi.org/10.1038/334395a0
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1038/sj.leu.2400736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040475109
    521 https://doi.org/10.1038/sj.leu.2400736
    522 rdf:type schema:CreativeWork
    523 sg:pub.10.1038/sj.leu.2400887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043492721
    524 https://doi.org/10.1038/sj.leu.2400887
    525 rdf:type schema:CreativeWork
    526 sg:pub.10.1038/sj.leu.2400903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053321235
    527 https://doi.org/10.1038/sj.leu.2400903
    528 rdf:type schema:CreativeWork
    529 sg:pub.10.1038/sj.leu.2400904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003716668
    530 https://doi.org/10.1038/sj.leu.2400904
    531 rdf:type schema:CreativeWork
    532 sg:pub.10.1038/sj.leu.2400972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035352523
    533 https://doi.org/10.1038/sj.leu.2400972
    534 rdf:type schema:CreativeWork
    535 sg:pub.10.1038/sj.leu.2401071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019826116
    536 https://doi.org/10.1038/sj.leu.2401071
    537 rdf:type schema:CreativeWork
    538 sg:pub.10.1038/sj.leu.2401172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051684187
    539 https://doi.org/10.1038/sj.leu.2401172
    540 rdf:type schema:CreativeWork
    541 sg:pub.10.1038/sj.leu.2401245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026799533
    542 https://doi.org/10.1038/sj.leu.2401245
    543 rdf:type schema:CreativeWork
    544 sg:pub.10.1038/sj.leu.2401276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022578009
    545 https://doi.org/10.1038/sj.leu.2401276
    546 rdf:type schema:CreativeWork
    547 sg:pub.10.1038/sj.leu.2401277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010153215
    548 https://doi.org/10.1038/sj.leu.2401277
    549 rdf:type schema:CreativeWork
    550 sg:pub.10.1038/sj.leu.2401427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014823000
    551 https://doi.org/10.1038/sj.leu.2401427
    552 rdf:type schema:CreativeWork
    553 sg:pub.10.1038/sj.leu.2401540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006931005
    554 https://doi.org/10.1038/sj.leu.2401540
    555 rdf:type schema:CreativeWork
    556 sg:pub.10.1038/sj.leu.2401750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034918434
    557 https://doi.org/10.1038/sj.leu.2401750
    558 rdf:type schema:CreativeWork
    559 sg:pub.10.1038/sj.leu.2401765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026859604
    560 https://doi.org/10.1038/sj.leu.2401765
    561 rdf:type schema:CreativeWork
    562 sg:pub.10.1038/sj.leu.2401889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012586847
    563 https://doi.org/10.1038/sj.leu.2401889
    564 rdf:type schema:CreativeWork
    565 sg:pub.10.1038/sj.leu.2401985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004952160
    566 https://doi.org/10.1038/sj.leu.2401985
    567 rdf:type schema:CreativeWork
    568 sg:pub.10.1038/sj.leu.2402019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051322446
    569 https://doi.org/10.1038/sj.leu.2402019
    570 rdf:type schema:CreativeWork
    571 sg:pub.10.1038/sj.leu.2402144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004563953
    572 https://doi.org/10.1038/sj.leu.2402144
    573 rdf:type schema:CreativeWork
    574 sg:pub.10.1038/sj.leu.2402198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022611760
    575 https://doi.org/10.1038/sj.leu.2402198
    576 rdf:type schema:CreativeWork
    577 sg:pub.10.1038/sj.leu.2402206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040343703
    578 https://doi.org/10.1038/sj.leu.2402206
    579 rdf:type schema:CreativeWork
    580 sg:pub.10.1038/sj.leu.2402387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005735020
    581 https://doi.org/10.1038/sj.leu.2402387
    582 rdf:type schema:CreativeWork
    583 sg:pub.10.1038/sj.leu.2402396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008402343
    584 https://doi.org/10.1038/sj.leu.2402396
    585 rdf:type schema:CreativeWork
    586 sg:pub.10.1038/sj.leu.2402475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038768462
    587 https://doi.org/10.1038/sj.leu.2402475
    588 rdf:type schema:CreativeWork
    589 sg:pub.10.1038/sj.leu.2402515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036928822
    590 https://doi.org/10.1038/sj.leu.2402515
    591 rdf:type schema:CreativeWork
    592 sg:pub.10.1038/sj.leu.2402552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029655664
    593 https://doi.org/10.1038/sj.leu.2402552
    594 rdf:type schema:CreativeWork
    595 sg:pub.10.1038/sj.leu.2402637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041074612
    596 https://doi.org/10.1038/sj.leu.2402637
    597 rdf:type schema:CreativeWork
    598 sg:pub.10.1038/sj.leu.2402799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003405116
    599 https://doi.org/10.1038/sj.leu.2402799
    600 rdf:type schema:CreativeWork
    601 https://app.dimensions.ai/details/publication/pub.1074273855 schema:CreativeWork
    602 https://app.dimensions.ai/details/publication/pub.1074355973 schema:CreativeWork
    603 https://app.dimensions.ai/details/publication/pub.1074362856 schema:CreativeWork
    604 https://app.dimensions.ai/details/publication/pub.1074473241 schema:CreativeWork
    605 https://app.dimensions.ai/details/publication/pub.1074619144 schema:CreativeWork
    606 https://app.dimensions.ai/details/publication/pub.1074664979 schema:CreativeWork
    607 https://app.dimensions.ai/details/publication/pub.1074673676 schema:CreativeWork
    608 https://app.dimensions.ai/details/publication/pub.1074690909 schema:CreativeWork
    609 https://app.dimensions.ai/details/publication/pub.1076046313 schema:CreativeWork
    610 https://app.dimensions.ai/details/publication/pub.1076886645 schema:CreativeWork
    611 https://app.dimensions.ai/details/publication/pub.1077606865 schema:CreativeWork
    612 https://app.dimensions.ai/details/publication/pub.1077609435 schema:CreativeWork
    613 https://app.dimensions.ai/details/publication/pub.1077626434 schema:CreativeWork
    614 https://app.dimensions.ai/details/publication/pub.1078044053 schema:CreativeWork
    615 https://app.dimensions.ai/details/publication/pub.1078297690 schema:CreativeWork
    616 https://app.dimensions.ai/details/publication/pub.1078426827 schema:CreativeWork
    617 https://app.dimensions.ai/details/publication/pub.1079210368 schema:CreativeWork
    618 https://app.dimensions.ai/details/publication/pub.1079472482 schema:CreativeWork
    619 https://app.dimensions.ai/details/publication/pub.1079484200 schema:CreativeWork
    620 https://app.dimensions.ai/details/publication/pub.1079550267 schema:CreativeWork
    621 https://app.dimensions.ai/details/publication/pub.1081364954 schema:CreativeWork
    622 https://app.dimensions.ai/details/publication/pub.1082392764 schema:CreativeWork
    623 https://app.dimensions.ai/details/publication/pub.1082402356 schema:CreativeWork
    624 https://app.dimensions.ai/details/publication/pub.1082421973 schema:CreativeWork
    625 https://app.dimensions.ai/details/publication/pub.1082459365 schema:CreativeWork
    626 https://app.dimensions.ai/details/publication/pub.1082482177 schema:CreativeWork
    627 https://app.dimensions.ai/details/publication/pub.1082516916 schema:CreativeWork
    628 https://app.dimensions.ai/details/publication/pub.1082558278 schema:CreativeWork
    629 https://app.dimensions.ai/details/publication/pub.1082620070 schema:CreativeWork
    630 https://app.dimensions.ai/details/publication/pub.1082623487 schema:CreativeWork
    631 https://app.dimensions.ai/details/publication/pub.1082670869 schema:CreativeWork
    632 https://app.dimensions.ai/details/publication/pub.1082687326 schema:CreativeWork
    633 https://app.dimensions.ai/details/publication/pub.1082695627 schema:CreativeWork
    634 https://app.dimensions.ai/details/publication/pub.1082700455 schema:CreativeWork
    635 https://app.dimensions.ai/details/publication/pub.1082707186 schema:CreativeWork
    636 https://app.dimensions.ai/details/publication/pub.1082719657 schema:CreativeWork
    637 https://app.dimensions.ai/details/publication/pub.1082729400 schema:CreativeWork
    638 https://app.dimensions.ai/details/publication/pub.1082742024 schema:CreativeWork
    639 https://app.dimensions.ai/details/publication/pub.1082778920 schema:CreativeWork
    640 https://app.dimensions.ai/details/publication/pub.1082836376 schema:CreativeWork
    641 https://app.dimensions.ai/details/publication/pub.1082878916 schema:CreativeWork
    642 https://app.dimensions.ai/details/publication/pub.1082881496 schema:CreativeWork
    643 https://app.dimensions.ai/details/publication/pub.1082889471 schema:CreativeWork
    644 https://app.dimensions.ai/details/publication/pub.1082900523 schema:CreativeWork
    645 https://app.dimensions.ai/details/publication/pub.1082910768 schema:CreativeWork
    646 https://app.dimensions.ai/details/publication/pub.1082913018 schema:CreativeWork
    647 https://app.dimensions.ai/details/publication/pub.1082916690 schema:CreativeWork
    648 https://app.dimensions.ai/details/publication/pub.1082989447 schema:CreativeWork
    649 https://app.dimensions.ai/details/publication/pub.1083023704 schema:CreativeWork
    650 https://app.dimensions.ai/details/publication/pub.1083118301 schema:CreativeWork
    651 https://app.dimensions.ai/details/publication/pub.1083152210 schema:CreativeWork
    652 https://app.dimensions.ai/details/publication/pub.1083167205 schema:CreativeWork
    653 https://app.dimensions.ai/details/publication/pub.1083215421 schema:CreativeWork
    654 https://app.dimensions.ai/details/publication/pub.1083230187 schema:CreativeWork
    655 https://app.dimensions.ai/details/publication/pub.1083265289 schema:CreativeWork
    656 https://app.dimensions.ai/details/publication/pub.1083326202 schema:CreativeWork
    657 https://app.dimensions.ai/details/publication/pub.1083354373 schema:CreativeWork
    658 https://app.dimensions.ai/details/publication/pub.1083390219 schema:CreativeWork
    659 https://doi.org/10.1001/archderm.136.8.1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037991920
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1002/(sici)1096-8652(199809)59:1<99::aid-ajh21>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1036244425
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1002/(sici)1097-0320(19960615)26:2<148::aid-cyto8>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1017525401
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1002/(sici)1097-0320(19961215)26:4<243::aid-cyto2>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1001818494
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1002/(sici)1098-2264(199801)21:1<17::aid-gcc4>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1035735066
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1002/(sici)1098-2264(200001)27:1<85::aid-gcc11>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053134854
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1002/1097-0142(19930701)72:1<231::aid-cncr2820720141>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042403823
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.1002/1097-0320(20000801)40:4<336::aid-cyto9>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002693341
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.1002/eji.1830181223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035751125
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.1002/eji.1830190907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006200826
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.1002/eji.1830220237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017553706
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.1002/eji.1830220937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036881884
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.1002/eji.1830230214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025275362
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.1002/eji.1830240312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023213364
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.1002/j.1460-2075.1988.tb03309.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079635214
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.1002/path.1197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004442643
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.1002/path.1711740402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028160221
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.1006/geno.1993.1217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003751282
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.1006/jmbi.1996.0636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004892202
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.1006/jmbi.1997.0956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042353257
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.1006/jmbi.1997.1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014181974
    700 rdf:type schema:CreativeWork
    701 https://doi.org/10.1006/jmbi.1999.3243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047415795
    702 rdf:type schema:CreativeWork
    703 https://doi.org/10.1016/0006-291x(85)90390-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040870428
    704 rdf:type schema:CreativeWork
    705 https://doi.org/10.1016/0009-8981(91)90246-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000134618
    706 rdf:type schema:CreativeWork
    707 https://doi.org/10.1016/0009-8981(91)90247-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1051565194
    708 rdf:type schema:CreativeWork
    709 https://doi.org/10.1016/0014-5793(87)80472-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044573603
    710 rdf:type schema:CreativeWork
    711 https://doi.org/10.1016/0022-1759(95)00178-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1048885398
    712 rdf:type schema:CreativeWork
    713 https://doi.org/10.1016/0165-4608(96)85244-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008354640
    714 rdf:type schema:CreativeWork
    715 https://doi.org/10.1016/s0002-9440(10)63032-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039086076
    716 rdf:type schema:CreativeWork
    717 https://doi.org/10.1016/s0092-8674(85)80070-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001046047
    718 rdf:type schema:CreativeWork
    719 https://doi.org/10.1016/s0140-6736(98)04058-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039481418
    720 rdf:type schema:CreativeWork
    721 https://doi.org/10.1016/s0167-5699(98)01330-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051223592
    722 rdf:type schema:CreativeWork
    723 https://doi.org/10.1016/s0379-0738(01)00641-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015760573
    724 rdf:type schema:CreativeWork
    725 https://doi.org/10.1016/s1074-7613(00)80592-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036917513
    726 rdf:type schema:CreativeWork
    727 https://doi.org/10.1016/s1092-9134(00)90014-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005955950
    728 rdf:type schema:CreativeWork
    729 https://doi.org/10.1016/s1525-1578(10)60610-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020646902
    730 rdf:type schema:CreativeWork
    731 https://doi.org/10.1023/a:1008207005567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056302586
    732 rdf:type schema:CreativeWork
    733 https://doi.org/10.1046/j.1365-2141.1997.3653179.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041400833
    734 rdf:type schema:CreativeWork
    735 https://doi.org/10.1046/j.1365-2141.1998.00764.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015649878
    736 rdf:type schema:CreativeWork
    737 https://doi.org/10.1046/j.1365-2141.1998.00879.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009690983
    738 rdf:type schema:CreativeWork
    739 https://doi.org/10.1046/j.1365-2141.1999.01757.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024047326
    740 rdf:type schema:CreativeWork
    741 https://doi.org/10.1046/j.1365-2141.2001.02871.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004520106
    742 rdf:type schema:CreativeWork
    743 https://doi.org/10.1046/j.1365-2567.1998.00417.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005641787
    744 rdf:type schema:CreativeWork
    745 https://doi.org/10.1053/beha.2002.0184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008048548
    746 rdf:type schema:CreativeWork
    747 https://doi.org/10.1056/nejm198412063112304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023488026
    748 rdf:type schema:CreativeWork
    749 https://doi.org/10.1056/nejm198711053171904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031358812
    750 rdf:type schema:CreativeWork
    751 https://doi.org/10.1056/nejm199808273390904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045206858
    752 rdf:type schema:CreativeWork
    753 https://doi.org/10.1056/nejm199911113412007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016446570
    754 rdf:type schema:CreativeWork
    755 https://doi.org/10.1073/pnas.82.21.7439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047611732
    756 rdf:type schema:CreativeWork
    757 https://doi.org/10.1073/pnas.82.24.8624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009758889
    758 rdf:type schema:CreativeWork
    759 https://doi.org/10.1073/pnas.83.13.4890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022134791
    760 rdf:type schema:CreativeWork
    761 https://doi.org/10.1073/pnas.85.13.4869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027866661
    762 rdf:type schema:CreativeWork
    763 https://doi.org/10.1073/pnas.87.16.6146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002215683
    764 rdf:type schema:CreativeWork
    765 https://doi.org/10.1073/pnas.87.21.8536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037138218
    766 rdf:type schema:CreativeWork
    767 https://doi.org/10.1073/pnas.90.6.2433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000219698
    768 rdf:type schema:CreativeWork
    769 https://doi.org/10.1084/jem.164.1.315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000536240
    770 rdf:type schema:CreativeWork
    771 https://doi.org/10.1084/jem.167.2.694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047529639
    772 rdf:type schema:CreativeWork
    773 https://doi.org/10.1084/jem.172.2.609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000406828
    774 rdf:type schema:CreativeWork
    775 https://doi.org/10.1084/jem.172.6.1717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000369550
    776 rdf:type schema:CreativeWork
    777 https://doi.org/10.1084/jem.184.6.2217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018966773
    778 rdf:type schema:CreativeWork
    779 https://doi.org/10.1084/jem.188.11.2151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040336011
    780 rdf:type schema:CreativeWork
    781 https://doi.org/10.1093/ajcp/95.2.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031378440
    782 rdf:type schema:CreativeWork
    783 https://doi.org/10.1093/hmg/4.6.983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645455
    784 rdf:type schema:CreativeWork
    785 https://doi.org/10.1093/intimm/9.10.1503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004730934
    786 rdf:type schema:CreativeWork
    787 https://doi.org/10.1093/nar/27.16.e12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059931851
    788 rdf:type schema:CreativeWork
    789 https://doi.org/10.1093/nar/gkg085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022931353
    790 rdf:type schema:CreativeWork
    791 https://doi.org/10.1093/rheumatology/34.10.978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060011133
    792 rdf:type schema:CreativeWork
    793 https://doi.org/10.1097/00002371-199809000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038446426
    794 rdf:type schema:CreativeWork
    795 https://doi.org/10.1097/00019606-199503000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015451217
    796 rdf:type schema:CreativeWork
    797 https://doi.org/10.1097/00019606-199706000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022134126
    798 rdf:type schema:CreativeWork
    799 https://doi.org/10.1097/00019606-199712000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050477375
    800 rdf:type schema:CreativeWork
    801 https://doi.org/10.1097/00019606-200112000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050155394
    802 rdf:type schema:CreativeWork
    803 https://doi.org/10.1101/gr.7.3.250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029897232
    804 rdf:type schema:CreativeWork
    805 https://doi.org/10.1111/j.1365-2141.1990.tb07836.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036827783
    806 rdf:type schema:CreativeWork
    807 https://doi.org/10.1111/j.1365-2141.1993.tb03141.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045564277
    808 rdf:type schema:CreativeWork
    809 https://doi.org/10.1111/j.1365-2141.1993.tb08669.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001670352
    810 rdf:type schema:CreativeWork
    811 https://doi.org/10.1111/j.1365-2141.1994.tb04913.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047720759
    812 rdf:type schema:CreativeWork
    813 https://doi.org/10.1111/j.1365-2141.1995.tb08938.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034452207
    814 rdf:type schema:CreativeWork
    815 https://doi.org/10.1111/j.1600-0625.1993.tb00017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007802696
    816 rdf:type schema:CreativeWork
    817 https://doi.org/10.1111/j.1600-065x.1991.tb00591.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015839958
    818 rdf:type schema:CreativeWork
    819 https://doi.org/10.1126/science.272.5269.1755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553361
    820 rdf:type schema:CreativeWork
    821 https://doi.org/10.1126/science.3110950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062591676
    822 rdf:type schema:CreativeWork
    823 https://doi.org/10.1126/science.6610211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639178
    824 rdf:type schema:CreativeWork
    825 https://doi.org/10.1136/jcp.42.8.840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052081071
    826 rdf:type schema:CreativeWork
    827 https://doi.org/10.1136/jcp.44.11.924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030421714
    828 rdf:type schema:CreativeWork
    829 https://doi.org/10.1136/jcp.50.10.811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036043611
    830 rdf:type schema:CreativeWork
    831 https://doi.org/10.1136/jcp.54.5.401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052176926
    832 rdf:type schema:CreativeWork
    833 https://doi.org/10.1136/mp.52.2.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014151376
    834 rdf:type schema:CreativeWork
    835 https://doi.org/10.1136/mp.53.1.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001936506
    836 rdf:type schema:CreativeWork
    837 https://doi.org/10.1136/mp.53.1.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022056869
    838 rdf:type schema:CreativeWork
    839 https://doi.org/10.1136/mp.53.4.194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004691993
    840 rdf:type schema:CreativeWork
    841 https://doi.org/10.1159/000245709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001515924
    842 rdf:type schema:CreativeWork
    843 https://doi.org/10.1172/jci113270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028504791
    844 rdf:type schema:CreativeWork
    845 https://doi.org/10.1172/jci115044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024876558
    846 rdf:type schema:CreativeWork
    847 https://doi.org/10.1182/blood-2002-11-3456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009185168
    848 rdf:type schema:CreativeWork
    849 https://doi.org/10.1182/blood.v97.4.1001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123465
    850 rdf:type schema:CreativeWork
    851 https://doi.org/10.1182/blood.v97.9.2716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045783290
    852 rdf:type schema:CreativeWork
    853 https://doi.org/10.1182/blood.v98.1.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052668532
    854 rdf:type schema:CreativeWork
    855 https://doi.org/10.1182/blood.v99.12.4386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000372558
    856 rdf:type schema:CreativeWork
    857 https://doi.org/10.1182/blood.v99.2.716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001875292
    858 rdf:type schema:CreativeWork
    859 https://doi.org/10.1210/endo.137.11.8895354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064280572
    860 rdf:type schema:CreativeWork
    861 https://doi.org/10.1515/bchm3.1993.374.7-12.1001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004497483
    862 rdf:type schema:CreativeWork
    863 https://doi.org/10.4049/jimmunol.169.1.271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075073834
    864 rdf:type schema:CreativeWork
    865 https://doi.org/10.4049/jimmunol.170.5.2711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075240060
    866 rdf:type schema:CreativeWork
    867 https://doi.org/10.4049/jimmunol.171.2.524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075311920
    868 rdf:type schema:CreativeWork
    869 https://www.grid.ac/institutes/grid.10417.33 schema:alternateName Radboud University Nijmegen Medical Centre
    870 schema:name Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    871 rdf:type schema:Organization
    872 https://www.grid.ac/institutes/grid.14095.39 schema:alternateName Freie Universität Berlin
    873 schema:name lnstitute of Pathology, Free University Berlin, Berlin, Germany
    874 rdf:type schema:Organization
    875 https://www.grid.ac/institutes/grid.411258.b schema:alternateName Complejo Hospitalario de Salamanca
    876 schema:name Servicio de Hematologia, Hospital Universitario de Salamanca, Salamanca, Spain
    877 rdf:type schema:Organization
    878 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
    879 schema:name Department of Hematology, Hôpital Pitié-Salpétriere, Paris, France
    880 rdf:type schema:Organization
    881 https://www.grid.ac/institutes/grid.412134.1 schema:alternateName Necker-Enfants Malades Hospital
    882 schema:name Laboratoire d'Hematologie and INSERM EMI 210, Hôpital Necker-Enfants Malades, Paris, France
    883 rdf:type schema:Organization
    884 https://www.grid.ac/institutes/grid.412468.d schema:alternateName University Hospital Schleswig-Holstein
    885 schema:name II Medizinische Klinik des Universitätsklinikums Schleswig-Holstein, Campus Kiel, Kiel, Germany
    886 rdf:type schema:Organization
    887 https://www.grid.ac/institutes/grid.418189.d schema:alternateName UniCancer Group
    888 schema:name Laboratoire de Genetique Oncologique, Centre Henri Becquerel, Rouen, France
    889 rdf:type schema:Organization
    890 https://www.grid.ac/institutes/grid.418711.a schema:alternateName Portuguese Oncology Institute
    891 schema:name Department of Hematology, Instituto Portugués de Oncologia, Lisboa, Portugal
    892 rdf:type schema:Organization
    893 https://www.grid.ac/institutes/grid.430506.4 schema:alternateName University Hospital Southampton NHS Foundation Trust
    894 schema:name Wessex Immunology Service, Molecular Pathology Unit, Southampton University Hospitals NHS Trust, Southampton, UK
    895 rdf:type schema:Organization
    896 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
    897 schema:name Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
    898 Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    899 rdf:type schema:Organization
    900 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
    901 schema:name Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    902 rdf:type schema:Organization
    903 https://www.grid.ac/institutes/grid.5650.6 schema:alternateName Academic Medical Center
    904 schema:name Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    905 rdf:type schema:Organization
    906 https://www.grid.ac/institutes/grid.9909.9 schema:alternateName University of Leeds
    907 schema:name Academic Unit of Haematology and Oncology, University of Leeds, Leeds, UK
    908 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...