Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34+ subpopulation ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-11

AUTHORS

K Stahnke, S Eckhoff, A Mohr, L H Meyer, K-M Debatin

ABSTRACT

In vitro studies demonstrating the induction of programmed cell death by cytotoxic drugs used in anticancer chemotherapy suggested that antileukemic treatment eliminates leukemia cells by apoptosis. We therefore analyzed apoptosis induction and activation of apoptosis signaling molecules in patients receiving remission induction treatment for AML and ALL during the initial phase of leukemia cell reduction. A coexistence of distinct populations of CD34(+) and CD34(-) leukemia cells could be identified. During chemotherapy, CD34(+) leukemia cells were more rapidly depleted than CD34(-) cells. Furthermore, a significant increase in leukemia cell apoptosis ex vivo was detected in CD34(+) cells, while no such increase was observed in the CD34(-) subpopulation, suggesting that CD34(+) leukemia cells are the main targets for apoptosis induction through antileukemic treatment. No alterations in Bax and Bcl-2 expression were found during in vivo chemotherapy, and CD95 expression and sensitivity remained low, indicating the induction of apoptosis independent of the CD95 system or regulation of protein levels of Bax and Bcl-2. The data suggest that analysis of leukemia cell subpopulations is required for further identification of apoptosis signaling molecules relevant for response to treatment and assessment of drug efficacy in vivo and in vitro. More... »

PAGES

2403144

References to SciGraph publications

  • 2000-07. Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment in LEUKEMIA
  • 2002-02. Diversity of the apoptotic response to chemotherapy in childhood leukemia in LEUKEMIA
  • 1999-03. Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis in LEUKEMIA
  • 1999-10. The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0): reduced immunogenicity and high frequency of CD34+/CD38− leukemic progenitors in LEUKEMIA
  • 1997-12. High bcl-2 expression in acute myeloid leukemia cells correlates with CD34 positivity and complete remission rate in LEUKEMIA
  • 1994-02. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice in NATURE
  • 2000-01. Drug resistance factors in acute myeloid leukemia: a comparative analysis in LEUKEMIA
  • 1998-11. In AML t(8;21) colony growth of both leukemic and residual normal progenitors is restricted to the CD34+, lineage-negative fraction in LEUKEMIA
  • 1999-11. Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid in LEUKEMIA
  • 1999-12. Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics in LEUKEMIA
  • 1997-07. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell in NATURE MEDICINE
  • 1996-05. Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/sj.leu.2403144

    DOI

    http://dx.doi.org/10.1038/sj.leu.2403144

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010422430

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14523471


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